Patent application number | Description | Published |
20100029634 | Chemokine Receptor Modulators - The invention provides compounds of Formula (I) | 02-04-2010 |
20130102677 | NOVEL SOLID FORMS OF TACEDINALINE - Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed. | 04-25-2013 |
20130150450 | NOVEL SOLID FORMS OF TACEDINALINE - Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Forms A, B, and D, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Forms A, B, and D, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed. | 06-13-2013 |
20130172330 | Chemokine Receptor Modulators - The invention provides compounds of Formula (I) | 07-04-2013 |
20140275268 | NOVEL SOLID FORMS OF TACEDINALINE - Novel solid forms of tacedinaline (4-(acetylamino)-N-(2-aminophenyl)benzamide), including crystalline tacedinaline Form B, a novel crystalline tacedinaline TFA salt, and amorphous tacedinaline, are disclosed. Pharmaceutical compositions comprising crystalline tacedinaline Form B, the novel crystalline tacedinaline TFA salt, and/or amorphous tacedinaline, and methods of treating various conditions by administering those novel solid forms, are also disclosed. | 09-18-2014 |
20140335550 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY - The invention relates to a compound of Formula I: | 11-13-2014 |
Patent application number | Description | Published |
20140080800 | Inhibitors of Histone Deacetylase - The present invention relates to compounds of formula (I): | 03-20-2014 |
20140080802 | Inhibitors of Histone Deacetylase - The present invention relates to compounds of formula (I): | 03-20-2014 |
20140107141 | KINASE INHIBITORS AND METHODS OF USE THEREOF - The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychriatic disorders, metabolic disorders, and cancer. | 04-17-2014 |
20150191427 | INHIBITORS OF HISTONE DEACETYLASE - The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X | 07-09-2015 |
20150313890 | KINASE INHIBITORS AND METHODS OF USE THEREOF - The present invention provides compounds of formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting kinase (e.g., GSK3 (e.g., GSK3α or GSK3β) or CK1) activity. The present invention further provides methods of using the compounds described herein for treating kinase-mediated disorders, such as neurological diseases, psychiatric disorders, metabolic disorders, and cancer. | 11-05-2015 |
20150368221 | CYCLOALKENYL HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS - The present invention provides compounds of formula (I) or a pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein W, X, n, s, t, and Ra are as described herein. The present invention relates generally to selective inhibitors of histone deacetylase and to methods of making and using them. | 12-24-2015 |
Patent application number | Description | Published |
20100144805 | Regulation of protein synthesis - A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins. | 06-10-2010 |
20100273676 | HIGH THROUGHPUT SCREENS FOR SMALL-MOLECULE INHIBITORS OF THE NUCLEAR RECEPTOR-LIKE PATHWAY REGULATING MULTIDRUG RESISTANCE IN FUNGI - The present invention relates to the identification of molecular mechanisms associated with multidrug resistance (MDR) in fungal infections. More specifically, fungi harbor a nuclear receptor-like pathway controlling MDR, which represents a novel therapeutic target for the treatment of MDR in pathogenic fungi such as | 10-28-2010 |
20110033522 | REAGENTS FOR INDUCING AN IMMUNE RESPONSE - The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell. | 02-10-2011 |
20130178505 | Compounds for the Inhibition of Cellular Proliferation - Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein. | 07-11-2013 |
20150374707 | Methods and Compounds for the Inhibition of Cellular Proliferation - Methods for inhibiting translation, treating a cellular proliferative disorder, and inhibiting proliferation of cells using the compounds disclosed herein are provided. | 12-31-2015 |
Patent application number | Description | Published |
20090026370 | PIXEL ARCHITECTURE FOR THERMAL IMAGING SYSTEM - A thermal imaging device including: a substrate; and an array of thermally tunable pixel elements for generating a thermal image, each thermally tunable pixel element including: a plurality of thermally tunable filter islands, each of which has a thermally tunable optical filter, wherein each of the plurality of tunable filter islands within that pixel element is thermally isolated from the other tunable filter islands within that tunable pixel element; an absorption structure for absorbing incident optical thermal energy; and a mechanical structure supporting the plurality of tunable filter islands and the absorption structure on the substrate. | 01-29-2009 |
20090195859 | METHOD OF SPATIALLY SEPARATING WAVELENGTHS OF MULTI-WAVELENGTH SIGNAL USING ELECTRONICALLY CONTROLLED THERMAL STRUCTURE - A thin-film interference filter structure has a generally wavelength-dependent resonant response to incident optical energy in a predetermined range of wavelengths. The thin-film interference filter structure includes a thermally tunable layer having a thermally tunable optical characteristic such that a range of wavelength-dependent resonant optical responses of the thermally tunable layer are induced by a corresponding range of thermal conditions of the thermally tunable layer. The thin-film interference filter structure is configured to (1) receive a spatially varying pattern of thermal energy at the thermally tunable layer to impart a corresponding spatially varying pattern to the thermally tunable characteristic of the thermally tunable layer, and (2) receive the incident optical energy into the thermally tunable layer and output optical energy having spatial modulation corresponding to the spatially varying pattern of the thermally tunable characteristic. | 08-06-2009 |
