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| 20100092452 | Replenishment and Enrichment of Ocular Surface Lubrication - An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface or for the treatment or care of ophthalmic devices. The ophthalmic composition comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The ophthalmic composition may also comprise one or more ophthalmically acceptable agents. | 04-15-2010 |
| 20110059902 | Therapeutic Replenishment and Enrichment of Ocular Surface Lubrication - The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration. | 03-10-2011 |
| 20110070222 | Therapeutic Modulation of Ocular Surface Lubrication - Provided herein are ophthalmically acceptable pharmaceutical compositions comprising a PRG4 inducing compound in combination with PRG4 (including a lubricant fragments, homologs, or isoforms thereof), and methods of using the same. The PRG4 inducing compound in the pharmaceutical composition of the present invention upregulates PRG4 expression and localization in the ocular surface for efficient surface boundary lubrication. In some instances, pharmaceutical compositions described herein are utilized for treating ophthalmic conditions, e.g., ocular boundary deficiency and symptoms associated therewith. | 03-24-2011 |
| 20110142908 | Ophthalmic Device, and Method of Use Thereof, for Increasing Ocular Boundary Lubrication - The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need. | 06-16-2011 |
| 20120321611 | Replenishment and Enrichment of Ocular Surface Lubrication - An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface or for the treatment or care of ophthalmic devices. The ophthalmic composition comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The ophthalmic composition may also comprise one or more ophthalmically acceptable agents. | 12-20-2012 |
| 20140099343 | Ophthalmic Device, and Method of Use Thereof, for Increasing Ocular Boundary Lubrication - The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need. | 04-10-2014 |
| 20140296159 | Method for Therapeutic Replenishment and Enrichment of Ocular Surface Lubrication - The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration. | 10-02-2014 |
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| 20120129155 | METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS - A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO:12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14. | 05-24-2012 |
| 20140199684 | METHODS FOR AMPLIFYING HEPATITIS C VIRUS NUCLEIC ACIDS - A method of amplifying an HCV nucleic acid in an HCV infected sample comprises amplifying a segment of a DNA template that is complementary to a genome of HCV RNA from the sample by a two-stage PCR, wherein a first stage PCR employs a first outer primer and a second outer primer, and a second stage PCR employs a first inner primer and a second inner primer. The nucleotide sequence of the first outer primer comprises a nucleotide sequence as set forth in SEQ ID NO: 2; or SEQ ID NO:9, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 9. The nucleotide sequence of the second outer primer comprises a nucleotide sequence set forth in SEQ ID NO: 3 or 4; or a nucleotide sequence as set forth in SEQ ID NO: 10 or 11, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 10 and 11. The nucleotide sequence of the first inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 5; or SEQ ID NO:12, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 12. The nucleotide sequence of the second inner primer comprises a nucleotide sequence as set forth in SEQ ID NO: 6 or 7; or a nucleotide sequence as set forth in SEQ ID NO: 13 or 14, wherein optionally 1, 2 or 3 nucleotides are other nucleotides than those of SEQ ID NO: 13 and 14. | 07-17-2014 |
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| 20100069958 | Tenodesis Implant - The present disclosure relates to a two-piece implant. The implant includes a first piece having at least two prongs and a protrusion located between the prongs and a second piece coupled to the first piece, wherein the second piece is configured to rotate relative to the first piece. A method of tissue repair is also disclosed. | 03-18-2010 |
| 20120310279 | SURGICAL FASTENING - A surgical device includes a first fastener having a planar profile, a second fastener having a concave surface, and a suture that can be manipulated to change a distance between the first and second fasteners. The second fastener has a curvature that substantially matches the curvature of a top surface of a clavicle bone in a direction perpendicular to a long axis of the clavicle bone. A method of treating an acromioclavicular joint injury includes forming axially aligned passages through a patient's clavicle and coracoid process, passing a fastener having a concave surface through the passages, positioning the concave surface of the fastener against a top surface of the patient's clavicle with a long axis of the fastener extending perpendicular to a long axis of the clavicle, positioning a fastener having a planar profile below the patient's coracoid process, and adjusting a suture that couples the fasteners. | 12-06-2012 |
| 20140309668 | Tenodesis Implant - The present disclosure relates to a two-piece implant. The implant includes a first piece having at least two prongs and a protrusion located between the prongs and a second piece coupled to the first piece, wherein the second piece is configured to rotate relative to the first piece. A method of tissue repair is also disclosed. | 10-16-2014 |
| 20140371790 | SUTURE PASSING SURGICAL INSTRUMENT - A surgical instrument includes first and second members configured to receive tissue therebetween. The first member is adapted to receive suture, the second member is coupled to the first member, and a grasper coupled to the second member engages the suture received by the first member. A method of passing suture includes loading suture into a first member of a suture passing surgical instrument, stabilizing tissue between the first member and a second member of the surgical instrument, passing suture through tissue via the first member of the surgical instrument, holding the passed suture via suture grasper of the surgical instrument, and removing the first member from the tissue. | 12-18-2014 |
| 20150039031 | SURGICAL FASTENING - A surgical device includes a first fastener having a planar profile, a second fastener having a concave surface, and a suture that can be manipulated to change a distance between the first and second fasteners. The second fastener has a curvature that substantially matches the curvature of a top surface of a clavicle bone in a direction perpendicular to a long axis of the clavicle bone. A method of treating an acromioclavicular joint injury includes forming axially aligned passages through a patient's clavicle and coracoid process, passing a fastener having a concave surface through the passages, positioning the concave surface of the fastener against a top surface of the patient's clavicle with a long axis of the fastener extending perpendicular to a long axis of the clavicle, positioning a fastener having a planar profile below the patient's coracoid process, and adjusting a suture that couples the fasteners. | 02-05-2015 |
