Patent application number | Description | Published |
20090069236 | PROCESS FOR THE PREPARATION OF HYPOALLERGENIC MAJOR BIRCH POLLEN ALLERGEN rBet v 1 - The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralisation. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy. | 03-12-2009 |
20120263741 | VARIANTS OF THE MAJOR ALLERGEN PHL P 1 FROM TIMOTHY GRASS - The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof. | 10-18-2012 |
20120288526 | DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS - The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies. | 11-15-2012 |
20150079120 | DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS - The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the | 03-19-2015 |
Patent application number | Description | Published |
20080315662 | Arrester Device For an Adjustable Vehicle Seat - An arrester device for an adjustable vehicle seat with at least one locking rail running parallel to an adjusting direction and having periodically arranged locking lugs and locking openings includes a locking unit which includes a plurality of locking pins with a cylindrical shaft. The locking pins are guided independently of one another in a guide device in a locking direction, are displaceable in the locking openings and are pretensioned in the locking direction. The locking pins have a circumferential thread structure at least on the portion of the cylindrical shaft thereof running through a guide portion of the guide device. | 12-25-2008 |
20110308340 | SPINDLE DRIVE FOR LONGITUDINALLY ADJUSTING A MOTOR VEHICLE SEAT - A spindle drive for longitudinally adjusting a motor vehicle seat is provided. The spindle drive comprising an adjustment rail that can be longitudinally adjusted relative to a body mounted rail and an adjusting mechanism that includes a driving worm connected to a driving device as well as a spindle nut, the external teeth of which mesh with the external teeth of the driving worm, and the internal teeth of which mesh with the external thread of a spindle. The spindle nut is formed by a hybrid spindle nut that has a functional part, which is located in the force flux between the driving worm and the spindle, and at least one strengthening part, deflecting crash forces from the adjustment rail into the spindle. | 12-22-2011 |
20120019037 | MOTOR VEHICLE SEAT - The invention relates to a motor vehicle seat comprising a seat sub-frame adjustable along a rail longitudinal guide to which a backrest is hinged in a pivoting manner and can be folded forward toward a seating surface of the seat sub-frame, a locking device for arresting the rail longitudinal guide in an adjustable seating longitudinal position, an entry aid by means of which the locking device is released, when the backrest is folded forward to the seating surface and a memory arrangement for adjusting and restoring a memory position having a position memory that has an adjustment means for adjusting the memory position in the rail longitudinal direction of the rail longitudinal guide and a locking element that is connected to the adjustment means in a pivoting manner that under the effect of a control element can be pivoted in a locking rail for locking the adjusted memory position and pivoted out of the locking rail for adjusting a memory position and is connected to the adjustment means via a slotted guide such that a virtual point of rotation of the locking element lies underneath the rail profile of the locking rail. | 01-26-2012 |
20120325033 | SPINDLE GEAR UNIT HAVING REINFORCEMENT - An adjusting means for adjusting two vehicle parts relative to each other, in particular for the longitudinal setting of a vehicle seat is provided. The adjusting means comprising an adjusting gear unit arranged on a first vehicle part and a spindle arranged on a second vehicle part, which extends in longitudinal direction, is in engagement with the adjusting gear unit and along which the adjusting gear unit is movable for adjusting the first vehicle part relative to the second vehicle part. There is provided a reinforcement part which supports the adjusting gear unit with respect to the first vehicle part in the longitudinal direction of the spindle such that due to the reinforcement part with forces introduced in the longitudinal direction from the first vehicle part into the adjusting gear unit the adjusting gear unit is supported with respect to the first vehicle part with a higher rigidity than with forces introduced against the longitudinal direction. | 12-27-2012 |
20130075571 | LONGITUDINAL GUIDE FOR A MOTOR VEHICLE SEAT - A longitudinal guide for vehicle seats, including two elongate rails, each including a lower rail, an upper rail supported on the lower rail and displaceable in a longitudinal direction, and two bearing areas for guiding means, the bearing areas lying diagonally opposite to and biased against each other, each upper rail and lower rail having an L-shaped region, if viewed in profile, formed by a base leg and an L-leg protruding from the base leg substantially perpendicularly, and two end regions adjoining the L-shaped region, each end region of the upper or lower rail together with the end region of the associated lower or upper rail forming an embracing area by mutually hooking, the end regions of the upper rail forming the bearing areas with opposite portions of the associated lower rail, and a plurality of balls being supported in a first bearing area on the end region. | 03-28-2013 |