20110169960 | VIDEO ENHANCEMENT SYSTEM - A video system includes first and second sensors generating respective primary and secondary video sequences of images of a scene. The first sensor is responsive to thermal infrared (IR) energy, and the second sensor is responsive to shorter-wavelength optical energy in a range from visible to near-IR wavelengths. The sensors are temporally and spatially registered. A motion estimation module generates an estimated motion vector field from the secondary video sequence, and a motion-based image processor applies one or more image-enhancement operations to the primary video sequence based on the estimated motion vector field. The video system may include an additional sensor motion estimation module operating on the primary video stream as well as a merging module that combines the estimated motion vector fields from the sensor motion estimation modules to produce a joint motion vector field having generally more precise motion estimation, further improving the quality of the enhanced video stream from the image processor. | 07-14-2011 |
20110254952 | SYSTEM FOR PRODUCING ENHANCED THERMAL IMAGES - An imaging device has a thermal sensor to remotely measure respective temperatures of regions within an imaging field and to generate temperature information signals. A motion tracking system tracks motion of the thermal sensor and generates position information signals representing positions of the thermal sensor during the temperature measurements. An image construction processor uses the position and temperature information signals to generate a two-dimensional image representative of the imaging field including respective temperature indications at different locations within the two-dimensional image, and stores the two-dimensional image within a memory. The two-dimensional image may be used as an output image for display to a user. | 10-20-2011 |
20120122084 | SYSTEM FOR IDENTIFYING AND SORTING LIVING CELLS - In embodiments of the present invention, a system and method of cytometry may include presenting a single sperm cell to at least one laser source configured to deliver light to the sperm cell in order to induce bond vibrations in the sperm cell DNA, and detecting the signature of the bond vibrations. The bond vibration signature is used to calculate a DNA content carried by the sperm cell which is used to identify the sperm cell as carrying an X-chromosome or Y-chromosome. Another system and method may include flowing cells past at least one QCL source one-by-one using a fluid handling system, delivering QCL light to a single cell to induce resonant mid-IR absorption by one or more analytes of the cell, and detecting, using a mid-infrared detection facility, the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a cell characteristic. | 05-17-2012 |
20120145903 | SYSTEM FOR PRODUCING ENHANCED THERMAL IMAGES - An imaging device has a thermal sensor to remotely measure respective temperatures of regions within an imaging field and to generate temperature information signals. A motion tracking system tracks motion of the thermal sensor and generates position information signals representing positions of the thermal sensor during the temperature measurements. An image construction processor uses the position and temperature information signals to generate a two-dimensional image representative of the imaging field including respective temperature indications at different locations within the two-dimensional image, and stores the two-dimensional image within a memory. The two-dimensional image may be used as an output image for display to a user. | 06-14-2012 |
20120196356 | COMBINED INSPECTION SYSTEM INCLUDING MID-IR VIBRATIONAL SPECTROSCOPY AND A FLUORESCENT CYTOMETRY FACILITY - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source configured to deliver light to a cell within the cells in order to induce resonant mid-infrared absorption by one or more analytes of the cell. The system includes a laser source that excites at least one fluorophore present in the cell or on the surface of the cell and a fluorescence detector that measures the fluorescence intensity of the fluorophore. A mid-infrared detection facility detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light and the fluorescence intensity are used to identify at least one cell characteristic. | 08-02-2012 |
20120199741 | MINIMALLY INVASIVE CYTOMETRY SYSTEM USING QCL VIBRATIONAL SPECTROSCOPY FOR DIFFERENTIATION OF PLURIPOTENT STEM CELLS FROM FUNCTIONALLY DIFFERENTIATED CELLS BASED ON INSPECTION OF SINGLE CELLS - This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The cytometry system also includes a detection facility that detects the transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify the differentiation status of the cell as either pluripotent or functionally differentiated. | 08-09-2012 |