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| 20120179146 | CANNULATED GUIDE TOOLS - According to a first configuration, a hand tool is configured to include a shaft, a handle disposed at a proximal end of the shaft, and a tubular tip disposed on a hinge at a distal end of the shaft. The tubular tip pivots about the hinge, providing a way to steer a resource to a specific location in a medical site. In accordance with a second configuration, a hand tool includes a flexible section of tube, a flexible sheathing, and a link. The flexible sheathing encases the flexible section of tube. At least a portion of the link resides between an outer surface of the flexible section of tube and an inner surface of the flexible sheathing. One end of the link is affixed to a distal tip of the flexible section of tube. Pulling on the link causes the flexible section of tube to arc. | 07-12-2012 |
| 20120271323 | SUTURE PASSER WITH SUTURE CAPTURING ARTICULATING JAW AT DISTAL END FOR SUTURING IN ARTHROSCOPIC SURGERY - A suture passer including a tubular member having a proximal end and a distal end and a central axis defined therethrough, in which the tubular member includes at least one lumen formed therein, an eyelet configured to receive a suture, a movable jaw formed on the distal end of the tubular member configured to move between an open position and a closed position, in which the movable jaw includes a plurality of portions, and an actuator configured to be received within the at least one lumen of the tubular member, in which the actuator is configured to move along the central axis of the tubular member between a first position and a second position, in which, in the first position, the movable jaw is in the closed position, and in which, in the second position, the movable jaw is in the open position. | 10-25-2012 |
| 20130035692 | SYSTEM FOR USE IN TISSUE REPAIR - The present disclosure relates to a system for use in tissue repair. The system includes a cannulated guide, an obturator configured for insertion through the guide, a drill configured for insertion through the guide, and an anchor delivery tool configured for insertion through the guide. | 02-07-2013 |
| 20140262923 | PACKAGE FOR MEDICAL PRODUCT - A package for a multi-component medical device is disclosed. The package includes a bottom portion with cavities providing individual access to different components of the medical device, thereby enabling a user to remove components from the package in any order without disturbing the remaining component or components. The package also includes a barrier affixed to the bottom portion for sealing the package. | 09-18-2014 |
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| 20080310766 | LINER WITH BLADDER - The present invention is a system for shipping and discharging contents. The system comprises a liner including a front portion, a rear portion, and first and second side portions, wherein the front, rear, and first and second side portions are sealed together to form a top panel, a bottom panel, a front panel, a rear panel, and two gusseted side panels. At least one opening is provided on one of the front portion, the rear portion, the first side portion, or the second side portion for receiving a fitting. A bladder including at least a front panel and a rear panel and an opening provided in at least one of the panels, wherein the opening is adapted to receive gas, and wherein the bladder is sealed to the top panel of the liner and the bottom panel of the liner. | 12-18-2008 |
| 20110114713 | Sustainable Packaging System for Shipping Liquid or Viscous Products - The present disclosure, in one embodiment, relates to a packaging assembly for holding liquids, viscous material, or particulate material. The packaging assembly includes a carton having side and bottom walls and an open top. A self-supporting plastic liner fits inside of the carton, and is for containing liquids, viscous material, or particulate material. The liner has a side wall, a closed bottom end, and an open top end having an outwardly-projecting rim. The rim has a radially-extending flange portion, and a dependent skirt portion. When the self-supporting plastic liner is inside of the carton, the dependent skirt portion of the rim hangs over the side walls of the carton. A lidding material is removeably affixed to the rim of the plastic liner. A carton lid closes off the open top of the carton. | 05-19-2011 |
| 20110114714 | SUSTAINABLE PACKAGING SYSTEM FOR SHIPPING LIQUID OR VISCOUS PRODUCTS - The present disclosure, in one embodiment, relates to a packaging assembly for holding liquids, viscous material, or particulate material. The packaging assembly includes a carton having side and bottom walls. The packaging assembly also includes a self-supporting plastic liner that fits inside of the carton for containing liquids, viscous material, or particulate material. The liner has either a substantially circular or substantially oval cylindrical side wall, a closed bottom end characterized by a bottom wall formed integral with said side wall, and an open top end having an outwardly-projecting rim. The rim has a radially-extending flange portion, and a dependent skirt portion, wherein when the self-supporting plastic liner is inside of the carton, the radially extending flange portion supports the liner on at least a portion of the carton. A lidding material is provided to seal the plastic liner. | 05-19-2011 |
| 20150083717 | SEMI-RIGID SHIPPING CONTAINER WITH PEEL-RESEAL CLOSURE - The present disclosure, in one embodiment, relates to a packaging assembly for holding liquids, viscous material, or particulate material. The packaging assembly includes a carton having side and bottom walls and an open top. A self-supporting plastic liner fits inside of the carton and is for containing liquids, viscous material, or particulate material. The liner has a side wall, a closed bottom end, and an open top end having an outwardly-projecting rim. The rim has a radially-extending flange portion, and a dependent skirt portion. When the self-supporting plastic liner is inside of the carton, the dependent skirt portion of the rim hangs over the side walls of the carton. A lidding material is removeably affixed to the rim of the plastic liner. A carton lid closes off the open top of the carton. | 03-26-2015 |
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| 20120199512 | FLEXIBLE LINER FOR FIBC OR BAG-IN-BOX CONTAINER SYSTEMS WITH IMPROVED FLEX CRACK RESISTANCE - A liner for use in a bulk container is provided. The liner comprises a first flexible portion, a second flexible portion, a first seal joining the first and second portions, a second seal joining the first and second portions, a third seal joining the first and second portions, and a fourth seal joining the first and second portions. The first portion is a better barrier than the second portion. | 08-09-2012 |
| 20120261411 | SECONDARY PACKAGING SYSTEM FOR PRE-PACKAGED PRODUCTS - A liner system for use with a carton of pre-packaged products to protect the carton from moisture may include a substantially continuous liner including a bottom panel and side and end wall panels extending upward from the bottom panel and defining an open top and the liner may be adapted for positioning in the carton prior to placement of the pre-packaged products and may include positioning features configured to maintain a position of the pre-packaged products. | 10-18-2012 |
