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| 20100008975 | Predicting response to a HER inhibitor - The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. | 01-14-2010 |
| 20100112603 | METHOD FOR PREDICTING THE RESPONSE TO A TREATMENT - The invention is related to a method of predicting the response to a treatment with a HER inhibitor in a patient comprising the steps of assessing a biomarker or a combination of biomarkers selected from the group consisting of amphiregulin, an epidermal growth factor, a transforming growth factor alpha, and a HER2 biomarker in a biological sample from the patient and predicting the response to the treatment with the HER inhibitor in the patient by evaluating the results of the first step. Further uses and methods wherein these markers are used are disclosed. | 05-06-2010 |
| 20110245103 | PREDICTING RESPONSE TO A HER INHIBITOR - The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. | 10-06-2011 |
| 20110246399 | PREDICTING RESPONSE TO A HER INHIBITOR - The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. | 10-06-2011 |
| 20130039909 | PREDICTING RESPONSE TO A HER INHIBITOR - The present application describes the use of low HER3 as a selection criterion for treating patients with a HER inhibitor, such as pertuzumab. | 02-14-2013 |
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| 20110274637 | Ethylene Oxide Free Antiperspirant/Deodorant Formulations - This invention relates to ethylene oxide free antiperspirant/deodorant formulations comprising at least one antiperspirant/deodorant active ingredient and at least one quaternary polymer having the INCI designation polyquaternium 37. | 11-10-2011 |
| 20110287073 | Emulsion Concentrate - The present invention relates to an emulsion concentrate with content of water-insoluble oil components (A), of hydrophilic non-ionic emulsifiers (B), of lipophilic co-emulsifiers (C), of polyols (D) and water, which comprises less than 50% by weight of water-insoluble oil component (A)—based on the total weight of the concentrate—comprising components (A), (B) and (C) and (D) in a ratio by weight A:B:C:D=1:(0.25-0.6):(0.25-0.6):(0.45-0.65). The invention further relates to the use of these emulsion concentrates, and also to preparations and paper product, non-woven product or textile product for body care and personal cleansing, which comprise water-insoluble oil components (A), hydrophilic non-ionic emulsifiers (B), lipophilic co-emulsifiers (C), and polyols (D) in a ratio by weight A:B:C:D=1:(0.25-0.6):(0.25-0.6):(0.45-0.65). | 11-24-2011 |
| 20120027826 | Free-Flowing Emulsion Concentrates - Emulsion concentrates comprising at least one alkyl and/or alkenyl oligoglycoside having 6 to 22 carbon atoms in the alk(en)yl radical, polyglycerol esters, at least one polyol, at least one glyceride having a melting point greater than or equal to 20° C., at least one oil component liquid at 20° C. and with a polarity of more than 30-40 mN/m and at least one oil component liquid at 20° C. and with a polarity of 5-30 mN/m are described. Methods of making and using such emulsion concentrates are also described. Articles employing the emulsion concentrates are also described. | 02-02-2012 |
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| 20090024337 | Apparatus for Detection and Processing of a Multiplicity of Measured Values in an HVDC Transmission Installation - An apparatus for detecting and processing a multiplicity of measured values in an HVDCT system has measuring units for detecting measured variables of the HVDCT system, while obtaining measured values, and preprocessing units which are connected to one another in series, are each connected to at least one measuring unit and are connected to a control, regulation and monitoring system by means of a last preprocessing unit which is connected downstream of the rest of the preprocessing units, each preprocessing unit being set up to receive and preprocess the measured values, while obtaining optical measured values, and transmitting both the optical measured values generated by it and the optical measured values received from the upstream preprocessing units to a downstream preprocessing unit or to the control, regulation and monitoring system, with the result that the last preprocessing unit provides all of the measured values for the control, regulation and monitoring system. | 01-22-2009 |
