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Thomas, MD

Blake K. Thomas, Ashton, MD US

Patent application numberDescriptionPublished
20100263566Reduced Collateral Damage Bomb (RCDB) Including Fuse System with Shaped Charges and a System and Method of Making Same - A reduced collateral damage bomb (RCDB) bomb casing is described and disclosed along with the system and method for making it. The RCDB bomb casing may be formed from conventional or penetrating warhead bomb casings. The RCDB bomb casing has a filler material/materials disposed on the interior walls that will assist in controlling the collateral damage caused by the finished bomb but not prevent the appropriate destructive power being delivered to a selected target. Further, the fusing system may include a shaped charge to control the ignition of the main explosive charge to control the amount of collateral damage when the bomb casing is filled with high explosives.10-21-2010
20110146521REDUCED COLLATERAL DAMAGE BOMB (RCDB) AND SYSTEM AND METHOD OF MAKING SAME - A reduced collateral damage bomb (RCDB) bomb casing is described and disclosed along with the system and method for making it. The RCDB bomb casing may be formed from conventional or penetrating warhead bomb casings. The RCDB bomb casing has a filler material/materials disposed on the interior walls that will assist in controlling the collateral damage caused by the finished bomb but not prevent the appropriate destructive power being delivered to a selected target.06-23-2011
20120036985Reduced Collateral Damage Bomb (RCDB) and System and Method of Making Same - A reduced collateral damage bomb (RCDB) bomb casing is described and disclosed along with the system and method for making it. The RCDB bomb casing may be formed from conventional or penetrating warhead bomb casings. The RCDB bomb casing has a filler material/materials disposed on the interior walls that will assist in controlling the collateral damage caused by the finished bomb but not prevent the appropriate destructive power being delivered to a selected target.02-16-2012
20120227612Shaped Charge Fuse Booster System for Dial Lethality in Reduce Collateral Damage Bombs (RCDB) That Include Penetrating Warheads or Warheads with High Explosives that are Difficult to Ignite - A fuse booster system for a reduced collateral damage bomb or penetrating warhead is described and disclosed. The fuse booster system uses shaped charges that will ignite the main high explosive charge of the bomb or penetrating warhead, and also remove portions of the bomb or penetrating warhead to reduce the power of the bomb at the target in a measurable manner to control the lethality and collateral damage of the bomb or penetrating warhead.09-13-2012
20120234197REDUCED COLLATERAL DAMAGE BOMB (RCDB) INCLUDING FUSE SYSTEM WITH SHAPED CHARGES AND A SYSTEM AND METHOD OF MAKING SAME - A reduced collateral damage bomb (RCDB) bomb casing is described and disclosed along with the system and method for making it. The RCDB bomb casing may be formed from conventional or penetrating warhead bomb casings. The RCDB bomb casing has a filler material/materials disposed on the interior walls that will assist in controlling the collateral damage caused by the finished bomb but not prevent the appropriate destructive power being delivered to a selected target. Further, the fusing system may include a shaped charge to control the ignition of the main explosive charge to control the amount of collateral damage when the bomb casing is filled with high explosives.09-20-2012

