Patent application number | Description | Published |
20080206307 | BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES AND METHODS FOR FABRICATING THE SAME - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer. | 08-28-2008 |
20080279898 | Biologically Degradable Compositions For Medical Applications - A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water. | 11-13-2008 |
20080287911 | CATHETER WITH LAMINAR FLOW DRUG DELIVERY PROPERTIES - Catheters with laminar flow bioactive agent delivery properties and methods of using for treating or preventing vascular disease are disclosed. | 11-20-2008 |
20080300669 | In situ trapping and delivery of agent by a stent having trans-strut depots - A method of delivering an agent into a bodily lumen, the method comprising: implanting an implantable medical device into a treatment site of a lumen, the device having an abluminal face and a luminal face, wherein the device includes depots that extend from an open end at a luminal face to an open end at an abluminal face; and introducing an agent into the open end of the depots at the luminal face such that the agent is delivered to the treatment site through the open end at the abluminal face. | 12-04-2008 |
20090005861 | STENT COATINGS WITH ENGINEERED DRUG RELEASE RATE - Coatings and methods of forming coatings for implantable medical devices, such as stents, are described. The coatings are used for the sustained release of a therapeutic agent or drug. | 01-01-2009 |
20090030508 | Stent Mandrel Fixture And Method For Reducing Coating Defects - A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. | 01-29-2009 |
20090030509 | Stent Mandrel Fixture And Method For Reducing Coating Defects - A stent mandrel fixture for supporting a stent during the application of a coating substance is provided. | 01-29-2009 |
20090041845 | Implantable medical devices having thin absorbable coatings - Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same. | 02-12-2009 |
20090104240 | Dual Drug Formulations For Implantable Medical Devices For Treatment of Vascular Diseases - The present invention relates to implantable medical devices coated with the polymer containing at least an olimus and a corticosteroid for the treatment of vascular diseases. | 04-23-2009 |
20090110711 | IMPLANTABLE DEVICE HAVING A SLOW DISSOLVING POLYMER - The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same. | 04-30-2009 |
20090110713 | Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices - The present invention is directed to polymeric materials (e.g., coatings) comprising biodegradable copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The biodegradable copolymers are derived from at least two relatively polar monomers and at least one relatively nonpolar monomer. Incorporation of at least one relatively nonpolar monomer into the copolymer improves controlled release of a hydrophobic drug from the polymeric material by increasing the copolymer's miscibility with and permeability to the hydrophobic drug. The polymeric materials can also contain at least one biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof. | 04-30-2009 |
20090148491 | Dual-Targeted Drug Carriers - The present invention relates to implantable medical devices containing surface-treated, dual-targeted drug carriers for treating vascular diseases. | 06-11-2009 |
20090258028 | Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug - This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention. | 10-15-2009 |
20090274741 | POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME - Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent. | 11-05-2009 |
20090286761 | Anti-Proliferative and Anti-Inflammatory Agent Combination for Treatment of Vascular Disorders with an Implantable Medical Device - A drug-delivery system is provided including at least 100 μg of everolimus and clobetasol, such that the ratio of everolimus to clobetasol is at least 10:1 (w/w) or the amount of everolimus by weight is at least 10 times more than clobetasol. The system can be a stent. Also provided a method of treating restenosis or vulnerable plaque of a blood vessel, the method includes locally administering to a patient a first drug selected from a group consisting of rapamycin (sirolimus), Biolimus A9, deforolimus, AP23572, tacrolimus, temsirolimus, pimecrolimus, zotarolimus (ABT-578), 40-O-(2-hydroxy)ethylrapamycin (everolimus), 40-O-(3-hydroxy)propylrapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethylrapamycin, 40-O-tetrazolylrapamycin and 40-epi-(N1-tetrazolyl)rapamycin, and locally administering to a patient a second drug consisting of clobetasol, wherein the minimum amount of the first drug that is locally administered is 100 μg, and wherein the ratio of the first drug to the second drug is, for example, 10:1 to 100:1 (w/w). | 11-19-2009 |
20090291111 | COATING COMPRISING AN AMORPHOUS PRIMER LAYER AND A SEMI-CRYSTALLINE RESERVOIR LAYER - The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same. | 11-26-2009 |
20090297575 | Implantable Drug Delivery Devices Having Alternating Hyrdrophilic And Amphiphilic Polymer Layers - An implantable drug delivery medical device with alternating hydrophilic and amphiphilic polymer layers and methods of using for the treatment of vascular disease are disclosed. | 12-03-2009 |
20090297578 | BIOSOLUBLE COATING COMPRISING ANTI-PROLIFERATIVE AND ANTI-INFLAMMATORY AGENT COMBINATION FOR TREATMENT OF VASCULAR DISORDERS - Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque. | 12-03-2009 |
20090297583 | POLY(ESTER AMIDES) FOR THE CONTROL OF AGENT-RELEASE FROM POLYMERIC COMPOSITIONS - The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article. | 12-03-2009 |