| 20130206763 | RESEALABLE LID CONTAINER - A container for holding contents includes a shell having a peripheral rim defining a substantially open top, a lid positioned on the shell, covering the substantially open top, and having a peripheral portion engaging the peripheral rim, and a liner disposed within the shell, conforming to the shape of the shell, and having peripheral ribbon secured to the lid forming a continuous seal between the liner and the lid. | 08-15-2013 |
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| 20090258411 | CENTRIFUGAL DEVICE AND METHOD FOR OVA DETECTION - A centrifugal device and method are provided for the separation of buoyant material such as parasitic ova from fecal matter. A rotor assembly, rotatable about its central axis in a centrifuge, includes a housing with a centrally located top opening leading to a centrally located mixing chamber. An annular sediment chamber is provided, also coaxial about the central axis, connected by a passage with the mixing chamber. A coring assembly is used to retrieve and insert a fecal sample into the mixing chamber for mixing with a flotation fluid. During centrifugation, heavier fecal components pass radially outwardly to the sediment chamber while the ova collect on the inward surface of the flotation fluid. After centrifugation, more flotation fluid is added, if needed, until a meniscus forms at the top opening. A coverslip is placed over the top opening and the ova float to the surface of the fluid and adhere to the coverslip. The coverslip is removed and the ova detected using standard microscopy procedures. In another aspect, a centrifugal device is provided in which the ova are delivered through centrifugation to a pipette tip for dispensing onto a microscope slide or coverslip. | 10-15-2009 |
| 20090291818 | Centrifugal device and method for fluid component separation - A rotor is provided for the centrifugal separation of a composite fluid, such as animal or human blood, into components. An inner surface of the rotor includes at least one hydrophobic area having a first surface energy sufficiently low to provide a flow path for a lower density fluid component to flow to the bottom of a central collection chamber after centrifugal separation. A method of separating a composite fluid into components using such a rotor is also provided. Additionally, a method of manufacturing such a rotor is provided. | 11-26-2009 |
| 20110177931 | CENTRIFUGAL ASSEMBLY AND METHOD FOR OVA DETECTION - A centrifugal assembly is provided that can be used in common laboratory fixed angle or swinging bucket centrifuges for the separation of material, such as parasitic ova, based on particle density. The centrifugal assembly allows the fluid level to be gently adjusted to form a meniscus without disruption of the buoyant matter, such as ova. The centrifugal assembly also enables a user to easily and hygienically collect and transfer a measured amount of a sample, such as fecal material, and to break apart and mix the sample with a floatation fluid contained in a centrifuge tube. | 07-21-2011 |
| 20130048089 | Analytical System For Performing Laboratory Protocols and Associated Methods - Systems, devices, and methods for automating laboratory protocols utilizing cooperative efforts between differing components including fluidics, agitation and thermal control for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a temperature input capable of interfacing with a temperature controller, a fluid input capable of interfacing with an input fluid controller, a fluid output capable of interfacing with an output fluid controller, and a standardized agitation connector capable of interfacing with an agitator. A control system interfaces with the temperature input, fluid input, fluid output, and agitation connector to enable the system to perform laboratory protocols that require complex, sequential fluidic steps in association with the temperature and agitation control. | 02-28-2013 |
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| 20090156475 | Gene defects and mutant ALK kinase in human solid tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 06-18-2009 |
| 20100240034 | Gene defects and mutant ALK kinase in human solid tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 09-23-2010 |
| 20120171696 | Gene Defects And Mutant ALK Kinase In Human Solid Tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 07-05-2012 |
| 20120288872 | GENE DEFECTS AND MUTANT ALK KINASE IN HUMAN SOLID TUMORS - Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 11-15-2012 |
| 20130209452 | GENE DEFECTS AND MUTANT ALK KINASE IN HUMAN SOLID TUMORS - Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have been identified herein in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 08-15-2013 |
| 20140134640 | Gene Defects And Mutant ALK Kinase In Human Solid Tumors - Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides. | 05-15-2014 |
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| 20090081709 | Protein markers of responsiveness to type III receptor tyrosine kinase inhibitors - The invention discloses ten (10) protein markers predictive of cancer resistance or responsiveness to Type III Receptor Tyrosine Kinase (RTK) inhibitors, and provides methods for identifying a cancer that is likely to be resistant to a Type III RTK-inhibiting therapeutic by examining expression and/or activity of one or more of the disclosed biomarkers in a biological sample from the cancer. Methods for identifying a compound that inhibits a cancer resistant to a Type III RTK-inhibiting therapeutic by determining the effect of the compound on one or more of the disclosed marker proteins are also provided. | 03-26-2009 |
| 20110021546 | Gene Defects And Mutant ALK Kinase In Human Solid Tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 01-27-2011 |
| 20110223609 | Gene defects and mutant ALK kinase in human solid tumors - In accordance with the invention, novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ALK kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein enables new methods for determining the presence of these mutant ALK kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention. | 09-15-2011 |
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| 20110230519 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 09-22-2011 |
| 20130018071 | Solid Forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 01-17-2013 |
| 20130079367 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 03-28-2013 |
| 20130131107 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 05-23-2013 |
| 20130143919 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 06-06-2013 |
| 20130338188 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 12-19-2013 |
| 20140329855 | SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE- -3-CARBOXAMIDE - The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | 11-06-2014 |
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| 20090090172 | Viscosity measurement - A micro-fluidic device and methods for measuring one or more rheologic properties of a fluid. The micro-fluidic device includes a substrate and at least one cover bonded to a surface of the substrate with a fluid channel formed in at least one of the cover or the substrate. Further, the micro-fluidic device includes a first differential pressure gauge that can have a first differential pressure sensor in fluid communication with both a first pressure site and a second pressure site. Further still, the micro-fluidic device includes the first pressure site and the second pressure site that can be spaced apart by a first section of the fluid channel. Also, the micro-fluidic device includes a data processor communicatively coupled to the first differential pressure sensor, so as to receive data generated by the first differential pressure sensor. | 04-09-2009 |
