Vendruscolo
Cristina Vendruscolo, Sao Jose Dos Campos BR
Patent application number | Description | Published |
---|---|---|
20140147525 | Two Component Systems For Delivering Stabilized Ascorbic Acid - Stable, topical compositions comprising high levels of ascorbic acid are provided, which comprise an anhydrous component containing at least 15 weight % ascorbic acid and an oil-in-water emulsion component combined at the point of use. Such compositions provide increased permeation of ascorbic acid. | 05-29-2014 |
Michele Vendruscolo, Cambridgeshire GB
Patent application number | Description | Published |
---|---|---|
20100261882 | METHOD AND APPARATUS FOR ASSESSING POLYPEPTIDE AGGREGATION - A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence. | 10-14-2010 |
20110035155 | PROTEIN AGGREGATION PREDICTION SYSTEMS - We describe methods for identifying aggregation-prone regions in structured—that is folded—proteins. Embodiments of the method use a local propensity for aggregation (A | 02-10-2011 |
Michele Vendruscolo, Cambridge GB
Patent application number | Description | Published |
---|---|---|
20100160602 | METHOD FOR PREDICTING PROTEIN AGGREGATION AND DESIGNING AGGREGATION INHIBITORS - The present invention provides methods of predicting protein aggregation and designing aggregation inhibitors. One such method for predicting potential protein aggregation inhibiting peptide sequences, includes the steps of: a) identifying a peptide sequence forming at least part of an aggregation region in a target protein; b) testing whether said peptide sequence forms part of a β-sheet; c) if a positive result is achieved in step b), extracting the adjacent strands of that sheet; d) identifying residues in the adjacent strands to said peptide sequence whose side chains interact with said peptide sequence, those residues forming a potential protein aggregation inhibiting peptide sequence. The present invention also provides methods of designing compounds using the residues identified in the above method; compounds produced by the methods and computer programs for carrying out the above methods. | 06-24-2010 |