| 20100145537 | Method for Avoidance of Inadvertent Protective Tripping as a Result of Measurement Errors Within a Protection System for an HVDC Transmission Installation - A method for avoiding undesired, measurement error-induced protective tripping within a protection system of an HVDC transmission system. State variables of components of the HVDC transmission system are detected by first measuring devices to obtain a first set of measured values and by further measuring devices, which are designed in redundant fashion with respect to the first measuring devices, to obtain further sets of measured values. The first and further sets of measured values are supplied to a closed-loop control unit and a protective unit. The protective unit checks the first set of measured values for the presence of a risk of protective tripping by way of internal logic, and the closed-loop control unit regulates the HVDC transmission system as a function of one of the further sets of measured values. In the event of the presence of a risk of protective tripping, the protective unit checking one of the further sets of measured values for the presence of switchover conditions and, if present, switches over to the further set of measured values and checks the further set of measured values for the presence of a risk of protective tripping. | 06-10-2010 |
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| 20090206352 | Luminescence conversion led - A luminescence conversion LED having a radiation emitting chip that is connected to electrical connections and is surrounded by a housing that comprises at least a basic body and a cap, the chip being seated on the basic body, in particular in a cutout of the basic body, and the primary radiation of the chip being converted at least partially into longer wave radiation by a conversion element, wherein the cap is formed by a vitreous body, the conversion means being contained in the vitreous body, the refractive index of the vitreous body being higher than 1.6, preferably at least n=1.7. | 08-20-2009 |
| 20090278441 | Luminescence conversion of led - A luminescence conversion of LED, which uses a blue emitting chip and two illuminating substances, whereby one emits a red and the other a yellow to green. Both illuminating substances are separated upstream from the chip. | 11-12-2009 |
| 20110143627 | Luminescence Conversion LED - A luminescence conversion LED having a radiation emitting chip that is connected to electrical connections and is surrounded by a housing that comprises at least a basic body and a cap, the chip being seated on the basic body, in particular in a cutout of the basic body, and the primary radiation of the chip being converted at least partially into longer wave radiation by a conversion element, wherein the cap is formed by a vitreous body, the conversion means being contained in the vitreous body, the refractive index of the vitreous body being higher than 1.6, preferably at least n=1.7. | 06-16-2011 |
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| 20080265268 | Optoelectronic Component - An optoelectronic component is described, comprising a semiconductor body that emits electromagnetic radiation of a first wavelength when the optoelectronic component is in operation, and a separate optical element disposed spacedly downstream of the semiconductor body in its radiation direction. The optical element comprises at least one first wavelength conversion material that converts radiation of the first wavelength to radiation of a second wavelength different from the first. | 10-30-2008 |
| 20090206352 | Luminescence conversion led - A luminescence conversion LED having a radiation emitting chip that is connected to electrical connections and is surrounded by a housing that comprises at least a basic body and a cap, the chip being seated on the basic body, in particular in a cutout of the basic body, and the primary radiation of the chip being converted at least partially into longer wave radiation by a conversion element, wherein the cap is formed by a vitreous body, the conversion means being contained in the vitreous body, the refractive index of the vitreous body being higher than 1.6, preferably at least n=1.7. | 08-20-2009 |
| 20090278441 | Luminescence conversion of led - A luminescence conversion of LED, which uses a blue emitting chip and two illuminating substances, whereby one emits a red and the other a yellow to green. Both illuminating substances are separated upstream from the chip. | 11-12-2009 |
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| 20110147629 | SOLENOID ARRANGEMENT AND VALVE ARRANGEMENT - A solenoid arrangement comprises a pole tube which is axially subdivided into a pole core section, a transition section, and a tube section. A magnetic flux between the pole core section and the tube section is interrupted by the transition section. An armature is movably guided in the pole tube and has, at its end facing the pole core section, a flange which axially projects from an end face. According to the invention, the pole core section has a stepped depression into which the armature can plunge and which, starting from the transition section, is subdivided into an annular collar, a shoulder, and a notch which is set back axially and radially. An axial dimension of the collar exceeds an axial dimension of the flange. | 06-23-2011 |
