Patent application number | Description | Published |
20100136019 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 06-03-2010 |
20140170750 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 06-19-2014 |
20160102143 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 04-14-2016 |
Patent application number | Description | Published |
20100196394 | ANTI-CANCER VACCINE COMPOSITION - Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies. | 08-05-2010 |
20130095114 | T Cell Regulation - Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells. The inhibitory antibodies may be generated in an animal by injection of fragments of CD223. Antibodies may be monoclonal antibodies or single chain antibodies or humanized antibodies. | 04-18-2013 |
20140127226 | T Cell Regulation - Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity. | 05-08-2014 |
Patent application number | Description | Published |
20120058096 | COMPOSITIONS AND METHODS FOR GENERATING INTERLEUKIN-35-INDUCED REGULATORY T CELLS - Compositions and methods are provided for generating T cells having a regulatory phenotype from conventional T (T | 03-08-2012 |
20120189578 | COMPOSITIONS AND METHODS FOR POTENTIATING INTERLEUKIN-35 - Compositions and methods are provided for potentiating activity of interleukin-35 (IL-35). Such compositions and methods include administering therapeutically effective amounts of non-blocking IL-35 binding agents. The non-blocking IL-35 binding agents do not block the binding of IL-35 to its target(s). Also provided are methods to identify non-blocking IL-35 binding agents that enhance IL-35 activity. | 07-26-2012 |
20120328637 | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF THE INTERLEUKIN-35 RECEPTOR COMPLEX - The receptor for Interleukin 35 (IL-35) is provided. The Interleukin 35 Receptor (IL-35R) comprises a heterodimeric complex of the Interluekin12Rβ2 receptor and the gp130 receptor. Various compositions comprising the IL-35R complex, along with polynucleotides encoding the same and kits and methods for the detection of the same the same are provided. Methods of modulating the activity of IL-35R or modulating effector T cell functions are also provided. Such methods employ various IL-35R antagonists and agonists that modulate the activity of the IL-35R complex and, in some embodiments, modulate effector T cell function. Further provided are methods for screening for IL-35R binding agents and for IL-35R modulating agents. Various methods of treatment are further provided. | 12-27-2012 |
20130183326 | METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF THE INTERLEUKIN-35 RECEPTOR COMPLEX - The receptor for Interleukin 35 (IL-35) is provided. The Interleukin 35 Receptor (IL-35R) comprises a heterodimeric complex of the Interluekin12Rβ2 receptor and the gp130 receptor. Various compositions comprising the IL-35R complex, along with polynucleotides encoding the same and kits and methods for the detection of the same the same are provided. Methods of modulating the activity of IL-35R or modulating effector T cell functions are also provided. Such methods employ various IL-35R antagonists and agonists that modulate the activity of the IL-35R complex and, in some embodiments, modulate effector T cell function. Further provided are methods for screening for IL-35R binding agents and for IL-35R modulating agents. Various methods of treatment are further provided. | 07-18-2013 |
20140348809 | COMPOSITIONS AND METHODS FOR GENERATING INTERLEUKIN-35-INDUCED REGULATORY T CELLS - Compositions and methods are provided for generating T cells having a regulatory phenotype from conventional T (T | 11-27-2014 |
Patent application number | Description | Published |
20100163161 | Process For Making Disposable Absorbent Garments Employing Elastomeric Film Laminates With Deactivated Regions - A process for making an absorbent garment comprises providing one or more panels that comprise an elastomeric film laminate. A region of the laminate panel is deactivated to create a deactivated region. An absorbent insert comprising an absorbent member is provided. The absorbent insert is attached to the panel, such that a portion of the absorbent member overlaps at least a portion of the deactivated region. Front and back laminate regions can be part of a single integral panel, or can be comprised of separate and longitudinally spaced-apart laminate panels. | 07-01-2010 |
20100168705 | Disposable Absorbent Garments Employing Elastomeric Film Laminates With Deactivated Regions - An absorbent garment comprises an absorbent member and a laminate. The laminate comprises a polymeric film layer and a nonwoven layer, wherein both the polymeric film layer and the nonwoven layer extend substantially throughout the entire area of the laminate. At least a portion of the absorbent member longitudinally overlaps at least a portion of the laminate to define in the laminate an overlapped region and a non-overlapped region. At least a portion of the overlapped region of the laminate is non-elastomeric, and at least a portion of the non-overlapped region of the laminate is elastomeric. In particular embodiments, the laminate is an elastomeric film laminate having an elastomeric film layer, and at least a portion of the overlapped region of the elastomeric film laminate is deactivated. | 07-01-2010 |
20140018762 | Containment Pant - A permanently closed containment pant includes an elastically extensible chassis and a sling positioned within the chassis. The sling is joined to the front waist region and the back waist region. The sling includes a fluid-impervious base sheet and a containment flap joined with the base sheet to create a fluid-impervious pouch. The sling also includes a first transition and a second transition that are elastically extensible in a longitudinal direction and in a transverse direction. Material properties of the pouch and chassis provide the proper fit for comfort and leakage protection. | 01-16-2014 |
