Strotman
Hallena Strotman, Somerset, NJ US
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20150368682 | IMMOBILIZED TRANSAMINASES AND PROCESS FOR MAKING AND USING IMMOBILIZED TRANSAMINASE - The invention is directed to immobilized transaminases and methods of making and using them. | 12-24-2015 |
Hallena R. Strotman, Rahway, NJ US
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20150259284 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: | 09-17-2015 |
Hallena R. Strotman, Somerset, NJ US
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20130149751 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates. | 06-13-2013 |
Hallena R. Strotman, Monmouth Junction, NJ US
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20130164794 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE - The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker. | 06-27-2013 |
Lindsay N. Strotman, Louisville, KY US
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20120059395 | ENDOSCOPIC CLOSURE DEVICE - An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue. | 03-08-2012 |
Lindsay N. Strotman, Madison, WI US
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20140065622 | Device for and Method of Isolating and Analyzing a fraction in a Biological Sample - A device and a method are provided for isolating a fraction in a biological sample. The fraction is bound to solid phase substrate to define a fraction-bound solid phase substrate. The device includes an input zone for receiving the biological sample therein to capture a desired fraction of the biological sample. A force is provided that is generally perpendicular to gravity. The force is movable between a first position adjacent the input zone multiple other positions adjacent various purification, protein analysis, separation and extraction zones. The force captures the fraction-bound solid phase substrate and the fraction-bound solid phase substrate moves from the input zone to the other zones to perform a multi-step assay on the isolated fraction within the device. | 03-06-2014 |
Neil Strotman, Somerset, NJ US
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20130331379 | PROCESS FOR THE PREPARATION OF AN OREXIN RECEPTOR ANTAGONIST - The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof. | 12-12-2013 |
Neil Strotman, Monmouth Junction, NJ US
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20100228036 | PROCESS FOR MAKING GLUCOCORTICOID RECEPTOR LIGANDS - The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases. | 09-09-2010 |