| 20110168932 | SOLENOID ARRANGEMENT AND VALVE ARRANGEMENT - The invention relates to a solenoid wherein a magnetic discontinuity is formed in the pole tube by means of reducing the effective material thickness, such as by reducing the thickness, particularly the wall thickness of the magnetically active material, the front face of the armature facing the polker segment and a floor in the interior of the pole tube at the polker segment each have a contour allowing mutual axial overlapping. This enables advantageous influencing of the force-stroke characteristic curve of the solenoid with low production effort. | 07-14-2011 |
| 20140026983 | HOUSING FOR A PRESSURE-LOADED COMPONENT - A housing of a pressure-loaded component includes a pressure-loaded channel system which corresponds to the tensile and/or compressive strength properties of the housing material and to the tensile and/or compressive stresses in the housing material during operation of the pressure-loaded component. The housing also includes a channel rounded profile configured to be adapted to include a formed asymmetry. The formed asymmetry is configured to reduce tensile stresses occurring in operation and thus increase the load carrying capacity of the housing as a whole. | 01-30-2014 |
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| 20100007728 | System for Determining Objects - A system for multimodal detection of objects in a field of vision located in front of or behind a vehicle, wherein a surroundings-sensing process is carried out by a radar sensor, the radar sensor output signal is fed to a radar signal analysis method, and a visual surroundings-sensing process is carried out by a video sensor, the video output signal being fed to a video analysis method. Object determination takes place such that objects detected by the radar signal analysis method are fed for verification to an object confirmation and situation analysis module by an object detected by the video analysis method. | 01-14-2010 |
| 20100045482 | Method and Appratus for Identifying Concealed Objects In Road Traffic - Method for detecting concealed objects in road traffic in which the surroundings of a vehicle and movement variables of the driver's vehicle are sensed by sensors, said variables are transmitted as information to vehicles which are located in the surroundings by an interface for vehicle-to-vehicle communication and are received from the vehicles which are located in the surroundings, wherein the following steps are executed:
| 02-25-2010 |
| 20100094509 | System for Reducing The Braking Distance of a Vehicle - Method for reducing the stopping distance of a vehicle, wherein data which are received via a vehicle-to-vehicle communication are analysed, and a surroundings analysis for the driver's own vehicle is carried out, and vehicle-specific data are transmitted and integrated into an existing safety concept. | 04-15-2010 |
| 20130035836 | Method for Automatically Preventing Aquaplaning - The invention relates to a method for automatically preventing aquaplaning during the driving operation of a motor vehicle on a route, which method provides according to the invention that
| 02-07-2013 |
| 20140240502 | Device for Assisting a Driver Driving a Vehicle or for Independently Driving a Vehicle - A device for assisting a driver driving a vehicle or for autonomously driving a vehicle includes several distance sensors ( | 08-28-2014 |
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| 20080219484 | Apparatus and Method for Controlling a Plurality of Speakers Means of a Dsp - In a reproduction environment, speakers are grouped in directional groups, wherein the directional groups overlap with respect to the associated speakers so that speakers are present which have a speaker parameter having different values for the first directional group and the second directional group. A controller for controlling a plurality of speakers has a provider for providing a source position of an audio source, wherein the source position is located between the first directional group position and the second directional group position. The apparatus further has a calculator for calculating a speaker signal for the at least one speaker, based on the first parameter value for the speaker parameter and based on the second parameter value for the speaker parameter. | 09-11-2008 |