20150216735 | ABSORBENT ARTICLE HAVING A ZONED ATTACHMENT AREA FOR SECURING AN ABSORBENT ASSEMBLY TO A CHASSIS - An absorbent article includes a chassis and an absorbent assembly. The absorbent assembly is formed separately from the chassis, and attached to the chassis by an attachment area. The attachment area includes a front attachment zone, a rear attachment zone, and a central attachment zone extending between the front and rear attachment zones. The front and rear attachment zones have a first width and a second width, respectively, and the central attachment zone has a third width less than the first and second widths. | 08-06-2015 |
Patent application number | Description | Published |
20090305065 | Composition for coloring ceramic articles - The present invention relates to new liquid coloring compositions to be applied before firing to obtain, after firing, the white coloration of ceramic manufactured articles, or the decoloration of colored ceramic manufactured articles. The present invention also relates to new processes for coloring or decoloring using said liquid coloring compositions as well as to colored or decolored ceramic objects, obtainable with the new processes. | 12-10-2009 |
20100291362 | INKS FOR DIGITAL PRINTING ON CERAMIC MATERIALS, A PROCESS FOR DIGITAL PRINTING ON CERAMIC MATERIALS USING SAID INKS, AND CERAMIC MATERIAL OBTAINED BY MEANS OF SAID PRINTING PROCESS - The present invention relates to an ink set containing chromophoric metals for digital printing on ceramic materials additive-treated with silica and titanium dioxide, a process for decorating ceramic materials by digital printing using said ink set and decorated ceramic articles obtainable by said process. | 11-18-2010 |
20110207595 | PROCESS FOR COLOURING CERAMIC MATERIALS - The invention relates to a new process for colouring ceramic materials by using aqueous solutions of chromophore ions. In particular, certain types of silica are added to the ceramic mixes which are to be coloured, after which aqueous or organic solutions comprising inorganic salts of Fe(II) and/or Fe (III), or organic derivatives of Fe (II) and/or Fe (III) are applied to the surface of the said additive-containing ceramic mixes. | 08-25-2011 |
Patent application number | Description | Published |
20100136019 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 06-03-2010 |
20140170750 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 06-19-2014 |
20160102143 | MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35 - Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine. | 04-14-2016 |
Patent application number | Description | Published |
20140045415 | CABIN AIR COMPRESSOR OUTLET DUCT - A cabin air compressor outlet duct includes an outlet portion, a first inlet portion fluidly connected to the outlet portion, and a second inlet portion fluidly connected to the outlet portion and joined to the first inlet through a curvilinear surface having a bend radius between about 2.50 inches (6.35 cm) and about 2.60 inches (6.60 cm). | 02-13-2014 |
20140120821 | ELBOW FOR CABIN AIR FLOW SYSTEM - An elbow for use in a cabin air supply system for an aircraft has an inlet duct. The inlet duct diverges into two outlet ducts with an interface area between the outlet ducts. Each of the outlet ducts has a nominal wall thickness, with a central portion of the interface having a first thickness at a point of maximum thickness, and the nominal wall thickness being of a second thickness. The central portion of the interface curves to the central portion of the interface area. A ratio of the first thickness to the second thickness is between 3 and 8. A cabin air supply system is also disclosed. | 05-01-2014 |
20140151518 | Three-Way Mount Bracket for Aircraft Cabin Air Supply System - A mount bracket for use in a cabin air supply system for an aircraft has three legs extending from a cylindrical central bore and at a first axial end of the bracket. There are two legs at an opposed second axial end. A central leg is on the first axial end, and two of the legs are positioned at each of two lateral sides at first and second ends. The legs extend to feet. Strengthening legs connect feet at each of the lateral sides, and to the central leg foot. A thickness of the strengthening legs connected to the central leg is defined as a first dimension. A distance along the first axial end between a laterally outermost portion of the feet at each of the lateral sides is defined as a second dimension. A ratio of the first dimension to the second dimension is between 0.032 and 0.037. | 06-05-2014 |
20140210167 | AIR CYCLE MACHINE WITH SEAL SHAFT - A seal shaft for use in an air cycle machine has two axial edges. An axial distance is measured between contact faces at the axial edges, with a tolerance to the dimension. A greatest variation between the axial distance at a plurality of spaced locations on the edge face is maintained with a ratio of the greatest variation to the tolerance being less than 0.2. A rotor assembly, an air cycle machine and a method are also disclosed. | 07-31-2014 |
20140245775 | Mixer and Air Pack for Use in Aircraft Air Supply System - A mixer has an internal bore with an inlet to a chamber, and an outlet at an opposed end/A duct is connected to receive a recirculated air flow. The duct communicates air into the chamber through recirculating air ports such that the recirculating air can mix with the air from the inlet. The mixer housing has a cockpit outlet for delivering air to a second outlet, with the cockpit output being located axially upstream from the recirculating air ports. An isolator is mounted at an outer periphery of the mixer housing, and has flat sides on each of two circumferentially spaced sides. A belly band is bolted to an outer periphery of the mixer housing and to flat sides of the isolator. | 09-04-2014 |