20100055295 | Apparatus and Method for Selectively Coating a Medical Article - A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article. | 03-04-2010 |
20100057198 | Abluminal, Multilayer Coating Constructs for Drug-Delivery Stents - Implantable medical devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers. | 03-04-2010 |
20100098834 | MOUNTING ASSEMBLY FOR A STENT AND A METHOD OF USING THE SAME TO COAT A STENT - A mounting assembly for a stent and a method of coating a stent using the assembly are provided. | 04-22-2010 |
20100136213 | Thermal Treatment of a Drug Eluting Implantable Medical Device - A coating and a method of coating an implantable medical device, such as a stent, is disclosed. The method includes subjecting the coating to a thermal condition such as a temperature above the glass transition temperature of a polymer included in the coating. | 06-03-2010 |
20100198330 | Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation. Upon complete absorption of the stent, the section moves and functions in a manner that is the same, more similar to, or substantially as a normal blood vessel. In particular, the section can have an increased diameter allowing increased blood flow and vasomotion is partially or substantially completely restored in the section. | 08-05-2010 |
20100198331 | Bioabsorbable Stent That Modulates Plaque Geometric Morphology And Chemical Composition - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters. | 08-05-2010 |
20100217379 | IMPLANTABLE MEDICAL DEVICE COMPRISING A PRO-HEALING POLY(ESTER-AMIDE) - The present invention relates to implantable medical devices, in particular stents, comprising pro-healing poly(ester-amide)s. | 08-26-2010 |
20100244329 | Medical Device with Regioselective Structure-Property Distribution - A medical device such as a stent having selected regions with different material properties than other regions is disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device. | 09-30-2010 |
20100255058 | BIOCOMPATIBLE POLYACRYLATE COMPOSITIONS FOR MEDICAL APPLICATIONS - A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed. | 10-07-2010 |
20100292426 | BIOCOMPATIBLE COATING FOR IMPLANTABLE MEDICAL DEVICES - A copolymer which includes at least one biologically compatible structural moiety and at least one biologically active moiety is disclosed. The copolymer can be used for fabricating a coating for an implantable medical device such as a stent. | 11-18-2010 |
20110008529 | Thermal Treatment Of An Implantable Medical Device - A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device. | 01-13-2011 |
20110009949 | Nanoparticle loaded electrospun implants or coatings for drug release - Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed. | 01-13-2011 |
20110066223 | Bioabsorbable Stent With Time Dependent Structure And Properties - A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state | 03-17-2011 |
20110066225 | Bioabsorbable Stent With Time Dependent Structure And Properties And Regio-Selective Degradation - A bioabsorbable polymeric stent with time dependent structure and properties and methods of treating a diseased blood vessel with the bioabsorable polymeric stent are disclosed. The structure and properties of the stent change with time and allow the vessel to be restored to a natural unstented state. The bioabsorbable stent loses mechanical integrity in a controlled manner due to modification of selected structural elements. | 03-17-2011 |
20110086162 | Concentration Gradient Profiles For Control of Agent Release Rates From Polymer Matrices - The present invention generally encompasses methods of coating which control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers. | 04-14-2011 |
20110117161 | BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES AND METHODS FOR FABRICATING THE SAME - Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer. | 05-19-2011 |
20110129514 | Hygroscopic coating on a balloon device - The present invention provides a hygroscopic coating on a balloon for an implantable device and methods of making and using the same. | 06-02-2011 |
20110268690 | POLYMERS CONTAINING POLY(HYDROXYALKANOATES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME - Compositions comprising poly(hydroxyalkanoates) and agents for use with medical articles are described. | 11-03-2011 |
20110274733 | POLYMERS CONTAINING POLY(HYDROXYALKANOATES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME - Embodiments of the present invention provides medical devices comprising poly(hydroxyalkanoates) and agents. | 11-10-2011 |
20110293675 | COATINGS OF ACRYLAMIDE-BASED COPOLYMERS - An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided. | 12-01-2011 |
20110293706 | NANOSHELLS ON POLYMERS - Nano-constructscomprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided. | 12-01-2011 |
20120185034 | Coating For Implantable Devices And A Method Of Forming The Same - Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can serve as a primer coating for subsequent coatings that can be used for the delivery of an active ingredient or a combination of active ingredients. | 07-19-2012 |
20120276185 | SOLUBLE COATING COMPRISING POLYELECTROLYTE WITH HYDROPHOBIC COUNTERIONS - The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same. | 11-01-2012 |
20130218263 | Medical Device with Regioselective Structure-Property Distribution - A medical device such as a stent having selected regions with different material properties than other regions is disclosed. Selection and modification of the regions may be based on facilitating a desired mechanical behavior and/or therapeutic prophylactic property of the device. | 08-22-2013 |