| 20100092014 | APPARATUS AND METHOD FOR GENERATING A NUMBER OF LOUDSPEAKER SIGNALS FOR A LOUDSPEAKER ARRAY WHICH DEFINES A REPRODUCTION SPACE - An apparatus for generating a number of loudspeaker signals for a loudspeaker array defining a reproduction space includes a prestage configured to generate a plurality of output audio signals while using one or more audio signals associated with one or more virtual positions, each output audio signal being associated to a loudspeaker position such that the plurality of output audio signals together replicate a reproduction of the input audio signal(s) at the virtual position(s), and a number of output audio signals being smaller than a number of loudspeaker signals. The apparatus further includes a main stage configured to obtain the plurality of output audio signals and further to obtain, as a virtual position for each output audio signal, the loudspeaker positions, and to generate the number of loudspeaker signals for the loudspeaker array such that the loudspeaker positions are replicated as a virtual sources by the loudspeaker array. | 04-15-2010 |
| 20130294624 | DEVICE AND METHOD FOR DRIVING A SOUND SYSTEM AND SOUND SYSTEM - A driving device for a sound system by loudspeaker signals, wherein the sound system has a wave field synthesis loudspeaker array and one or several supply loudspeakers arranged separate from the wave field synthesis array includes an audio input for receiving at least one audio signal from at least one sound source, a position input for receiving information on a position of the sound source, a wave field synthesis unit for calculating loudspeaker signals for the loudspeakers of the wave field synthesis loudspeaker array, and a provider for providing the loudspeaker signal for the one or the several supply loudspeakers. The driving device enables a sound system by means of which sound localization becomes possible for the audience and at the same time pleasant levels can be achieved also in the first rows of the audience. | 11-07-2013 |
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| 20100273024 | DUAL-PHASE STEEL, FLAT PRODUCT MADE OF A DUAL-PHASE STEEL OF THIS TYPE AND PROCESSES FOR THE PRODUCTION OF A FLAT PRODUCT - A dual-phase steel, a flat product produced therefrom and a process for the production thereof. The dual-phase steel has, in addition to a strength of at least 950 MPa and good deformability, a surface finish which, when a simple production process is used, makes it possible for the flat product produced from this steel to be formed into a complexly formed component, such as a part of a car bodywork, in an uncoated state or in a state provided with an anti-corrosion coating. The steel according to the invention comprises 20-70% martensite, up to 8% retained austenite and the remainder ferrite and/or bainite and comprises (in % by weight): C: 0.10-0.20%, Si: 0.10-0.60%, Mn: 1.50-2.50%, Cr: 0.20-0.80%, Ti: 0.02-0.08%, B: <0.0020%, Mo: <0.25%, Al: <0.10%, P: ≦0.2%, S: ≦0.01%, N: ≦0.012%, the remainder iron and unavoidable impurities. | 10-28-2010 |
| 20110220252 | DUAL-PHASE STEEL, FLAT PRODUCT MADE OF SUCH A DUAL-PHASE STEEL AND PROCESS FOR THE PRODUCTION OF A FLAT PRODUCT - A dual-phase steel, a flat product and processes for the production thereof. The dual-phase steel having a strength of at least 950 MPa, good deformability, and good surface finish. It is possible, when a simple production process is used, for the flat product produced from this steel to be formed into a complexly formed component, such as part of a car body, either uncoated or provided with an anti-corrosion coating. The steel according to the invention has a structure comprising 20-70% martensite, up to 8% retained austenite and the remainder ferrite and/or bainite and has the following composition (in % by weight): C: 0.050-0.105%, Si: 0.20-0.60%, Mn: 2.10-2.80%, Cr: 0.20-0.80%, Ti: 0.02-0.10%, B: <0.0020%, Mo: <0.25%, Al: <0.10%, Cu: up to 0.20%, Ni: up to 0.10%, Ca: up to 0.005%, P: up to 0.2%, S: up to 0.01%, N: up to 0.012%, remainder iron and unavoidable impurities. | 09-15-2011 |
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| 20130284289 | DEVICE FOR CONTROLLING A HYDRAULIC ACCUMULATOR OF A HYDRAULIC SYSTEM - A device is described for controlling a hydraulic accumulator of a hydraulic system, for example a vehicle transmission, having a valve device which may connect and disconnect an accumulator-side port of the device to and from a system-side port, the valve device including at least one first check valve which is situated hydraulically between the accumulator-side port and the system-side port, and which is blocking in the direction of the system-side port, the valve device also including an electrically actuated control valve which is situated between a control port of the first check valve and the accumulator-side port in such a way that the control valve may hydraulically unblock the first check valve, using the pressure prevailing at the accumulator-side port. | 10-31-2013 |
