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| 20090197269 | Translocation and mutant CSF1R Kinase in human leukemia - In accordance with the invention, a novel gene translocation, (3p21, 5q33), in human myelogenous leukemia (AML) that results in a fusion protein combining part of RNA Binding Protein-6 (RBM6) with Macrophage Colony Stimulating Factor-1 Receptor (CSF1R) kinase has now been identified. The RBM6-CSF1R fusion protein and truncated CSF1R kinase itself, which both retain CSF1R tyrosine kinase activity, were confirmed to drive the proliferation and survival of acute megakaryoblastic leukemia (AML-M7). The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant CSF1R kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein and truncated kinase enables new methods for determining the presence of these mutant CSF1R kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 08-06-2009 |
| 20090285796 | MUTANT JAK3 KINASE IN HUMAN LEUKEMIA - In accordance with the invention, a novel activating mutation (alanine 572 to valine) in JAK3 kinase has been discovered in human acute myelogenous leukemia (AML). The mutant JAK3 kinase was confirmed to drive the proliferation and survival of acute megakaryoblastic leukemia (AML-M7). The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant JAK3 kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the mutant polypeptides. The disclosed identification of this new mutant protein and enables new methods for determining the presence of mutant JAK3 kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the mutant proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 11-19-2009 |
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| 20120329700 | SOLIDIFICATION MATRICES USING PHOSPHONOCARBOXYLIC ACID COPOLYMERS AND PHOSPHONOPOLYACRYLIC ACID HOMOPOLYMERS - Stability enhancement agents for use in a solidification matrices and solid detergent compositions are described. Stability enhancement is provided by a hydratable salt, water and phosphonocarboxylic acid copolymers or phosphonopolyacrylic acid homopolymers binding agents forming a dimensionally stable composition. Preferred phosphonocarboxylic acid copolymers or phosphonopolyacrylic acid homopolymers have phosphono end groups and a molecular weight of between about 1,000 and about 30,000 grams/mole. The stability enhancement composition for use in a solid detergent and solid detergent compositions are preferably biodegradable and substantially free of phosphorus and NTA-free. | 12-27-2012 |
| 20130109606 | STABILITY ENHANCEMENT AGENT FOR SOLID DETERGENT COMPOSITIONS | 05-02-2013 |
| 20140121150 | DETERGENT COMPOSITION COMPRISING ALKALI METAL HYDROXIDE AND METHODS OF MODIFYING A SURFACE - An alkaline detergent is described which includes the use of polycarboxylic acid copolymers or salts thereof in combination with alkali metal hydroxide. The detergent composition reduces spotting and filming and prevents hard water scale accumulation between 145-180 degrees Fahrenheit and with a pH of 10.5 to about 13. | 05-01-2014 |
| 20150099685 | ALKALINE DETERGENT COMPOSITION CONTAINING A CARBOXYLIC ACID/POLYALKYLENE OXIDE COPOLYMER FOR HARD WATER SCALE CONTROL - An alkaline detergent is described which includes the use of a copolymer in combination with an alkali metal hydroxide. The detergent maintains cleaning functions and also prevents hard water scaling, for example at application temperatures of between 145-180 degrees Fahrenheit and with a pH of 9.5 to about 13. | 04-09-2015 |
| 20150099686 | ALKALINE DETERGENT COMPOSITION CONTAINING A CARBOXYLIC ACID TERPOLYMER FOR HARD WATER SCALE CONTROL - A highly alkaline detergent is described which includes the use of a carboxylic acid terpolymer in combination with an alkali metal hydroxide. The detergent maintains cleaning functions and also prevents hard water scaling at application temperatures, for example at temperatures of between about 145-180 degrees Fahrenheit and, for example, at a pH of 9.5 to about 13. | 04-09-2015 |
| 20150099687 | SOLIDIFICATION MATRIX COMPRISING A CARBOXYLIC ACID TERPOLYMER - Stability enhancement agents for use in a solidification matrices and solid detergent compositions are described. Stability enhancement is provided by a hydratable salt, water and a carboxylic acid terpolymer forming a dimensionally stable solid compositions. Preferred carboxylic acid terpolymers include from about 40 to 90% by weight of a carboxylic acid monomer, anhydride or salt thereof, from about 4 to 40% by weight of a monomer comprising sulfo groups, and from about 4 to 40% by weight of a nonionic monomer set forth in formula (I). The stability enhancement composition for use in solid detergent compositions are preferably biodegradable and may be substantially free of phosphate and/or NTA-free and provide beneficial hard water scale control. | 04-09-2015 |
