Patent application number | Description | Published |
20130040360 | Crystal Structure of the Pro Form of a Matrix Metalloproteinase and an Allosteric Processing Inhibitor - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 02-14-2013 |
20130040994 | Methods of Treatment Using Allosteric Processing Inhibitors for Matrix Metalloproteinases - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 02-14-2013 |
20130166268 | Crystal Structure of the Pro Form of a Matrix Metalloproteinase and an Allosteric Processing Inhibitor - The present invention includes a crystal comprising a complex of the pro form of a matrix metalloprotease (proMMP) and a small-molecule allosteric processing inhibitor that inhibits that activation of the proMMP, methods for identifying small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP, and methods of treatment using small-molecule allosteric processing inhibitors that inhibit the activation of a proMMP. The present invention relates to the crystal structure of a complex of proMMP9 bound to a small-molecule allosteric processing inhibitor that inhibits activation of proMMP9. The invention further relates to the use of the methods and the crystal and related structural information for designing, selecting and/or optimizing small-molecule allosteric processing inhibitors that inhibit activation of proMMP9 and proMMP9 homologues. The present invention also relates to the use of small-molecule allosteric processing inhibitors for the treatment of diseases mediated by inappropriate matrix metalloproteinase (MMP) activity. | 06-27-2013 |
Patent application number | Description | Published |
20130170987 | Wind Turbine Tower with Yaw Bearing System - A wind turbine includes a vertically standing non-uniform tower adapted to support a horizontally oriented rotor. A fixed base portion of the turbine is adapted to support a separate rotatable tower having an upper rotor swept portion along the main body of the tower. The tower is adapted to be secured to the base for being rotatably yawed into the wind. A bearing system is housed between the base and lower tower extremity includes a pair of vertically spaced tracks situated on an annular support rail adapted to be fixed to a ground structure, for example a reinforced concrete foundation. The bearing system is further defined by pluralities of yaw bearing cartridge assemblies adapted to extend through flanged apertures of a skirt portion in the lower extremity of the tower. | 07-04-2013 |
20130171002 | Hybrid Wind Turbine Tower with Integrated Yaw Bearing System - A wind turbine includes a vertically standing hybrid tower adapted to support a horizontally oriented rotor. The tower includes a fixed base portion and a separate rotatable upper rotor swept portion adapted to be secured to the base portion and rotatably yawed into the wind. The interface between the base and upper tower portions includes a bearing system defined by a pair of vertically spaced ring bearings adapted to encase and secure a downwardly depending spindle of the upper tower portion for rotatable support thereof within a vertically oriented cup-shaped opening in the base portion. Pluralities of contact rollers situated between inner and outer races of the ring bearings are each mounted on a single spindle and preloaded in angular orientation relative to the vertical axis of the tower. | 07-04-2013 |
20130343887 | Variable Speed Friction Wheel Drive Train for Wind Turbines - A variable speed ratio speed increaser drive train for a wind turbine is disclosed. The drive train may include at least one drive wheel adapted to receive mechanical energy from a main shaft of the wind turbine and capable of rotating at a variable input rotational speed and at least one driven wheel in at least indirect contact with the at least one drive wheel, the at least one driven wheel capable of at least indirectly translating against the at least one drive wheel to vary a speed ratio of the drive train to provide a constant output rotational speed. | 12-26-2013 |
20130343889 | Friction Wheel Drive Train for a Wind Turbine - A constant speed ratio speed increaser friction wheel drive train for a wind turbine is disclosed. The drive train may include at least one drive wheel adapted to receive mechanical energy from a main shaft of a wind turbine and capable of rotating at an input rotational speed, the at least one drive wheel constructed of a plurality of drive wheel segments and at least one driven wheel in contact with and rotating against a surface of the at least one drive wheel at an output rotational speed, the output rotational speed varying with the input rotational speed. | 12-26-2013 |
Patent application number | Description | Published |
20080239317 | SYSTEMS, METHODS, AND DEVICES FOR HANDLING TERAHERTZ RADIATION - Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed. | 10-02-2008 |
20110006226 | TERAHERTZ RADIATION SOURCE MOUNTING ARRANGEMENTS AND METHODS OF MOUNTING A TERAHERTZ SOURCE - Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed. | 01-13-2011 |
20140306128 | TERAHERTZ RADIATION SOURCE MOUNTING ARRANGEMENTS AND METHODS OF MOUNTING A TERAHERTZ SOURCE - Methods and apparatus for detecting variations in electromagnetic fields, in particular, terahertz (THz) electromagnetic fields, are provided. The methods and apparatus employ polarization detection devices and controllers to maintain or vary the polarization of modulated signals as desired. The methods and apparatus are provided to characterize electromagnetic fields by directing the electromagnetic field and a probe beam upon an electro-crystal and detecting the modulation of the resulting probe beam. Detection of the modulation of the probe beam is practiced by detecting and comparing the polarization components of the modulated probe beam. Aspects of the invention may be used to analyze or detect explosives, explosive related compounds, and pharmaceuticals, among other substances. A compact apparatus, modular optical devices for use with the apparatus, sample holders, and radiation source mounts are also disclosed. | 10-16-2014 |