Patent application number | Description | Published |
20080309929 | METHOD AND SYSTEM FOR STANDARDIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 12-18-2008 |
20090074266 | METHOD AND SYSTEM FOR DETERMINING AN OPTIMAL DILUTION OF A REAGENT - A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay. | 03-19-2009 |
20090074282 | METHODS AND SYSTEM FOR VALIDATING SAMPLE IMAGES FOR QUANTITATIVE IMMUNOASSAYS - A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation. Results can be examined at a user interface allowing for user inspection of samples determined to be unsuitable, the user interface also having provisions for manual override of the determination. | 03-19-2009 |
20100136549 | REPRODUCIBLE QUANTIFICATION OF BIOMARKER EXPRESSION - A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator. | 06-03-2010 |
20110116086 | METHOD AND SYSTEM FOR STANDARDIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 05-19-2011 |
20110116087 | METHOD AND SYSTEM FOR STANDARDIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 05-19-2011 |
20110299070 | METHOD AND SYSTEM FOR STANDARDIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 12-08-2011 |
20120133930 | METHOD AND SYSTEM FOR STANDARDIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 05-31-2012 |
20120176487 | METHODS AND SYSTEM FOR VALIDATING SAMPLE IMAGES FOR QUANTITATIVE IMMUNOASSAYS - A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation. Results can be examined at a user interface allowing for user inspection of samples determined to be unsuitable, the user interface also having provisions for manual override of the determination. | 07-12-2012 |
20120201435 | METHOD AND SYSTEM FOR DETERMINING AN OPTIMAL DILUTION OF A REAGENT - A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay. | 08-09-2012 |
20130216111 | COMPARTMENT SEGREGATION BY PIXEL CHARACTERIZATION USING IMAGE DATA CLUSTERING - The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression. | 08-22-2013 |
20130310268 | METHOD AND SYSTEM FOR STANDARIZING MICROSCOPE INSTRUMENTS - Methods and apparatus for standardizing quantitative measurements from a microscope system. The process includes a calibration procedure whereby an image of a calibration slide is obtained through the optics of the microscope system. The calibration slide produces a standard response, which can be used to determine a machine intrinsic factor for the particular system. The machine intrinsic factor can be stored for later reference. In use, images are acquired of a target sample and of the excitation light source. The excitation light source sample is obtained using a calibration instrument configured to sample intensity. The calibration instrument has an associated correction factor to compensate its performance to a universally standardized calibration instrument. The machine intrinsic factor, sampled intensity, and calibration instrument correction factor are usable to compensate a quantitative measurement of the target sample in order to normalize the results for comparison with other microscope systems. | 11-21-2013 |
Patent application number | Description | Published |
20090041559 | SCREW WITH BREAKAWAY AND METHODS OF USING THE SAME - A fastener with a breakaway and methods of using the same. In one embodiment the fastener is a screw having a head and elongated stem, adapted to be easily manipulated by a user when using the screw as a fastener in a hinge or joint. A means of holding a screw by providing a breakaway tab or non-threaded portion of the elongated stem which can be used to align and insert the screw into a screw hole in the process of engaging threads in the screw hole with threads of the screw. After engaging the threads in the screw hole, such as after the screw has been essentially completely inserted into the screw hole, the breakaway tab or non-threaded portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 02-12-2009 |
20090051865 | COUPLING DEVICE WITH BREAKAWAY AND METHODS OF USING THE SAME - A coupling device with a breakaway tab and methods of using the same for operably coupling an ornament to a joint or hinge. The coupling device comprises an elongated body having openings at each end. One opening has been adapted to receive a screw of a joint or hinge, the other to receive an ornamental fastener. A breakaway tab or non-threaded portion of the elongated stem is provided to manipulate the screw and coupling device so the coupling device may be inserted between a head of the screw and a first surface of the joint or hinge. After engaging the threads in the hollow threaded channel of the hinge, and the screw has been essentially completely inserted into the hollow threaded channel of the hinge, the breakaway tab or non-threaded portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 02-26-2009 |
20100045926 | COUPLING DEVICE WITH BREAKAWAY AND METHODS OF USING THE SAME - A coupling device with a breakaway tab and methods of using the same for operably coupling an ornament to a side arm of an apparatus having ornamentation. The coupling device comprises an elongated body having openings at each end. One opening has been adapted to receive a screw of a side arm, the other to receive an ornamental fastener. A breakaway tab or non-threaded portion of the elongated stem is provided to manipulate the screw and coupling device so the coupling device may be inserted between a head of the screw and an inside surface of the side arm. After engaging the side arm by the screw, the breakaway tab or non-threaded portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 02-25-2010 |
Patent application number | Description | Published |
20110103915 | Screw With Breakaway and Methods of Using The Same - A fastener with a breakaway and methods of using the same. In one embodiment the fastener is a screw having a head and elongated stem, adapted to be easily manipulated by a user when using the screw as a fastener in a hinge or joint. A means of holding a screw by providing a breakaway tab or non-threaded second portion of the elongated stem which can be used to align and insert the screw into a screw hole in the process of engaging threads in the screw hole with threads of the screw. After engaging the threads in the screw hole, such as after the screw has been essentially completely inserted into the screw hole, the breakaway tab or non-threaded second portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 05-05-2011 |
20110123287 | Screw With Breakaway And Methods Of Using The Same - A fastener with a breakaway and methods of using the same. In one embodiment the fastener is a screw having a head and elongated stem, adapted to be easily manipulated by a user when using the screw as a fastener in a hinge or joint. A means of holding a screw by providing a breakaway tab or non-threaded portion of the elongated stem which can be used to align and insert the screw into a screw hole in the process of engaging threads in the screw hole with threads of the screw. After engaging the threads in the screw hole, such as after the screw has been essentially completely inserted into the screw hole, the breakaway tab or non-threaded portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 05-26-2011 |
20130139356 | Screw With Breakaway And Methods Of Using The Same - A fastener with a breakaway and methods of using the same. In one embodiment the fastener is a screw having a head and elongated stem, adapted to be easily manipulated by a user when using the screw as a fastener in a hinge or joint. A means of holding a screw by providing a breakaway tab or non-threaded portion of the elongated stem which can be used to align and insert the screw into a screw hole in the process of engaging threads in the screw hole with threads of the screw. After engaging the threads in the screw hole, such as after the screw has been essentially completely inserted into the screw hole, the breakaway tab or non-threaded portion of the elongated stem of the screw may be broken off at a breakaway and discarded. | 06-06-2013 |