Patent application number | Description | Published |
20130206134 | SUBSURFACE THERMAL ENERGY STORAGE OF HEAT GENERATED BY CONCENTRATING SOLAR POWER - Techniques for subsurface thermal energy storage of heat generated by concentrating solar power enable smoothing of available energy with respect to daily and/or seasonal variation. Solar thermal collectors produce saturated steam that is injected into a producing or wholly/partially depleted oil reservoir that operates as a heat storage reservoir. Some of the saturated steam generated by the collectors is optionally used to generate electricity. Heat is withdrawn from the reservoir as saturated steam and is used to operate an active thermal recovery project (such as a producing thermally enhanced oil reservoir) and/or to generate electricity. Withdrawn heat is optionally augmented by heat produced by firing natural gas. The reservoir is optionally one that has been used for thermally enhanced oil recovery and thus is already warm, minimizing heat losses. | 08-15-2013 |
20130210734 | METHOD OF PREVENTING PROGRESSION OF HYPERTENSION-INDUCED HEART FAILURE WITH PKC PEPTIDES - Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an εPKC, β | 08-15-2013 |
20130210897 | MINI-INTRONIC PLASMID VECTORS - Compositions and methods are provided for achieving persistent, high level expression of transgenes in vitro and in vivo. Aspects of the invention include vectors comprising an intronic cassette that comprises plasmid elements, and methods that rely on the use of vectors comprising an intronic cassette that comprises plasmid elements. These compositions and methods find use in many applications, including therapeutic applications such as in gene therapy; synthesis applications such as in the synthesis of peptides, proteins, and RNAs, e.g. for research or therapeutic purposes; and research applications, such as in the production of transgenic cells and animals. In addition, reagents, devices and kits thereof that find use in making the subject compositions and practicing the subject methods are provided. | 08-15-2013 |
20130215431 | OPTICAL COHERENCE TOMOGRAPHY SYSTEM AND METHOD THEREFOR - A method for increasing the imaging rate for an optical coherence tomography system is disclosed. The method comprises generating an interferometric signal by interrogating each of M object points on a sample with a unique set of wavelength components that are collectively spectrally interleaved within a spectral range, forming the interferometric signal based on the wavelength components reflected from the interrogated object points, dispersing the interferometric signal across a two-dimensional array of detectors, and forming an image based on the dispersed spectral components. | 08-22-2013 |
20130215805 | Systems and Methods for Full-Duplex Signal Shaping - The current subject matter relates to a system and a method for processing signals. The system can include a transmitting antenna for transmitting a signal over a plurality of wireless spectrum fragments, a receiving antenna for receiving a signal from the plurality of wireless spectrum fragments, and a signal processing layer in communication with the transmitting and receiving antennas for simultaneously causing reception of the received signal and transmission of the transmitted signal. The signal processing layer can include an interference cancellation component for removing a first portion of interference from the received signal and a filtering component for removing a second portion of the interference from the received signal. | 08-22-2013 |
20130215979 | Method and Apparatus for Efficient Communication with Implantable Devices - Described herein are methods of making and using and apparatus for wirelessly communicating data and providing power, particularly from a location exterior to a body and to an implantable device disposed within a body with tissue. The described embodiments provide apparatus and methods for efficiently transfer data and power between an external transceiver and an (implanted) biomedical device. The method is to modulate power carrier, which wirelessly powers the device, using an asynchronous modulation scheme, such as amplitude shift keying (ASK) modulation, with minimal modulation depth in order to not disrupt the power flow. The digital data is encoded in the pulse width, eliminating the need for synchronization to the power carrier signal and further minimizing the power consumption necessary for data transfer. Additionally, a reverse backscatter method for obtaining data from the implant is described that has flexible, low power operation. | 08-22-2013 |
20130222393 | Method and System for Interactive Layout - In an embodiment of the present invention, an interactive system employs sets of interior design guidelines. In an embodiment, the user begins by specifying the shape of a room and the set of furniture that must be arranged within it. The user then interactively moves furniture pieces. In response, the system suggests a set of furniture layouts that follow the interior design guidelines. The user can interactively select a suggestion and move any piece of furniture to modify the layout. | 08-29-2013 |
20130224122 | MAGNETOTATIC BACTERIA MRI POSITIVE CONTRACT ENHANCEMENT AGENT AND METHODS OF USE - Magnetic resonance imaging (MRI) is enhanced by contrast agents such as superparamagnetic iron-oxide (SPIO) particles that resemble magnetite particles produced by magnetotactic bacteria. | 08-29-2013 |
