Patent application number | Description | Published |
20120142586 | TREATMENT FOR OBESITY - The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like. | 06-07-2012 |
20120149635 | TREATMENT FOR OBESITY - The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like. | 06-14-2012 |
20120302497 | METHODS OF TREATING MEDICAL CONDITIONS USING CALCITONIN ANALOGS - The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like. | 11-29-2012 |
20140073561 | METHODS OF TREATING MEDICAL CONDITIONS USING PEPTIDES - The present invention provides peptides and pharmaceutical compositions thereof for appetite suppression and weight control. Preferred peptides are calcitonin analogs, preferably with specific amino acid changes to make the peptide more amylin-like. | 03-13-2014 |
Patent application number | Description | Published |
20130183385 | PEPTIDE ANALOGS FOR TREATING DISEASES AND DISORDERS - A peptide having a sequence selected from SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17 and SEQ ID NO:18. Said peptide used for the treatment of type I diabetes, Type II diabetes, metabolic syndrome, or obesity, or of apetite suppression, or for mitigating insulin resistance, or for reducing an undesirably high fasting serum glucose level, or for reducing an undesirably high peak serum glucose level, or for reducing an undesirably high peak serum insulin level, or for reducing an undesirably large response to a glucose tolerance test. | 07-18-2013 |
20150196617 | Peptide Analogs for Treating Diseases and Disorders - Provided herein are methods for the treatment of type I diabetes, Type II diabetes, metabolic syndrome, or obesity, or of appetite suppression, or for mitigating insulin resistance, or for reducing an undesirably high fasting serum glucose level, or for reducing an undesirably high peak serum glucose level, or for reducing an undesirably high peak serum insulin level, or for reducing an undesirably large response to a glucose tolerance test in synergistic combination with metformin. Treatment is effected with a combination therapy of metformin and a peptide with a sequence selected from SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 22, SEQ ID NO: 23, and SEQ ID NO: 24 administered to a patient. | 07-16-2015 |
Patent application number | Description | Published |
20130205944 | Torque Transmission Assembly, In Particular Hydrodynamic Torque Converter, Fluid Coupling Or Wet-Running Clutch - A torque transmission assembly, particularly a hydrodynamic torque converter, a fluid coupling or a wet clutch, includes a housing arrangement that includes a torsional vibration damper arrangement having an input region which is coupled to or can be coupled to the housing arrangement and an output region to be coupled to a driven member. The torque transmission assembly also includes at least one mass damper arrangement having a damper mass arrangement which is coupled to the torque transmission assembly by a mass damper elastic arrangement. | 08-15-2013 |
20150285332 | TORSIONAL VIBRATION DAMPER - A torsional vibration damper has a damper mass carrier at which is received at least one damper mass movable relative to the damper mass carrier and with at least one stop. The at least one damper mass has a stop side with a geometric shaping. At least one stop is associated with the damper mass, and has an axial overlap with the at least one damper mass in extension direction of a central axis and a stop profile at its side facing the stop side of the damper mass. At least one stop receiver is associated with the least one stop for the at least one damper mass. The geometric shaping which is provided at the at least one damper mass has a first contact region operative at least substantially in radial direction and a second contact region operative at least substantially in tangential direction. The first contact region can be brought into operative connection with the stop, and the second contact region can be brought into operative connection with the stop receiver. | 10-08-2015 |
20150316124 | Torsional Vibration Damper - A torsional vibration damper is provided with a damper mass carrier at which is received at least one damper mass that is movable relative to the damper mass carrier and at least one stop. The at least one stop is associated with each stop side of the at least one damper mass. The at least one damper mass and the stop have an extension in extension direction of a central axis. The at least one damper mass has a plurality of damper mass elements in extension direction of the central axis, while the stop has in extension direction of the central axis a stop profile at its side facing the stop sides of the damper mass elements. The stop profile has different radial distances from the central axis in association with the damper mass elements. | 11-05-2015 |
Patent application number | Description | Published |
20100009421 | Method For The Enzymatic Reduction Of Alkyne Derivates - The invention relates to a method for the enzymatic reduction of alkyne derivatives of the formula (1), | 01-14-2010 |
20100035315 | PROCESS FOR ENZYMATIC REDUCTION OF ALKENE DERIVATIVES - A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3. | 02-11-2010 |
20100041922 | METHOD FOR THE ENANTIOSELECTIVE PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-2-ENONE DERIVATIVES - The present invention relates to a process for enantioselectively preparing optically active 4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-one derivatives of the formulae (I) or (Ia) and to a process for preparing (3S,3′S)-astaxanthin of the formula (III), comprising the process for preparing the compound of the formula (I). | 02-18-2010 |
20100196970 | Butynol I esterase - The invention relates to novel proteins from | 08-05-2010 |
20100304448 | METHOD FOR THE ENZYMATIC REDUCTION OF ALPHA- AND BETA-DEHYDROAMINO ACIDS USING ENOATE REDUCTASES - A method for the enzymatic preparation of amino acids of the general formula (3) or (4) from alpha-dehydroamino acids of the general formula (1) or (2) | 12-02-2010 |
20110045560 | METHOD FOR PRODUCING OPTICALLY ACTIVE 2-METHYL-ALKANOLS - A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps:
| 02-24-2011 |
20120301931 | PROCESS FOR THE REDUCTION OF CINNAMALDEHYDE DERIVATIVE EMPLOYING ENOATE REDUCTASES - The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents. | 11-29-2012 |
Patent application number | Description | Published |