20120199742 | SINGLE PARTICLE QCL-BASED MID-IR SPECTROSCOPY SYSTEM WITH ANALYSIS OF SCATTERING - This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information. | 08-09-2012 |
20120202277 | MINIMALLY INVASIVE CYTOMETRY SYSTEM WITH QCL INSPECTION OF SINGLE CELLS FOR CANCER DETECTION - This disclosure concerns a minimally invasive cytometry system including a handling system that presents single cells to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The cytometry system also includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either cancerous or non-cancerous. | 08-09-2012 |
20120202278 | SYSTEM AND METHOD FOR REPEAT MEASUREMENT OF SINGLE CELLS USING VIBRATIONAL SPECTROSCOPY - This disclosure concerns a high-throughput cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light successively to single cells over a time period in order to make successive measurements of induced resonant mid-infrared absorption by one or more analytes of the cells. The cytometry system also includes a mid-infrared detection facility that detects the successively transmitted mid-infrared wavelength light, wherein the transmitted mid-infrared wavelength light is used to identify a changing cell characteristic over the time period. | 08-09-2012 |
20120204628 | USE OF VIBRATIONAL SPECTROSCOPY FOR DNA CONTENT INSPECTION - This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to calculate a DNA content carried by the cell. | 08-16-2012 |
20120225474 | SYSTEM AND METHOD FOR PATHOGEN DETECTION AND IDENTIFICATION - This disclosure concerns a pathogen inspection system that includes a handling system that presents single cells from a sample to at least one QCL laser source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce vibrational bond absorption in one or more analytes within the cell. The system includes a detection facility that detects the mid-infrared wavelength light transmitted by the cell and identifies the cell as either a pathogen or not a pathogen. | 09-06-2012 |
20120225475 | CYTOMETRY SYSTEM WITH QUANTUM CASCADE LASER SOURCE, ACOUSTIC DETECTOR, AND MICRO-FLUIDIC CELL HANDLING SYSTEM CONFIGURED FOR INSPECTION OF INDIVIDUAL CELLS - This disclosure concerns a cytometry system including a handling system that presents single cells to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to a cell within the cells in order to induce resonant mid-IR vibrational absorption by one or more analytes, leading to local heating that results in thermal expansion and an associated shockwave. An acoustic detection facility that detects the shockwave emitted by the single cell. | 09-06-2012 |
20120281098 | SYSTEM FOR PRODUCING ENHANCED THERMAL IMAGES - An imaging device has a thermal sensor to remotely measure respective temperatures of regions within an imaging field and to generate temperature information signals. A motion tracking system tracks motion of the thermal sensor and generates position information signals representing positions of the thermal sensor during the temperature measurements. An image construction processor uses the position and temperature information signals to generate a two-dimensional image representative of the imaging field including respective temperature indications at different locations within the two-dimensional image, and stores the two-dimensional image within a memory. The two-dimensional image may be used as an output image for display to a user. | 11-08-2012 |
20130252237 | CYTOMETRY SYSTEM WITH INTERFEROMETRIC MEASUREMENT - This disclosure concerns methods and apparatus for interferometric spectroscopic measurements of particles with higher signal to noise ratio utilizing an infrared light beam that is split into two beams. At least one beam may be directed through a measurement volume containing a sample including a medium. The two beams may then be recombined and measured by a detector. The phase differential between the two beams may be selected to provide destructive interference when no particle is present in the measurement volume. A sample including medium with a particle is introduced to the measurement volume and the detected change resulting from at least one of resonant mid-infrared absorption, non-resonant mid-infrared absorption, and scattering by the particle may be used to determine a property of the particle. A wide range of properties of particles may be determined, wherein the particles may include living cells. | 09-26-2013 |
20140091014 | SINGLE PARTICLE QCL-BASED MID-IR SPECTROSCOPY SYSTEM WITH ANALYSIS OF SCATTERING - This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information. | 04-03-2014 |
20150192511 | USE OF VIBRATIONAL SPECTROSCOPY FOR DNA CONTENT INSPECTION - This disclosure concerns a cytometry system including a handling system that enables presentation of single cells to at least one laser source. The laser source is configured to deliver light to a cell within the cells in order to induce bond vibrations in the cellular DNA. The system further includes a detection facility that detects the signature of the bond vibrations, wherein the bond vibration signature is used to determine the folding or packing of the DNA. | 07-09-2015 |
