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| 20110296556 | POLYNUCLEOTIDE MOLECULES FOR GENE REGULATION IN PLANTS - This invention provides polynucleotide molecules and methods for regulating genes in plants, e.g., by providing RNA for systemic regulation of genes. Various aspects of the invention provide polynucleotide molecules and methods for regulating endogenous genes and transgenes in a plant cell and polynucleotide molecules. | 12-01-2011 |
| 20130047297 | POLYNUCLEOTIDE MOLECULES FOR GENE REGULATION IN PLANTS - This invention provides polynucleotide molecules and methods for regulating genes in plants, e. g., by providing RNA for systemic regulation of genes. Various aspects of the invention provide polynucleotide molecules and methods for regulating endogenous genes and transgenes in a plant cell and polynucleotide molecules. | 02-21-2013 |
| 20140018241 | Polynucleotide Molecules for Gene Regulation in Plants - This invention provides polynucleotide molecules and methods for regulating genes in plants, e.g., by providing RNA for systemic regulation of genes. Various aspects of the invention provide polynucleotide molecules and methods for regulating endogenous genes and transgenes in a plant cell and polynucleotide molecules. | 01-16-2014 |
| 20140057789 | Polynucleotide Molecules for Gene Regulation in Plants - This invention provides polynucleotide molecules and methods for regulating genes in plants, e.g., by providing RNA for systemic regulation of genes. Various aspects of the invention provide polynucleotide molecules and methods for regulating endogenous genes and transgenes in a plant cell and polynucleotide molecules. | 02-27-2014 |
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| 20110247094 | Transgenic Plants with Enhanced Agronomic Traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 10-06-2011 |
| 20120005773 | TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait. | 01-05-2012 |
| 20130145493 | Transgenic Plants with Enhanced Agronomic Traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits | 06-06-2013 |
| 20130298281 | TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 11-07-2013 |
| 20150135372 | Transgenic Plants With Enhanced Agronomic Traits - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits. | 05-14-2015 |
| 20150197764 | TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS - This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait. | 07-16-2015 |
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| 20100113465 | 7-AZASPIRO[3.5]NONANE-7-CARBOXAMIDE COMPOUNDS - Provided herein are 7-azaspiro[3.5]nonane-7-carboxamide compounds and the pharmaceutically acceptable salts of such compounds useful in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, conditions including including acute pain, chronic pain, neuropathic pain, nociceptive pain, inflammatory pain, cancer and cancer pain, fibromyalgia, rheumatoid arthritis, inflammatory bowel disease, lupus, diabetes, allergic asthma, vascular inflammation, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease. | 05-06-2010 |
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| 20120275262 | SECTION-ILLUMINATION PHOTOACOUSTIC MICROSCOPY WITH ULTRASONIC ARRAY DETECTION - Imaging systems, probes for imaging systems, and methods for noninvasive imaging are disclosed. In one example, a probe for use with an imaging system includes a slit configured to spatially filter a light beam from a light source. The probe includes a focusing device configured to cylindrically focus the spatially filtered light beam into an object, and an ultrasound transducer array configured to detect a photoacoustic signal emitted by the object in response to the cylindrically focused light beam. | 11-01-2012 |
| 20120307250 | OPTICAL TIME REVERSAL BY ULTRASONIC ENCODING IN BIOLOGICAL TISSUE - Generating an optical-phase conjugation of ultrasonically-modulated diffuse light emitted by a scattering medium includes illuminating the medium with a light beam from a coherent light source, modulating the diffuse light transmitted through the medium with an ultrasonic wave focused on a region of interest within the medium, and retro-reflectively illuminating the medium using a phase-conjugated copy of the diffuse light that was ultrasonically modulated. | 12-06-2012 |