Patent applications by Blake K. Thomas, Ashton, MD US

Bradley S. Thomas, Timonium, MD US

Patent application numberDescriptionPublished
20090082734Method And Apparatus For Delivering A Therapeutic Substance Through An Injection Port - Adapters for utilizing a syringe or pen injector with a subcutaneous injection port to deliver a therapeutic substance through the injection port and methods of using the adapters are provided. A syringe adapter has a body having a first end and a second end. The first end of the body is configured to receive and engage the end of a syringe so that the cannula of the syringe is held at a fixed position with the respect to the adapter. The second end of the adapter configured to mate with a mating portion of the injection port. When the second end of the adapter engages the mating portion of the injection port, the adapter assures that the cannula of the syringe is properly aligned with the subcutaneous injection port and assures that the cannula penetrates the injection port to the proper depth. Adapters for use with pen style delivery systems are also disclosed. Additionally, an adapter to facilitate loading a syringe with a therapeutic substance from a vial is disclosed.03-26-2009
20090155808Automated system for isolating, amplifying and detecting a target nucleic acid sequence - A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.06-18-2009
20110022006Method and apparatus for delivering a therapeutic substance through an injection port - Adapters for utilizing a syringe or pen injector with a subcutaneous injection port to deliver a therapeutic substance through the injection port and methods of using the adapters are provided. A syringe adapter has a body having a first end and a second end. The first end of the body is configured to receive and engage the end of a syringe so that the cannula of the syringe is held at a fixed position with the respect to the adapter. The second end of the adapter configured to mate with a mating portion of the injection port. When the second end of the adapter engages the mating portion of the injection port, the adapter assures that the cannula of the syringe is properly aligned with the subcutaneous injection port and assures that the cannula penetrates the injection port to the proper depth. Adapters for use with pen style delivery systems are also disclosed. Additionally, an adapter to facilitate loading a syringe with a therapeutic substance from a vial is disclosed.01-27-2011
20110064628MICROFLUIDIC CHIP FEATURES FOR OPTICAL AND THERMAL ISOLATION - A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.03-17-2011
20110200991AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE - A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.08-18-2011
20120282603AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE - A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively compliant articulated robot arm (SCARA). This synergistic integration of previously separate diagnostic tools creates a system and method whereby a minimum of human intervention is required. The resulting system provides a substantially more accurate and precise method of isolating, amplifying and detecting targeted nucleic acids for diagnosing diseases.11-08-2012
20130217104MICROFLUIDIC CHIP FEATURES FOR OPTICAL AND THERMAL ISOLATION - A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.08-22-2013
20150118738MICROFLUIDIC CHIP FEATURES FOR OPTICAL AND THERMAL ISOLATION - A microfluidic chip includes microfluidic channels, elements for thermally and optically isolating the microfluidic channels, and elements for enhancing the detection of optical signal emitted from the microfluidic channels. The thermal and optical isolation elements may comprise barrier channels interposed between adjacently-arranged pairs of microfluidic channels for preventing thermal and optical cross-talk between the adjacent microfluidic channels. The isolation element may alternatively comprise reflective film embedded in the microfluidic chip between the adjacent microfluidic channels. The signal enhancement elements comprise structures disposed adjacent to the microfluidic channels that reflect light passing through or emitted from the microfluidic channel in a direction toward a detector. The structures may comprise channels or a faceted surface that redirects the light by total internal reflection or reflective film material embedded in the microfluidic chip.04-30-2015

