Wagers
Amy Wagers US
| Patent application number | Description | Published |
|---|---|---|
| 20160120945 | Thymic Regeneration - Methods for regenerating thymic tissues, e.g., for the treatment of subjects who have thymic insufficiency, i.e., whose thymic tissues are absent or atrophied due to illness, age, or injury, by administration of growth differentiation factor 11 (GDF11). | 05-05-2016 |
Amy Wagers, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090220453 | ENHANCING STEM CELL MOBILIZATION - This invention relates to methods and compositions for enhancing hematopoietic stem cell mobilization by inhibiting early growth response-1 (egr1) activity. | 09-03-2009 |
| 20140112898 | UNIQUE POPULATION OF REGULATORY T CELLS THAT REGULATE TISSUE REGENERATION AND WOUND HEALING - A unique type of regulatory T cell has been identified in muscle. These tissue-regenerative Treg cells play a role in regulating wound healing. These cells, as well as agents that control their differentiation and/or activity and agents produced by the cells, can be used to modulate wound healing and the differentiation of muscle cells. | 04-24-2014 |
| 20160120945 | Thymic Regeneration - Methods for regenerating thymic tissues, e.g., for the treatment of subjects who have thymic insufficiency, i.e., whose thymic tissues are absent or atrophied due to illness, age, or injury, by administration of growth differentiation factor 11 (GDF11). | 05-05-2016 |
Amy Wagers, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20150045297 | GROWTH DIFFERENTIATION FACTOR (GDF) FOR TREATMENT OF DIASTOLIC HEART FAILURE - The technology described herein relates to treatments for, e.g., diastolic heart failure, cardiac hypertrophy, and related conditions. | 02-12-2015 |
| 20150250826 | ISOLATION AND CHARACTERIZATION OF MUSCLE REGENERATING CELLS - Cell populations enriched for human myogenic progenitors are obtained by selection on the basis of expression of specific cell surface markers. The muscle progenitor cells are characterized as being CD45−, Mac-1−, GlycophorinA−, CD31− and CD34−, ITGA7hi and CD56 intermediate and methods of use thereof. Methods are provided for the separation and characterization of human myogenic cells, which are precursor cells having the ability to form muscle. The cells are identified and isolated from cells found within the pool of muscle satellite cells, located beneath the basal lamina of mature muscle fibers in the muscle tissue. | 09-10-2015 |
Amy J. Wagers, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20140294855 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION - The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject. | 10-02-2014 |
| 20150147807 | HIGH-THROUGHPUT IMAGE-BASED CHEMICAL SCREENING IN ZEBRAFISH BLASTOMERE CELL CULTURE - Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof. Also disclosed is a screening assay for screening test compounds using blastomere cultures. | 05-28-2015 |
| 20160074477 | METHODS AND COMPOSITIONS FOR REJUVENATING SKELETAL MUSCLE STEM CELLS - Methods and compositions for rejuvenating skeletal muscle stem cells are disclosed. | 03-17-2016 |
Amy Jo Wagers, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20160046951 | COMPOSITIONS AND METHODS FOR BACTERIAL DELIVERY OF POLYPEPTIDES - The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria comprising a type three secretion system (T3SS) and T3SS-compatible substrates. In one aspect, described herein are non-pathogenic microbial cells that have been engineered to express both a functional type three secretion system (T3SS) and at least one polypeptide that is compatible with the T3SS. Due to the wide variety of polypeptides that can be delivered to a target eukaryotic cell using the compositions and systems described herein, a commensurately wide variety of applications is contemplated, e.g. therapeutics and reprogramming. | 02-18-2016 |
Jesse Wagers, Sioux Falls, SD US
| Patent application number | Description | Published |
|---|---|---|
| 20130175133 | WRAP SPRING CLUTCH ACTUATOR AND METHODS FOR SAME - A wrap spring clutch system includes one or more wrap spring clutch assemblies each having a latching actuator assembly. The latching actuator assembly includes an armature plunger movably coupled with a solenoid coil, and in a powered solenoid coil state the solenoid coil moves the armature plunger between deployed and retracted configurations. A latching magnet latches the armature plunger in one of the deployed or retracted configuration in an unpowered solenoid coil state. A latching spring latches the armature plunger in the other of the deployed or retracted configuration in an unpowered solenoid coil state. The wrap spring clutches include a rotatable input hub and a rotatable output hub configured for rotation by the input hub. A helical spring is engaged with the output hub and selectively engaged in slipping and locking engagement with the input hub according to the deployed or retracted configuration of the armature plunger. | 07-11-2013 |
