Patent application number | Description | Published |
20090326203 | Framework Selection - The present invention relates to improved methods for the selection of appropriate human acceptor framework regions for non-human (donor) antibodies and methods for obtaining humanized antibodies of high affinity using such acceptor frameworks. | 12-31-2009 |
20100104573 | BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF - This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions. | 04-29-2010 |
20110171215 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 07-14-2011 |
20130045219 | BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF - This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions. | 02-21-2013 |
20140302016 | BINDING PROTEINS, INCLUDING ANTIBODIES, ANTIBODY DERIVATIVES AND ANTIBODY FRAGMENTS, THAT SPECIFICALLY BIND CD154 AND USES THEREOF - This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions. | 10-09-2014 |
20150152180 | PD-1 SPECIFIC ANTIBODIES AND USES THEREOF - One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject. | 06-04-2015 |
Patent application number | Description | Published |
20100260773 | ANTIBODY MOLECULES HAVING BINDING SPECIFICITY FOR HUMAN IL-13 - The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules. | 10-14-2010 |
20110229461 | PD-1 Antibodies - A humanised agonistic antibody which binds human PD-1 comprising a heavy chain and a light chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the variable domain of the light chain comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:7 for CDR-L3. The invention also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules. | 09-22-2011 |
20140178387 | ANTIBODY MOLECULES HAVING BINDING SPECIFICITY FOR HUMAN IL-13 - The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods for producing said antibody molecules. | 06-26-2014 |
20140348844 | NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE - This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of | 11-27-2014 |
Patent application number | Description | Published |
20150157756 | Device for Evaporating a Volatile Fluid - An assembly for evaporating a volatile fluid is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough; and wherein the refill comprises a reservoir for the volatile fluid, a volatile fluid transport means to draw the fluid from the reservoir, and at least one susceptor arranged to heat the volatile fluid transport means when said alternating current is passed through the induction coil. Refills, devices and methods of operation are also described. | 06-11-2015 |
20150195871 | Device for Evaporating a Volatile Material - An assembly for evaporating a volatile material is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough; and wherein the refill comprises at least one susceptor and a substantially liquid-tight sealed reservoir containing the volatile material; wherein, in use, the susceptor(s) is arranged to heat the material when the susceptor(s) is at least partially positioned in the induced magnetic field generated, in use, when said alternating current is passed through the induction coil. Refills, devices and methods of use are also described. | 07-09-2015 |
20150223292 | Device for Evaporating a Volatile Material - An assembly for evaporating a volatile material is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough at a frequency of between substantially 20 KHz to substantially 500 KHz; and wherein the refill comprises at least one magnetic susceptor having a coercivity of substantially 50 ampere/metre (H | 08-06-2015 |
20150250028 | Device for Evaporating a Volatile Fluid - An assembly for evaporating a volatile fluid is described, the assembly comprising a device and a refill which are detachable from one another: wherein the device comprises a magnetic induction coil configured to operate with an alternating current passed therethrough at a frequency of between substantially 20 KHz to substantially 500 KHz; and wherein the refill comprises a reservoir for the volatile fluid, a volatile fluid transport means to draw the fluid from the reservoir, and at least one magnetic susceptor arranged to heat the wick predominately by magnetic hysteresis when said alternating current is passed through the induction coil, wherein the magnetic susceptor has a coercivity of substantially 50 ampere/metre (H | 09-03-2015 |
Patent application number | Description | Published |
20090045641 | Compact Hand Tool and Packaging For a Hand Tool - A compact hand tool comprising an operating portion terminating in a collar and a handle portion adapted to be received within the collar. The handle portion is operable to be securely retained in a first position where the hand tool may be used to perform its normal function as determined by the operating portion. The handle portion is slidably movable to a second position where the handle portion overlays the operating portion to facilitate storage of the hand tool. The hand tool is made of a substantially light-weight material. | 02-19-2009 |
20100140279 | Collapsible Container - A collapsible container includes a compressive wall and a base. The base includes a retaining ring extending from at least a portion of its circumference, and the base is also made of a hardened material compared to the material making up the compressive wall. The compressive wall is adapted to be retained around the circumference of the base via the retaining ring. | 06-10-2010 |
20130270795 | Cart for Watercraft - A cart is provided for a watercraft including at least two apertures provided therein. The cart includes a transportation portion, and a carrying portion. The carrying portion includes at least two vertical shafts protruding from the transportation portion. A watercraft engaging portion is formed around at least a portion of each vertical shaft. When received within one of the at least two apertures, at least a portion of the watercraft engaging portion compresses to create a frictional engagement between the watercraft and the cart. | 10-17-2013 |
20140151976 | Cart for Watercraft - A cart is provided for a watercraft including at least two apertures provided therein. the cart includes a transportation portion, and a carrying portion. The carrying portion includes at least two vertical shafts protruding from the transportation portion. The protruding end of each shaft is connected to, or received within, a watercraft engaging portion that tapers off in size as it extends further away from the transportation portion such that at least a section of each watercraft engaging portion deforms and compresses when received within one of the at least two apertures to create frictional engagement between the aperture and the section of the watercraft engaging portion. | 06-05-2014 |