| 20130284295 | METHOD FOR MANUFACTURING A HYDRAULIC DEVICE - A method for manufacturing a hydraulic device is described, in which at least one hydraulic channel and at least one connection are manufactured and/or hydraulically connected to one another, the hydraulic device being manufactured from at least two plates, and the plates being formed and connected to one another with the aid of the processes of cold forming, deep drawing, punching, punch riveting, and/or clinching. | 10-31-2013 |
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| 20090057000 | Connecting element - Connecting element for mounting on a printed circuit board, which connecting element has at least two connecting lines which cross one another and are not electrically connected between respectively associated contacts. | 03-05-2009 |
| 20090301765 | Printed circuit board - A printed circuit board is provided with at least one via hole, in which a heat dissipating element is arranged, wherein at least one radiant source is arranged on the heat dissipating element. The lighting device is provided with at least one such printed circuit board. | 12-10-2009 |
| 20100258819 | SUBSTRATE FOR AN LED SUBMOUNT, AND LED SUBMOUNT - A substrate for an LED submount may include a plurality of placement locations on its substrate top side and a plurality of pairs each composed of an electrical anode connection and an electrical cathode connection, wherein the anode connections are arranged on a first side section of the substrate top side and the cathode connections are arranged on a second side section of the substrate top side, having at least one connection dividing conductor track leading from one placement location past at least two other placement locations to an electrical connection, wherein the connection dividing conductor track leads past the at least two other placement locations on the inside. | 10-14-2010 |
| 20110211357 | METHOD FOR PRODUCING A FLEXIBLE LIGHT STRIP - A method for producing a flexible light strip having a substrate designed for bending and provided for fitting with light sources, is provided. The method may include singularizing the light strip from an endless intermediate product; and the endless intermediate product having at least one fiberglass composite layer. | 09-01-2011 |
| 20110291125 | LIGHTING MODULE - A lighting module may include a lighting band with a band-shaped flexible substrate, wherein at least one semiconductor light source is applied to a top side of the substrate, wherein the lighting module is faced with a protective layer such that at least one emission area of the at least one semiconductor light source is exposed thereby. | 12-01-2011 |
| 20120044689 | LIGHTING SYSTEM COMPRISING AT LEAST ONE LUMINOUS BAND - In various embodiments, a lighting system may comprise at least one connection element and at least one luminous band having at least one band-shaped unit circuit board, whereby the unit circuit board is equipped with at least two semiconductor light sources, and has at least one contact area arranged between at least two semiconductor light sources, whereby the contact area is configured so it can be severed and the contact area and the connection element are configured such that after severing of the contact area the connection element can be applied onto the contact area and at least one circuit can be closed on the unit circuit board by applying the connection element onto the contact area. | 02-23-2012 |
| 20120069556 | ILLUMINATION MODULE AND ILLUMINATION DEVICE - An illumination module may include at least one flexible carrier for a plurality of heat sources, including light sources, wherein the carrier is provided for being bent over at least part of its width. | 03-22-2012 |
| 20120081889 | POWER SUPPLY MODULE, AND LIGHTING STRIP - A power supply module may include an at least partially flexible support; a supply unit arranged on the support; and at least one outlet connection for a lighting module which can be fed by the supply unit. | 04-05-2012 |
| 20120112235 | Luminous Device Having a Flexible Printed Circuit Board - A lighting device ( | 05-10-2012 |
