Patent application number | Description | Published |
20090039489 | METHOD OF PRODUCING OPTICAL MEMS - A method and apparatus for constructing MEMS devices is provided which employs a low cost molded housing that simultaneously provides precise and accurate alignment, mechanical protection, electrical connections and structural integrity for mounting optical and MEMS components. The package includes a MEMS die mounting surface, an optical component mounting surface and an optical imaging window monolithically fabricated with the MEMS die mounting surface in a predetermined orientation for providing alignment between the MEMS die and optical components. A MEMS adaptor plate is provided to facilitate connections of a MEMS die to external components. | 02-12-2009 |
20090043211 | MEMS BASED OPTICAL COHERENCE TOMOGRAPHY PROBE - A micro-electromechanical system (MEMS) probe package is provided including a first reflective element receiving a light beam directed into to the probe package and a second reflective element receiving light directed from the first reflective element. The second reflective element directs light in an optical path extending from the probe package. At least one of the reflective elements includes a MEMS mirror. An embodiment of the package is made with a monolithic housing having mounting surfaces formed therein for aligning the first reflective element with the second reflective element. The monolithic housing also includes a mounting surface for aligning at least one lens with at least one of the reflective elements. | 02-12-2009 |
20150198782 | PACKAGING MEMS IN FLUIDIC ENVIRONMENTS - A method and apparatus for packaging a MEMS device is disclosed that includes a MEMS die mounting surface, a MEMS device disposed on the mounting surface, and a fluid contained within the package and surrounding at least a portion of the MEMS device. The fluid may be selected to provide certain advantageous features. For example, the fluid may have a selected index of refraction that is matched with a lens index of refraction of the lens, have a viscosity selected to provide a predetermined mechanical damping to the MEMS device, be thermally coupled with the MEMS device and configured to remove heat from the MEMS device. The fluid may also be configured in mechanical cooperation with a spring mounted scanning element, a linear translation actuator, a rotational actuator, a lens, etc. to actuate or apply fluidic pressure to such elements. | 07-16-2015 |
Patent application number | Description | Published |
20090149631 | Methods and compositions for protein labeling using lipoic acid ligases - The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants. | 06-11-2009 |
20110130348 | KINETICALLY EFFICIENT SUBSTRATE FOR LIPOIC ACID LIGASE - The invention provides methods for identifying and optimizing peptide substrates for enzymes such as lipoic acid ligase (Lp1A). | 06-02-2011 |
20120129159 | METHODS AND COMPOSITIONS FOR PROTEIN LABELING USING LIPOIC ACID LIGASES - The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase. | 05-24-2012 |
20120214201 | PROBE INCORPORATION MEDIATED BY ENZYMES - The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants. | 08-23-2012 |
20140186870 | IN VIVO PROTEOMICS - The application discloses methods, materials, and compositions for the labeling of molecules, for example, proteins, in living cells or in subcellular compartments of living cells. In particular, the application relates to proteomic analysis methods; materials and compositions and means based on direct tagging of unknown proteins with tagging enzymes (such as biotin ligase or a peroxidase) within the vicinity of a tagging substrate (such as a tyramide) within living cells, with optional targeting to specific subcellular locations by expression of genetic constructs. | 07-03-2014 |
20140206013 | SPLIT PEROXIDASES AND METHODS OF USE - An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. Also disclosed herein are split peroxidases, related products and kits. | 07-24-2014 |
20150037829 | CYTOSOLICALLY-ACTIVE PEROXIDASES AS REPORTERS FOR MICROSCOPY - An imaging method comprising expressing in cells a Class I heme peroxidase, which optionally is fused with a protein of interest or a cellular localization signal peptide, and contacting the cells with a substrate of the Class I heme peroxidase to allow conversion of the substrate into a product via an oxidation reaction catalyzed by the Class I heme peroxidase, wherein the product releases a signal detectable by a microscope such as an electron microscope. Also disclosed herein are monomeric mutants of a Class I heme peroxidase and mutants of the enzyme that exhibit elevated enzymatic activity as compared to the corresponding wild-type counterpart. | 02-05-2015 |
20150125904 | PROBE INCORPORATION MEDIATED BY ENZYMES - Compositions (e.g., lipoic acid ligase polypeptides and lipoic acid analogs) and uses thereof in the Probe Incorporation Mediated By Enzymes (PRIME) methods both in vitro and in vivo. Also described herein are kits for performing the PRIME method and vectors/kits for expressing the lipoic acid ligases. | 05-07-2015 |