20140346302 | CABIN AIR COMPRESSOR CROSS-SUPPORT BRACKET - A cross-support bracket for a cabin air compressor assembly includes a mating portion having a first group of apertures at a first end and a second group of apertures at a second end. A reference line is defined between a lowermost primary aperture of the first group of apertures and a lowermost primary aperture of the second group of apertures. A stiffener portion is formed along a lower edge of the mating portion. A curved region is formed in the mating portion between a first and second upper edge of the mating portion. The curved region includes a first curved portion, a substantially straight portion, and a second curved portion. A ratio of a radius of the first and second curved portions of the curved region to a length from the substantially straight portion to the reference line is between 9.06 and 10.19. | 11-27-2014 |
20140353461 | CABIN AIR COMPRESSOR SUPPORT BRACKET - A support bracket for a cabin air compressor (CAC) assembly includes a CAC mounting portion with a plurality of CAC mounting holes distributed in an arc configuration along a CAC mounting hole circle radius. A support portion includes a ramped face that transitions to an upper lug portion and a substantially perpendicular face relative to the CAC mounting portion. An upper lug extends from the upper lug portion. The upper lug includes a coupling hole that is offset from a first CAC mounting hole of the CAC mounting holes at a length in a first direction and a length in a second direction. A ratio of the CAC mounting hole circle radius to the length in the first direction is between 2.14 and 2.20, and a ratio of the CAC mounting hole circle radius to the length in the second direction is between 1.16 and 1.19. | 12-04-2014 |
20140353462 | CABIN AIR COMPRESSOR SUPPORT BRACKET - A support bracket for a cabin air compressor (CAC) assembly includes a CAC mounting portion with a plurality of CAC mounting holes distributed in an arc configuration along a CAC mounting hole circle radius defined from an origin. A support portion includes a ramped face that transitions to an upper lug portion and a substantially perpendicular face relative to the CAC mounting portion. An upper lug includes a coupling hole offset from a first CAC mounting hole at a first length in a first direction and a second length in a second direction. The first CAC mounting hole is offset from the origin by a third length in the first direction and a fourth length in the second direction. A ratio of the first length to the third length is between 0.48 and 0.50, and a ratio of the second length to the fourth length is between 2.48 and 2.54. | 12-04-2014 |
20140367543 | CABIN SUPPLY BRACKET - A cabin supply bracket for a cabin supply duct assembly is provided. The cabin supply bracket includes a base plate with a first, second, and third mounting hole distributed in a substantially triangular arrangement. The first mounting hole has a centerline defined therethrough. A coupling socket extends from the base plate. The coupling socket includes a first and second tie rod coupling support having a tie rod coupling hole formed therethrough and a first and second outer edge. The first outer edge is proximate the second mounting hole, and the second outer edge is proximate the third mounting hole. The coupling socket has a socket width defined between a first socket edge proximate the first outer edge and a second socket edge proximate the second outer edge. A ratio of the socket width to a thickness of the base plate is between 6.31 and 7.84. | 12-18-2014 |
20150247408 | FAN ROTOR WITH THICKENED BLADE ROOT - A fan rotor of an air cycle machine includes a hub with fan blades extending from the hub. Each of the plurality of fan blades includes a main airfoil portion located distally from the hub. The main airfoil portion generally has a uniform thickness along its span. A base portion located between the hub and the main airfoil portion of each of the fan blades has a chord length that is longer than a chord length of the main airfoil portion. | 09-03-2015 |
Patent application number | Description | Published |
20160059981 | CONTAINER HANDLING MACHINE AND METHOD - A container handling machine having at least one operative unit is disclosed. The container handling machine includes a first support unit configured to support a base of a filled and closed container, a second support unit configured to cooperate with an end of the container opposite the base, a plunger configured to selectively move along a longitudinal axis to deform the base of the container from a first swollen configuration to a second inwardly-retracted configuration, and an actuator configured to selectively move the plunger along the longitudinal axis between a first position, in which the plunger is detached from the base of the container, and a second position, in which the plunger deforms the base to the second configuration. | 03-03-2016 |
20160059982 | CONTAINER HANDLING MACHINE AND METHOD - A container handling machine having at least one operative unit is disclosed. The container handling machine includes a plunger configured to selectively move along a longitudinal axis and to deform a base of a container from a first swollen configuration to a second inwardly-retracted configuration, and an actuator configured to selectively move the plunger along the longitudinal axis between a first position, in which the plunger is detached from the base of the container, and a second position, in which the plunger deforms the base to the second configuration. The container handling machine further includes a control unit configured to selectively activate the actuator for producing a first stroke of the plunger along the longitudinal axis between the first position and the second position, in order to deform the base of the container. | 03-03-2016 |