Patent application number | Description | Published |
20080291463 | POLARIZATION-SENSITIVE SPECTRAL INTERFEROMETRY - A polarization sensitive spectral interferometer apparatus and method for analyzing a sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample. | 11-27-2008 |
20090018393 | CATHETER FOR IN VIVO IMAGING - A catheter for in vivo imaging comprising a monolithic outer sheath terminating in a monolithic atraumatic tip having a guidewire lumen. The catheter for in vivo imaging comprising a rotary drive shaft that passes through a central lumen of the monolithic outer sheath to impart rotary motion. | 01-15-2009 |
20090043191 | OCT-IVUS CATHETER FOR CONCURRENT LUMINAL IMAGING - The invention relates to an apparatus for in vivo imaging. More specifically, the present invention relates to a catheter that incorporates an Optical Coherence Tomography (OCT) system and an Intravascular Ultrasound (“IVUS) system for concurrent imaging of luminal systems, such as imaging the vasculature system, including, without limitation, cardiac vasculature, peripheral vasculature and neural vasculature. | 02-12-2009 |
20090043198 | MAGNETO-MOTIVE ULTRASOUND DETECTION OF MAGNETIC NANOPARTICLES - Provided herein are systems, methods and compositions for the use of ultrasound for detection of cells and nanoparticles. | 02-12-2009 |
20090046295 | APPARATUS AND METHODS FOR UNIFORM SAMPLE CLOCKING - A method and a system for Uniform Frequency Sample Clocking to directly sample the OCT signal with a temporally-non-linear sampling clock derived from a k-space wavemeter on the external sample clock input port of a digitizer. | 02-19-2009 |
20100168587 | CATHETER IMAGING PROBE AND METHOD - A catheter imaging probe for a patient. The probe includes a conduit through with energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit. | 07-01-2010 |
20100220334 | FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBES - Provided are forward-imaging optical coherence tomography (OCT) systems and probes. | 09-02-2010 |
20100237258 | Systems and Methods for Altering Visual Acuity - Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject. | 09-23-2010 |
20100249609 | MEASUREMENT OF NEURAL FUNCTIONALITY USING PHASE SENSITIVE OPTICAL COHERENCE REFLECTOMETRY - Optical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents. | 09-30-2010 |
20100298716 | METHODS AND COMPOSITIONS TO REDUCE SCATTERING OF LIGHT DURING THERAPEUTIC AND DIAGNOSTIC IMAGING PROCEDURES - Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues. | 11-25-2010 |
20110009701 | OCT USING SPECTRALLY RESOLVED BANDWIDTH - The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient. The endoscope comprises an optical fiber array and can comprise a plurality of optical fibers adapted to be disposed in the patient. The optical fiber array transmits the light from the light source into the patient, and transmits the light reflected by the patient out of the patient. The plurality of optical fibers in the array is in optical communication with the light source. The multichannel optical coherence tomography system comprises a detector for receiving the light from the array and analyzing the light. The methods and apparatus may be applied for imaging a vessel, biliary, GU and/or GI tract of a patient. | 01-13-2011 |
20110077528 | METHOD AND APPARATUS FOR SIMULTANEOUS HEMOGLOBIN REFLECTIVITY MEASUREMENT AND OCT MEASUREMENT, THROMBUS DETECTION AND TREATMENT, AND OCT FLUSHING - A method and apparatus for simultaneous hemoglobin reflectivity measurement and OCT measurement, thrombus detection and treatment, and OCT flushing. A first optical energy for OCT and a second optical energy for hemoglobin may be used. | 03-31-2011 |
20110112409 | ROTATING CATHETER PROBE USING A LIGHT-DRIVE APPARATUS - The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow. | 05-12-2011 |
20110137124 | OPTICAL IMAGING CATHETER FOR ABERRATION BALANCING - An Optical imaging catheter that balances optical aberrations and allows recording of high quality optical images while relaxing the requirement of a fluid occupying the space between the prism and the inner sheath of the catheter. | 06-09-2011 |
20110152771 | ROTATING OPTICAL CATHETER TIP FOR OPTICAL COHERENCE TOMOGRAPHY - The present invention relates to a rotating catheter tip for optical coherence tomography based on the use of an optical fiber that does not rotate, that is enclosed in a catheter, which has a tip rotates under the influence of a fluid drive system to redirect light from the fiber to a surrounding vessel and the light reflected or backscattered from the vessel back to the optical fiber. | 06-23-2011 |
20120010603 | TISSUE OPTICAL CLEARING DEVICES FOR SUBSURFACE LIGHT-INDUCED PHASE-CHANGE AND METHOD OF USE - Tissue optical clearing devices for subsurface photodisruption and methods of use generally comprise an energy source in conjunction with mechanical optical clearing for the creation of high precision surface and subsurface photodisruption and/or photoablation. | 01-12-2012 |
20120013914 | APPARATUS AND METHODS FOR UNIFORM FREQUENCY SAMPLE CLOCKING - A method and a system for Uniform Frequency Sample Clocking to directly sample the OCT signal with a temporally-non-linear sampling clock derived from a k-space wavemeter on the external sample clock input port of a digitizer. | 01-19-2012 |
