Patent application number | Description | Published |
20110053139 | Detection of bioagents using a shear horizontal surface acoustic wave biosensor - Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×10 | 03-03-2011 |
20140249042 | DETECTION OF BIOAGENTS USING A SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR - Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×10 | 09-04-2014 |
Patent application number | Description | Published |
20090298090 | METHODS TO MEASURE IMMUNOSUPPRESSIVE TACROLIMUS, SIROLIMUS, AND CYCLOSPORIN A COMPLEXES IN A BLOOD SAMPLE - The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed in the blood of a drug-treated patient or in a patient candidate to immunosuppressive drug therapy. These methods, assays and kits are especially useful when using automated systems. | 12-03-2009 |
20090325197 | ASSAY FOR IMMUNOSUPPRESSANT DRUGS - The invention provides immunoassays for immunosuppressant drugs, wherein the assay is carried out under high salt conditions to achieve improved sensitivity. The invention also provides kits that are useful for performing the methods of the invention. | 12-31-2009 |
20120156805 | Assay For Immunosuppressant Drugs - The invention provides immunoassays for immunosuppressant drugs, wherein the assay is carried out under high salt conditions to achieve improved sensitivity. The invention also provides kits that are useful for performing the methods of the invention. | 06-21-2012 |
Patent application number | Description | Published |
20130143609 | METHODS AND APPARATUS FOR UPDATING A COMMUNICATIONS DEVICE USING SMS MESSAGES - Method and apparatus for using text messages, e.g., SMS messages, to trigger a device update and/or to update a communications device, e.g., cell phone, are described. The cell phone can be updated/programmed from a remote device. The updating can use SMS messages to accomplish the update. An SMS message may include a command and, optionally, other update information in the message body. Received SMS messages are checked to determine if they include an update command. If an update command is present the command is performed after a security check is satisfied. In some but not necessarily all embodiments, a simplified user interface is supported in addition to SMS update features. | 06-06-2013 |
20150333955 | METHODS AND APPARATUS FOR UPDATING A COMMUNICATIONS DEVICE USING SMS MESSAGES - Method and apparatus for using text messages, e.g., SMS messages, to trigger a device update and/or to update a communications device, e.g., cell phone, are described. The cell phone can be updated/programmed from a remote device. The updating can use SMS messages to accomplish the update. An SMS message may include a command and, optionally, other update information in the message body. Received SMS messages are checked to determine if they include an update command. If an update command is present the command is performed after a security check is satisfied. In some but not necessarily all embodiments, a simplified user interface is supported in addition to SMS update features. | 11-19-2015 |
Patent application number | Description | Published |
20130336563 | Medical Diagnostic Image Change Highlighter - Systems and methods are disclosed which enable more accurate examination of medical diagnostic images, for example x-ray, ultrasound and magnetic resonance imaging (MRI) images. The systems and methods highlight anomalies that have changed between the collection times of two or more diagnostic images, and can also provide objective scoring of the degree of change. | 12-19-2013 |
20130343621 | Industrial Diagnostic Image Change Highlighter - Systems and methods are disclosed which enable more accurate examination of industrial diagnostic images, for example x-ray, ultrasound and terahertz camera images. The systems and methods highlight anomalies that have changed between the collection times of two or more diagnostic images, and can also provide objective scoring of the degree of change. | 12-26-2013 |
20140334699 | Diagnostic Image Change Highlighter - Systems and methods are disclosed which enable more accurate examination of industrial diagnostic images, for example x-ray, ultrasound and terahertz camera images. The systems and methods highlight anomalies that have changed between the collection times of two or more diagnostic images, and can also provide objective scoring of the degree of change. | 11-13-2014 |
Patent application number | Description | Published |
20090311659 | System and Method For Scoring Constructed Responses - A computerized system for scoring constructed responses to one or more prompts. The system receives a plurality of constructed responses in an electronic font-based format and separates the plurality of constructed responses into a first group of constructed responses that are scorable by the system and a second group of constructed responses that are not scorable by the system. The constructed responses in the first group are assigned scores based on predetermined rules, and the scores are sent to a score database. In a preferred embodiment, the first group includes constructed responses that do not answer the prompt and constructed responses that match pre-scored responses. The second group of constructed responses are sent by the system to a hand-scorer for manual scoring. | 12-17-2009 |
20110071978 | System, Method, and Computer-Readable Medium for Plagiarism Detection - A system, method, and computer-readable medium for detecting plagiarism in a set of constructed responses by accessing and pre-processing the set of constructed responses to facilitate the pairing and comparing of the constructed responses. The similarity value generated from the comparison of a pair of constructed responses serves as an indicator of possible plagiarism. | 03-24-2011 |