| 20140028899 | IMAGING USING METAMATERIALS - A system for imaging an object is provided. The system includes a light source configured to emit light having a predetermined wavelength towards the object. The system further includes a metalens including a metallic film having a plurality of slits defined therethrough, the plurality of slits having a width a and a periodicity d that are both less than the predetermined wavelength, wherein the object is positioned between the light source and the metalens. The system further includes a detector configured to acquire measurements indicative of light transmitted through the metalens, and a computing device communicatively coupled to the detector and configured to reconstruct an image of the object based on the acquired measurements. | 01-30-2014 |
| 20140356897 | IN VIVO LABEL-FREE HISTOLOGY BY PHOTOACOUSTIC MICROSCOPY OF CELL NUCLEI - The present disclosure is directed to methods of non-invasively imaging cell nuclei. More particularly, the present disclosure is directed to methods of imaging cell nuclei in vivo using ultraviolet photoacoustic microscopy (UV-PAM), in which ultraviolet light is used to excite unlabeled DNA and RNA in cell nuclei to produce photoacoustic waves. | 12-04-2014 |
| 20150185187 | MULTI-FOCUS OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY WITH ULTRASONIC ARRAY DETECTION - A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest is disclosed. | 07-02-2015 |
| 20150272444 | COMPACT LASER AND EFFICIENT PULSE DELIVERY FOR PHOTOACOUSTIC IMAGING - A photoacoustic medical-imaging device includes a wavelength conversion assembly ( | 10-01-2015 |
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| 20090138215 | Photoacoustic Doppler Flow Sensing and Imaging - A method for measuring a fluid flow includes employing small light-absorbing particles as tracers that flow at the same speed as the fluid, measuring the photoacoustic Doppler shifts of the photoacoustic signals produced by these tracer particles, and determining, from the measurements, information about the flow including one or more of the flow speed, flow profile, and flow direction. | 05-28-2009 |
| 20090171210 | SONOELECTRIC TOMOGRAPHY USING A FREQUENCY-SWEPT ULTRASONIC WAVE - Sonoelectric tomography to achieve high-resolution bioelectric imaging. Bioelectrical signals originating from various locations in an object are ultrasonically encoded to carry different frequencies that vary with time via a frequency-swept signal or chirp. The frequency-sweeping parameters are chosen so that no frequencies are duplicated in the medium at any given time. The frequency distribution is decoded, for example, by means of the Fourier transformation to recover a bioelectric image with high spatial resolution. The spatial resolution of the image is defined by the ultrasonic frequency parameters, whereas the image contrast is derived from the bioelectric signals. In an embodiment, an ultrasonic transducer transmits a frequency-swept (e.g., chirped) ultrasonic wave into the region of interest in the tissue. The ultrasonic wave may be focused to achieve high transverse resolution within the focal zone. | 07-02-2009 |
| 20100079768 | OPTICAL COHERENCE COMPUTED TOMOGRAPHY - A system, method, and device for imaging a sample. In embodiments, a light from a low-coherence source or a wavelength-swept source is used to illuminate the sample. Pathlength-resolved intensity profiles of the light reemitted from the sample are recorded and measurements are taken. A reconstruction algorithm is used to invert the pathlength-resolved measurements to form an image. | 04-01-2010 |
| 20100268042 | CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION - A confocal photoacoustic microscopy system includes a laser configured to emit a light pulse, a focusing assembly configured to receive the light pulse and to focus the light pulse into an area inside an object, an ultrasonic transducer configured to receive acoustic waves emitted by the object in response to the light pulse, and an electronic system configured to process the acoustic waves and to generate an image of the area inside the object. The focusing assembly is further configured to focus the light pulse on the object in such a way that a focal point of the focusing assembly coincides with a focal point of the at least one ultrasonic transducer. | 10-21-2010 |
| 20110201914 | Reflection-Mode Photoacoustic Tomography Using A Flexibly-Supported Cantilever Beam - Noninvasively imaging biological tissue using a handheld device. A light pulse is focused into a predetermined area inside an object using a flexibly mounted cantilever beam, acoustic waves emitted by the object in response to the at least one light pulse are detected by a transducer, and an image of the predetermined area inside the object is generated based on a signal generated by the transducer representative of the acoustic waves. | 08-18-2011 |