20150276589 | MOTION MODULATION FLUIDIC ANALYZER SYSTEM - A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Motion control devices determine position of the interrogation region. Flow-control devices conduct analyte and reference fluids and manipulate fluid flow in response to control signals to position a fluid boundary across the interrogation region. A controller (1) generates a time-varying motion modulation signal to move the interrogation region across the fluid boundary, (2) samples an output signal from the optical detector at one time in which the interrogation region contains more analyte fluid than reference fluid and at a time at which the interrogation region contains more reference fluid than analyte fluid, thereby generating corresponding output signal samples, and (3) determines from the output signal samples a measurement value indicative of an optically measured characteristic of the analyte fluid. | 10-01-2015 |
Patent application number | Description | Published |
20110183863 | PROTEIN SCREENING METHODS - The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro. | 07-28-2011 |
20120004137 | IDENTIFICATION OF NUCLEIC ACID DELIVERY VEHICLES USING DNA DISPLAY - The present invention features methods and compositions for the identification of molecules that facilitate the intracellular delivery of a, e.g., nucleic acid molecule. The methods and compositions of the invention utilize any display methodology wherein a library (e.g., a small molecule or protein library) is coupled to a nucleic acid (e.g., RNA or DNA) that encodes each library member. | 01-05-2012 |
20120107840 | Methods for Label Free Testing of Cells - The invention provides methods of detecting activation of an immune cell, methods for detecting blocking or enhancing properties of a test reagent or stimuli on activation of one or more immune cells or platelets, methods for selecting hybridomas producing antibodies to an antigen for quality of strength of binding to the antigen, methods for determining if a subject has had an immune response to an immunogen, methods of isolating neutralizing antibodies for an immunogen, methods of classifying a B cell lymphoma, and methods for selecting activated B-cells expressing an antibody to one or more antigens. | 05-03-2012 |
20130177572 | PDGF RECEPTOR BETA BINDING POLYPEPTIDES - The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFRβ) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention. | 07-11-2013 |
20140113831 | ANTIBODY SCREENING METHODS - Provided are methods and compositions for the production of novel antibodies that bind specifically to a target anti gen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody. | 04-24-2014 |
20140315762 | METHODS FOR TAGGING DNA-ENCODED LIBRARIES - The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation. | 10-23-2014 |
20150299335 | BI-SPECIFIC ANTIGEN-BINDING POLYPEPTIDES - The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention. | 10-22-2015 |
Patent application number | Description | Published |
20130223709 | SYSTEMS FOR DETECTING A CONDITION - The invention generally relates to systems for measuring impedance change in order to detect a condition. In certain aspects, the invention provides systems for monitoring tissue and detecting a condition that include at least one energy source, a transduction unit, and a pattern recognition component that compares impedance signatures recorded from the transduction unit with a database of impedance signatures associated with medical conditions. | 08-29-2013 |
20140148726 | METHODS FOR DETECTING A CONDITION - The invention generally relates to methods for measuring impedance change detecting a condition. In certain embodiments, the invention provides a method for detecting a condition that involves measuring impedance change over time in a region of tissue suspected to be associated with a condition to obtain an impedance signature, and comparing the impedance signature to a reference signature, thereby detecting the condition. | 05-29-2014 |
20140276249 | SYSTEMS AND METHODS FOR STIMULATING CELLULAR FUNCTION IN TISSUE - The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue. | 09-18-2014 |
20140357934 | SYSTEMS AND METHODS FOR CHANGING TISSUE IMPEDANCE IN A REGION OF A BIOLOGICALLY GENERATED FIELD - The present invention generally relates to systems and methods for changing tissue impedance in a region of a biologically generated field. In certain embodiments, the invention provides methods for changing tissue impedance in a region of a biologically generated field that involve applying focused energy to a region of charged particles in a region of tissue that includes a biologically based field, whereby the energy provided to the region of charged particles results in an impedance change to the region of tissue. | 12-04-2014 |
20140378740 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 12-25-2014 |
20150025421 | STIMULATION TO GUIDE PHYSICAL THERAPY - The invention generally relates to methods for guiding physical therapy to a subject. In certain embodiments, methods of the invention involve providing stimulation to a subject's central nervous system to modulate one or more signals sent to or from a plurality of target regions of the subject. Methods of the invention further involve assessing the response of the plurality of target regions to the stimulation to determine if there is a differential response among the target regions to the stimulation, and providing focused physical therapy to at least one of the target regions based on the assessment of the response of the plurality of peripheral target regions to the stimulation. | 01-22-2015 |