| 20090120168 | MICROFLUIDIC DOWNHOLE DENSITY AND VISCOSITY SENSOR - The present invention recited a method and apparatus for providing a parameter of a fluid within a fluid channel using a MEMS resonating element in contact with the fluid moving through the fluid channel. Additionally an actuating device associated with the MEMS resonating element is further provided, such that the actuating device can induce motion in the MEMS resonating element. In communication with the MEMS resonating element is an interpretation element capable of calculating a parameter of the fluid moving through the fluid channel based upon data from the MEMS resonating element upon actuation by the actuating device. | 05-14-2009 |
| 20090120171 | VIBRATING WIRE VISCOSITY SENSOR - A method and apparatus for providing, e.g., identifying or determining, at least one parameter of a fluid moving through a fluid channel using a vibrating wire in contact with the fluid moving through the fluid channel that is clamped under tension. The vibrating wire is actuated by an actuating device capable of displacing the vibrating wire from an initial position. An interpretation element further is utilized to provide a parameter of the fluid moving through the fluid channel based upon data from the vibrating wire following actuation by the actuation element. | 05-14-2009 |
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| 20100241407 | METHODS, APPARATUS AND ARTICLES OF MANUFACTURE TO PROCESS MEASUREMENTS OF WIRES VIBRATING IN FLUIDS - Example methods, apparatus and articles of manufacture to process measurements of wires vibrating in fluids are disclosed. A disclosed example apparatus includes a downhole assembly and a surface assembly. The downhole assembly including a sensor to measure a waveform representative of a motion of a wire vibrating within a fluid at a downhole location in a wellbore, a waveform modeler to compute a model parameter from the measured waveform, and a first telemetry module to transmit the computed model parameter to a surface location. The surface assembly including a second telemetry module to receive the computed model parameter from the downhole assembly, and a viscosity analyzer to estimate a viscosity of the fluid from the computed model parameter. | 09-23-2010 |
| 20100269579 | DETECTING GAS COMPOUNDS FOR DOWNHOLE FLUID ANALYSIS USING MICROFLUIDICS AND REAGENT WITH OPTICAL SIGNATURE - A gas separation and detection tool for performing in situ analysis of borehole fluid is described. The tool operates by introducing a reagent to a test sample and causing the resulting mixture to flow through a microfluidic channel where optical testing is performed. The optical testing detects a change in a characteristic of the reagent in response to expose to one or more particular substances in the test sample. The test sample may be borehole fluid, a mixture of borehole fluid and scrubbing fluid subsequently mixed with reagent, a mixture of reagent and gas separated from borehole fluid, or a mixture of scrubbing fluid and gas separated from borehole fluid which is subsequently mixed with reagent. A membrane may be employed to separate one or more target gasses from the borehole fluid. | 10-28-2010 |
| 20130100453 | MEASUREMENT OF LIQUID FRACTION DROPOUT USING MICROPATTERNED SURFACES - Accurate, real-time detection of dew point of a gaseous sample can be accomplished using the systems and techniques described herein. A gaseous sampling chamber defining an interior volume includes a patterned structure having a roughened surface exposed to the gaseous sampling chamber. The patterned structure includes an open volume accessible by the roughened surface, for example, representing at least about 10% of the interior volume of the gaseous sampling chamber. An illumination source is configured to illuminate at least a portion of the patterned structure. A light detector is configured to receive at least a portion of illumination returned from the patterned structure. A condensate detector is configured to determine a presence of a condensate on the roughened surface in response to an optical property of the patterned surface as modified by the presence of dew. | 04-25-2013 |
| 20130186185 | Vibrating Wire Viscometers - Vibrating wire viscometers are disclosed herein. An example viscometer includes a housing defining a chamber and a wire holder disposed in the chamber. The wire holder has an elongated, electrically insulating body and a channel extending along a length of the body. A wire is at least partially disposed in the channel and coupled to the wire holder at opposing ends of the wire holder to tension the wire and electrically isolate the wire from the housing. | 07-25-2013 |
| 20130188169 | APPARATUS AND METHODS FOR DETERMINING COMMINGLING COMPATIBILITY OF FLUIDS FROM DIFFERENT FORMATION ZONES - An apparatus and a method including exposing a first fluid to a pre-filter, observing the first fluid, introducing a second fluid to the first fluid, exposing the first and second fluids to a filter, and observing the first and second fluids wherein the observing the first fluid and observing the first and second fluids comprise optical measurements and the first fluid comprises material from a subterranean formation. Some embodiments may compare the optical measurements of the first fluid and the first and second fluids and/or estimate the first fluid's likelihood of forming precipitants with other fluids and/or the first fluid's asphaltene content. An apparatus and method for characterizing a fluid property including a pre-filter in communication with a fluid from a formation, an optical sensor to observe the fluid from the pre-filter, a fluid combination device in communication with the fluid and a second fluid source, a filter in communication with the combination device, a second optical sensor to observe a third fluid from the filter, and a processor to compare data collected by the sensor and second sensor. | 07-25-2013 |
| 20130219997 | Systems and Methods of Determining Fluid Properties - Systems and methods of determining fluid properties are disclosed. An example apparatus to determine a saturation pressure of a fluid includes a housing having a detection chamber and a heater assembly partially positioned within the detection chamber to heat a fluid. The example apparatus also includes a sensor assembly to detect a property of the fluid and a processor to identify a saturation pressure of the fluid using the property of the fluid. | 08-29-2013 |
| 20130255368 | Methods and Apparatus for Determining A Viscosity of Oil in A Mixture - Methods and apparatus for determining a viscosity of oil in a mixture are disclosed herein. An example method includes determining water fractions of a mixture flowing into a downhole tool and determining viscosities of the mixture. The mixture includes water and oil. The example method also includes determining a viscosity of the oil based on the water fractions and the viscosities. | 10-03-2013 |