20130224259 | Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of Use Thereof - The present disclosure provides DDAH modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive NO production and/or elevated DDAH activity, the method comprising administering to said patient an effective amount of a compound of one of formulae I-X. The present disclosure also provides a pharmaceutical composition comprising a compound of one of formulae I-X. | 08-29-2013 |
20130224821 | Light-Activated Chimeric Opsins and Methods of Using the Same - Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons. | 08-29-2013 |
20130225431 | ASSESSMENT OF CELLULAR FRAGMENTATION DYNAMICS FOR DETECTION OF HUMAN EMBRYONIC ANEUPLOIDY - Methods of evaluating the developmental potential of human embryos are disclosed. In particular, the invention relates to methods of detecting embryonic aneuploidy by assessment of cellular fragmentation dynamics in individual blastomeres of embryos up to the 4-cell stage. The methods of the invention should improve in vitro fertilization (IVF) outcomes by reducing inadvertent transfer of non-viable embryos likely to result in spontaneous miscarriage. | 08-29-2013 |
20130226018 | NON-INVASIVE CARDIAC MONITOR AND METHODS OF USING CONTINUOUSLY RECORDED CARDIAC DATA - Embodiments of the invention provide methods of obtaining continuous cardiac information from a mammal. First, attach a self-contained, wearable, portable continuous cardiac monitor to he mammal to create a chamber containing electrodes used to detect cardiac signals from the mammal. Next, continuously detect without analyzing the cardiac signals from the mammal for at least 24 hours. Next, store information related to substantially all detected cardiac signals in the cardiac monitor. | 08-29-2013 |
20130226548 | SYSTEMS AND METHODS FOR ANALYSIS TO BUILD PREDICTIVE MODELS FROM MICROSCOPIC CANCER IMAGES - Aspects of the present disclosure are directed towards methods, apparatus, and systems that predict a survival outcome for a patient using a prognostic model and cancer tissue image data from the patient. Cancer data is received, and superpixels are constructed that are representative of the data. Nuclear and cytoplasmic features are constructed for the superpixels based upon the image data and nuclei within the superpixels, and the superpixels are classified as epithelium or stroma based thereon. Relational feature data is computed for both the epithelium superpixels and the stroma superpixels, and a prognostic model is constructed based on the relational feature data. | 08-29-2013 |
20130230539 | Anti-Leukocyte Recruitment Therapy for the Treatment of Seizures and Epilepsy - Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy. | 09-05-2013 |
20130243848 | NANOPARTICLES, NANOPARTICLE DELIVERY METHODS, AND SYSTEMS OF DELIVERY - In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to nanoparticles, compositions including nanoparticles, methods of making nanoparticles, and the like. In particular, embodiments of the present disclosure include nanoparticles and compositions for the sustained release (e.g., release at a predetermined rate to maintain a certain concentration for a certain period of time) of an agent, such as a small interfering RNA (siRNA) from the nanoparticle. | 09-19-2013 |
20130244323 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to a light stimulus. The method includes engineering the light-activated ion channel molecule in a cell; and activating the ion channel molecule, in response to light stimulus that is provided to the ion channel molecule and that has properties that do not activate a ChR2 ion channel, to allow ions to pass through the light-activated ion channel molecule. | 09-19-2013 |
20130244326 | Markers of Acute Myeloid Leukemia Stem Cells - Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. | 09-19-2013 |
20130244688 | Method and System for Signal-based Localization - In an embodiment of the present invention, a GraphSLAM-like algorithm for signal strength SLAM is presented. This algorithm as an embodiment of the present invention shares many of the benefits of Gaussian processes yet is viable for a broader range of environments since it makes no signature uniqueness assumptions. It is also more tractable to larger map sizes, requiring O(N | 09-19-2013 |
20130244938 | Relaxin Analogs - Human relaxin analogs, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. | 09-19-2013 |
20130244990 | GENETIC POLYMORPHISMS ASSOCIATED WITH DEPRESSION - The present disclosure provides methods for determining risk for depression, as well as compositions for use in such methods. | 09-19-2013 |
20130245371 | APPARATUS AND METHODS FOR CORONARY SINUS ACCESS - Apparatus and methods for locating features within a body cavity using a catheter including proximal and distal ends, a transparent balloon carried on the distal end, and an optical imaging assembly carried on the distal end for imaging through the balloon. The balloon includes a channel extending therethrough to a lumen extending through the catheter. A guidewire or other localization member is received in the lumen that is extendable through the channel. During use, the catheter is inserted into a right atrium of a heart, and the balloon is expanded and placed against the wall of the heart to locate the coronary sinus. Sufficient force is applied to clear blood between the surface and the wall and clear the field of view of the imaging assembly. The catheter is manipulated to locate the coronary sinus, whereupon the localization member is advanced into the coronary sinus. | 09-19-2013 |
20130245505 | Noninvasive Ultrasound-Based Retinal Stimulator: Ultrasonic Eye - A retinal stimulation and prosthetic device is provided that includes at least one ultrasonic transducer having a focused ultrasonic signal, where the focused ultrasonic signal includes an acoustic frequency, a spot size, a temporal pattern, a pulse duration and a power capable of stimulating retinal neurons when the at least one ultrasonic transducer is disposed proximal to an eye. | 09-19-2013 |