20080281471 | Droplet Actuator Analyzer with Cartridge - A droplet actuator with cartridge is provided. According to one embodiment, a sample analyzer is provided and includes an analyzer unit comprising electronic or optical receiving means, a cartridge comprising self-contained droplet handling capabilities, and a wherein the cartridge is coupled to the analyzer unit by a means which aligns electronic and/or optical outputs from the cartridge with electronic or optical receiving means on the analyzer unit. According to another embodiment, a sample analyzer is provided and includes a sample analyzer comprising a cartridge coupled thereto and a means of electrical interface and/or optical interface between the cartridge and the analyzer, whereby electrical signals and/or optical signals may be transmitted from the cartridge to the analyzer. | 11-13-2008 |
20100194408 | Capacitance Detection in a Droplet Actuator - A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode. | 08-05-2010 |
20110213499 | Methods, Systems, and Products for Conducting Droplet Operations - The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. An aspect of the software components of the invention is an interface description file for each hardware component of a microfluidics system that allows hardware components to be changed without modifying the program for performing droplet operations protocols. Another aspect of the software components of the invention is the establishment of electrode-to-electrode relationships and other aspects of droplet actuator configurations, which may be used when programming droplet operations protocols. Another aspect of the software components of the invention is a physical design library of predefined electrode elements that may be used by a droplet actuator designer when constructing a layout of electrodes. Another aspect of the software components of the invention is a droplet actuator description file that contains the physical and electrical description of the droplet actuator. Another aspect of the software components of the invention is a router component for determining routes of droplet operations in a droplet actuator. Another aspect of the software components of the invention is the use of tri-state vectors for programming sequences in a droplet actuator. Still other aspects are provided. | 09-01-2011 |
20130018611 | Systems and Methods of Measuring Gap Height - A method of determining a gap height in a droplet actuator including measuring an impedance between a droplet operations electrode of a first substrate in a droplet actuator and ground electrode of a second substrate in the droplet actuator, storing a lookup table that associates impedances to heights of gaps between the first substrate and the second substrate, querying the lookup table for the impedance measured between the droplet operations electrode of the first substrate and the ground electrode of the second substrate; and retrieving a height of a gap associated with the impedance. | 01-17-2013 |
20130168250 | Droplet Actuator Systems, Devices and Methods - The present invention is directed to droplet actuator systems, devices, and methods. In one embodiment, a microfluidic article of manufacture is provided. The microfluidic article of manufacture includes a first substrate; a second substrate separated from the first substrate to form a droplet operations gap; gap height setting spacers associated with the first and/or second substrate or situated between the first and second substrates; a spring forcing the second substrate against the gap height setting spacers, thereby establishing a substantially uniform gap height between the first and second substrates; and electrodes associated with the first and/or second substrate and configured to conduct droplet operations in the droplet operations gap. | 07-04-2013 |
20130178968 | Methods, Systems, and Products for Conducting Droplet Operations - The present invention provides modified droplet actuator systems, software, and software-executed methods for use in droplet actuator operation and droplet actuator systems that are configured and programmed to execute such software. The invention provides a computer readable medium storing processor executable code for performing a method, the method comprising receiving a selection of a function to be performed by a droplet actuator, associating the function to a predefined electrode element, associating the predefined electrode element to a grouping of one or more electrodes that perform the function, and adding the grouping of one or more electrodes to an electronic layout of the droplet actuator. | 07-11-2013 |
20130217113 | SYSTEM FOR AND METHODS OF PROMOTING CELL LYSIS IN DROPLET ACTUATORS - The invention relates to a droplet actuator for conducting droplet operations. The actuator includes a bottom substrate and a top substrate separated from the bottom substrate to form a gap. An arrangement of droplet operations electrodes may be located on a surface of the bottom substrate and/or top substrate. Optionally, a sample reservoir may hold a quantity of a sample fluid containing cells. A disruption device which can take various forms is used to lyse the cells in the sample or in a sample droplet to thereby conduct operations on samples having lysed cells therein. | 08-22-2013 |
20130293246 | Capacitance Detection in a Droplet Actuator - The embodiments described herein provide methods of measuring capacitance, detecting a droplet at a position, determining a thickness of an oil film and determining temperature in a droplet actuator. Specifically, the capacitance detection method may be used as a real-time verification tool in order to detect the absence, presence, and/or partial presence of a droplet at an electrode, analyze droplet properties, measure droplet size or volume, optimize the speed of droplet operation and detect air bubbles. | 11-07-2013 |
20140332380 | Capacitance Detection in a Droplet Actuator - A method, circuit and apparatus for detecting capacitance on a droplet actuator, inter alia, for determining the presence, partial presence or absence of a droplet at an electrode on a droplet actuator by: (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged on the substrate for conducting droplet operations on a surface of the substrate; (ii) a capacitance detection circuit for detecting capacitance at the droplet operations surface at one or more of the electrodes; (b) detecting capacitance at the droplet operations surface at one or more of the electrodes; and (c) determining from the capacitance the presence, partial presence or absence of a droplet at the droplet operations surface at the electrode. | 11-13-2014 |