| Patent application number | Description | Published |
|---|
| 20090054788 | METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY - A method and an apparatus for displaying a part of a brain of a patient is described. Laser-Doppler-images are acquired before and after a stimulation. The laser-Doppler-images include information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation. | 02-26-2009 |
| 20090118623 | Instrument and Method for High-Speed Perfusion Imaging - A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps. | 05-07-2009 |
| 20100130869 | METHOD AND APPARATUS FOR DISPLAYING A FIELD OF A BRAIN OF A PATIENT AND NAVIGATION SYSTEM FOR BRAIN SURGERY - A method and an apparatus for displaying a part of a brain of a patient is provided. Laser Doppler images are acquired before and after a stimulation. The laser Doppler images comprise information about a blood motion or about a perfusion at the acquired part. Then, the blood motion images acquired before and after the stimulation are compared to identify areas in the brain of the patient which are related to the stimulation. The identified areas are displayed in dependence of topography data representing a topography of the brain. | 05-27-2010 |
| 20100141956 | DUAL BEAM HETERODYNE FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY - The present invention relates to an apparatus and a method combining achromatic complex FDOCT signal reconstruction with a common path and dual beam configuration. The complex signal reconstruction allows resolving the complex ambiguity of the Fourier transform and to enhance the achievable depth range by a factor of two. The dual beam configuration shares the property of high phase stability with common path FDOCT. This is of importance for a proper complex signal reconstruction and is in particular useful in combination with handheld probes such as in endoscopy and catheter applications. The advantages of the present invention are in particular the flexibility to choose arbitrarily positioned interfaces in the sample arm as reference together with the possibility to compensate for dispersion. | 06-10-2010 |
| 20110090325 | SYSTEM AND METHOD FOR EXAMINING AN OBJECT - In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object. | 04-21-2011 |
| 20110169978 | FUNCTIONAL OPTICAL COHERENT IMAGING - The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions. | 07-14-2011 |
| 20130010283 | DARK FIELD OPTICAL COHERENCE MICROSCOPY - The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object. | 01-10-2013 |
| 20130016887 | APPARATUS AND METHOD FOR DETECTING AND MEASURING BIOMOLECULAR INTERACTIONSAANM Durand; NicolasAACI BlonayAACO CHAAGP Durand; Nicolas Blonay CHAANM Marki; IwanAACI YverdonAACO CHAAGP Marki; Iwan Yverdon CHAANM Lasser; TheoAACI DengesAACO CHAAGP Lasser; Theo Denges CH - A method and system for the rapid detection of biomolecular interactions, the system comprising a sensing platform which comprises a primary support structure including recesses designed to be located in front of a detection unit, said recesses containing one or several arrays of biosensors, said system furthermore comprising a reader unit for optical excitation and detection. | 01-17-2013 |
| 20130017967 | NANOFLUIDIC BIOSENSOR AND ITS USE FOR RAPID MEASUREMENT OF BIOMOLECULAR INTERACTIONS IN SOLUTION AND METHODSAANM Durand; NicolasAACI BlonayAACO CHAAGP Durand; Nicolas Blonay CHAANM Fournier; YannickAACI EcublensAACO CHAAGP Fournier; Yannick Ecublens CHAANM Lasser; TheoAACI DengesAACO CHAAGP Lasser; Theo Denges CHAANM Marki; IwanAACI YverdonAACO CHAAGP Marki; Iwan Yverdon CH - A method and device for the rapid detection of biomolecules ( | 01-17-2013 |
| 20130172735 | OPTICAL COHERENT IMAGING MEDICAL DEVICE - The invention concerns an OCI medical device ( | 07-04-2013 |
| 20130296715 | INSTRUMENT AND METHOD FOR HIGH-SPEED PERFUSION IMAGING - A high-speed laser perfusion imaging instrument including a laser source, a detector, a signal-processing unit, data memory, and a screen to display results. A section of a sample surface is illuminated with laser light; reemitted light from the irradiated surface is collected by focusing optics on a 2D array of integrating photodetectors having elements that can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array measures intensity variations at each individual pixel. Average amplitude and mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, exposure time is used as a parameter to measure relative perfusion changes. These data are stored and processed with the signal-processing unit to deliver 2D flow maps of the illuminated sample section, and allow a simple overlay between a conventional image and processed flow maps. | 11-07-2013 |
| 20140198198 | CUMULANT MICROSCOPY - The invention describes a method and a microscopy system for imaging and analysing stochastically and independently blinking point-like emitters. A multiple-order cumulants analysis in conjunction with an established blinking model enables the extraction of super-resolved environment-related parameter maps, such as molecular state lifetimes, concentration and brightness distributions of the emitter. In addition, such parameter maps can be used to compensate for the non-linear brightness and blinking response of higher-order cumulant images—used for example in Super-resolution Optical Fluctuation Imaging (SOFI)—to generate a balanced image contrast. Structures that otherwise would be masked by brighter regions in the conventional cumulant image become samples using spectral cross-cumulants. | 07-17-2014 |
| 20140256573 | RAPID QUANTIFICATION OF BIOMOLECULES IN A SELECTIVELY FUNCTIONALIZED NANOFLUIDIC BIOSENSOR AND METHOD THEREOF - A method and device for the rapid quantification of biomolecules ( | 09-11-2014 |