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| 20130252871 | CLEANING COMPOSITION INCLUDING A TERPOLYMER CONTAINING MALEIC ACID, VINYL ACETATE, AND ALKYL ACRYLATE MONOMERS FOR ENHANCED SCALE CONTROL - The present invention is related to a cleaning composition including at least one alkalinity source and a biodegradable terpolymer including maleic acid, vinyl acetate and alkyl acrylate segments or monomers for controlling scale. The diluted for use solution has a pH range of between about 9.5 and about 14. | 09-26-2013 |
| 20130252873 | METHOD FOR REDUCED ENCRUSTATION OF TEXTILES USING A POLYMER COMPRISING MALEIC ACID, VINYL ACETATE, AND ALKYL ACRYLATE - A laundry detergent composition includes an alkalinity source, at least one nonionic surfactant and a polymer comprising maleic acid, vinyl acetate and alkyl acrylate monomers. The alkalinity source is present in an amount between about 1% and about 75% by weight of the laundry detergent composition and includes at least one member selected from alkali metal hydroxides, carbonates, and bicarbonates. The polymer comprising maleic acid, vinyl acetate and alkyl acrylate monomers is present in an amount equal to or greater than about 0.5% by weight of the laundry detergent composition. | 09-26-2013 |
| 20140031273 | BIODEGRADABLE STABILITY BINDING AGENT FOR A SOLID DETERGENT - A solid composition includes a polysaccharide hybrid polymer composition and a hydratable salt. In one embodiment, the polysaccharide hybrid polymer composition includes a polysaccharide residue present in an amount from approximately 5% to 90% by weight of the polysaccharide hybrid polymer composition and a residue of at least one ethylenically unsaturated monomer present in an amount from approximately 10% to 75% by weight of the polysaccharide hybrid polymer composition. | 01-30-2014 |
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| 20140256611 | SOLIDIFICATION MATRICES USING PHOSPHONOCARBOXYLIC ACID COPOLYMERS AND PHOSPHONOPOLYACRYLIC ACID HOMOPOLYMERS - Stability enhancement agents for use in a solidification matrices and solid detergent compositions are described. Stability enhancement is provided by a hydratable salt, water and phosphonocarboxylic acid copolymers or phosphonopolyacrylic acid homopolymers binding agents forming a dimensionally stable composition. Preferred phosphonocarboxylic acid copolymers or phosphonopolyacrylic acid homopolymers have phosphono end groups and a molecular weight of between about 1,000 and about 30,000 grams/mole. The stability enhancement composition for use in a solid detergent and solid detergent compositions are preferably biodegradable and substantially free of phosphorus and NTA-free. | 09-11-2014 |
| 20140336097 | DETERGENT COMPOSITION COMPRISING ALKALI METAL HYDROXIDE AND METHODS OF MODIFYING A SURFACE - An alkaline detergent is described which includes the use of polycarboxylic acid copolymers or salts thereof in combination with alkali metal hydroxide. The detergent composition reduces spotting and filming and prevents hard water scale accumulation between 145-180 degrees Fahrenheit and with a pH of 10.5 to about 13. | 11-13-2014 |
| 20150105314 | BIODEGRADABLE STABILITY BINDING AGENT FOR A SOLID DETERGENT - A solid composition includes a polysaccharide hybrid polymer composition and a hydratable salt. In one embodiment, the polysaccharide hybrid polymer composition includes a polysaccharide residue present in an amount from approximately 5% to 90% by weight of the polysaccharide hybrid polymer composition and a residue of at least one ethylenically unsaturated monomer present in an amount from approximately 10% to 75% by weight of the polysaccharide hybrid polymer composition. | 04-16-2015 |
| 20150252295 | DETERGENT COMPOSITION COMPRISING A POLYMER THAT PERFORMS BOTH A CLEANING AND RINSING FUNCTION - Industrial 2-in-1 cleaning compositions providing both detergency and rinseability in a single cleaning composition comprising a polymer are disclosed. Alkali metal carbonate-based cleaning compositions and methods of both making and using the same provide user-friendly, solid, detergent compositions without the need for using a separate rinse aid composition. The compositions and methods are particularly well suited for use in industrial cleaning using alkali metal carbonate compositions that beneficially provide cleaning and rinseability in the rinse cycle. | 09-10-2015 |