Patent applications by Bradley S. Thomas, Timonium, MD US

Bradley Scott Thomas, Timonium, MD US

Patent application numberDescriptionPublished
20140112558AUTOMATED PELLETIZED SAMPLE VISION INSPECTION APPARATUS AND METHODS - A method for visually inspecting pelletized samples. The method generates an inspection image of the bottom of a sample tube holder. The sample tube holder has a number of sample tube locations, and each sample tube location is configured to receive a sample tube in it. The inspection image is evaluated to determine whether a tube image exists for each sample tube location, and each sample tube image is evaluated to determine whether a pellet is located in each sample tube.04-24-2014
20140112829TUBE STRIP HANDLING AND HEATING APPARATUS - A tube strip handling and heating frame having a rectangular outer frame having two spaced longitudinal walls extending in a longitudinal direction, and two spaced lateral walls extending in a lateral direction and extending between respective ends of the longitudinal walls. The outer frame forms an enclosure having an open upper side and an open lower side. The frame also has a number of tube strip wells located inside the outer frame, each tube strip well has a slot elongated in the lateral direction, and each slot is configured to receive a respective tube strip through the open upper side and support the respective tube strip in a vertical direction. The tube strip wells are arranged in a series along the longitudinal direction.04-24-2014
20140112842AUTOMATED PELLETIZED SAMPLE BLOTTING APPARATUS AND METHODS - An automated sample tube blotting system having one or more rotating grippers, a supply of absorbent material, a transporter, and an absorbent material removal mechanism. Each rotating gripper has a respective holder configured to selectively mate with a respective interface on a tube strip, and the one or more rotating grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the rotating gripper in a lateral direction from a starting location to a location above the absorbent material, and in a vertical direction towards and away from the absorbent material.04-24-2014
20140112843AUTOMATED PELLETIZED SAMPLE DECANTING APPARATUS AND METHODS - An automated sample tube decanting system having one or more decanting grippers, a decant waste receptacle, a transporter, and means for rotating the decanting gripper. Each decanting gripper has a respective holder configured to selectively mate with a respective interface on a tube strip. The one or more decanting grippers are rotatable between a first position in which the tube strip is upright and a second position in which the tube strip is inverted. The transporter is configured to move the one or more decanting grippers in a lateral direction from a starting location to a location above the decant waste receptacle.04-24-2014
20140113277ULTRASONIC BIOLOGICAL SAMPLE ANALYSIS APPARATUS AND METHODS - An ultrasonic sample evaluation process in which a vial containing a liquid medium is placed on a receptacle and a ultrasonic source signal is propagated upwards in the vertical direction through the liquid medium. A number of reflected ultrasonic signals is received at the bottom of the sample vial and evaluated to identify a pattern characteristic of a reflection off the meniscus, and the presence of a pattern characteristic of a collection implement located in the liquid medium. An estimate of the amount of liquid medium contained in the sample vial is generated based on a time characteristic of the pattern characteristic of a reflection off the meniscus, and a signal indicating the presence of a collection implement in the liquid medium is generated upon identifying such a pattern.04-24-2014
20140113278SAMPLE PROCESSING APPARATUS AND METHODS - An automated process for converting samples includes: receiving tube strips having a number of sample tubes and samples therein, transferring multiple tube strips to a tube strip holder, dispensing sample conversion buffer into each tube, shaking the tube strip holder a first time, centrifuging the tube strip holder, removing a liquid supernatant from each tube, simultaneously inspecting the contents of each tube, dispensing a specimen transport medium and a denaturation reagent into each tube, shaking the tube strip holder a second time, heating the tube strip holder for a first length of time, shaking the tube strip holder a third time, heating the tube strip holder for a second length of time, shaking the tube strip holder a fourth time, and transferring at least a portion of each sample to a respective well on an output plate.04-24-2014
20140260699VISION-GUIDED ASPIRATION APPARATUS AND METHODS - A method for removing supernatant from a sample tube. The method includes providing a sample tube having a pellet at a bottom of the sample tube and a supernatant liquid above the pellet, visually inspecting the sample tube to determine one or more geometric properties of the pellet, and determining an expected height of a top surface of the pellet based on the one or more geometric properties determined in the visual inspection step. The method also includes inserting an aspirator into the supernatant liquid, moving the aspirator downwards towards the expected height of the top surface of the pellet, and aspirating the supernatant liquid through the aspirator.09-18-2014

Brian B. Thomas, Frederick, MD US

Patent application numberDescriptionPublished
20130315780DIAGNOSTIC SYSTEMS AND INSTRUMENTS - Provided is a clinical diagnostic system that comprises a diagnostic instrument and a disposable cartridge. The diagnostic system can be used to measure assays in point of care clinical settings.11-28-2013
20150132860CLINICAL DIAGNOSTIC SYSTEM INCLUDING INSTRUMENT AND CARTRIDGE - In embodiments disclosed herein, a diagnostic system is provided having a cartridge comprising at least one needle; at least one reservoir; at least one fluidic seal; and at least one fluidic channel of a fluidic pathway, wherein the cartridge is configured to store at least one reagent and at least one waste material on the cartridge. The diagnostic system is provided also having a diagnostic instrument comprising the fluidic pathway; an electrochemiluminescence (ECL) detection system; and a pump, wherein the fluidic pathway begins and ends in the cartridge and has a substantially single direction of flow in a pathway fluidically connecting the diagnostic instrument and the cartridge.05-14-2015
20150132861CLINICAL DIAGNOSTIC SYSTEMS - A diagnostic system is provided herein that includes an instrument comprising an electrochemiluminescence (ECL) detector, and a cartridge configured to fit within a portion of the instrument, wherein the cartridge includes at least one reagent including an ECL label and a blood collection holder. Also provided herein is a system that includes a diagnostic instrument, which includes a pump, an ECL detector, an incubator, a magnet, and an output device, and a cartridge configured to fit within a portion of the diagnostic instrument, a sample holder configured to fit within the cartridge, and a closed fluidic loop between the diagnostic instrument and the cartridge when the cartridge is fit within a portion of the diagnostic instrument, wherein the cartridge is configured to accept a sample from the sample holder and place the sample in fluidic communication with the diagnostic instrument via the closed fluidic loop.05-14-2015