| 20120235206 | LIGHTING DEVICE AND METHOD FOR CONTACTING A LIGHTING DEVICE - A lighting device may include a printed circuit board, wherein the printed circuit board has wiring on at least one of the front side and the back side thereof, the respective wiring is covered by at least one potting layer, the lighting device furthermore has at least one electrically conductive punched bushing and the punched bushing extends through a potting layer at least to the wiring and contacts the wiring. | 09-20-2012 |
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| 20100009076 | Voc-free or voc-poor polyurethane coating - The invention relates to humidity hardening compounds containing at least one polyurethane polymer, P, exhibiting an isocyanate group, at least one polyimine ALD of Formula (I) of at least 22% by weight, in relation to the sum of the components of the compound which contain the isocyanate group, as well as, if necessary, a polyisocyanate oligomer OP. The humidity hardening compound is particularly suitable for providing coatings and linings. The use of the imines makes possible VOC-free or VOC-poor compounds, which is a substantial advantage for indoor applications. | 01-14-2010 |
| 20110294931 | LIQUID FILM BASED ON SILANE-TERMINATED POLYMERS - A composition that includes at least one silane-functional polymer P and 20 to 60% by weight of aluminum hydroxide or magnesium hydroxide or mixture thereof, is disclosed. The composition has a viscosity of 500 to 20,000 mPa·s measured according to DIN 53018 at a temperature of 20° C. The composition is suitable as a liquid membrane and has very good flammability properties, i.e., it is difficult to ignite and is self-extinguishing. | 12-01-2011 |
| 20150079296 | LIQUID FILM BASED ON SILANE-TERMINATED POLYMERS - A composition that includes at least one silane-functional polymer P and 20 to 60% by weight of aluminum hydroxide or magnesium hydroxide or mixture thereof, is disclosed. The composition has a viscosity of 500 to 20,000 mPa·s measured according to DIN 53018 at a temperature of 20° C. The composition is suitable as a liquid membrane and has very good flammability properties, i.e., it is difficult to ignite and is self-extinguishing. | 03-19-2015 |
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| 20110295481 | METHOD FOR SETTING A WHEEL TORQUE IN A VEHICLE - In a method for setting a wheel torque in a vehicle, a setpoint value for a slip-adhesion coefficient gradient for one wheel of one vehicle axle is ascertained, and the wheel torque is set in such a way that the actual value of the gradient is approximated to the setpoint value. | 12-01-2011 |
| 20150035982 | IMAGE CAPTURING DEVICE FOR A VEHICLE - An image capturing device for a vehicle includes: a first image capturing apparatus configured to image a surrounding environment of the vehicle, situated outside a window of the vehicle, through a first region of the window, in a first image; and a second image capturing apparatus configured to image a second region of the window in a second image, the first region and the second region overlapping at least partly. | 02-05-2015 |
| 20150070499 | CAMERA SYSTEM, IN PARTICULAR FOR A VEHICLE - A camera system, e.g., for a vehicle, includes: at least one objective for detecting a detection region, one image sensor for outputting image signals, and one auxiliary optics situated in the detection region, the auxiliary optics together with the objective forming an optical imaging system for imaging a two-dimensional detection region on the image sensor. The auxiliary optics is formed by one auxiliary lens having an entrance surface and an exit surface, and the two-dimensional detection region does not extend vertically with respect to the optical axis of the auxiliary lens and is imaged sharply on the image sensor by the optical imaging system. The entrance and exit surfaces do not have a spherical curvature. | 03-12-2015 |
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| 20090263826 | MEANS AND METHOD FOR DIAGNOSING HEMOLYTIC ANEMIA - The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject. | 10-22-2009 |
| 20120209535 | METHOD FOR GENERATING BIOMARKER REFERENCE PATTERNS - The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods. | 08-16-2012 |
| 20140186964 | MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject. | 07-03-2014 |
| 20140342379 | Means and Methods for Assessing Gonadal Toxicity - The present invention pertains to the field of diagnostics for gonadal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing gonadal toxicity. It also relates to a method for determining whether a compound is capable of inducing such gonadal toxicity in a subject and to a method of identifying a drug for treating gonadal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing gonadal toxicity. | 11-20-2014 |
