Patent application number | Description | Published |
20100160299 | DENDRIMER CONJUGATES - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. | 06-24-2010 |
20140128327 | DENDRIMER CONJUGATES - The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. | 05-08-2014 |
Patent application number | Description | Published |
20150216993 | MULTIFUNCTIONAL SMALL MOLECULES - The present invention relates to novel therapeutic dendrimer conjugates configured for the treatment and/or prevention of organophosphate poisoning. In particular, the present invention is directed to dendrimers complexed with organophosphate poisoning antidotes (e.g., pralidoxime (2-PAM) (4-PAM), obidoxime, trimedoxime, asoxime (HI-6), hydroxamate, and related analogs, salts and derivatives thereof), compositions comprising such dendrimer conjugates, related methods of synthesizing such dendrimer conjugates, as well as systems and methods utilizing such dendrimer conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in the treatment and/or prevention of organophosphate poisoning)). | 08-06-2015 |
Patent application number | Description | Published |
20120017699 | APPLICATIONS FOR REAL-TIME MASS RATIO, MASS FLOW AND PARTICLE SIZE MEASUREMENT OF PARTICLE LADEN FLOWS - Techniques are provided for monitoring particle laden flows in a pipe, that include receiving signalling containing information about a parameter related to a particle laden flow in a pipe, the parameter including either (a) a sound level propagating through the particle laden flow in the pipe, or (b) a static pressure due to an acceleration of the particle laden flow in the pipe; and determining a measurement of a particle size and either a mass flow rate, or a particle-to-air mass ratio, or both the mass flow rate and the particle-to-air mass ratio, associated with the particle laden flow, based at least partly on a change in the parameter. | 01-26-2012 |
20120060930 | Determining shear rate and/or shear stress from sonar based velocity profiles and differential pressure - The present invention provides a new method and apparatus for receiving signals containing information about a plurality of velocity profiles of a flow in a pipe and about a pressure gradient of the flow over a length of the pipe; and determining information about an injection of a chemical into the flow in the pipe based at least partly on the information contained in the signals. | 03-15-2012 |
20120141301 | METHOD AND APPARATUS FOR PREDICTING MAINTENANCE NEEDS OF A PUMP BASED AT LEAST PARTLY ON PUMP PERFORMANCE ANALYSIS - A signal processor is provided comprising one or more signal processor modules configured to: compare signaling containing information about historical data related to the performance of a pump; and provide corresponding signaling containing information about predicted maintenance needs of the pump on a real time basis based at least partly on the signaling compared containing information about the historical data related to the performance of the pump. The one or more signal processor modules may be configured to compare over time the hydraulic power generated by the pump and electric power consumed by a motor driving the pump, including tracking a ratio of hydraulic to electric power. The one or more signal processor modules may be configured to predict maintenance needs based on an algorithm that takes into account a trade-off between the cost of power consumed by a motor driving the pump and the cost associated with the pump maintenance in order to substantially minimize the total cost of operating the pump. | 06-07-2012 |
Patent application number | Description | Published |
20110056298 | FLOW AND PIPE MANAGEMENT USING VELOCITY PROFILE MEASUREMENT AND/OR PIPE WALL THICKNESS AND WEAR MONITORING - The present invention provides new techniques for non-invasive and real-time measurement of the velocity profile of slurry flow in horizontal pipes, as well as the measurement and trending of pipe wear on slurry lines. In the first case, this information can be used to determine the approach and onset of solid deposition on the bottom of the pipe. Having this information in real time can enable operation at lower velocities or higher solids concentration or both while avoiding solids deposition or plugging and their associated operational costs. In the second case, the present invention uses a permanently or semi-permanently installed ring of conformable ultrasonic transducers clamped onto the outside of the pipe. These transducers are used to measure the thickness of the pipe under their respective locations. | 03-10-2011 |
20120209550 | PERFORMANCE MONITORING OF INDIVIDUAL HYDROCYCLONES USING SONAR- BASED SLURRY FLOW MEASUREMENT - Apparatus, including a signal processor, featuring at least one module configured to respond to signals containing information about sound propagating through a slurry flowing in part, including overflow pipes, of cyclones operating in parallel on a cyclone battery, and determine the performance of individual cyclones based at least partly on the information contained in the signals. The signal process may form part of a non-invasive acoustic-based passive monitoring system, comprising: cyclones and sensors; where the cyclones are configured in parallel to form a cyclone battery in order to process a slurry, each cyclone having an overflow pipe for providing some portion of the slurry flowing in the cyclone battery, where each sensor is configured to mount on a respective overflow pipe of a respective cyclone, to respond to sound propagating through the slurry flowing in the respective overflow pipe of the respective cyclone, and to provide a respective signal containing information about the sound propagating through the slurry flowing in the respective overflow pipe of the respective cyclone; and where the signal processor is configured to respond to respective signals from the sensors and determine the performance of individual cyclones based at least partly on the information contained in the respective signals. | 08-16-2012 |
20140026666 | WEAR MONITORING WITH ROTATIONAL SENSOR AND SENSOR THICKNESS - Apparatus for determining a thickness of a wall of a pipe, featuring a signal processing module configured to respond to signaling containing information about traveling stress waves transmitted to and reflected back from a wall of a pipe by a sensor band that includes a series, ring or array having multiple transducers circumferentially arranged and mounted around, and attached to or clamped onto, an outside wall of the pipe; and determine a profile of a thickness of the wall of the pipe corresponding to circumferential locations of the multiple transducers based on the signaling received from the sensor band; and one or more orientation or rotation sensors, each responding to its orientation in relation to its displacement on the pipe and to provide an orientation signal containing information about the same. | 01-30-2014 |
20140026667 | GRAPHICAL USER INTERFACE RE WEAR MONITORING - Apparatus for determining a thickness of a wall of a pipe, featuring a signal processing module configured to respond to signaling containing information about traveling stress waves transmitted to and reflected back from a wall of a pipe by a sensor band that includes a series, ring or array having multiple transducers circumferentially arranged and mounted around, and attached to or clamped onto, an outside wall of the pipe; determine a profile of a thickness of the wall of the pipe corresponding to circumferential locations of the multiple transducers based on the signaling received from the sensor band, and the provides corresponding signaling containing information about the profile of the thickness of the wall of the pipe; and another module configured to receive the corresponding signaling and provide a visual indication of either data or a graph of the thickness of the wall of the pipe. | 01-30-2014 |