20150252336 | SPLIT PEROXIDASES AND METHODS OF USE - An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. Also disclosed herein are split peroxidases, related products and kits. | 09-10-2015 |
Patent application number | Description | Published |
20120252810 | FATTY ACID NON-FLUSHING NIACIN DERIVATIVES AND THEIR USES - The invention relates to fatty non-flushing acid niacin derivatives; compositions comprising an effective amount of a fatty acid non-flushing niacin derivative; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid non-flushing niacin derivative. | 10-04-2012 |
20120264791 | FATTY ACID NIACIN CONJUGATES AND THEIR USES - The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin conjugate. | 10-18-2012 |
20120277305 | FATTY ACID GUANIDINE AND SALICYLATE GUANIDINE DERIVATIVES AND THEIR USES - The invention relates to fatty acid guanidine or salicylate guanidine derivatives; compositions comprising an effective amount of a fatty acid guanidine or salicylate guanidine derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid guanidine or salicylate guanidine derivative. | 11-01-2012 |
20120283292 | FATTY ACID LENALIDOMIDE AND THEIR USES - The invention relates to fatty acid lenalidomide derivatives; compositions comprising an effective amount of a fatty acid lenalidomide derivative; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid lenalidomide derivative. | 11-08-2012 |
20130059801 | FATTY ACID AMIDES, COMPOSITIONS AND METHODS OF USE - The invention relates to fatty acid amides; compositions comprising an effective amount of a fatty acid amide; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a fatty acid amide. | 03-07-2013 |
20130244966 | FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES - The invention relates to fatty acid antiviral conjugates; compositions comprising an effective amount of a fatty acid antiviral conjugate; and methods for treating or preventing a viral infection comprising the administration of an effective amount of a fatty acid antiviral conjugate. | 09-19-2013 |
20130316995 | FATTY ACID CONJUGATES OF STATIN AND FXR AGONISTS; COMPOSITIONS AND METHOD OF USES - The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate. | 11-28-2013 |
20140094462 | SONIC HEDGEHOG MODULATORS - Sonic Hedgehog modulators and methods of use thereof are provided for. | 04-03-2014 |
20140288025 | FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES - The invention relates to fatty acid antiviral conjugates; compositions comprising an effective amount of a fatty acid antiviral conjugate; and methods for treating or preventing a viral infection comprising the administration of an effective amount of a fatty acid antiviral conjugate. | 09-25-2014 |
20150353503 | INDAZOLE DERIVATIVES AND USES THEREOF - The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. The fungus may be a | 12-10-2015 |
20160046590 | SONIC HEDGEHOG MODULATORS - Sonic Hedgehog modulators and methods of use thereof are provided for. | 02-18-2016 |
Patent application number | Description | Published |
20120204245 | SECURE AUTHENTICATION USING ONE-TIME PASSWORDS - Embodiments of the invention facilitate the use of a contactless memory token to automate log-on procedures to a remote access server using dynamic one-time passwords (OTPs). A series of workflow steps establishes the identity of the user and charges a token with a number of dynamic OTPs that can be subsequently verified using, for example, a Radius server sitting behind a VPN or SSL/VPN server. | 08-09-2012 |
20130145420 | SECURE AUTHENTICATION USING MOBILE DEVICE - Representative embodiments of secure authentication include receiving, by a server, information from a mobile device identifying (i) the mobile device and (ii) an identifying tag read by the mobile device; accessing, by the server, a database to identify (i) a user associated with the mobile device, (ii) a secure device associated with the identifying tag, and (iii) a security policy associated with the secure device; and if the policy permits access by the identified user to the identified secure device, causing access to the secure device to be accorded to the user. | 06-06-2013 |
20140123237 | SECURE CONTENT SHARING - Convenient sharing of information among authorized network users may be facilitated by allowing a user to send information originating from multiple applications in aggregate form to another user, e.g., using a secure messaging service. In scenarios where data access is restricted, a server may check the recipient's access privileges prior to forwarding the information to her. | 05-01-2014 |
20160006711 | DEVICE-AGNOSTIC USER AUTHENTICATION - A user of a client device that executes a remote application is authenticated by first receiving an HTTP or HTTPS request to authenticate the user from the remote application. The user is prompted for authentication information, and authentication information is obtained by communicating with a hardware device in electronic communication with the client device. The user's authorization to use the remote application is then verified using a computer processor and using the authentication information. | 01-07-2016 |