20130249821 | Method and System for Virtual Keyboard - In an embodiment of the invention, a virtual Braille keyboard is disclosed that makes use of a touch-sensitive computing device. In an embodiment of the invention, a calibration procedure is initiated by a user for determining the general position of various finger tips that will subsequently be used for the input of Braille characters. After calibration, the operation of a physical Braille keyboard is mimicked using methods according to an embodiment of the invention. | 09-26-2013 |
20130252282 | OPTICAL CONTROL OF PROTEIN ACTIVITY AND LOCALIZATION BY FUSION TO PHOTOCHROMIC PROTEIN DOMAINS - Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent protein domains linked to selected proteins and shown that such fusion proteins can be used to control the activity or localization of selected proteins with light. | 09-26-2013 |
20130267501 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof - The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. | 10-10-2013 |
20130272966 | RET2IR CONJUGATES, RET2IR CONJUGATE SYSTEMS AND METHODS OF USE THEREOF - Embodiments of the present disclosure include conjugate systems, methods of using conjugate systems, RET | 10-17-2013 |
20130274131 | Advanced Reverse-phase Magnetic Immunoassay - A magnetic assay is provided where capture probes are disposed on the sensor array as capture probe spots that overlap with the sensor elements. The capture probes on the sensor elements can be the same or they can be different. Two or more sample solutions are also disposed on the sensor array as sample spots that overlap with the sensor elements. Targets in the sample solutions can bind to the capture probes to provide immobilized targets. Magnetically labeled probes capable of binding to targets are provided to the assay, and the resulting assay signal is from immobilized magnetically labeled probes at the sensor elements. | 10-17-2013 |
20130277278 | Micro-Structure-based Adhesives for Size-Selective Particle Trapping and Sorting - A method of separating particles is provided that includes exposing a selective PDMS adhesive to a particle-contaminated surface, where the selective PDMS adhesive captures particles present on the particle-contaminated surface to form a fouled selective PDMS adhesive, and exposing the fouled selective PDMS adhesive to a PDMS transfer sheet, where particles outside of a desired range are transferred over to the PDMS transfer sheet, where the fouled selective PDMS adhesive retains only the particles of a desired range. | 10-24-2013 |
20130281409 | Myelin Sheath Fatty Acids that Resolve Neuroinflammation - Methods are provided for decreasing inflammatory disease in a subject by administering an effective dose of a lipid, fatty acid, or analog thereof. | 10-24-2013 |
20130284920 | System, Method and Applications Involving Identification of Biological Circuits Such as Neurological Characteristics - Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response at a level sufficiently detailed in space and time to differentiate between polarization-based events of two respective portions of the subfield, and then assessing neural activity by correlating space and time information, from the captured data, for the two respective portions of the sub-field. Other more specific aspects of the invention involve different preparation and neural stimulation approaches which can vary depending on the application. | 10-31-2013 |
20130289386 | Optogenetic Magnetic Resonance Imaging - Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain. | 10-31-2013 |
20130294722 | Practical multiply resonant photonic crystal nanocavity - Intersecting photonic crystal structures provide overlapping cavity modes that can have widely separated resonant frequencies. These photonic crystal structures can be either 1-D photonic crystal structures or 2-D photonic crystal structures. If a material having the zincblende crystal structure is employed (e.g., GaAs), it is preferred for the crystal orientation to be (110) or (111), because these orientations can provide three wave mixing for three TE-like modes. | 11-07-2013 |
20130299707 | OPTICAL COUPLING TECHNIQUE FOR CONTIGUOUS MONOLITHIC SCINTILLATION CRYSTAL DETECTORS - Embodiments of the invention provide a high energy photon detector. A first scintillation crystal is provided. A first plurality of photosensors is on a first face of the first scintillation crystal, wherein the first plurality is at least two. A second scintillation crystal is provided. A second plurality of photosensors is on a first face of the second scintillation crystal, wherein the second plurality is at least two. An optical coupling interface is between a second face of the first scintillation crystal and a second face of the second scintillation crystal, wherein the optical coupling interface provides an optical transmission between the first scintillation crystal and the second scintillation crystal, so that the distribution of scintillation light created in one crystal is allowed to spread into the second crystal. | 11-14-2013 |
20140021907 | Wireless energy transfer - Electromagnetic energy transfer is facilitated. In accordance with an example embodiment, a first resonator transmits electromagnetic energy using an electromagnetic wave, based on frequency matching and alignment of an electromagnetic field with a second resonator within one wavelength of the electromagnetic wave distance from the first resonator. An electromagnetic energy reflector adjacent the first resonator redirects reflected portions of the electromagnetic wave back towards the first resonator circuit. | 01-23-2014 |