20140324413 | SYSTEM, METHOD, AND COMPUTER-READABLE MEDIUM FOR PLAGIARISM DETECTION - A system, method, and computer-readable medium for detecting plagiarism in a set of constructed responses by accessing and pre-processing the set of constructed responses to facilitate the pairing and comparing of the constructed responses. The similarity value generated from the comparison of a pair of constructed responses serves as an indicator of possible plagiarism. | 10-30-2014 |
20150050636 | SYSTEM AND METHOD FOR SCORING CONSTRUCTED RESPONSES - A computerized system for scoring constructed responses to one or more prompts. The system receives a plurality of constructed responses in an electronic font-based format and separates the plurality of constructed responses into a first group of constructed responses that are scorable by the system and a second group of constructed responses that are not scorable by the system. The constructed responses in the first group are assigned scores based on predetermined rules, and the scores are sent to a score database. In a preferred embodiment, the first group includes constructed responses that do not answer the prompt and constructed responses that match pre-scored responses. The second group of constructed responses are sent by the system to a hand-scorer for manual scoring. | 02-19-2015 |
Patent application number | Description | Published |
20090028131 | TEST AUTOMATION FOR AN INTEGRATED TELEPHONY CALL MANAGEMENT SERVICE - A test application includes instructions for configuring a digital cross connect. A first modem and a second modem are each connected to at least one telecommunications network and a digital cross connect. An integrated telephony call management service (ITCMS) client includes computer-executable instructions stored on a computer-readable medium included in the test computer. | 01-29-2009 |
20120155623 | METHOD FOR PROVIDING CUSTOM RING-BACK TONES - A method is provided for providing customized ring-back tones to callers on a wireline network such as a public switched telephone network having an advanced intelligent network or a VoIP network. When a call request is received from a calling party to connect to a called party through a wireline telephone network it is determined if the calling party is identified in a screening list for the called party. If so, then a customized audible ring-back tone is played to the calling party until the called party is connected to the calling party or until the call request is terminated. | 06-21-2012 |
20140029740 | SYSTEMS AND METHODS FOR USING THE ADVANCED INTELLIGENT NETWORK TO REDIRECT DATA NETWORK TRAFFIC - A method and system are disclosed for providing a low cost mechanism for remotely rerouting queries in a telecommunications network. A service control point (SCP) executes an application which causes a queries to be launched over a LAN or WAN to a remotely located data center. The system contains a primary and secondary data center, in which the secondary data center operations on a ‘hot-standby’ basis. Based on a manually provided indication, maintenance personnel may telephone and interact with a voice response unit or a web-based interface, which indicates that the SCP or SCP application should route queries to the secondary data center. Similarly, the same mechanism can be used to indicate that queries should be re-routed back to the primary data center. This allows remote management for controlling the queries without having to extensively modify the related infrastructure. | 01-30-2014 |
20140341084 | METHOD FOR PROVIDING CUSTOM RING-BACK TONES - A method is provided for providing customized ring-back tones to callers on a wireline network such as a public switched telephone network having an advanced intelligent network or a VoIP network. When a call request is received from a calling party to connect to a called party through a wireline telephone network it is determined if the calling party is identified in a screening list for the called party. If so, then a customized audible ring-back tone is played to the calling party until the called party is connected to the calling party or until the call request is terminated. | 11-20-2014 |
Patent application number | Description | Published |
20090024523 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 01-22-2009 |
20090024529 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 01-22-2009 |
20090048967 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 02-19-2009 |
20090048974 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 02-19-2009 |
20090089210 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 04-02-2009 |
20090094149 | WIDE AREA NETWORK PERSON-TO-PERSON PAYMENT - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 04-09-2009 |
20100145858 | MONEY ORDER DEBIT FROM STORED VALUE FUND - According to the invention, a method for transferring a credit amount out of an online system using a money order is disclosed. In one step, pay-out instructions are received at a server computer system from a wide-area computer network coupled to a payor. The pay-out instructions include at least two of a payee, a delivery location, and the credit amount. A first handler associated with the payor and a second handler for preparation of the money order according to the pay-out instructions are determined. The credit amount is transferred from the first handler to the online system. The pay-out instructions are sent to the second handler. | 06-10-2010 |
20130173462 | REQUESTOR-BASED FUNDS TRANSFER SYSTEM AND METHODS - According to the invention, transferring money using a computer network is disclosed. In one step, information is saved on credit received for a first user ( | 07-04-2013 |
Patent application number | Description | Published |
20120135984 | DUAL-ACTION INHBITORS AND METHODS OF USING SAME - Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition. | 05-31-2012 |
20120196916 | BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS - Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds. | 08-02-2012 |