Cherian Thomas, Bethesda, MD US

Patent application numberDescriptionPublished
20150186920Optimizing and Distributing Discounts - Methods, systems, computer-readable media, and apparatuses for optimizing and distributing discounts are presented. In some embodiments, a computing device may receive a request for a randomized discount. In response to receiving the request for the randomized discount, the computing device, may select a merchant from a hub that includes at least two merchants grouped based on geographical proximity of business locations of the at least two merchants. Subsequently, the computing device may determine a discount for the selected merchant. The computing device then may cause the determined discount for the selected merchant to be presented.07-02-2015

Craig Thomas, Gaithersburg, MD US

Patent application numberDescriptionPublished
20120294843CASPASE INHIBITORS - A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I:11-22-2012
20140249181TROPOLONE COMPOUNDS FOR TREATING OR PREVENTING RETROVIRAL INFECTION - Disclosed are compounds that inhibit RNase H activity of retroviruses, for example, a compound of formula (I) wherein R09-04-2014

Craig Thomas, Rockville, MD US

Patent application numberDescriptionPublished
20130251761ORGANIC COMPOUNDS - The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.09-26-2013
20150050325ORGANIC COMPOUNDS - The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.02-19-2015
20150374697ORGANIC COMPOUNDS - The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.12-31-2015

Craig J. Thomas, Gaithersburg, MD US

Patent application numberDescriptionPublished
20090203716Pyrimidine low molecular weight ligands for modulating hormone receptors - Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula08-13-2009
20110112079PHOSPHODIESTERASE INHIBITORS - The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4.05-12-2011
20110195018LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.08-11-2011
20110195958ACTIVATORS OF HUMAN PYRUVATE KINASE - Disclosed are pyruvate kinase M2 activators, which are bis sulfonamide piperazinyl and piperidinyl compounds of Formula (I), 2,4-disubstituted 4H-thieno[3,2-c]pyrrole-2-(substituted benzyl)pyridazin-3(2H)-ones of Formula (II) and 6-(3,4-dimethylphenylaminosulfonyl)-3,4-dihydro-1H-quinolin-2-one of formula (III), wherein L, R08-11-2011
20110207784OXADIAZOLE-2-OXIDES AS ANTISCHISTOSOMAL AGENTS - The invention provides 1,2,5-oxadiazole-containing compounds of Formula (I), wherein R08-25-2011
20120245141ACTIVATORS OF HUMAN PYRUVATE KINASE - Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R09-27-2012
20120315217INVERSE AGONISTS AND NEUTRAL ANTAGONISTS FOR THE TSH RECEPTOR - TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.12-13-2012
20130109672ACTIVATORS OF HUMAN PYRUVATE KINASE05-02-2013
20130251631LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.09-26-2013
20140301944LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.10-09-2014
20150105395ACTIVATORS OF HUMAN PYRUVATE KINASE - Disclosed are pyruvate kinase M2 activators, which are, bis sulfonamide piperazinyl compounds of Formula (I) and 2,4-disubstituted 4H-thieno[3,2-b]pyrrole-2-(substituted benzyl)pyridazin-3(2H)ones of Formula (II), wherein L and R04-16-2015
20150183744ACTIVATORS OF HUMAN PYRUVATE KINASE - Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A07-02-2015
20160024023LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.01-28-2016

Patent applications by Craig J. Thomas, Gaithersburg, MD US

Darby Thomas, Frederick, MD US

Patent application numberDescriptionPublished
20130244331RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION - The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the recombinant AAV particles in gene therapy.09-19-2013

David L. Thomas, Baltimore, MD US

Patent application numberDescriptionPublished
20090186045USE OF CONSENSUS SEQUENCE AS VACCINE ANTIGEN TO ENHANCE RECOGNITION OF VIRULENT VIRAL VARIANTS - The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as compositions or vaccines for prophylactic use or treating HCV-infected individuals. Also provided are methods for lessening the chances for a HCV-infected individual to enter a chronic phase of infection and methods of diagnosing an individual with HCV 1a or HCV 1b infection.07-23-2009

Fairwell Thomas, Rockville, MD US

Patent application numberDescriptionPublished
20100203099MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE - Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.08-12-2010
20120148642MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE - Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.06-14-2012

