Patent application number | Description | Published |
20090022720 | Conjugate of an antibody against CD4 and antifusogenic peptides - The current invention is related to a conjugate comprising two or more antifusogenic peptides and an anti-CD4 antibody (mAb CD4) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CD4 antibody and to the pharmaceutical use of said conjugate. | 01-22-2009 |
20090028881 | Conjugate of an antibody against CCR5 and an antifusogenic peptide - The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate. | 01-29-2009 |
20100035817 | METHOD FOR THE PRODUCTION OF CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant. | 02-11-2010 |
20100121036 | METHOD FOR THE PRODUCTION OF INSULIN-LIKE GROWTH FACTOR-1 - Method for the production of IGF-I, characterized by cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding a fusion protein comprising said IGF-I N-terminally linked to the C-terminus of a propeptide, whereby said propeptide ends C-terminally with amino acids -Y-Pro, wherein Y is selected from the group consisting of Pro, Pro-Ala, Pro-Gly, Pro-Thr, Ala-Pro, Gly-Pro, Thr-Pro, Arg-Pro, or Pro-Arg-Pro, recovering and cleaving said fusion protein with IgA protease, and recovering said IGF-I. IGF-I is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease. | 05-13-2010 |
20100210547 | METHOD FOR THE PRODUCTION OF CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant. | 08-19-2010 |
20110165182 | CONJUGATE OF AN ANTIBODY AGAINST CCR5 AND AN ANTIFUSOGENIC PEPTIDE - The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate. | 07-07-2011 |
20130065831 | METHOD FOR THE PRODUCTION OF CONJUGATES OF INSULIN-LIKE GROWTH FACTOR-1 AND POLY(ETHYLENE GLYCOL) - The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant. | 03-14-2013 |
Patent application number | Description | Published |
20080229583 | Safety Razor with Filament Guard - A razor cartridge is provided with a skin engaging structure at the cap and/or guard surface of the razor cartridge. The skin engaging structure has an array of closely spaced elongated protrusions integrally formed with a substrate. In use, the protrusions produce a pleasant tactile sensation tending to reduce shaving discomfort. The protrusions are formed by closely packed molded flexible filaments that can be less than 0.25 mm wide and have spacing between adjacent protrusions less than 0.2 mm. The protrusions can have a density greater than 5 protrusions per mm | 09-25-2008 |
20080250647 | MULTI-USE SHAVING IMPLEMENT - According to one aspect of the present invention, a razor cartridge includes an outer shell, and a support structure. The outer shell defines a primary blade opening and a trimming blade opening. The support assembly is located at least partially inside the outer shell and includes at least one primary blade slot and a trim blade slot. A primary blade is located within each of the primary blade slots in the support assembly such that a cutting edge on the primary blade extends through the primary blade opening in the outer shell. A trim blade is located within the trim blade slot in the support structure such that a cutting edge on the trim blade extends through the trim blade opening in the outer shell. | 10-16-2008 |
20100107425 | Razor Blade and Method of Manufacture - A method for making a razor blade having a bent portion is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process. When the razor blade is bent to define an included angle of 90 degrees between planar regions adjacent the bent portion and an inner surface having a radius about 0.3-0.35 mm, the outer surface of the bent portion is free from macro-cracks. | 05-06-2010 |
20120132036 | Razor Blade and Method of Manufacture - A method for making a razor blade having a bent portion is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process. When the razor blade is bent to define an included angle of 90 degrees between planar regions adjacent the bent portion and an inner surface having a radius about 0.3-0.35 mm, the outer surface of the bent portion is free from macro-cracks. | 05-31-2012 |
20130205595 | Razor Cartridge - A method of making a razor cartridge is provided. A housing of the razor cartridge has an elongated body having, integrally formed, a guard, a cap and an interior wall extending between the guard and the cap close to an end of the elongated body. An exterior wall extends outwardly of the interior wall and is joined to the interior wall by a film hinge. A portion of a body of a razor blade is positioned in a slot of the interior wall. The exterior wall is folded about the film hinge so that a lip of the exterior wall overlays an end portion of the cutting edge of the razor blade to secure to razor blade within the housing. The exterior wall is additionally secured to the elongated body. A razor cartridge is thus provided. | 08-15-2013 |