Patent application number | Description | Published |
20100129379 | STABILIZED ANTIBODY FORMULATIONS AND USES THEREOF - The present invention provides methods of optimizing certain stable liquid formulations of antibodies that immunospecifically bind to antigens of interest. Such formulations are suitable for parenteral administration to a subject, and exhibit increased stability, low to undetectable levels of aggregation, low to undetectable levels of antibody fragmentation/degradation, and very little to no loss of the biological activities of the antibodies, even during long periods of storage. The methods of the invention provide formulations that offer multiple advantages over formulations produced by non-optimized methods, including less stringent or more readily available transportation and storage conditions, less frequent dosing, and/or smaller dosage amounts in the therapeutic, prophylactic and diagnostic uses of such formulations. The invention further provides methods of identifying antibodies exhibiting certain phase behaviors such that the antibodies can be formulated by the methods of the invention. Also provided are prophylactic, therapeutic, and diagnostic uses of such antibody formulations. | 05-27-2010 |
20100209434 | ANTIBODY FORMULATION - The present invention provides high concentration liquid formulations of antibodies or fragments thereof that specifically bind to a human interferon alpha polypeptide. | 08-19-2010 |
20100254985 | Protein Formulations - The present invention provides formulations of proteins comprising a variant Fc region that improve the stability in part by reducing the propensisty of such molecules to rapidly aggregate. The invention provides both liquid and lyophilized formulations either of which can be utilized to generate a high protein concentration liquid suitable for administration to a subject. The invention further provides methods of utilizing the formulations of the present invention for therapeutic or prophylactic treatment of diseases and disorders or for diagnostic purposes. | 10-07-2010 |
20110256149 | ANTIBODY FORMULATION - The present invention provides high concentration liquid formulations of antibodies or fragments thereof that specifically bind to a human interferon alpha polypeptide The formulation provides for an anti-13H5 anti-human interferon alpha antibody A pre-filled syringe containing the formulation is also disclosed. | 10-20-2011 |
Patent application number | Description | Published |
20090312707 | NEEDLED PHARMACEUTICAL DELIVERY DEVICE WITH TRIGGERED AUTOMATIC NEEDLE INSERTION AND MANUALLY CONTROLLED PHARMACEUTICAL INJECTION - A pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection. The pharmaceutical delivery device includes a housing, a pharmaceutical containing needled syringe having an injection tip that is recessed within the housing when the syringe is in a first position and which projects from the housing when the syringe is in a second position, a syringe advancing assembly operable to automatically advance the needled syringe from the first position to the second position, a plunger including an input portion projecting from the housing for manual access by a user, wherein the plunger is operable by the user directly shifting the input portion when the syringe is disposed in the second position to inject pharmaceutical from the syringe through the needle at a rate adjustably controlled by a user during the injection, and wherein the plunger includes a plunger extender automatically movable within the housing from a first location to a second location upon the needled syringe advancing from the first position to the second position, wherein the plunger extender, when in the second location, occupies a space vacated by the needled syringe during advancement from the first position to the second position, whereby the plunger input portion remains stationary relative to the housing during the advancement of the needled syringe. | 12-17-2009 |
20100102945 | VEHICLE INFORMATION DISPLAY AND METHOD - An information display system for a vehicle includes an information display for displaying a plurality of selectable information display levels according to an information display hierarchy. Each selectable information display level may include one or more visual gauges for conveying vehicle information. Each successive selectable information display level may include additional and/or alternative vehicle information when compared to the preceding selectable information display level. The information display system further includes a controller configured to display the plurality of selectable information display levels according to an at least one driver input. In this way, the information display can display a particular selectable information display level best suited to a driver's individual preferences or understanding of the vehicle's operations. | 04-29-2010 |
20100207755 | MULTI-FUNCTIONAL VEHICLE FUEL DISPLAY - A multi-functional, composite fuel display for displaying both fuel level information and fuel economy information is provided. The fuel level is displayed using a plurality of bar segments, each corresponding to a single unit of fuel. Once a single unit of fuel is consumed, the corresponding bar segment changes size to indicate an average fuel economy for that unit of fuel. The bar segment corresponding to the current unit of fuel being consumed changes size in real time to indicate instantaneous fuel economy. An indicator is provided over the bar segments corresponding to single unit of consumed fuel to indicate average fuel economy for the current tank of fuel. | 08-19-2010 |
20100207757 | SYSTEM AND METHOD FOR ADJUSTING THE RESOLUTION OF AN INFORMATION DISPLAY FOR A VEHICLE - A system and method for adjusting the resolution setting of an operating condition of a vehicle displayed using an information display system. The information display system comprising an information display that includes at least one gauge configured to display information indicative of a vehicle operating parameter. A controller may receive information indicative of the vehicle operating condition to be displayed on the at least one gauge. The controller may allow adjustment to the resolution setting of the at least one gauge. Also, the controller may transmit the resolution setting and the vehicle operating parameter so that the at least one gauge displays the vehicle operating condition using the resolution setting. | 08-19-2010 |
20120042716 | Multi-Functional Vehicle Fuel Display - A multi-functional, composite fuel display for displaying both fuel level information and fuel economy information is provided. The fuel level is displayed using a plurality of bar segments, each corresponding to a single unit of fuel. Once a single unit of fuel is consumed, the corresponding bar segment changes size to indicate an average fuel economy for that unit of fuel. The bar segment corresponding to the current unit of fuel being consumed changes size in real time to indicate instantaneous fuel economy. An indicator is provided over the bar segments corresponding to single unit of consumed fuel to indicate average fuel economy for the current tank of fuel. | 02-23-2012 |
20120235806 | Vehicle Information Display And Method - An information display system for a vehicle includes an information display for displaying a plurality of selectable information display levels according to an information display hierarchy. Each selectable information display level may include one or more visual gauges for conveying vehicle information. Each successive selectable information display level may include additional and/or alternative vehicle information when compared to the preceding selectable information display level. The information display system further includes a controller configured to display the plurality of selectable information display levels according to an at least one driver input. In this way, the information display can display a particular selectable information display level best suited to a driver's individual preferences or understanding of the vehicle's operations. | 09-20-2012 |