Fairwell Thomas, Rockyille, MD US

Patent application numberDescriptionPublished
20090270331MULTI-DOMAIN AMPHIPATHIC HELICAL PEPTIDES AND METHODS OF THEIR USE - Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.10-29-2009

Gene Raymond Thomas, Frederick, MD US

Patent application numberDescriptionPublished
20100227171SURFACE COATING AND RESTORATION - A surface coating system and process and a construction surface restoration system and process are disclosed that utilize advantageous protective materials as coating and filling media. The bonding characteristics of the protective materials are such that surfaces coated with the protective materials and process possess improved and more diversified force absorption attributes. The filler material is capable of imitating pre-existing construction surfaces and possesses a substantial longevity.09-09-2010

Glen B. Thomas, College Park, MD US

Patent application numberDescriptionPublished
20110165067CARBOHYDRATE FUNCTIONALIZED CATANIONIC SURFACTANT VESICLES FOR DRUG DELIVERY - Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.07-07-2011

Jackson Thomas, Severna Park, MD US

Patent application numberDescriptionPublished
20130088354System, Method and Device for Tracking Surgical Sponges - A system, method, and device for tracking surgical sponges for a medical procedure is provided. In one embodiment, the system includes a sleeve having a first open end and a second open end and being configured to be removably disposed outside an outer surface of a receptacle. The sleeve including an RF reader having a first antenna assembly comprised of at least one antenna and configured to radiate sponges that enter the receptacle and to receive identifying (ID) information from radiated sponges. The sleeve may include a wireless transmitter electrically connected to said RF reader and configured to receive from said RF reader the ID information of radiated sponges and to wirelessly transmit the ID information of radiated sponges.04-11-2013

Jay Thomas, Baltimore, MD US

Patent application numberDescriptionPublished
20120260601Reinforced Balcony and Method of Reinforcing a Balcony - Systems and methods for reinforcing a concrete slab or balcony are disclosed. The systems and methods may include cutting a groove in a portion of the concrete slab and inserting a rod into the groove. The groove may then be filled with a resin. The rod may optionally be secured by other or additional methods. The integrity of the concrete slab or balcony may then be strengthened by the inclusion of the rod in the slab.10-18-2012

Jeffrey D. Thomas, Westminster, MD US

Patent application numberDescriptionPublished
20160023420Sheet feeding in box making machines - Plastic sheets are fed along a horizontal path from the bottom of a stack to a box making machine by a conveyor. The rear end of the stack rests on a metering bar located above the path at the rear end of the stack so that when the lowermost sheet is fed by the conveyor, its rear end drops and air jets from an air knife are introduced in the space between the stack and the lowermost sheet at the rear end of the stack to overcome friction forces and separate the lower most sheet from the stack as the sheet is conveyed along the path.01-28-2016

John A. Thomas, Ellicott City, MD US

Patent application numberDescriptionPublished
20120236901Time-Temperature Indicator - A time-temperature indication device includes a first reservoir having a fluid disposed therein, and a capillary tube. The capillary tube is disposed proximate to the first reservoir to receive fluid from the first reservoir responsive to changes in viscosity of the fluid based on changes in temperature. The capillary tube restricts flow of the fluid out of the first reservoir into the capillary tube to enable fluid flow only in a single direction.09-20-2012

John F. Thomas, Silver Spring, MD US

Patent application numberDescriptionPublished
20090162244Products and methods for dispensing of air fresheners, deodorizers or sanitizers - A device, such as a home air freshener, which is mounted to the main positive pressure air duct of a forced air furnace heating system and or a central air conditioning system by which an outside agent, such as an air freshener, is introduced into the air duct for the distribution to areas served by the air duct system. By means of a sub-duct properly positioned in the path of the airflow, the device can create a low pressure area in the sub-duct which will draw and distribute the air freshener and thus operate with out means of outside pressure, power, or moving parts.06-25-2009

Jordan Faulkner Thomas, Montgomery Village, MD US

Patent application numberDescriptionPublished
20130297933MOBILE ENTERPRISE SMARTCARD AUTHENTICATION - Utilities that allow for multi-factor authentication into an enterprise network with a smart card using mobiles devices (e.g., smartphones, tablets, etc.), where almost any application (app) or website that accesses enterprise resources can be launched or executed to automatically establish of a VPN connection with the enterprise network free of necessarily having to specially configure the apps or websites to be useable with smart cards, card readers, etc. Virtually any app can be used and take advantage of the multifactor authentication free or substantially free of modification to the app itself as the disclosed utilities may take advantage of the native VPN clients and capabilities provided with the mobile device operating system (OS) (e.g., Android®, iOS). As a result, a much more flexible solution may be provided that allows the use of commercially available apps (e.g., from an “App Store”) as well as, for instance, enterprise developed apps.11-07-2013