| 20150011423 | MEANS AND METHODS FOR ASSESSING KIDNEY TOXICITY - The present invention pertains to the field of diagnostics for kidney toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing kidney toxicity. It also relates to a method for determining whether a compound is capable of inducing such kidney toxicity in a subject and to a method of identifying a drug for treating kidney toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing kidney toxicity. | 01-08-2015 |
| 20150017667 | MEANS AND METHODS FOR ASSESSING LIVER DISORDERS - The present invention pertains to the field of diagnostics for liver disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver disorders. It also relates to a method for determining whether a compound is capable of inducing such liver disorders in a subject and to a method of identifying a drug for treating liver disorders. Furthermore, the present invention relates to a device and a kit for diagnosing liver disorders. | 01-15-2015 |
| 20150018237 | MEANS AND METHODS FOR ASSESSING BONE DISORDERS - The present invention pertains to the field of diagnostics for bone disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing a bone disorder. It also relates to a method for determining whether a compound is capable of inducing such a bone disorder in a subject and to a method of identifying a drug for treating a bone disorder. Furthermore, the present invention relates to a device and a kit for diagnosing a bone disorder. | 01-15-2015 |
| 20150018244 | MEANS AND METHODS FOR ASSESSING HYPERTHYROIDISM - The present invention pertains to the field of diagnostics for hyperthyroidism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hyperthyroidism. It also relates to a method for determining whether a compound is capable of inducing such hyperthyroidism in a subject and to a method of identifying a drug for treating hyperthyroidism. Furthermore, the present invention relates to a device and a kit for diagnosing hyperthyroidism. | 01-15-2015 |
| 20150031572 | MEANS AND METHODS FOR ASSESSING NEURONAL TOXICITY - The present invention pertains to the field of diagnostics for neuronal toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing neuronal toxicity. It also relates to a method for determining whether a compound is capable of inducing such neuronal toxicity in a subject and to a method of identifying a drug for treating neuronal toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing neuronal toxicity. | 01-29-2015 |
| 20150037825 | Means and Methods for Assessing Hematopoietic Toxicity - The present invention pertains to the field of diagnostics for hematopoietic toxicity and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing hematopoietic toxicity. It also relates to a method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject and to a method of identifying a drug for treating hematopoietic toxicity. Furthermore, the present invention relates to a device and a kit for diagnosing hematopoietic toxicity. | 02-05-2015 |
| 20150044702 | MEANS AND METHODS FOR ASSESSING DISORDERS RELATED TO IMPAIRED IRON ADSORPTION OR ENERGY METABOLISM - The present invention pertains to the field of diagnostics for iron adsorption disorder or impaired energy metabolism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing iron adsorption disorder or impaired energy metabolism. It also relates to a method for determining whether a compound is capable of inducing such iron adsorption disorder or impaired energy metabolism in a subject and to a method of identifying a drug for treating iron adsorption disorder or impaired energy metabolism. Furthermore, the present invention relates to a device and a kit for diagnosing iron adsorption disorder or impaired energy metabolism. | 02-12-2015 |
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| 20110129933 | MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION - The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18:cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18:cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidyl-choline (C18:0/C22:6). Different multimarker sets are proposed for male and female subjects. | 06-02-2011 |
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| 20110163226 | MEANS AND METHODS FOR ASSESSING LIVER TOXICITY - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol, myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (d18:1, C24:1), Ceramide (d18:2, C24:0), Sphingomyelin (d18:1, C16:0), 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, Coenzyme Q9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides. | 07-07-2011 |
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| 20110091929 | MEANS AND METHODS FOR ASSESSING LIVER ENZYME INDUCTION - The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate. | 04-21-2011 |