| 20150252296 | DETERGENT COMPOSITION THAT PERFORMS BOTH A CLEANING AND RINSING FUNCTION - Industrial 2-in-1 cleaning compositions providing both detergency and rinseability in a single cleaning composition are disclosed. Alkali metal carbonate-based cleaning compositions and methods of both making and using the same provide user-friendly, solid, detergent compositions without the need for using a separate rinse aid composition. The compositions and methods are particularly well suited for use in industrial cleaning using alkali metal carbonate compositions that beneficially provide cleaning and rinseability in the rinse cycle. | 09-10-2015 |
| 20150272124 | ANTIMICROBIAL COMPOSITIONS CONTAINING CATIONIC ACTIVE INGREDIENTS - The antimicrobial composition of the present invention comprises a cationic active ingredient, a foam boosting surfactant, a foam boosting copolymer, a foam stabilizer, and a chelating agent. The present antimicrobial compositions are free of the antimicrobial agent triclosan (i.e., 2,4,4′-trichloro-2′hydroxy-diphenylether), have rapid cidal activity, provide stable copious foam and exhibit enhanced tissue (e.g. skin) compatibility as defined by an in vitro whole toxicology assessment method. | 10-01-2015 |
| 20150329804 | ALKALINE DETERGENT COMPOSITION CONTAINING A CARBOXYLIC ACID/POLYALKYLENE OXIDE COPOLYMER FOR HARD WATER SCALE CONTROL - An alkaline detergent is described which includes the use of a copolymer in combination with an alkali metal hydroxide. The detergent maintains cleaning functions and also prevents hard water scaling, for example at application temperatures of between 145-180 degrees Fahrenheit and with a pH of 9.5 to about 13. | 11-19-2015 |
| 20150329805 | ALKALINE DETERGENT COMPOSITION CONTAINING A CARBOXYLIC ACID TERPOLYMER FOR HARD WATER SCALE CONTROL - A highly alkaline detergent is described which includes the use of a carboxylic acid terpolymer in combination with an alkali metal hydroxide. The detergent maintains cleaning functions and also prevents hard water scaling at application temperatures, for example at temperatures of between about 145-180 degrees Fahrenheit and, for example, at a pH of 9.5 to about 13. | 11-19-2015 |
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| 20090077736 | Lavatory System - A lavatory system is disclosed to include one or more integrated hand washing stations. Each hand washing station includes a basin, a faucet, a solenoid valve configured to control water flow to the faucet, and a electric hand dryer located adjacent the basin and the faucet so that the user of the washing station may use the faucet and the electric hand dryer without leaving the washing station. The electric hand dryer preferably includes an outlet to direct air across the associated basin so that any water that drips from the user's hands will fall within the basin. A control system may be provided to control activation of the fixtures such as the solenoid valve, the electric hand dryer, and/or soap dispenser. The control system may be configured, for example, to inhibit simultaneous activation of the solenoid valve and the hand dryer. A photovoltaic system may be provided to provide power to one or more of electrical fixtures. | 03-26-2009 |
| 20090241263 | MEDICAL EXAMINATION TABLE - A medical examination table is provided. The medical examination table comprises a base providing a storage area, a patient support movable independent of the base between a lowered position and a raised position, and a lift mechanism coupled to the patient support for moving the patient support between the lowered position and the raised position. The patient support comprises a backrest and a seat. Movement of the patient support independent or separately from the base and without interfering with the storage areas within the base may allow for the efficient use of the examination table as a storage area. | 10-01-2009 |