| 20110251515 | IMPLANTABLE PRESSURE INDICATOR WITH EXTERNAL INTERROGATION - Observing intracranial physiology includes inserting a bladder at least partially filled with a fluid into a subdural region of interest within a subject, wherein the bladder is coupled in flow communication with a means of indicating a pressure exerted on the bladder within the region of interest. Embodiments also include non-invasively interrogating the means of indicating to determine the pressure exerted on the bladder. | 10-13-2011 |
| 20110275890 | MINIATURIZED PHOTOACOUSTIC IMAGING APPARATUS INCLUDING A ROTATABLE REFLECTOR - A reflection-mode photoacoustic endoscope includes a light source configured to emit a light pulse, a signal detection or transmission unit configured to detect or emit an ultrasonic pulse, and a rotatable reflector. The rotatable reflector is configured to reflect at least one of the light pulse and the ultrasonic pulse into a target area of an object, and reflect a response signal to the signal detection unit. The response signal is one of a photoacoustic wave generated by the object responsive to the light pulse and an ultrasonic pulse echo generated by the object responsive to the ultrasonic pulse. | 11-10-2011 |
| 20120204648 | MULTI-FOCUS OPTICAL-RESOLUTION PHOTOACOUSTIC MICROSCOPY WITH ULTRASONIC ARRAY DETECTION - A probe for use with an imaging system, including a scanning device configured to receive a first light beam from a light source, a beam-divider configured to split the first light beam into a plurality of second light beams, and a focusing device configured to focus each of the second light beams on respective locations in an object of interest. | 08-16-2012 |
| 20130131576 | CATHETER ASSEMBLY FOR USE WITH SHUNT SYSTEMS AND METHOD OF USING SAME - A catheter assembly for inserting in a fluid filled space in a body includes a main body having a first end portion and a second end portion. The first end portion is positionable within the fluid filled space and the second end portion is adapted to extend outward from the fluid filled space when the first end portion is positioned within the fluid filled space. The catheter assembly also includes a catheter tip that is connected to the second end portion. The catheter tip includes a housing having a cavity defined therein. The catheter tip also includes a rotating element positioned within the cavity. The rotating element is configured to rotate within the cavity to facilitate movement of the first end portion of the main body within the fluid filled space. | 05-23-2013 |
| 20130199299 | QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY - Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths. | 08-08-2013 |
| 20130245406 | CONFOCAL PHOTOACOUSTIC MICROSCOPY WITH OPTICAL LATERAL RESOLUTION - A method for determining a ratio of hemoglobin absorption within a biological tissue using a handheld device is provided. The method includes focusing at least one light pulse into a predetermined area inside an object using at least one excitation wavelength, wherein a fluorescence signal is based on at least a local excitation optical fluence and properties of fluorophores in the predetermined area. The method further includes receiving a photoacoustic signal emitted by the object in response to the at least one light pulse, the photoacoustic signal being a product of the local excitation optical fluence, an optical absorption coefficient of hemoglobin, and an acoustic detection sensitivity. The method further includes determining the ratio of hemoglobin absorption based on a hemoglobin absorption coefficient that is based at least partially on the fluorescence signal and the photoacoustic signal. | 09-19-2013 |
| 20150272446 | QUANTIFICATION OF OPTICAL ABSORPTION COEFFICIENTS USING ACOUSTIC SPECTRA IN PHOTOACOUSTIC TOMOGRAPHY - Accurately quantifying optical absorption coefficient using acoustic spectra of photoacoustic signals. Optical absorption is closely associated with many physiological parameters, such as the concentration and oxygen saturation of hemoglobin, and it can be used to quantify the concentrations of non-fluorescent molecules. A sample is illuminated by, for example, a pulsed laser and following the absorption of optical energy, a photoacoustic pressure is generated via thermo-elastic expansion. The acoustic waves then propagate and are detected by a transducer. The optical absorption coefficient of the sample is quantified from spectra of the measured photoacoustic signals. Factors, such as system bandwidth and acoustic attenuation, may affect the quantification but are canceled by dividing the acoustic spectra measured at multiple optical wavelengths. | 10-01-2015 |
