Patent application number | Description | Published |
20090118269 | Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds - Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described. | 05-07-2009 |
20090131401 | Transcription factor modulating compounds and methods of use thereof - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. | 05-21-2009 |
20090131481 | Transcription Factor Modulating Compounds and Methods of Use Thereof - Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided. | 05-21-2009 |
20090131696 | Reducing Tetracycline Resistance in Living Cells - The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-deoxy 13-(substituted mercapto) derivatives of tetracycline, in combination with other tetracycline-type antibiotics as a synergistic combination of compositions to be administered simultaneously, sequentially or concurrently. In another embodiment, certain novel compositions are provided which may be administered alone against, for example, a sensitive or resistant strain of gram positive bacteria such as | 05-21-2009 |
20090298873 | METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS - The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided. | 12-03-2009 |
20100227850 | METHODS FOR PREVENTING AND TREATING MICROBIAL INFECTIONS BY MODULATING TRANSCRIPTION FACTORS - The current invention is based, inter alia, on the finding that the transcription factor MarA, and homologues of MarA, e.g., Rob and SoxS, are virulence factors. Accordingly, the invention discloses methods for screening compounds for their ability to modulate these virulence factors. The invention further describes methods for treating and preventing bacterial infections by modulating the expression and/or activity of transcription factors. In addition, the invention provides a method for identifying other virulence factors. | 09-09-2010 |
20100292091 | MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE - An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix domains, mutant MarA family protein helix-turn-helix domains and methods of their use, for example, in screening assays to identify compounds which are useful as antiinfective agents and in screening assays to identify loci which are involved in mediating antibiotic resistance are described. | 11-18-2010 |
20100298540 | Crystal Structure of a MarR Family Polypeptide - The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in | 11-25-2010 |
20110015375 | Methods for Identifying and Using MarR Family Polypeptide Binding Compounds - Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides. | 01-20-2011 |
20110059962 | TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided. | 03-10-2011 |
20110086821 | Tetracycline Compounds for Treatment of Cryptosporidium Parvum Related Disorders - Methods and compositions for treating | 04-14-2011 |
20110092467 | 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds - Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included. | 04-21-2011 |
20110207706 | Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds - Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described. | 08-25-2011 |
20110230523 | TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. | 09-22-2011 |
20110251095 | MARA FAMILY HELIX-TURN-HELIX DOMAINS AND THEIR METHODS OF USE - An important advance in the battle against drug resistance by elucidating the domains of MarA which are critical in mediating its function. Accordingly, MarA family protein helix-turn-helix domains, mutant MarA family protein helix-turn-helix domains and methods of their use, for example, in screening assays to identify compounds which are useful as antiinfective agents and in screening assays to identify loci which are involved in mediating antibiotic resistance are described. | 10-13-2011 |
20110301127 | METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS - The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided. | 12-08-2011 |
20120209003 | METHODS FOR IDENTIFYING AND USING MarR FAMILY POLYPEPTIDE BINDING COMPOUNDS - Methods for identifying MarR family inhibiting compounds are described. The methods include the use of computer aided rational based drug design programs and three dimensional structures of MarR family polypeptides. | 08-16-2012 |
20120245130 | Methods of Using Substituted Tetracycline Compounds to Modulate RNA - A method for modulating RNA with tetracycline compounds is described. | 09-27-2012 |
20130144038 | CRYSTAL STRUCTURE OF A MarR FAMILY POLYPEPTIDE - The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in | 06-06-2013 |
20140343020 | METHODS OF USING SUBSTITUTED TETRACYCLINE COMPOUNDS TO MODULATE RNA - A method for modulating RNA with tetracycline compounds is described. | 11-20-2014 |