| 20140268156 | METHOD AND SYSTEM FOR DETERMINING BUBBLE POINT PRESSURE - Method and systems for determining bubble point pressure of a fluid sample are described herein. The method includes transmitting light through the fluid sample and detecting transmitted light. The method also includes applying a series of thermal pulses to the fluid sample. The series of thermal pulses includes a time interval between each thermal pulse. The pressure of the fluid sample is varied and the bubble point pressure of the fluid sample is determined using an intensity of the transmitted light that corresponds to a time interval between the thermal pulses. | 09-18-2014 |
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| 20090212680 | Microchannel Plate Devices With Multiple Emissive Layers - A microchannel plate includes a substrate defining a plurality of pores extending from a top surface of the substrate to a bottom surface of the substrate. The plurality of pores includes a resistive material on an outer surface that forms a first emissive layer. A second emissive layer is formed over the first emissive layer. The second emissive layer is chosen to achieve at least one of an increase in secondary electron emission efficiency and a decrease in gain degradation as a function of time. A top electrode is positioned on the top surface of the substrate and a bottom electrode is positioned on the bottom surface of the substrate. | 08-27-2009 |
| 20090215211 | Method Of Fabricating Microchannel Plate Devices With Multiple Emissive Layers - A method of fabricating a microchannel plate includes defining a plurality of pores extending from a top surface of a substrate to a bottom surface of the substrate where the plurality of pores has a resistive material on an outer surface that forms a first emissive layer. A second emissive layer is formed over the first emissive layer. The second emissive layer is chosen to achieve at least one of an increase in secondary electron emission efficiency and a decrease in gain degradation as a function of time. A top electrode is formed on the top surface of the substrate and a bottom electrode is formed on the bottom surface of the substrate. | 08-27-2009 |
| 20090256063 | Image Intensifying Device - An image intensifying device includes a lens that is positioned at a light input that forms an image of a scene. The image intensifying device also includes an image intensifier tube that includes a photocathode that is positioned to receive the image formed by the lens. The photocathode generates photoelectrons in response to the light image of the scene. The image intensifier tube also includes a microchannel plate having an input surface comprising the photocathode. The microchannel plate receives the photoelectrons generated by the photocathode and generating secondary electrons. An electron detector receives the secondary electrons generated by the microchannel plate and generates an intensified image of the scene. | 10-15-2009 |
| 20090315443 | MICROCHANNEL PLATE DEVICES WITH TUNABLE RESISTIVE FILMS - A microchannel plate includes a substrate defining a plurality of channels extending from a top surface of the substrate to a bottom surface of the substrate. A resistive layer is formed over an outer surface of the plurality of channels that provides ohmic conduction with a predetermined resistivity that is substantially constant. An emissive layer is formed over the resistive layer. A top electrode is positioned on the top surface of the substrate. A bottom electrode positioned on the bottom surface of the substrate. | 12-24-2009 |
| 20100044577 | MICROCHANNEL PLATE DEVICES WITH TUNABLE RESISTIVE FILMS - A microchannel plate for detecting neutrons includes a hydrogen-rich polymer substrate that defines a plurality of channels extending from a top surface of the substrate to a bottom surface of the substrate, where neutrons interact with the plurality of channels to generate at least one secondary electron. A top electrode is positioned on the top surface of the substrate and a bottom electrode is positioned on the bottom surface of the substrate. A resistive layer is formed over an outer surface of the plurality of channels that provides ohmic conduction with a resistivity that is substantially constant. An emissive layer is formed over the resistive layer. Neutron interaction products interact with the plurality of channels defined by the substrate and the emissive films to generate secondary electrons that cascade within the plurality of channels to provide an amplified signal related to the detection of neutrons. | 02-25-2010 |
| 20100075445 | Silicon Microchannel Plate Devices With Smooth Pores And Precise Dimensions - A method of fabricating a microchannel plate includes forming a plurality of pores in a silicon substrate. The plurality of pores is oxidized, thereby consuming silicon at surfaces of the plurality of pores and forming a silicon dioxide layer over the plurality of pores. At least a portion of the silicon dioxide layer is stripped, which reduces a surface roughness of the plurality of pores. A semiconducting layer can be deposited onto the surface of the silicon dioxide layer. The semiconducting layer is then oxidized, thereby consuming at least some of the polysilicon or amorphous silicon layer and forming an insulating layer. Resistive and secondary electron emissive layers are then deposited on the insulating layer by atomic layer deposition. | 03-25-2010 |
| 20110226933 | Image Intensifying Device - An image intensifying device includes a lens that is positioned at a light input that forms an image of a scene. The image intensifying device also includes an image intensifier tube that includes a photocathode that is positioned to receive the image formed by the lens. The photocathode generates photoelectrons in response to the light image of the scene. The image intensifier tube also includes a microchannel plate having an input surface comprising the photocathode. The microchannel plate receives the photoelectrons generated by the photocathode and generating secondary electrons. An electron detector receives the secondary electrons generated by the microchannel plate and generates an intensified image of the scene. | 09-22-2011 |
| 20120273689 | Microchannel Plate Devices With Tunable Resistive Films - A microchannel plate for detecting neutrons includes a hydrogen-rich polymer substrate that defines a plurality of channels extending from a top surface of the substrate to a bottom surface of the substrate, where neutrons interact with the plurality of channels to generate at least one secondary electron. A top electrode is positioned on the top surface of the substrate and a bottom electrode is positioned on the bottom surface of the substrate. A resistive layer is formed over an outer surface of the plurality of channels that provides ohmic conduction with a resistivity that is substantially constant. An emissive layer is formed over the resistive layer. Neutron interaction products interact with the plurality of channels defined by the substrate and the emissive films to generate secondary electrons that cascade within the plurality of channels to provide an amplified signal related to the detection of neutrons. | 11-01-2012 |
| 20130193831 | Microchannel Plate Devices With Tunable Conductive Films - A microchannel plate includes a substrate defining a plurality of channels extending from a top surface of the substrate to a bottom surface of the substrate. A resistive layer is formed over an outer surface of the plurality of channels that provides ohmic conduction with a predetermined resistivity that is substantially constant. An emissive layer is formed over the resistive layer. A top electrode is positioned on the top surface of the substrate. A bottom electrode positioned on the bottom surface of the substrate. | 08-01-2013 |