20130137721 | 6-AMINOISOQUINOLINE COMPOUNDS - 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided. | 05-30-2013 |
20130158015 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE - Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved. | 06-20-2013 |
20140187617 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE - Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved. | 07-03-2014 |
20140249201 | BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS - Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds. | 09-04-2014 |
20150119419 | 6-AMINOISOQUINOLINE COMPOUNDS - 6-Amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided. | 04-30-2015 |
20150175549 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE - Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved. | 06-25-2015 |
20150299159 | BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS - Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds. | 10-22-2015 |
Patent application number | Description | Published |
20120087964 | HIGHLY WETTABLE, WATER DISPERSIBLE, GRANULES INCLUDING TWO PESTICIDES - The present disclosure relates to water dispersible granular pesticide compositions, and methods of making and using the compositions. The pesticide compositions include an inner layer including a first pesticide coated on to a substrate, and an outer layer comprising a second pesticide coated on the inner layer. The outer layer increases the water dispersibility of the granular composition, and protects the first pesticide against hydrolysis and photolysis. | 04-12-2012 |
20120088828 | HIGH SURFACE ACTIVITY PESTICIDES - The present disclosure relates generally to the field of pesticides. In particular, the present disclosure relates to pesticide compositions that include high surface activity and slower drying surfactant pesticides. | 04-12-2012 |
20150140056 | HIGHLY WETTABLE, WATER DISPERSIBLE, GRANULES INCLUDING TWO PESTICIDES - The present disclosure relates to water dispersible granular pesticide compositions, and methods of making and using the compositions. The pesticide compositions include an inner layer including a first pesticide coated on to a substrate, and an outer layer comprising a second pesticide coated on the inner layer. The outer layer increases the water dispersibility of the granular composition, and protects the first pesticide against hydrolysis and photolysis. | 05-21-2015 |
Patent application number | Description | Published |
20090208493 | Compounds and methods for the selective inhibition of ABCB1, ABCC1 and ABCG2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors - Compounds disclosed which inhibit ABCB1 transporter protein are useful for treating diseases in which ABCB1 transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCB1 transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCB1 efflux is also disclosed. Methods of identifying inhibitors of ABCB1, ABCG2 and ABCC1 transporter proteins are also disclosed. | 08-20-2009 |
20110092533 | COMPOUNDS FOR BINDING TO ER ALPHA/BETA AND GPR30, METHODS OF TREATING DISEASE STATES AND CONDITIONS MEDIATED THROUGH THESE RECEPTORS AND IDENTIFICATION THEREOF - The current invention is in the field of molecular biology/pharmacology and provides compounds which modulate the effects of GPR30 as well as the classical estrogen receptors alpha and beta (ERα and ERβ). These compounds may function as agonists and/or antagonists of one or more of the disclosed estrogen receptors. Diseases which are mediated through one or more of these receptors include cancer (particularly breast, reproductive and other hormone-dependent cancers, leukemia, colon cancer, prostate cancer), reproductive (genito-urological) including endometreitis, prostatitis, polycystic ovarian syndrome, bladder control, hormone-related disorders, hearing disorders, cardiovascular conditions including hot flashes and profuse sweating, hypertension, stroke, obesity, osteoporosis, hematologic diseases, vascular diseases or conditions such as venous thrombosis, atherosclerosis, among numerous others and disorders of the central and peripheral nervous system, including depression, insomnia, anxiety, multiple sclerosis, neuropathy, neurodegenerative disoders such as Parkinson's disease and Alzheimer's disease, as well as inflammatory bowel disease, Crohn's disease, coeliac (celiac) disease and related disorders of the intestine. A contraceptive indication to prevent or reduce the likelihood of pregnancy after intercourse is a further aspect of the present invention. | 04-21-2011 |
Patent application number | Description | Published |
20090100499 | Database System and Method for Encryption and Protection of Confidential Information - A database system for encryption and protection of confidential data is provided. The database system includes a data source system receiving confidential data and first associated data. A secure data network interface system is connected to the data source system over an open network, the data network interface system receives the confidential data and the first associated data from the data source system and further comprises a secure data storage system coupled to the data network interface system and isolated from the open network, a data encryption system generating a unique encrypted identifier for the confidential data, and a data association system associating the confidential data with the unique encrypted identifier and storing the confidential data, the first associated data and the unique encrypted identifier in the secure data storage system. | 04-16-2009 |
20110314277 | ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier. | 12-22-2011 |
20130232077 | ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier. | 09-05-2013 |
20140249940 | ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier. | 09-04-2014 |