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| 20080261941 | Biaryl Ether Urea Compounds - The present invention relates to compounds of Formula (I) | 10-23-2008 |
| 20110053982 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS - The present invention relates to compounds of the Formula (I), and pharmaceutically acceptable salts thereof, and their use in the treatment of FAAH-mediated diseases or condition. | 03-03-2011 |
| 20110144159 | ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS - The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-membered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease. | 06-16-2011 |
| 20110230493 | 1-OXA-8-Azaspiro [4,5] Decabe-8-Carboxamide Compounds as FAAH Inhibitors - Provided herein are 1-oxa-8-azaspiro[4.5]decane-8-carboxamide compounds of formula I | 09-22-2011 |
| 20130261129 | CHEMOKINE RECEPTOR ANTAGONISTS - Disclosed herein are chemokine receptor antagonists of formula (I) | 10-03-2013 |
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| 20140038194 | Method For Early Detection of Lung Cancer - The invention provides a blood-based noninvasive early lung cancer detection method, which investigates a panel of miRNA levels in a blood or plasma sample. The panel of miRNA includes miR-17, miR-21, miR-24, miR-106a, miR-125b, miR-128, miR-155, miR-182, miR-183, miR-197, miR-199b, miR-203, miR-205, miR-210, miR-221, and a combination thereof. Preferably, the panel of miRNA may include miR-21, miR-128, miR-155, miR-182, miR-183, and miR-197. The inventive method can not only detect stage I lung cancer patients with high accuracy, but also differentiate between all stages of lung cancer patients and lung cancer-free individuals, metastatic and non-metastatic lung cancer patients and monitor the significant changes of miRNA levels during chemotherapy. | 02-06-2014 |
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| 20100261904 | Preparation of Saturated Ketone Morphinan Compounds by Catalytic Isomerization - The present invention provides processes for the preparation of saturated ketone morphinan compounds by catalytic isomerization. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an allyl-transition metal catalyst. | 10-14-2010 |
| 20100261907 | Preparation of Saturated Ketone Morphinan Compounds - The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal. | 10-14-2010 |
| 20110071299 | One-Pot Preparation of Hexahydroisoquinolines from Amides - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 03-24-2011 |
| 20110071300 | One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 03-24-2011 |
| 20110082297 | Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts - An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives. | 04-07-2011 |
| 20110269963 | Preparation of Saturated Ketone Morphinan Compounds Having Low Metal Content - The present invention provides processes for the preparation of saturated ketone morphinan compounds from a morphinan comprising an allyl alcohol ring moiety, wherein the final product has a low metal content. In particular, the invention provides processes that utilize isomerization reactions catalyzed by transition metal catalysts and the subsequent removal of the transition metal using metal scavengers. | 11-03-2011 |
| 20120035366 | N-Demethylation of 6-Keto Morphinans - The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan. | 02-09-2012 |
| 20120035367 | Tandem Process for Preparing N-Alkyl Morphinans - The present invention provides processes for the preparation of N-alkyl morphinans without the isolation of nor-morphinan intermediates. In particular, the invention provides tandem hydrolysis/alkylation reactions for the synthesis of N-alkyl morphinans. | 02-09-2012 |
| 20130066080 | Production of Alkaloids without the Isolation of Intermediates - The invention relates to processes for the production of alkaloids without the isolation of intermediates. | 03-14-2013 |
| 20130137874 | One-Pot Preparation of Hexahydroisoquinolines from Amides - The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines. | 05-30-2013 |
| 20130203999 | One Pot Process for Producing 6-Hydroxyl Nal-Opiate - The present invention provides processes for preparing nal-opiates without the isolation of intermediates. In general, the process provides for alkylation and reduction in the same pot to give the nal-opiate. | 08-08-2013 |
| 20150099773 | PROCESS FOR THE PREPARATION OF QUATERNARY N-ALKYL MORPHINAN ALKALOID SALTS - An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives. | 04-09-2015 |
