Patent application number | Description | Published |
20120244132 | T-CELL RECEPTOR - The present invention provides a T-cell receptor (TCR) which binds to a peptide from latent membrane protein 2 (LMP-2) from the Epstein Barr Virus (EBV) having the amino acid sequence CLGGLLTMV (SEQ ID No. 1) when presented by a major histocampatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a EBV-specific T-cell. The present invention also provides the use of EBV-specific T-cell for cellular immunotherapy. | 09-27-2012 |
20130045221 | T-CELL RECEPTOR CAPABLE OF RECOGNISING AN ANTIGEN FROM CYTOMEGALOVIRUS - The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy. | 02-21-2013 |
20140112925 | SINGLE CHAIN ANTIGEN RECOGNIZING CONSTRUCTS (scARCs) STABILIZED BY THE INTRODUCTION OF NOVEL DISULFIDE BONDS - The present invention relates to a single chain antigen recognizing construct (scARC), which is composed of stabilized variable domains by the introduction of novel disulfide bonds, in order to prevent residual mis-pairing with endogenous ARC chains. The invention further discloses a method for the design of a novel structurally stabilized scARC, the method being based on the visual inspection of the crystal structure of the underlying scARC and the selection of appropriate amino acid substitutions to generate a novel disulfide bond in the protein structure. Furthermore, the invention discloses a method for the production of a cell which expresses the scARC of the invention. Also described are nucleic acids encoding an inventive scARC, as well as DNA and RNA constructs that allow for the expression of the inventive scARC. The invention further encompasses pharmaceutical compositions containing the scARC of the invention and the use of the scARC in therapy of cancerous or infectious diseases, or for use in the quantification and/or visualization of disease associated antigens. | 04-24-2014 |
20140134720 | METHOD - The present invention provides a method for increasing the sensitivity of a T cell expressing a cell-surface antibody to a target antigen, which comprises the step of lowering the affinity of the antibody to the target antigen by at least 100-fold. The invention also provides chimeric antigen receptor comprising an antibody domain having an affinity for antigen in the range 100-1 μM, its encoding nucleic acid sequence and uses thereof. | 05-15-2014 |
Patent application number | Description | Published |
20100097212 | Dynamic information projection for a wall sensor - An implementation of a system, device and method for projecting a visual indicator against a surface is provided. A display projection system in a handheld sensor device (e.g. a handheld wall scanner) projects a static or computer-controlled dynamic pattern of light onto a surface being scanned to indicate a specific feature, such as existence of solid structures of wood, metal or plastic, electric or magnetic fields, or a disturbance of a field. The projected light may be controlled by a computer via an aperture to allow flexibility in what is projected, such as icons, lines, graphics, characters and colors. | 04-22-2010 |
20140139348 | Dynamic information projection for a wall sensor - An implementation of a system, device and method for projecting a visual indicator against a surface is provided. A display projection system in a handheld sensor device (e.g. a handheld wall scanner) projects a static or computer-controlled dynamic pattern of light onto a surface being scanned to indicate a specific feature, such as existence of solid structures of wood, metal or plastic, electric or magnetic fields, or a disturbance of a field. The projected light may be controlled by a computer via an aperture to allow flexibility in what is projected, such as icons, lines, graphics, characters and colors. | 05-22-2014 |