Joshua Thomas, Frederick, MD US

Patent application numberDescriptionPublished
20100104510SELENOCYSTEINE MEDIATED HYBRID ANTIBODY MOLECULES - The invention provides methods and compositions employing hybrid molecules of a synthetic molecule and antibody or antibody fragment comprising a selenocysteine residue, wherein the synthetic molecule is covalently linked to the antibody or antibody fragment at the selenocysteine residue. The invention also provides a composition comprising a hybrid molecule as described above and a pharmaceutically acceptable carrier. The invention further provides for methods of making the hybrid molecules, and methods of using the hybrid molecule described above to inhibit cell surface receptor binding.04-29-2010
20150104383SELENOCYSTEINE MEDIATED HYBRID ANTIBODY MOLECULES - The invention provides methods and compositions employing hybrid molecules of a synthetic molecule and antibody or antibody fragment comprising a selenocysteine residue, wherein the synthetic molecule is covalently linked to the antibody or antibody fragment at the selenocysteine residue. The invention also provides a composition comprising a hybrid molecule as described above and a pharmaceutically acceptable carrier. The invention further provides for methods of making the hybrid molecules, and methods of using the hybrid molecule described above to inhibit cell surface receptor binding.04-16-2015

Justin Thomas, Saint Leonard, MD US

Patent application numberDescriptionPublished
20100171758Method and system for generating augmented reality signals - Embodiments consistent with the present disclosure provide method and systems for providing customized augmented reality data comprising. The method includes Some embodiments consistent with the present disclosure provide a method for providing customized augmented reality data. The method includes receiving geo-registered sensor data including data captured by a sensor and metadata describing a position of the sensor at the time the data was captured and receiving geospatial overlay data including computer-generated objects having a predefined geospatial position. The method also includes receiving a selection designating at least one portion of the geo-registered sensor data, said at least one portion of the geo-registered sensor data including some or all of the geo-registered sensor data, and receiving a selection designating at least one portion of the geospatial overlay data, said at least one portion of the geospatial overlay data including some or all of the geospatial overlay data. And the method includes providing a combination of the at least one selected portion of the geo-registered sensor data and the at least one selected portion of geospatial overlay data, said combination being operable to display the at least one selected portion of the geo-registered sensor data overlaid with the at least one selected portion of geospatial overlay data based on the position of the sensor without receiving other geo-registered sensor data or other geospatial overlay data.07-08-2010

Michael Joseph Thomas, Severna Park, MD US

Patent application numberDescriptionPublished
20140213925SYSTEMS, METHODS AND KITS FOR MEASURING RESPIRATORY RATE AND DYNAMICALLY PREDICTING RESPIRATORY EPISODES - This disclosure is directed to devices, systems, kits and methods for measuring peak expiratory or inspiratory flow-rate and dynamically predicting respiratory episodes. Additionally, systems for analyzing and processing the measurement in a communication networked environment are also provided. An aspect of the disclosure is directed to a respiratory device, In some configurations the respiratory device comprises a housing adaptable and configurable to communicate with an electronic device, a mouth piece having a proximal end and a distal end configurable to engage a mouth of a patient and transmit an air flow, one or more diaphragm sensors configured to detect a breath vibration from the air flow in the mouth piece, and a processor adaptable and configurable to analyze the breath vibration detected by the one or more diaphragm sensors.07-31-2014

Peter C. Thomas, Germantown, MD US

Patent application numberDescriptionPublished
20110086418HIGHLY SENSITIVE OXYGEN SENSOR FOR CELL CULTURE - An oxygen sensor comprising an oxygen sensing compound and configured to substantially mitigate leaching of the oxygen sensing compound from the oxygen sensor to an outer surface thereof is provided. The oxygen sensor may comprise one or more layers. A first portion of the oxygen sensor is configured to be permeable to gas and comprises an oxygen sensing material. A second portion is disposed with or on the first portion and is configured to be permeable to gas and substantially impermeable to the oxygen sensing material.04-14-2011

