Patent application number | Description | Published |
20080241931 | System For Expression of Genes In Plants - The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants. | 10-02-2008 |
20080279877 | HPV antigens, vaccine compositions, and related methods - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by human papilloma virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and vaccine compositions. | 11-13-2008 |
20090324634 | Trypanosoma Antigens, Vaccine Compositions, and Related Methods - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by | 12-31-2009 |
20100227373 | Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides - Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B(Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest. | 09-09-2010 |
20100239594 | Compositions and methods for production of immunoglobulins - Provided are oligonucleotides for isolating human antibody cDNAs from cells or cell lines, such as hybridomas. The invention also provides cDNAs that encode at least one provided CDR of a heavy chain or a light chain of a human monoclonal antibody that binds to | 09-23-2010 |
20110027304 | YERSINIA PESTIS ANTIGENS, VACCINE COMPOSITIONS AND RELATED METHODS - The present invention provides antigens and vaccines useful in prevention of infection by | 02-03-2011 |
20110059130 | PROPHYLACTIC AND THERAPEUTIC INFLUENZA VACCINES, ANTIGENS, COMPOSITIONS AND METHODS - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by influenza virus. Provided are recombinant protein antigens, compositions, and methods for the production and use of such antigens and subunit vaccine compositions. In some embodiments, influenza antigens include hemagglutinin polypeptides neuraminidase polypeptides, and/or combinations thereof. | 03-10-2011 |
20110070609 | Production of Foreign Nucleic Acids and Polypeptides in Sprout Systems - The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid or protein of interest. The sprouted seedlings of the invention are grown in a contained, regulatable environment, wherein expression of a pharmaceutically active protein is controlled by an exogenously inducible promoter or a viral promoter. The sprouted seedlings may be eaten live or preferably harvested live to preserve the maximal biological activity of the nucleic acid or protein. | 03-24-2011 |
20110142870 | Bacillus anthracis antigens, vaccine compositions, and related methods - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by | 06-16-2011 |
20110311612 | Humanized Neuraminidase Antibody and Methods of Use Thereof - Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein. | 12-22-2011 |
20110314575 | Plasmodium Vaccines, Antigens, Compositions and Methods - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and vaccines useful in prevention of infection by | 12-22-2011 |
20120034253 | Influenza Vaccines, Antigens, Compositions, and Methods - The present invention relates to the intersection of the fields of immunology and protein engineering, and particularly to antigens and compositions useful in inducing or enhancing an immune response agains influenza antigens. Provided are recombinant protein antigens, compositions, and methods for the production of such antigens in plants. In some embodiments, influenza antigens include hemagglutinin polypeptides, neuraminidase polypeptides, and/or combinations thereof. | 02-09-2012 |
20120096585 | SYSTEM FOR EXPRESSION OF GENES IN PLANTS - The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants. | 04-19-2012 |
20120219579 | VIRUS LIKE PARTICLES COMPRISING TARGET PROTEINS FUSED TO PLANT VIRAL COAT PROTEINS - Virus like particles comprising a fusion protein and substantially free of nucleic acid, wherein the fusion protein comprises a plant viral coat protein and a target protein, are provided. Immunogenic compositions comprising the virus like particles can be administered to subjects to induce protective immune responses in the subjects. Methods of producing the virus like particles are also provided. | 08-30-2012 |
20120279127 | CASCADING PLANT GROWTH SYSTEM AND PLANT GROWTH TRAY - A plant growth container includes a tray, an inlet channel in the tray, a growth media retainer in the tray, one or more protrusions within the growth media retainer, an outlet channel connected to the growth media retainer, and a lid capable of being fixedly attached to the tray. The tray can be used in a hydroponic growth system for plants, where the system includes a container for growing plants. The container includes a tray, an inlet channel in the tray, a growth media retainer in the tray connected to the inlet channel, one or more protrusions in the growth media retainer, the protrusions capable of securing growth media from lateral movement, an outlet channel connected to the growth media retainer, and a lid. The system may include a reservoir for holding a liquid and a pump capable of pumping the liquid from the reservoir to the container. | 11-08-2012 |
20120282288 | Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides - Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest. | 11-08-2012 |
20120315323 | INFLUENZA HEMAGGLUTININ ANTIBODIES, COMPOSITIONS AND RELATED METHODS - Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein. | 12-13-2012 |
20130149327 | YERSINIA PESTIS ANTIGENS, VACCINE COMPOSITIONS, AND RELATED METHODS - The present invention provides antigens and vaccines useful in prevention of infection by | 06-13-2013 |
20130196011 | ANTIMICROBIAL BACTERIA STRAINS AND USES THEREOF - The present invention provides novel antimicrobial bacteria strains and uses thereof to prepare novel antimicrobial agents. Also provided are the novel antimicrobial agents. | 08-01-2013 |
20140056908 | CLOSTEROVIRUS-BASED NUCLEIC ACID MOLECULES AND USES THEREOF - The present invention relates to novel nucleic acid molecules for producing target polypeptides in plant cells. More specifically, the novel nucleic acid molecules comprise a minireplicon derived from a Closteroviridae virus and heterologous polynucleotides encoding the target polypeptides. Also provided are compositions comprising the target polypeptides and uses thereof. | 02-27-2014 |
20140141508 | Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides - Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest. | 05-22-2014 |
20140186886 | IN VIVO DE-GLYCOSYLATION OF RECOMBINANT PROTEINS BY CO-EXPRESSION WITH PNGASE F - Materials and methods for in vivo de-glycosylation of recombinant N-glycosylated proteins by co-expression with bacterial PNGase F (Peptide: N-glycosidase F) in plants, using a transient expression system are described. Methods are described which, for example, produce recombinant proteins of interest in plants in a non-glycosylated form. A method of expressing active bacterial PNGase F in plants also is provided. | 07-03-2014 |
20140220674 | SYSTEM FOR EXPRESSION OF GENES IN PLANTS - The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g., replication, cell-to-cell movement, or long distance movement. The carrier vector supplies the missing function in trans. Certain producer vectors lack a functional coat protein coding sequence, in which case the corresponding producer vector supplies coat protein in trans. The invention also provides novel plant viral vectors and methods of use, e.g., to produce polypeptides or active RNAs in plants. | 08-07-2014 |
20140314754 | Humanized Neuraminidase Antibody and Methods of Use Thereof - Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein. | 10-23-2014 |
20140331366 | INFLUENZA HEMAGGLUTININ ANTIBODIES, COMPOSITIONS AND RELATED METHODS - Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein. | 11-06-2014 |
20150086589 | VIRUS-LIKE PARTICLES COMPRISING A MATRIX PROTEIN FROM A PLANT ENVELOPED VIRUS AND USES THEREOF - The present invention relates to novel virus-like particles (VLPs) comprising a matrix protein derived from a first plant enveloped virus and a surface polypeptide. The surface polypeptide comprises (a) a surface exposed portion derived from a target polypeptide (b) a transmembrane domain, and (c) a cytosolic tail derived from a transmembrane (e.g., glycoprotein) of a second plant enveloped virus. The target polypeptide may be antigenic or therapeutic. The first and the second plant enveloped viruses may be the same. Either plant enveloped virus may be a plant rhabdovirus. Also provided are methods of making and using the VLPs. | 03-26-2015 |