| 20150126741 | CONVENIENT PREPARATION OF N-SUBSTITUTED MORPHINAN-6-OLS FROM MORPHINAN-6-ONES - Described herein are methods of preparing 6-hydroxy N-alkyl morphinan-6-ols from morphinan-6-ones, as illustrated below: | 05-07-2015 |
| 20150126742 | PRODUCTION OF 6-HYDROXY MORPHINANS WITHOUT THE ISOLATION OF INTERMEDIATES - The present invention provides a process for preparing a saturated 6,14-dihydroxy morphinan. The process comprises contacting an unsaturated 6-O-hydrocarbyl morphinan with hydrogen peroxide and an organic acid to form an unsaturated 6-keto-14-hydroxy morphinan. The unsaturated 6-keto-14-hydroxy morphinan is contacted with a first reducing agent to form an unsaturated 6,14-dihydroxy morphinan, and the unsaturated 6,14-dihydroxy morphinan is contacted with a second reducing agent to form the saturated 6,14-dihydroxy morphinan. | 05-07-2015 |
| 20150141649 | PREPARATION OF NORMORPHINANS - The present invention provides processes for preparing normorphinans from N-substituted morphinans. In particular, the invention provides methods for removing the N-substituent from the N-substituted morphinan to from a normorphinan carbamate, and then removing the carbamate functionality from the normorphinan carbamate to form the normorphinan. | 05-21-2015 |
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| 20120270954 | METHODS FOR MAINTAINING EYE HEALTH AND AMELIORATING OPTHALMIC MALADIES IN CANINES - The invention provides novel methods for maintaining eye health and ameliorating ophthalmic maladies in canines by administering to the canines an ophthalmic malady ameliorating amount of one or more carotenes. Generally, the carotenes are administered to the canines in amounts of from about 0.1 to about 5000 mg or in amounts of from about 0.1 to about 500 mg per day to ameliorate maladies such as impaired vision, cataracts, cloudy eye, retinal degeneration, eye injury caused by radiation, reducing or preventing a decline of social interaction, promoting overall health and wellness, improving the quality of life, and extending the prime for canines. | 10-25-2012 |
| 20140107218 | METHODS FOR MAINTAINING EYE HEALTH AND AMELIORATING OPTHALMIC MALADIES IN ANIMALS - The invention provides novel methods for maintaining eye health and ameliorating ophthalmic maladies in animals by administering to the animals an ophthalmic malady ameliorating amount of one or more polyamines. Generally, the polyamines are administered to the animals in amounts of from about 1 to about 200 mg/kg/day to ameliorate maladies such as cataracts and cloudy eye. | 04-17-2014 |
| 20150201830 | DEVICES AND METHODS FOR MEASURING PARAMETERS ASSOCIATED WITH ANIMAL EYE HEALTH - The invention provides methods and devices for securing the head of an animal in position while obtaining objective measurements associated with eye health. In one aspect, the devices comprise a rest for receiving a portion of the animal's head and a pole configured to enable the rest to pivot about a first axis of rotation and rotate about a second axis of rotation perpendicular to the first axis of rotation. In an embodiment, the rest can move up and down the second axis of rotation. | 07-23-2015 |
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| 20090038546 | Preparation of Cured in Place Liner Using Resin Impregnation Tower - A method of continuously impregnating a resin impregnable cured in place liner in a resin impregnation tower is provided. A cured in place liner having at least one layer of resin impregnable material is fed into the top of the tower, drawn down about a roller at the bottom, removed from the top of the tower and then wrapped with an outer impermeable coating. The tower is filled with resin at a suitable height to provide a sufficient pressure head of resin to impregnate the resin impregnable material fully. The impregnated liner is suitable for inversion or the pull-in-and-inflate method of installation. For liners formed with an inner impermeable layer, the liner is suitable for curing with steam. | 02-12-2009 |
| 20140110368 | COUPLER KNUCKLE PIN - An improved polymeric knuckle pin with at least one indented area that elastomer rings rest in. The indented area is strategically placed in an area on the shaft of the pin where the coupler-knuckle connection exerts impact, force, and stress on the pin. The elastomer rings in the indented area provide cushion to the pin from the impact, force, and stress, allow the pin to avoid hard contact with the coupler and knuckle, distribute the loads exerted by the coupler and knuckle more evenly, realign the coupler and knuckle positions, and protect the pin itself from surface cuts and scratches. The elastomer rings on the shaft of the pin improve the life of both the coupler-knuckle assembly and the pin. | 04-24-2014 |