20140024701 | Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor - Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia. | 01-23-2014 |
20140029011 | OPTICAL SENSOR HAVING A NON-NEGLIGIBLE SOURCE COHERENCE LENGTH - An optical sensor, a method of configuring an optical sensor, and a method of using an optical sensor are provided. The optical sensor includes an optical loop having a length and a laser source optically coupled to the loop. The laser source has a coherence length. Light from the source is transmitted to the loop as a first signal and a second signal counterpropagating along the loop. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after counterpropagating through the loop to generate a third signal. A ratio of the coherence length to the length of the loop is greater than 1. | 01-30-2014 |
20140042606 | Low Loss Nano-aperture - Low loss optical apertures are provided. A silicon intermediate layer sandwiched between a metal aperture layer and a dielectric layer has been found to offer a good combination of low optical loss combined with superior mechanical properties. | 02-13-2014 |
20140044144 | Vertical Cavity Surface Emitting Laser Nanoscope for Near-field Applications - A vertical cavity surface emitting laser (VCSEL) nanoscope is provided. The VCSEL nanoscope combines a VCSEL with a nano-scale aperture using a support member to separate the aperture from the VCSEL emission face. The resulting device is a useful near-field probe with a wide variety of applications. | 02-13-2014 |
20140062255 | PIEZOELECTRIC APPARATUSES, SYSTEMS AND METHODS THEREFOR - Various aspects as described herein are directed to piezoelectric materials. As consistent with one or more embodiments, an apparatus includes a nanomaterial and structures coupled to the nanomaterial. This nanomaterial-structure combination manifests piezoelectric characteristics, via the combination. In certain implementations, neither the nanomaterial nor the coupled structures independently exhibit piezoelectric characteristics, yet do so in combination. | 03-06-2014 |
20140064654 | MULTIMODE FIBER FOR SPATIAL SCANNING - A method for imaging a scan region by controlling at least one of the relative phase and relative amplitude of multiple optical modes propagating through a multimode optical fiber to control the position of an output beam emitted from the output facet of the optical fiber is disclosed. | 03-06-2014 |
20140113367 | Systems, Methods and Compositions for Optical Stimulation of Target Cells - Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments). | 04-24-2014 |
20140130213 | INTERFEROMETRIC ATOMIC-FORCE MICROSCOPY DEVICE AND METHOD - A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes in accordance with the present invention are capable of high-sensitivity performance over a broad range of operating conditions, such as operating wavelength and measurement media. A method for estimating at least one physical property of a surface based on high-frequency signal components in the output signal from a high-bandwidth AFM probe is also disclosed. The method enables determination of tip-surface interaction forces based on the relationship between a first motion of the base of the AFM probe and a second motion of the tip of the AFM probe. | 05-08-2014 |
20140177794 | SYSTEM AND METHOD FOR FOCAL SPOT DEFLECTION - An X-ray tube and methods for imaging are disclosed. The X-ray tube includes an emitter configured to generate an electron beam. Further, the X-ray tube includes a target configured to generate X-rays in response to the electron beam, where a target surface includes at least a first region having a first elevation and a second region having a second elevation different from the first elevation. The X-ray tube also includes a detector configured to generate projection data based on the X-rays and a computing device coupled to the emitter, the detector and/or the target. The computing device is configured to deflect a focal spot on the target surface by controlling target rotation such that the electron beam impinges alternatively on the first and second regions. The computing device processes the projection data corresponding to the deflected focal spot positions and reconstructs images of a subject using the processed projection data. | 06-26-2014 |
20140207426 | SIMULATION OF PHENOMENA CHARACTERIZED BY PARTIAL DIFFERENTIAL EQUATIONS - Various aspects of the present disclosure are directed toward apparatus, methods, and articles of manufacture for simulating a physical phenomenon characterized by a set of partial differential equations that are reduced based on harmonic time dependence. The system of linear equations represent an operation in the differential equations, and are characterized by a coefficient matrix multiplied by an unknown column vector, with the product thereof being equal to a column vector. The system of linear equations is solved using at least one of three sets of operations. | 07-24-2014 |
20140319461 | SINGLE-WALLED CARBON NANOTUBE-BASED PLANAR PHOTODECTOR - A single-walled carbon nanotube-based planar photodetector includes a substrate; a first electrode and a second electrode disposed on the substrate and spaced apart from each other; a plurality of single-walled carbon nanotubes, each of the plurality of single-walled carbon nanotubes contacting the first electrode and the second electrode; and an adsorbent attached to a surface of at least one of the plurality of single-walled carbon nanotubes, wherein the adsorbent is capable of doping the at least one of the plurality of single-walled carbon nanotubes by photo-excitation. | 10-30-2014 |