Patent application number | Description | Published |
20080301816 | Method and system for handling keystroke commands - Keystroke commands are safeguarded from keyboard logging malware based on a destination application's memory address. | 12-04-2008 |
20110145908 | System and Method for Data and Request Filtering - Data and data requests of users of applications are filtered using a client-resident agent. A user profile may contain data pertaining to restrictions on content the user is permitted to view or types of requests the user is permitted to make. within one or more applications. Data in the user profile may be used to grant or deny access to applications, filter particular content from the user's view, or filter particular data requests made by the user. | 06-16-2011 |
20130291056 | QUORUM-BASED SECURE AUTHENTICATION - Representative embodiments of secure authentication to a resource in accordance with a predefined, electronically stored quorum-based authentication policy include causing electronic interaction among multiple devices that constitute a quorum in accordance with the policy, computationally determining whether the interaction satisfies the policy, and if so, electronically according access to the resource to one or more individuals associated with the interacting device(s). | 10-31-2013 |
20140109076 | SECURE, NON-DISRUPTIVE FIRMWARE UPDATING - Firmware updates for, e.g., thin client devices may be achieved in a seamless, non-disruptive manner using a two-stage firmware loader, including a base loader pre-installed on the device and a caching loader downloaded, by the base loader, from a firmware server and thereafter responsible for downloading and updating other firmware application packages. | 04-17-2014 |
20140109243 | SECURE ACCESS SUPERSESSION ON SHARED WORKSTATIONS - Transitions between users at shared workstations that permit access to private health information or other secure data may be handled, without incurring unnecessary delays due to shut-down of all applications used by the departing user, by selectively hiding applications with sensitive information on a shared desktop while allowing temporary system access for the interrupting user. | 04-17-2014 |
20140215495 | TASK-SPECIFIC APPLICATION MONITORING AND ANALYSIS - User interactions with multiple applications executed on a computational device may be monitored by intercepting messages corresponding to application-level events and recording data associated with the events, including, e.g., contents of application screens presented when the events occurred. The screen contents may be used, based on comparison with task-specific screen-sequence patterns, to link sub-sequences of the events to tasks, facilitating subsequent task-related analysis. | 07-31-2014 |
20150113603 | SYSTEM AND METHOD FOR DATA AND REQUEST FILTERING - Data and data requests of users of applications are filtered using a client-resident agent. A user profile may contain data pertaining to restrictions on content the user is permitted to view or types of requests the user is permitted to make. within one or more applications. Data in the user profile may be used to grant or deny access to applications, filter particular content from the user's view, or filter particular data requests made by the user. | 04-23-2015 |
20150332011 | COORDINATING COMMUNICATIONS AMONG HEALTHCARE PROVIDERS - Computer-implemented systems and methods automatically track the dynamic composition of a patient-care team by combining and harvesting information from at least two electronic audit trails: (1) a trail recording access to electronic medical records (EMR), e.g., read-access to patient data, electronic prescriptions and physician orders, etc., and (2) a trail recording electronic communications (email, text messages, etc.) regarding and referencing the patient. | 11-19-2015 |
20160044046 | SECURE, NON-DISRUPTIVE FIRMWARE UPDATING - Firmware updates for, e.g., thin client devices may be achieved in a seamless, non-disruptive manner using a two-stage firmware loader, including a base loader pre-installed on the device and a caching loader downloaded, by the base loader, from a firmware server and thereafter responsible for downloading and updating other firmware application packages. | 02-11-2016 |
Patent application number | Description | Published |
20140308336 | LOCAL DRUG DELIVERY DEVICES AND METHODS FOR TREATING CANCER - Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site. | 10-16-2014 |
20150232935 | METHODS FOR DIAGNOSING IGG4-RELATED DISEASE - Methods for diagnosing and treating IgG4-related disease (IgG4-RD), e.g., based on detecting levels of IgG4 mRNA, preferably using a branched DNA assay. | 08-20-2015 |
20150247204 | DIFFERENTIAL DIAGNOSIS OF HEPATIC NEOPLASMS - Methods for making a differential diagnosis of hepatic neoplasms, e.g., tumors, and for identifying metastatic tumors of hepatic origin, based on detection of levels of albumin mRNA. The methods can also be used to select treatments or guide treatment decisions. | 09-03-2015 |
Patent application number | Description | Published |