| 20140174317 | BRAKE BEAM PADDLE CAPS - A brake beam assembly for a railway car truck includes a brake beam configured to be mounted between opposed side frames of the railway car truck, a strut extending from the brake beam and brake heads coupled to the brake beam proximate to right hand and left hand ends thereof. Each brake head holds a brake shoe configured to engage a wheel of the railway car truck. Paddles extend exterior of the brake heads. The paddles have distal ends received in corresponding guide brackets of the side frames to guide movement of the brake beam. Paddle caps cover the distal ends of the paddles. The paddle caps are configured to be received in brake beam wear liners in corresponding side frames of the railway car truck. The paddle caps have a lower coefficient of friction than the paddles. | 06-26-2014 |
| 20140190307 | RAILCAR HANDBRAKE WHEEL - A railcar handbrake wheel of polymeric composition including an outer ring connected to a hub by at least two spokes. The hub containing an insert or core molded into the hub. The core is a shaft member having a first end and a second end, with a head connected to the first end. The head on the first end of the core having a greater cross-sectional area than the second end of the core. The core containing an opening extending from the first end to the second end. | 07-10-2014 |
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| 20130209391 | FUNCTIONALIZED POLYMER COMPOSITIONS - The invention relates to functionalized polymers including homopolymers and copolymers and their uses in industrial applications and in agricultural applications. In particular, the homopolymers and copolymers may be, for example, used in polymer blends, used as nutritives and in feed compositions, and used in combination with a pharmaceutical or nutritive. | 08-15-2013 |
| 20130209392 | HETEROATOM CONTAINING CYCLIC DIMERS - The present invention provides cyclic dimers of alpha acids and polymers derived therefrom. Also provided are processes for preparing and methods of using the cyclic dimers and the polymers derived from the cyclic dimers. | 08-15-2013 |
| 20150157577 | MATRIX AND LAYER COMPOSITIONS FOR PROTECTION OF BIOACTIVES - The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive. | 06-11-2015 |
| 20150191444 | HETEROATOM CONTAINING CYCLIC DIMERS - The present invention provides cyclic dimers of alpha acids and polymers derived therefrom. Also provided are processes for preparing and methods of using the cyclic dimers and the polymers derived from the cyclic dimers. | 07-09-2015 |
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| 20120221572 | CONTEXTUAL WEIGHTING AND EFFICIENT RE-RANKING FOR VOCABULARY TREE BASED IMAGE RETRIEVAL - Systems and methods are disclosed to search for a query image, by detecting local invariant features and local descriptors; retrieving best matching images by quantizing the local descriptors with a vocabulary tree; and reordering retrieved images with results from the vocabulary tree quantization. | 08-30-2012 |
| 20120243789 | FAST IMAGE CLASSIFICATION BY VOCABULARY TREE BASED IMAGE RETRIEVAL - Systems and methods are disclosed to categorize images by detecting local features for each image; applying a tree structure to index local features in the images; and extracting a rank list of candidate images with category tags based on a tree indexing structure to estimate a label of a query image. | 09-27-2012 |
| 20130336581 | MULTI-CUE OBJECT DETECTION AND ANALYSIS - Foreground objects of interest are distinguished from a background model by dividing a region of interest of a video data image into a grid array of individual cells that are each smaller than that a foreground object of interest. More particularly, image data of the foreground object of interest spans a contiguous plurality of the cells. Each of the cells are labeled as foreground if accumulated edge energy within the cell meets an edge energy threshold, if color intensities for different colors within each cell differ by a color intensity differential threshold, or as a function of combinations of said determinations in view of one or more combination rules. | 12-19-2013 |
| 20150063689 | MULTI-CUE OBJECT DETECTION AND ANALYSIS - Foreground objects of interest are distinguished from a background model by dividing a region of interest of a video data image into a grid array of individual cells. Each of the cells are labeled as foreground if accumulated edge energy within the cell meets an edge energy threshold, or if color intensities for different colors within each cell differ by a color intensity differential threshold, or as a function of combinations of said determinations. | 03-05-2015 |