Jesse L. Wagers, Sioux Falls, SD US
| Patent application number | Description | Published |
|---|---|---|
| 20110054743 | MULTI-VARIABLE RATE AGRICULTURAL PRODUCT APPLICATION SYSTEM, DEVICE AND METHOD - The invention provides a system, device and method that can control the rates of seed dispensation and fertilizer application as a function of forward speed as well as across all rows. Thus, the system and control device allow control of each individual row unit, whereby dispensation and application are effected, by a central controller which controls a plurality of pulse width modulation valves, each of which controls a hydraulic motor with an integrated rpm reduction and which drives a stub drive shaft which rotates at the proper speed in order to provide the desired seed and fertilizer metering. Each of the stub drive shafts may rotate at completely different speeds and/or may be shut down while the remaining stub drive shafts rotate at the desired speed. The integrated rpm reduction within each hydraulic motor allows very fine rotational control of the dispensation and application rates. | 03-03-2011 |
| 20140277959 | MULTI-SEED PLANTER CONTROL SYSTEM AND METHOD FOR THE SAME - A method of automatically planting two or more seed types with an agricultural planter includes monitoring a planter location on a prescription map of an agricultural field. The planter includes one or more remotely adjustable planting characteristics. A seed type is selected based on the monitored planter location on the prescription map, the seed type including two or more seed types. The selected seed type is dispensed to one or more seed metering systems of one or more row units based on the selected seed type. As the planter moves in the agricultural one or more of the remotely adjustable planting characteristics of the planter field is dynamically changed based on at least the seed type selected according to the monitored planter location. | 09-18-2014 |
Jesse Lee Wagers, Sioux Falls, SD US
| Patent application number | Description | Published |
|---|---|---|
| 20140263409 | GRANULAR SPREADER SECTION CONTROL - This application discusses, among other things, granular spreaders. In an example, a granular spreader can include a blower configured to provide a flow of air, a metering device configured to provide a flow of granular material to the flow of air to provide a hybrid flow of air and granular material, a plurality of sections configured to release the granular material using the flow of air, wherein each section is configured to release an adjustable portion of the hybrid flow and a controller. The controller can be configured to receive control information for each section, to enable or disable each section responsive to the control information, and to adjust a speed of the blower based on the control information. | 09-18-2014 |
Matthew Wagers, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20130190551 | DRIVELINE CABLE ASSEMBLY - A blood pump assembly includes a blood pump configured for implantation and a cable assembly for providing power and control signals to the blood pump. The cable assembly includes a strain relief assembly and a driveline. The strain relief assembly secures the cable assembly to the blood pump and has an outer surface that is curved along a longitudinal extent of the strain relief assembly at least along an outer peripheral side of the outer surface. The strain relief assembly defines a compartment and an internal passage that leads to the compartment. The driveline houses a plurality of conductors that extend from the driveline through the internal passage and into the compartment. | 07-25-2013 |
| 20140235930 | DRIVELINE CABLE ASSEMBLY - A blood pump assembly includes a blood pump configured for implantation and a cable assembly for providing power and control signals to the blood pump. The cable assembly includes a strain relief assembly and a driveline. The strain relief assembly secures the cable assembly to the blood pump and has an outer surface that is curved along a longitudinal extent of the strain relief assembly at least along an outer peripheral side of the outer surface. The strain relief assembly defines a compartment and an internal passage that leads to the compartment. The driveline houses a plurality of conductors that extend from the driveline through the internal passage and into the compartment. | 08-21-2014 |
Nathan Wagers, Henderson, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20160131395 | Furnace Cabinet with Three Baffles - A condensing gas-fired furnace has a furnace cabinet, a primary heat exchanger, a secondary heat exchanger located upstream relative to the primary heat exchanger with regard to location within a circulation airflow path, a first baffle carried by a first wall of the furnace cabinet, a second baffle carried by a second wall of the furnace cabinet, wherein the second baffle is located opposite the first baffle, and wherein the second wall is located opposite the first wall, and a third baffle carried by a third wall of the furnace cabinet, wherein the third baffle is located adjacent to the first baffle and the second baffle, and wherein the third wall is located adjacent to the first wall and the second wall. | 05-12-2016 |