20140031250 | Biomarkers of Cancer - Methods for diagnosing cancer based on detecting the presence of increased levels of expression of satellite repeats and/or Line-1. | 01-30-2014 |
20140234869 | Cadherins as Cancer Biomarkers - Methods of isolating, enriching, capturing, identifying, or detecting the presence of, cancerous cells in a sample, e.g., a blood sample from a subject, by detecting the presence of one or more cancer cell surface markers selected from the group consisting of cadherin 1 (CDH1), CDH2, CDH3, CDH4, CDH5, CDH9, CDH11, CDH17, CDH19, protocadherin 9 (PCDH9) and/or PCDH beta 13 (PCDHb13), and optionally an additional cancer cell surface marker, e.g., EpCAM, MUC1, EphB4, EGFR, CEA, and/or HER2. | 08-21-2014 |
20140287956 | Biomarkers of Cancer - Methods for diagnosing cancer and monitoring treatment efficacy based on detecting the presence of increased levels of expression of satellite correlated genes. | 09-25-2014 |
20150247205 | DIAGNOSIS OF MULTIPLE MYELOMA AND LYMPHOMA - The present application relates to methods for diagnosing and treating multiple myeloma (MM) and non-Hodgkin lymphoma (NHL), e.g., based on the detection of clonal IgK or IgL-expressing cells. | 09-03-2015 |
Patent application number | Description | Published |
20100041974 | Physiological monitoring garment - A physiological monitoring garment includes a fabric portion. At least one elongate stretchable textile data/power bus is disposed the fabric portion. The elongate stretchable textile data/power bus includes a plurality of integral conductors, woven, knitted, or braided along the length thereof. One or more sensors are connected to the elongate stretchable textile data/power bus. | 02-18-2010 |
20110066216 | COOLING DEVICE FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces. | 03-17-2011 |
20120179258 | SPINAL SPACER DEVICES, TOOLS, AND METHODS - A spacer device for spinal fixation, such as in corpectomies and discectomies, includes a core and two end plates mounted to the core. One end plate is mounted to each respective end of the core. The core can be configured and adapted to be adjustable to allow for contraction and/or distraction of the end plates. The end plates can include apertures therethrough to facilitate osseointegration of the spacer device within a patient's spine. The angle of the endplates can each be adjusted with respect to the core of the spacer device, for example to accommodate lordosis. A containment mesh is included around the spacer device, wrapping circumferentially around the end plates, and spanning from end plate to end plate. The containment mesh defines a containment volume between the end plates for containing bone replacement materials such as allograft or man-made materials. | 07-12-2012 |
20130158636 | COOLING DEVICE FOR REMOVING HEAT FROM SUBCUTANEOUS LIPID-RICH CELLS - A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces. | 06-20-2013 |
20140012387 | SPINAL SPACER DEVICES, TOOLS, AND METHODS - A spacer device for spinal fixation, such as in corpectomies and discectomies, includes a core and two end plates mounted to the core. One end plate is mounted to each respective end of the core. The core can be configured and adapted to be adjustable to allow for contraction and/or distraction of the end plates. The end plates can include apertures therethrough to facilitate osseointegration of the spacer device within a patient's spine. The angle of the endplates can each be adjusted with respect to the core of the spacer device, for example to accommodate lordosis. A containment mesh is included around the spacer device, wrapping circumferentially around the end plates, and spanning from end plate to end plate. The containment mesh defines a containment volume between the end plates for containing bone replacement materials such as allograft or man-made materials. | 01-09-2014 |
20140066810 | ORTHOPEDIC MEASUREMENT DEVICES, SYSTEMS AND METHODS - A device for orthopedic measurements includes a main housing, a center member, a measurement indicator, and a flexible member. The main housing has a proximal end with a top opening and a distal end with a side opening, and defines a longitudinal axis and includes a main housing cavity. The center member is disposed along the longitudinal axis within the main housing cavity. The measurement indicator is operatively connected to the center member, and is configured and adapted to display a measurement of a distance. The flexible member is threaded through the main housing cavity, and includes a first end and an opposed second end with an eyelet disposed proximate the side opening of the main housing. The eyelet is configured to be drawn away from the main housing, extending the flexible member outward with respect to the side opening to display a measurement on the measurement indicator. | 03-06-2014 |
Patent application number | Description | Published |
20080197145 | Method for Dispensing Ophthalmic Fluid - An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump. | 08-21-2008 |
20140371689 | METHOD FOR DISPENSING OPHTHALMIC FLUID - An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump. | 12-18-2014 |