Rickey J. Thomas, Lineboro, MD US

Patent application numberDescriptionPublished
20080253851Push button holesaw mandrel assembly - A holesaw mandrel assembly has a mandrel body with a first end to be coupled with a drill motor and a second end extending from the body. The second end receives a holesaw. The first member is positioned on the second end. The first member is axially movable on the second end. A friction surface is on the first member. The friction surface is adapted to contact a base surface of the holesaw such that upon contact with the friction surface, the holesaw is fixed in position. The friction surface moves between a first contact position and a second release position. A mechanism on the first member moves the friction surface between the first and second position.10-16-2008
20080253852Push Button Holesaw Mandrel Assembly - A holesaw mandrel assembly has a mandrel body with a first end to be coupled with a drill motor and a second end extending from the body. The second end receives a holesaw. A housing covers a portion of the mandrel. A first member is coupled with the housing and moves between a first and second position. A friction surface is on the first member. The friction surface is adapted to contact the holesaw such that upon contact with the friction surface, the holesaw is fixed in position. The friction surface moves between a first contact position and a second release position. A mechanism coupled with the housing moves the friction face between the first and second positions.10-16-2008
20100054881Metal Cutting Drill Bit - A combination drill bit for use in both hand held drills and stationary drill presses has a shanking end, a working end and a helical flute portion between the shanking and working ends. The helical portion has a helix length (L) of03-04-2010
20100215450Depth Gauge For Drill Bit - A depth gauge for use with a drill bit includes a body configured to receive a drill bit, a retention mechanism coupled to the body and configured to removably couple the body to the drill bit, and a cap configured to be removably coupled to the body. The cap can be coupled to the body in one of a first position relative to the body where the cap contacts a workpiece surface to prevent the drill bit from entering the workpiece more than a first depth, and a second position relative to the body where the cap contacts the workpiece surface to prevent the drill bit from entering the workpiece more than a second depth that is different from the first depth.08-26-2010
20100260565Depth Gauge For Drill Bit - A drill bit has a shank portion having a plurality of SDS-type slots, a cutting portion comprising at least one cutting flute, and an intermediate portion connecting the shank to the cutting portion, the intermediate portion including at least one additional slot. A depth gauge includes a body configured to receive the drill bit, a retention mechanism coupled to the body and having an inward projection to removably couple the body to the at least one additional slot in the drill bit, and a cap coupled to the body such that the cap contacts a workpiece surface to prevent the drill bit from entering the workpiece more than a predetermined depth, wherein the cap is movable relative to the body among a plurality of positions, wherein each of the plurality of positions corresponds to a different predetermined drilling depth.10-14-2010
20140126972DEPTH GAUGE AND DRILL BIT - A drill bit has a shank portion having a plurality of SDS-type slots, a cutting portion comprising at least one cutting flute, and an intermediate portion connecting the shank to the cutting portion, the intermediate portion including at least one longitudinal slot. A depth gauge includes a body configured to receive the drill bit, a retention mechanism coupled to the body and having an inward projection to removably couple the body to the at least one additional slot in the drill bit, and a cap coupled to the body such that the cap contacts a workpiece surface to prevent the drill bit from entering the workpiece more than a predetermined depth, wherein the cap is movable relative to the body among a plurality of positions, wherein each of the plurality of positions corresponds to a different predetermined drilling depth.05-08-2014

Patent applications by Rickey J. Thomas, Lineboro, MD US

Rickey J. Thomas, Manchester, MD US

Patent application numberDescriptionPublished
20080309029Chuck jaw face profile - A chuck is described. The chuck may include: a plurality of chuck jaws. Each chuck jaw is radially movable toward and way from a chuck axis, and each chuck jaw including: two substantially coplanar surfaces perpendicular to a chuck jaw axis and substantially parallel to the chuck axis; a ridge located between the two substantially coplanar surfaces; and two troughs, one trough located between the ridge and one of the substantially coplanar surface and the other trough located between the ridge and the other coplanar surface. A chuck jaw and method of configuring a chuck are also described.12-18-2008