| 20140028175 | Microchannel Plate Devices With Tunable Resistive Films - A microchannel plate includes a substrate defining a plurality of channels extending from a top surface of the substrate to a bottom surface of the substrate. A resistive layer is formed over an outer surface of the plurality of channels that provides ohmic conduction with a predetermined resistivity that is substantially constant. An emissive layer is formed over the resistive layer. A top electrode is positioned on the top surface of the substrate. A bottom electrode positioned on the bottom surface of the substrate. | 01-30-2014 |
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| 20120126347 | PACKAGES AND METHODS FOR PACKAGING - Packaged integrated devices and methods of forming the same are provided. In one embodiment, a packaged integrated device includes a package substrate, a package lid, and an integrated circuit or microelectromechanical systems (MEMS) device. The package lid is mounted to a first surface of the package substrate using an epoxy, and the package lid and the package substrate define a package interior. The package lid includes an interior coating suited to good adhesion with the epoxy, and an exterior coating suited to RF shielding, where the materials of the interior and exterior coatings are different. In one example, the interior lid coating is nickel whereas the exterior lid coating is tin. | 05-24-2012 |
| 20140332947 | PACKAGES AND METHODS FOR PACKAGING - Packaged integrated devices and methods of forming the same are provided. In one embodiment, a packaged integrated device includes a package substrate, a package lid, and an integrated circuit or microelectromechanical systems (MEMS) device. The package lid is mounted to a first surface of the package substrate using an epoxy, and the package lid and the package substrate define a package interior. The package lid includes an interior coating suited to good adhesion with the epoxy, and an exterior coating suited to RF shielding, where the materials of the interior and exterior coatings are different. In one example, the interior lid coating is nickel whereas the exterior lid coating is tin. | 11-13-2014 |
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| 20100174405 | Automated Material Handling System for Semiconductor Manufacturing Based on a Combination of Vertical Carousels and Overhead Hoists - A highly efficient Automated Material Handling System (AMHS) that allows an overhead hoist transport vehicle to load and unload Work-In-Process (WIP) parts directly to/from one or more WIP storage units included in the system. The AMHS includes an overhead hoist transport subsystem and at least one vertical carousel stocker having a plurality of storage bins. The overhead hoist transport subsystem includes an overhead hoist transport vehicle traveling along a suspended track defining a predetermined route, which runs adjacent to the carousel stocker, thereby allowing the overhead hoist transport vehicle to access a WIP part directly from one of the storage bins. At least one of the storage bins includes a movable shelf operative to move laterally from a first position along the carousel path to a second position near the overhead hoist transport vehicle. The storage unit is at least partially open to allow the movable shelf to move to the second position, thereby allowing the overhead hoist to access a material unit directly from the movable shelf for subsequent transport along the track between various locations within a product manufacturing facility. | 07-08-2010 |
| 20110016891 | Cryopump Network - A vacuum network control system includes a plurality of nodes configured for control over operational processes of the system. The plural nodes are configured, in a network ring or other topology, as a selectable master node for controlling the operational processes. Control can be distributed among, and passed between, each of the nodes. Each node on the network monitors adjacent network connectors to detect a fault in the network. In response to a detected fault, a disconnect is mapped to the fault, and the network topology is reconfigured for continued communication among the nodes and with external devices. | 01-27-2011 |
| 20110162391 | Method and Apparatus for Providing Temperature Control to a Cryopump - Cryopump components are improved using thin layer heating elements for temperature control or to serve as heaters. These heating elements may be located and prevent pooling during regeneration. The temperature control may also be achieved through the use of ceramic heating elements. The ceramic heating elements may also include a second function of structural support within the cryopump. Temperature control may further be achieved via the radiation shield, where the radiation shield includes a clad sheeting or coating. | 07-07-2011 |
| 20110241845 | Automated Material Handling System with Identification Features - Amongst other things, a material handling system comprises a controller; a transport system, the transport system comprising transport track sections and at least one transport vehicle, the at least one transport vehicle configured to move along the transport track sections and configured to transport a carrier; and at least one identification tag reader located along a particular transport track section, the at least one identification tag reader being configured to read an identification tag of the carrier being transported by the at least one transport vehicle and being further configured to send a information signal to the controller; wherein the controller is configured to verify at least a location of the carrier based on the information signal. | 10-06-2011 |
| 20110245964 | Self Aligning Automated Material Handling System - A semiconductor workpiece processing system comprises at least one processing tool; a transport section configured to transport carriers to and from the processing tool; and a transport vehicle movably mounted on the transport section; wherein the transport vehicle is configured to: sense a location of a transport carrier alignment feature; adjust a location of a transport vehicle gripper based on the location of the transport carrier alignment feature; sense an attitude of the gripper at a point of engagement with the transport carrier; and adjust the location of the gripper based on the attitude of the gripper. | 10-06-2011 |
| 20120288348 | Automated Material Handling System for Semiconductor Manufacturing Based on a Combination of Vertical Carousels and Overhead Hoists - An overhead hoist transport vehicle comprising: an overhead hoist; a translating stage; and a gripper coupled to the translating stage, the gripper being configured to grip a material unit; wherein the overhead hoist is configured to transport the material unit to one of a load port and a storage location by performing operations comprising: the overhead hoist being configured to vertically move the gripper to the load port and the storage location; and the translating stage being configured to horizontally move the overhead hoist to the load port and the storage location; and wherein the load port is beneath an overhead rail; and wherein at least a portion of the storage location is disposed lateral to the overhead rail. | 11-15-2012 |