| 20110047704 | MEDICAL EXAMINATION TABLE - A medical examination table is provided. The medical examination table comprises a base providing a storage area, a patient support movable independent of the base between a lowered position and a raised position, and a lift mechanism coupled to the patient support for moving the patient support between the lowered position and the raised position. The patient support comprises a backrest and a seat. Movement of the patient support independent or separately from the base and without interfering with the storage areas within the base may allow for the efficient use of the examination table as a storage area. | 03-03-2011 |
| 20120186018 | MEDICAL EXAMINATION TABLE - A medical examination table is provided. The medical examination table comprises a base providing a storage area, a patient support movable independent of the base between a lowered position and a raised position, and a lift mechanism coupled to the patient support for moving the patient support between the lowered position and the raised position. The patient support comprises a backrest and a seat. Movement of the patient support independent or separately from the base and without interfering with the storage areas within the base may allow for the efficient use of the examination table as a storage area. | 07-26-2012 |
| 20130067658 | Lavatory System - A lavatory system is disclosed including one or more integrated hand washing stations. Each hand washing station includes a basin, a faucet, a solenoid valve configured to control water flow to the faucet, and an electric hand dryer located adjacent the basin and the faucet so that the user of the washing station may use the faucet and the electric hand dryer without leaving the washing station. The electric hand dryer preferably includes an outlet to direct air across the associated basin so that any water that drips from the user's hands fall within the basin. A control system may be provided to control activation of the fixtures such as the solenoid valve, the electric hand dryer, and/or soap dispenser. The control system may be configured to inhibit simultaneous activation of the solenoid valve and the hand dryer. A photovoltaic system may be provided to provide power. | 03-21-2013 |
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| 20110132402 | MODULAR HUB CONSOLE FOR FLOOR CLEANING MACHINE - A floor surface maintenance vehicle including a frame, a plurality of wheels, a cleaning component extending from an underside of the frame, a steering wheel having a central aperture and rotatable about a central axis, and a steering wheel hub located within the central aperture of the steering wheel and having a panel, wherein the panel is stationary relative to the central axis. Buttons are provided on the panel, including a first button that is C-shaped and extends around a portion of a periphery of the panel. The C-shaped button may by used to control frequently used functions such as cleaning functions or operation of a horn, for example. | 06-09-2011 |
| 20110291840 | HAND HYGIENE COMPLIANCE SYSTEM - A system and method for performing hand hygiene compliance. The method includes receiving a notification that an individual has entered a physical location. The notification is received by a node in a wireless mesh network that includes a plurality of nodes corresponding to objects in the physical location. A hand hygiene protocol is identified for the individual. It is determined that the individual has not followed the hand hygiene protocol. The determining is performed by software executing on the nodes in the wireless mesh network and responsive to a previous and a current location of the individual relative to the objects in the physical location. The individual is notified in response to determining that the individual has not followed the hand hygiene protocol. | 12-01-2011 |
| 20150235550 | HAND HYGIENE COMPLIANCE SYSTEM - A system and method for performing hand hygiene compliance. The method includes receiving a notification that an individual has entered a physical location. The notification is received by a node in a wireless mesh network that includes a plurality of nodes corresponding to objects in the physical location. A hand hygiene protocol is identified for the individual. It is determined that the individual has not followed the hand hygiene protocol. The determining is performed by software executing on the nodes in the wireless mesh network and responsive to a previous and a current location of the individual relative to the objects in the physical location. The individual is notified in response to determining that the individual has not followed the hand hygiene protocol. | 08-20-2015 |