| 20160131396 | FURNACE - A furnace is disclosed. The furnace may include an enclosure having a vertical support column formed by a heat exchanger compartment panel and a blower compartment panel. The furnace may include a window assembly having venting openings hidden by a viewing window. The furnace may also include a rail to support a removable heat exchanger system. The furnace may further include a wire retaining fin assembly to retain a wire. A heat exchanger header design including features to retain a sealant is also disclosed. | 05-12-2016 |
| 20160131397 | Furnace Cabinet with Nozzle Baffles - A condensing gas-fired furnace has a furnace cabinet, a primary heat exchanger, a secondary heat exchanger located upstream relative to the primary heat exchanger with regard to location within a circulation airflow path, a first baffle carried by a first wall of the furnace cabinet, and a second baffle carried by a second wall of the furnace cabinet, wherein the second baffle is located opposite the first baffle, and wherein the second wall is located opposite the first wall. The first baffle and the second baffle cooperate to form a nozzle within the furnace cabinet. A third baffle and a fourth baffle extend from the bottom of the first baffle and the second baffle, respectively, to the blower deck located adjacent to a secondary heat exchanger. | 05-12-2016 |
Patrick Wagers, Akron, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20140142307 | AZOLIUM AND PURINIUM SALT ANTICANCER AND ANTIMICROBIAL AGENTS - Singly and multiply charged imidazolium cations (ICs) have been identified as a class of chemical compositions that possess potent antineoplastic, antibacterial and antimicrobial properties. The imidazolium cations disclosed demonstrate greater or equivalent potency towards cancerous cells as the current clinical standard, cisplatin. These imidazolium cations, however, achieve this efficacy without any of the known toxic side effects caused by heavy metal-based antineoplastic drugs such as cisplati. | 05-22-2014 |
Shannon Dale Wagers, Liberty Township, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090014034 | BENEFIT COMPOSITIONS AND FORMALDEHYDE SCAVENGERS FOR SAME - Cleaning and/or benefit compositions comprising a formaldehyde-generating agent, particularly a formaldehyde-containing crosslinking agent, and a formaldehyde scavenger are disclosed. Processes for making and using the aforementioned compositions are further disclosed. | 01-15-2009 |
| 20160128913 | Personal Care Compositions With Two Benefit Phases - A personal care composition includes a structured cleansing phase and two separate benefit phases, wherein the first benefit phase containing a high viscosity benefit agent with an average particle size of about 50 μm to about 500 μm, wherein the second benefit phase comprises a low viscosity benefit agent with an average particle size of about 0.5 μm to about 10 μm. | 05-12-2016 |
| 20160128927 | Personal Care Compositions With Two Benefit Phases - Methods of enhancing deposition of a high viscosity benefit agent can include manufacturing a personal care composition comprising the high viscosity benefit agent and a low viscosity benefit agent by adding the high viscosity benefit agent and the low viscosity benefit agent separately to a cleansing phase. | 05-12-2016 |
Sue Kay Wagers, Newport, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20130139786 | METHOD AND SYSTEM FOR PRE-IGNITION CONTROL - Methods and systems are provided for addressing pre-ignition that may be induced in response to actions taken to mitigate a cylinder misfire. An amount of engine load limiting applied may be adjusted to reduce the likelihood pre-ignition while also addressing component over-temperature issues. By limiting an engine load while shutting off fuel in a misfiring cylinder, and while combusting a lean air-fuel mixture in the remaining cylinders, pre-ignition induced by the misfire-mitigating lean combustion conditions can be reduced. | 06-06-2013 |
| 20150252748 | METHOD AND SYSTEM FOR PRE-IGNITION CONTROL - Methods and systems are provided for addressing pre-ignition that may be induced in response to actions taken to mitigate a cylinder misfire. An amount of engine load limiting applied may be adjusted to reduce the likelihood pre-ignition while also addressing component over-temperature issues. By limiting an engine load while shutting off fuel in a misfiring cylinder, and while combusting a lean air-fuel mixture in the remaining cylinders, pre-ignition induced by the misfire-mitigating lean combustion conditions can be reduced. | 09-10-2015 |