20120136238 | HEMOGLOBIN CONTRAST IN MAGNETO-MOTIVE OPTICAL DOPPLER TOMOGRAPHY, OPTICAL COHERENCE TOMOGRAPHY, AND ULTRASOUND IMAGING METHODS AND APPARATUS - A novel contrast mechanism for imaging blood flow using magneto-motive optical Doppler tomography (MM-ODT), Optical Coherence Tomography, and Ultrasound. MM-ODT, OCT, and ultrasound combined with an externally applied temporally oscillating high-strength magnetic field detects erythrocytes moving according to the field gradient. | 05-31-2012 |
20120136259 | POLARIZATION-SENSITIVE SPECTRAL INTERFEROMETRY - A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample. | 05-31-2012 |
20120184847 | HEMOGLOBIN CONTRAST IN ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY FOR DIAGNOSING DISEASED TISSUE, CANCERS, AND THE LIKE - A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field. | 07-19-2012 |
20130023714 | Medical and Imaging Nanoclusters - In one embodiment the present invention discloses a nanocluster or a nanorose composition comprising two or more closely spaced nanoparticles each comprising one or more metals, metal oxides, inorganic substances, or a combination thereof and one or more stabilizers. The stabilizers are in contact with the two or more closely spaced nanoparticles to form a nanocluster composition in which the inorganic weight percentage is greater than 50% and the average size is below 300 nm, and the nanocluster composition has magnetic properties, optical properties or a combination of both. | 01-24-2013 |
20130032024 | SYSTEMS AND METHODS FOR ALTERING VISUAL ACUITY - Provided are systems and methods to temporarily alter visual acuity of a subject. An example system includes a first light source configured to produce infrared light in an infrared wavelength spectrum for transient propagation into an eye of the subject and a second light source configured to produce visible light in a visible wavelength spectrum for transient propagation into the eye of the subject. The system further includes a transmission unit configured to propagate the infrared light and the visible light into the eye, wherein the light propagated into the eye temporarily alters visual acuity of the subject. | 02-07-2013 |
20130090536 | ANALYTE SENSOR METHOD AND APPARATUS - Provided herein are systems, methods, and apparatuses for an analyte sensor. In one aspect, an analyte sensing device comprises a sensor body member including at least one nanopore and an optical conduit in optical communication with the sensor body member. The optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member. A photodetector is optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy. | 04-11-2013 |
20130091941 | DETERMINATION OF OIL SATURATION IN RESERVOIR ROCK USING PARAMAGNETIC NANOPARTICLES AND MAGNETIC FIELD - Methods for detection of the presence and distribution of oil in subsurface formation are described herein. The present invention involves injection of an aqueous dispersion of the nanoparticles into the potentially oil containing subsurface formation, followed by a remote detection of the oscillation responses of the nanoparticles in the oil/water interfaces in the reservoir rock by applying magnetic field. | 04-18-2013 |
20130178916 | SYSTEM, DEVICES, AND METHODS FOR OPTICALLY CLEARING TISSUE - Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated. | 07-11-2013 |
20130197346 | HEMOGLOBIN CONTRAST IN MAGNETO-MOTIVE OPTICAL DOPPLER TOMOGRAPHY, OPTICAL COHERENCE TOMOGRAPHY, AND ULTRASOUND IMAGING METHODS AND APPARATUS - Provided herein are systems, methods, and compositions for the use of optical coherence tomography for detection of cells. | 08-01-2013 |
20130245378 | ROTATING CATHETER PROBE USING A LIGHT-DRIVE APPARATUS - The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow. | 09-19-2013 |
20130331701 | MAGNETO-MOTIVE ULTRASOUND DETECTION OF MAGNETIC NANOPARTICLES - Provided herein are systems, methods and compositions for the use of ultrasound for detection of cells and nanoparticles. | 12-12-2013 |
20130338495 | OCT USING SPECTRALLY RESOLVED BANDWIDTH - The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically. The multichannel optical coherence tomographic methods can be incorporated into an endoscopic probe for imaging a patient. | 12-19-2013 |
20140083970 | FORWARD-IMAGING OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEMS AND PROBES - Provided are forward-imaging optical coherence tomography (OCT) systems and probes. | 03-27-2014 |
20140098373 | POLARIZATION-SENSITIVE SPECTRAL INTERFEROMETRY - A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample. | 04-10-2014 |
20140098374 | APPARATUS AND METHODS FOR UNIFORM FREQUENCY SAMPLE CLOCKING - A method and a system for Uniform Frequency Sample Clocking to directly sample the OCT signal with a temporally-non-linear sampling clock derived from a k-space wavemeter on the external sample clock input port of a digitizer. | 04-10-2014 |
20140191140 | SYSTEMS AND METHODS FOR ALTERING VISUAL ACUITY - Provided are methods, systems, and apparatus for altering a modulation transfer function of an imaging system. The described methods, systems and apparatus can be used to temporarily alter visual acuity of a subject. | 07-10-2014 |
20140268163 | Methods and Apparatus Related to Multi Wavelength Photothermal Optical Coherence Tomography - Embodiments of the invention include apparatus and methods of non-invasively detecting one or more constituents of a target using multiple wavelength photothermal optical coherence tomography. | 09-18-2014 |