Selina I. Thomas, Hyattsville, MD US

Patent application numberDescriptionPublished
20120088845Synthesis, capping and dispersion of nanocrystals - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.04-12-2012
20130207053SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.08-15-2013
20140045323SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.02-13-2014
20140295649SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.10-02-2014
20140302664SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.10-09-2014
20150203989SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.07-23-2015

Patent applications by Selina I. Thomas, Hyattsville, MD US

Selina L. Thomas, Hyattsville, MD US

Patent application numberDescriptionPublished
20130221279SYNTHESIS, CAPPING AND DISPERSION OF NANOCRYSTALS - Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.08-29-2013

Silko Renaldo Thomas, Waldorf, MD US

Patent application numberDescriptionPublished
20150174474Music Trivia Board Game - A music trivia game having a music trivia game board, timer, die, plurality of game pieces, and plurality of trivia cards. A plurality of game space sequences each have a first genre space, second genre space, third genre space, fourth genre space, fifth genre space, and category space corresponding to a first set of genre cards, second set of genre cards, third set of genre cards, fourth set of genre cards, fifth set of genre cards, and set of category cards, respectively, from the plurality of trivia cards. The plurality of game space sequences is positioned about a main path, first bypass route, and second bypass route, wherein the object of the music trivia game is to move a designated game piece from a start space to a finish space along the main path by rolling the die and answering a music trivia question corresponding to each game space.06-25-2015

Stefani Thomas, Parkville, MD US

Patent application numberDescriptionPublished
20140294839Methylated Peptides Derived from Tau Protein and Their Antibodies for Diagnosis and Therapy of Alzheimer's Disease - In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.10-02-2014

Steven D. Thomas, Abingdon, MD US

Patent application numberDescriptionPublished
20090230018BATTERY PACKAGING - A display package includes a front cover having a first bulbous portion defining a flashlight retaining cavity. A display portion is adjacent the first bulbous portion. A container includes a first side wall and a second side wall, wherein the first side wall of the container is connected to the display package by a living hinge. At least one battery is disposed inside the container and at least one flashlight is disposed inside the first bulbous portion.09-17-2009

Susan Napier Thomas, Baltimore, MD US

Patent application numberDescriptionPublished
20110003710SELECTIN LIGANDS USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.01-06-2011

Tojo Thomas, Odenton, MD US

Patent application numberDescriptionPublished
20110258328Secure location session manager - A Secure Location Session Manager (SLSM) is an intelligent router for open mobile alliance (OMA) Secure User Plane Location (SUPL) Version 1.0 (and later) messages best implemented when multiple, geo-diverse SUPL servers are deployed in a distributed environment, such as an active-active redundant configuration within a wireless carrier's network. In a standalone option, the SLSM acts as a “middleman” for all SUPL positioning messages between a mobile device and a responsible SUPL server. In an embedded option, the SLSM resides within an existing server. The SLSM manages and stores session information for all pending and ongoing SUPL positioning sessions in internal tables for routing and load balancing purposes. The external interfaces of the SLSM consist of OMA ULP messages.10-20-2011
20140057602Secure Location Session Manager - A Secure Location Session Manager (SLSM) is an intelligent router for open mobile alliance (OMA) Secure User Plane Location (SUPL) Version 1.0 (and later) messages best implemented when multiple, geo-diverse SUPL servers are deployed in a distributed environment, such as an active-active redundant configuration within a wireless carrier's network. In a standalone option, the SLSM acts as a “middleman” for all SUPL positioning messages between a mobile device and a responsible SUPL server. In an embedded option, the SLSM resides within an existing server. The SLSM manages and stores session information for all pending and ongoing SUPL positioning sessions in internal tables for routing and load balancing purposes. The external interfaces of the SLSM consist of OMA ULP messages.02-27-2014

Vincent Philip Thomas, Severna Park, MD US

Patent application numberDescriptionPublished
20080275800METHOD AND SYSTEM FOR DEBT COLLECTION OPTIMIZATION - The present invention employs data processing systems to handle debt collection by formulation the collections process as a Markov Decision Process with constrained resources, thus making it possible automatically to generate an optimal collections policy with respect to maximizing long-term expected return throughout the course of a collections process, subject to constraints on the available resources possibly in multiple organizations. This is accomplished by coupling data modeling and resource optimization within the constrained Markov Decision Process formulation and generating optimized rules based on constrained reinforcement learning process comprising applied on the basis of past historical data.11-06-2008
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