20150039055 | INTERFACE APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue. | 02-05-2015 |
20150105702 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 04-16-2015 |
20150119629 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 04-30-2015 |
20150148713 | INTERFACE APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue. | 05-28-2015 |
20150151123 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 06-04-2015 |
20150246248 | SYSTEMS AND METHODS FOR STIMULATING CELLULAR FUNCTION IN TISSUE - The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue. | 09-03-2015 |
20150343213 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 12-03-2015 |
20150360026 | SYSTEMS AND METHODS FOR SYNCHRONIZING THE STIMULATION OF CELLULAR FUNCTION IN TISSUE - The present invention generally relates to systems and methods for stimulating tissue using synchronized energy from multiple sources. In certain embodiments, the invention provides a system for stimulating tissue that includes a first energy source, a second energy source, and a synchronizing element that synchronizes the two energies such that the combined effect stimulates the tissue. | 12-17-2015 |
Patent application number | Description | Published |
20100070006 | INTERFACE APPARATUS FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for interfacing between tissues being stimulated is provided. The apparatus includes an electric source capable of generating an applied electric field across a region of tissue and/or a means for altering at least one electromagnetic characteristic of the region of tissue relative to the applied electric field and an interface component, such interface component creating an interface between the region of tissue and the applied electric field or the means for altering at least one electromagnetic characteristic of the region of tissue. | 03-18-2010 |
20110245734 | TREATMENT METHODS - The invention generally relates to methods for treating osteoarthritis. In certain embodiments, methods of the invention involve providing stimulation to a subject's central nervous system to modulate a signal sent to or from the subject's joint, thereby treating osteoarthritis. | 10-06-2011 |
20110264013 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 10-27-2011 |
20110275927 | SYSTEMS AND METHODS FOR STIMULATING AND MONITORING BIOLOGICAL TISSUE - The invention generally relates to apparatuses and methods for stimulating and monitoring biological tissue. In certain aspects, the invention provides a system for stimulating and monitoring tissue, the system including a first energy source, a second energy source, and an imaging device, in which the system is configured such that the first and second energy sources target the same region of tissue and the combined effect of the first and second energy sources stimulates the region of tissue. | 11-10-2011 |
20110275963 | SYSTEMS AND METHODS FOR STIMULATING TISSUE USING FOCUSED ENERGY - The present invention generally relates to systems and methods for stimulating tissue using focused energy. In certain embodiments, the invention provides a system for stimulating tissue that includes a first energy source, a second energy source, and a focusing element that focuses at least the first or second energy source so that the first and second energy sources target the same region of tissue such that the combined effect stimulates the tissue. | 11-10-2011 |
20120004580 | APPARATUS AND METHOD FOR STIMULATION OF BIOLOGICAL TISSUE - An apparatus for generating focused currents in biological tissue is provided. The apparatus comprises an electric source capable of generating an electric field across a region of tissue and means for altering the permittivity of the tissue relative to the electric field, whereby a displacement current is generated. The means for altering the permittivity may be a chemical source, optical source, mechanical source, thermal source, or electromagnetic source. | 01-05-2012 |
20120109020 | METHODS FOR MODIFYING NEURAL TRANSMISSION PATTERNS - The invention generally relates to methods for modifying neural transmission patterns. In certain embodiments, methods of the invention involve noninvasively applying a first type of energy to a region of neural tissue, noninvasively applying a second type of energy to the region of tissue, such that the combined effect modifies a neural transmission pattern between cells of the neural tissue. | 05-03-2012 |
20120226200 | METHODS OF STIMULATING TISSUE BASED UPON FILTERING PROPERTIES OF THE TISSUE - The invention generally relates to methods of stimulating tissue based upon filtering properties of the tissue. In certain aspects, the invention provides methods for stimulating tissue that involve analyzing at least one filtering property of a region of at least one tissue, and providing a dose of energy to the at least one region of tissue based upon results of the analyzing step. | 09-06-2012 |
20130053905 | SYSTEMS AND METHODS FOR STIMULATING CELLULAR FUNCTION IN TISSUE - The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue. | 02-28-2013 |