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| 20120164390 | PROCESSES TO PATTERN SMALL FEATURES FOR ADVANCED PATTERNING NEEDS - Methods of forming microelectronic structure are provided. The methods comprise the formation of T-shaped structures using a controlled undercutting process, and the deposition of a selectively etchable composition into the undercut areas of the T-shaped structures. The T-shaped structures are subsequently removed to yield extremely small undercut-formed features that conform to the width and optionally the height of the undercut areas of the T-shaped structures. These methods can be combined with other conventional patterning methods to create structures having extremely small feature sizes regardless of the wavelength of light used for patterning. | 06-28-2012 |
| 20120264056 | METHOD OF MAKING RADIATION-SENSITIVE SOL-GEL MATERIALS - Radiation-sensitive sol-gel compositions are provided, along with methods of forming microelectronic structures and the structures thus formed. The compositions comprise a sol-gel compound and a base generator dispersed or dissolved in a solvent system. The sol-gel compound comprises recurring monomeric units comprising silicon with crosslinkable moieties bonded to the silicon. Upon exposure to radiation, the base generator generates a strong base, which crosslinks the sol-gel compound in the compositions to yield a crosslinked layer that is insoluble in developers or solvents. The unexposed portions of the layer can be removed to yield a patterned sol-gel layer. The invention can be used to form patterns from sol-gel materials comprising features having feature sizes of less than about 1 μm. | 10-18-2012 |
| 20130011630 | METAL-OXIDE FILMS FROM SMALL MOLECULES FOR LITHOGRAPHIC APPLICATIONS - Metal-oxide films for lithographic applications are provided. The films are formed from compositions comprising metal-oxide precursor compounds including metals and metalloids other than silicon. These films are easily produced and can be modified with a variety of ligands, including alkoxides, phenoxides, carboxylates, beta-diketones, and beta-ketoesters. | 01-10-2013 |
| 20130089716 | SPIN-ON CARBON COMPOSITIONS FOR LITHOGRAPHIC PROCESSING - The invention described herein is directed towards spin-on carbon materials comprising polyamic acid compositions and a crosslinker in a solvent system. The materials are useful in trilayer photolithography processes. Films made with the inventive compositions are not soluble in solvents commonly used in lithographic materials, such as, but not limited to PGME, PGMEA, and cyclohexanone. However, the films can be dissolved in developers commonly used in photolithography. In one embodiment, the films can be heated at high temperatures to improve the thermal stability for high temperature processing. Regardless of the embodiment, the material can be applied to a flat/planar or patterned surface. Advantageously, the material exhibits a wiggling resistance during pattern transfer to silicon substrate using fluorocarbon etch. | 04-11-2013 |
| 20130273330 | SILICON HARDMASK LAYER FOR DIRECTED SELF-ASSEMBLY - Compositions for directed self-assembly patterning techniques are provided which avoid the need for separate anti-reflective coatings and brush neutral layers in the process. Methods for directed self-assembly are also provided in which a self-assembling material, such as a directed self-assembly block copolymer, can be applied directly to the silicon hardmask neutral layer and then self-assembled to form the desired pattern. Directed self-assembly patterned structures are also disclosed herein. | 10-17-2013 |
| 20140356593 | SPIN-ON CARBON COMPOSITIONS FOR LITHOGRAPHIC PROCESSING - The invention described herein is directed towards spin-on carbon materials comprising polyamic acid compositions and a crosslinker in a solvent system. The materials are useful in trilayer photolithography processes. Films made with the inventive compositions are not soluble in solvents commonly used in lithographic materials, such as, but not limited to PGME, PGMEA, and cyclohexanone. However, the films can be dissolved in developers commonly used in photolithography. In one embodiment, the films can be heated at high temperatures to improve the thermal stability for high temperature processing. Regardless of the embodiment, the material can be applied to a flat/planar or patterned surface. Advantageously, the material exhibits a wiggling resistance during pattern transfer to silicon substrate using fluorocarbon etch. | 12-04-2014 |