| 20140119857 | Automated Material Handling System for Semiconductor Manufacturing Based on a Combination of Vertical Carousels and Overhead Hoists - A highly efficient Automated Material Handling System (AMHS) that allows an overhead hoist transport vehicle to load and unload Work-In-Process (WIP) parts directly to/from one or more WIP storage units included in the system. The AMHS includes an overhead hoist transport subsystem and at least one vertical carousel stocker having a plurality of storage bins. The overhead hoist transport subsystem includes an overhead hoist transport vehicle traveling along a suspended track defining a predetermined route, which runs adjacent to the carousel stocker, thereby allowing the overhead hoist transport vehicle to access a WIP part directly from one of the storage bins. At least one of the storage bins includes a movable shelf operative to move laterally from a first position along the carousel path to a second position near the overhead hoist transport vehicle. | 05-01-2014 |
| 20140130527 | Helium Management Control System - A refrigerant management system controls the supply of refrigerant from two or more variable speed and fixed speed compressors to a plurality of cryogenic refrigerators. The system employs a plurality of sensors to monitor and regulate the overall refrigerant supply to deliver an appropriate refrigerant supply to each of the cryogenic refrigerators. The amount of refrigerant to supply is based on an aggregate demand for refrigerant from the plurality of cryogenic refrigerators and a refrigerant correction metric. An appropriate supply of refrigerant is distributed to each cryogenic refrigerator by adjusting the speed of the variable speed compressors or, alternatively, selectively turning the compressors on or off. The speed of the variable speed compressors is adjusted by determining an amount of refrigerant to supply to the plurality of cryogenic refrigerators. If the aggregate demand for refrigerant exceeds the capacity of the compressors, then the speed of a refrigerator within the plurality of refrigerators is adjusted. | 05-15-2014 |
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| 20090216265 | Tissue fasteners and related deployment systems and methods - Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. Other tissue fastener embodiments include means for applying a substantially constant force on the tissue layers and/or means for adjusting a length of the connecting member between the first and second members. | 08-27-2009 |
| 20110105844 | MANUALLY CONTROLLED ENDOSCOPE - A control handle for use with a steerable endoscopic device. The endoscopic device having a pair of control wires to effect steering. The control handle includes a steering mechanism that includes an actuator, such as a control knob, drivingly connected to a drive member, such as a sprocket or drive gear. To transmit force from the drive member to the control wires, a length of transmission structure, such as bead chain, is connected to the proximal ends of the control wires and is engaged with the drive member. In one embodiment, a single-use endoscope may be provided, which includes a control handle, a steerable endoscopic device, and a umbilical cord or communications conduit for functionally connecting the control handle to a control cabinet of an endoscopic imaging system. | 05-05-2011 |
| 20140031841 | TISSUE FASTENERS AND RELATED DEPLOYMENT SYSTEMS AND METHODS - Surgical tissue fasteners and related deployment systems and methods are disclosed. A tissue fastener used to join multiple tissue layers includes a first member, a second member, and a connecting member connecting the first and second members. In some embodiments, the first and second members are configured to expand from a delivered state to a deployed state in which the fastener secures the tissue layers together. Other tissue fastener embodiments include means for applying a substantially constant force on the tissue layers and/or means for adjusting a length of the connecting member between the first and second members. | 01-30-2014 |
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| 20110021875 | STEERING SYSTEM TENSION CONTROL DEVICES - A steerable shaft of a medical instrument is steered by one or more control cables. The control cables are in contact with a steering system tension control device that reduces the tension in the control cables caused by bends in the shaft. | 01-27-2011 |
| 20110124963 | DEVICES AND METHODS FOR FASTENING TISSUE LAYERS - Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers. | 05-26-2011 |
| 20110213202 | ENDOSCOPE WORKING CHANNEL WITH MULTIPLE FUNCTIONALITY - Endoscopic instrument assemblies and methods for making and using the same. An example endoscopic instrument assembly includes an endoscope having a working channel and an endoscopic instrument slidably disposed in the working channel. The inside surface of the working channel and the outside surface of the endoscopic instrument each have a non-circular cross-sectional shape along at least a portion of their respective lengths. | 09-01-2011 |
| 20120004505 | DEVICES AND METHODS FOR TISSUE INVAGINATION - Surgical devices and methods used for invaginating tissue during, for example, an endoscopic fundoplication procedure, are disclosed. The device includes an elongated tube having a proximal end configured to extend outside of the body and a distal end configured to extend proximate the tissue to be invaginated, and a distal member coupled to the distal end of the tube. The distal member is configured to hold or grasp the tissue to be invaginated. The devices may include a protective distal sleeve. | 01-05-2012 |
| 20120065647 | Endoscopic Hemostatic Clipping Apparatus - An apparatus for applying clips to tissue, comprises a plurality of clips, each of the clips including a proximal end having a pair of opposed jaws and a distal end including a linking feature, where the clips are linked to one another to form a clip chain with a linking feature of a distal-most one of the clips being gripped between the jaws of an immediately proximal one of the clips and a control linkage coupled to a proximal-most one of the clips for applying tension and compression to the clip chain in combination with a magazine containing the clip chain, the magazine including an abutment surface sized to prevent passage distally therebeyond of a clip having received between its jaws a linking feature of an immediately distal clip and an opening location within which the jaws of a clip are permitted to open to release a linking feature therefrom. | 03-15-2012 |
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| 20080249553 | METHOD, SYSTEM AND DEVICE FOR TISSUE REMOVAL - A method and device for tissue removal. The device may be used to remove uterine fibroids and other abnormal gynecological tissue. According to one embodiment, the device includes a housing, an outer tube, and an inner tube. The outer tube is fixed to the housing and includes a side window proximate to its distal end. The side window may have sloped proximal and distal ends. The inner tube has a distal end positioned within the outer tube, the distal end being adapted to rotate and, at the same time, to move back and forth past the side window, with the rotational and translational movement of the inner tube being independently controllable. The distal end of the inner tube may have an external bevel. Suction is applied to the proximal end of the inner tube to draw tissue into the side window and to remove resected tissue through the inner tube. | 10-09-2008 |
| 20090270895 | LOW ADVANCE RATIO, HIGH RECIPROCATION RATE TISSUE REMOVAL DEVICE - Disclosed is a tissue removal device having an outer tube with a resection window and an inner tube disposed within the outer tube. The inner tube is slidable and rotatable relative to the outer tube so that the distal end of the inner tube moves back and forth across the resection window to sever tissue extending therethrough. The inner tube may be driven to rotate at a speed of at least about 1100 rpm, to axially translate at a rate of at least about 1.5 cps, and with an advance ratio of no more than about 0.25. The drive system for controlling axial reciprocation and rotation of the inner tube may be totally mechanical. | 10-29-2009 |
| 20090270896 | TISSUE CUTTER WITH DIFFERENTIAL HARDNESS - Disclosed is a tubular cutting element for axial reciprocal movement within an outer tubular sleeve. The cutting element has an elongate tubular body, having a proximal end, a distal end and a cutting tip. The tubular body is formed in a drawing operation and the cutting tip is formed in a milling operation. The tubular body may have a Rockwell C hardness of no more than about 40, and the cutting tip may have a Rockwell C hardness of at least about 50. | 10-29-2009 |
| 20090270897 | METHODS OF HIGH RATE, LOW PROFILE TISSUE REMOVAL - Disclosed are methods and devices for removing tissue from a site in a hollow organ, where the device has a low crossing profile and is capable of removing tissue at a high rate of speed. The device includes an elongate outer tube with a side opening and an inner tube moveably coaxially positioned within the outer tube. Tissue drawn into the side opening can be severed by moving the inner tube across the opening. Tissue may be removed through the device at a rate of at least about 1.4 cc per minute, through a lumen having a cross-sectional area of no greater than about 12.0 | 10-29-2009 |
| 20090270898 | TISSUE REMOVAL DEVICE WITH HIGH RECIPROCATION RATE - Disclosed is a tissue removal device. The device includes an outer tubular body, an inner tubular body and a cutting edge on the inner tubular body. The outer tubular body includes a window, which may be opened or closed by moving the cutting edge. The cutting edge has a hardness that exceeds the hardness of the material of the inner tube. The cutting edge may have a Rockwell C hardness of at least about 50, while the inner tube has a Rockwell C hardness of no more than about 40. The cutting edge may be formed by a milling step, and the inner tube may be formed by a drawing step. Tissue severed by the cutting edge may be removed at a rate of at least about 1.8 grams per minute through the inner tube, and the outer tubular body may have an outside diameter of no more than about 3.5 mm. | 10-29-2009 |
| 20110077674 | TISSUE CUTTER WITH DIFFERENTIAL HARDNESS - Disclosed is a tubular cutting element for axial reciprocal movement within an outer tubular sleeve. The cutting element has an elongate tubular body, having a proximal end, a distal end and a cutting tip. The tubular body is formed in a drawing operation and the cutting tip is formed in a milling operation. The tubular body may have a Rockwell C hardness of no more than about 40, and the cutting tip may have a Rockwell C hardness of at least about 50. | 03-31-2011 |
| 20120172889 | TISSUE REMOVAL SYSTEM - A tissue removal system includes an inner tubular member configured to rotate and oscillate axially relative to an outer tubular member, and a reversible motor comprising a rotatable output shaft operatively coupled to the inner tubular member. A proximal end of the inner tubular member is disposed within, and configured to rotate and oscillate axially relative to, a housing. A first control switch disposed within the housing is actuated when the inner tubular member is in a distal position relative to the housing, and a second control switch disposed external to the housing is actuated by a user. The system further includes motor control circuitry configured such that when the second control switch is actuated, actuation of the first control switch causes the motor output shaft to change direction, and when the second control switch is not actuated, actuation of the first control switch causes the motor to turn off. | 07-05-2012 |
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| 20090049100 | METHOD AND APPARATUS FOR HUMAN-POWERED MOBILE VISUAL SEARCH AND FEEDBACK - A system and a method for receiving live human feedback of an image provided using a mobile device equipped with a camera. The method includes capturing an image with the mobile device equipped with a camera, inputting a text query, where the text query corresponds with the image, transmitting the image and the text query to a server, determining at least one client user to send the image and the text query to, sending the image and the text query from the server to the at least one client user, reviewing the image and the text query, formulating at least one text response relating to the image and the text query, accepting the at least one text response from the at least one client user, and outputting the at least one text response to a user. | 02-19-2009 |
| 20100281158 | ENVIRONMENTAL FOOTPRINT MONITOR FOR COMPUTER NETWORKS - A system and method for obtaining an environmental footprint of a website are presented. The system includes a website embedded with a unique identifying tag, a user terminal to view the website, an environmental footprint server which identifies the unique identifying tag of the website, and a processor to calculate the environmental footprint of the website based upon time data and the average emissions emitted by a user terminal, the server hosting the website and a network connecting the user terminal and the server. | 11-04-2010 |
| 20130215058 | In-Room Hospitality Devices and Systems - The present invention is generally directed to hospitality systems and in-room hospitality computer devices that are configured to communicate with or control other devices or systems within a hotel. In some aspects, a unified in-room hospitality device comprises a mobile computing device, such as a tablet computer, that is secured in place by an encasement in a hotel room. The encasement can be, for example, secured to a table surface of a night stand. | 08-22-2013 |
| 20130293581 | Back-to-Back Video Displays - The present invention extends to methods, systems, and computer program products for displaying advertisements to customers using multiple display devices that are positioned in a back-to-back orientation. Visual content captured by one display device can be transmitted to the other display device for display such that the display devices appear to be transparent. In this way, items positioned in front of one display device can be captured by the display device and augmented prior to being displayed on the other display device. These augmentations can provide dynamic and customized advertisements of items as they appear on a shelf or other location within a retail environment to thereby increase a customer's interest in the product while the customer is near the product. | 11-07-2013 |
