Spier
Carolyn Spier, Nashua, NH US
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20100083056 | PROGNOSTIC DIAGNOSTIC CAPABILITY TRACKING SYSTEM - A universal on-board system is provided for automatic fault detection and on-the-spot repair instructions that includes a module adapted to be coupled to a wide variety of platforms and Line Replaceable Units. | 04-01-2010 |
Don Spier, Silver Lake, WI US
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20150267114 | MOISTURIZING AGENTS - A concentrated aqueous composition may be prepared by from a formulation including: a. from 10 to 30 % by weight (% wt) of a depolymerized carboxymethyl cellulose having a weight average molecular weight of from about 10,000 to about 80,000 dalton (Da); b. from 15 to 50% of a compatibilizer selected from the group consisting of glycerol and sodium xylene sulfonate; and c. from about 0.5 to about 20% by weight of a surfactant. The concentrated aqueous solution may be employed to prepare an aqueous solution which is useful for moisturizing soil. | 09-24-2015 |
Emmet Spier, Oxford GB
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20150146015 | COLLABORATIVE SIGHTING - Collaborative sighting is performed using plural optical sighting apparatuses that each comprise: a camera unit and a display device. Geometric calibration of the camera units with respect to the imaged scene is performed by detecting features within captured images, generating descriptors from respective patches of the image at the features; detecting corresponding descriptors from different images, Position and deriving the geometric calibration from the positions in the respective images of the corresponding descriptors. A target location in the image captured by a first optical sighting apparatus is designated and a corresponding location relative to the image captured by the second one optical sighting apparatus is identified from the geometric calibration. The display device of the second optical sighting apparatus indicates where the corresponding location lies relative to the displayed image. | 05-28-2015 |
Erin Spier, North Olmsted, OH US
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20110084434 | MULTIPLE AXIS POSITIONER - An embodiment of a multiple axis positioner comprises a main headstock that has a main hollow bore. A main indexing table is attached to the main headstock. The main indexing table has a through-hole near the its center. The through-hole aligns or is substantially coaxial with the main hollow bore of the main headstock. The embodiment of the multiple axis positioner further includes at least three minor headstocks mounted to the main indexing table. The at least three minor headstocks have minor hollow bores. | 04-14-2011 |
20130200560 | MULTIPLE AXIS POSITIONER - An embodiment of a multiple axis positioner comprises a main headstock that has a main hollow bore. A main indexing table is attached to the main headstock. The main indexing table has a through-hole near the its center. The through-hole aligns or is substantially coaxial with the main hollow bore of the main headstock. The embodiment of the multiple axis positioner further includes at least three minor headstocks mounted to the main indexing table. The at least three minor headstocks have minor hollow bores. | 08-08-2013 |
Eugene Spier, Los Altos, CA US
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20110212846 | Methods and compositions for universal detection of nucleic acids - Provided are methods and compositions for detecting the presence or amount of one or more target nucleic acids in a sample. Methods of the present invention include linking universal nucleic acid segments into a single molecule in a linking reaction dependent on a target nucleic acid of interest. A variety of universal segment linking strategies are provided, including preamplification by polymerase chain reaction, ligation-based strategies, reverse transcription and linear polymerase extension. Linking the universal segments into a single molecule generates a tagged target nucleic acid which is detected in a manner dependent on an intramolecular interaction between one universal segment and a second portion of the tagged target nucleic acid. In certain embodiments, the intramolecular interaction includes the formation of a hairpin having a stem between a universal segment at one end of the tagged target nucleic acid and a second universal segment at the opposite end of the tagged target nucleic acid. A variety of detection formats are provided, including solution-phase and surface-based formats. The methods and compositions are well-suited for highly multiplexed nucleic acid detection, and are applicable for the detection of any target nucleic acid of interest in both research and clinical settings. | 09-01-2011 |
20110257385 | METHODS FOR FLIP-STRAND IMMOBILIZING AND SEQUENCING NUCLEIC ACIDS - Provided herein are compositions, materials, methods and kits for immobilizing a template polynucleotide in a first orientation, and immobilizing a complementary sequence of the template polynucleotide in an orientation that is flipped compared to the orientation of the template polynucleotide. Provided herein are adaptive oligonucleotides that can be used in various nucleic acid manipulations to generate immobilized complement polynucleotides that are flipped in orientation compared to the orientation of the immobilized template polynucleotides. | 10-20-2011 |
20140329245 | Methods and Compositions for PCR Using Blocked and Universal Primers - Provided herein are methods and compositions for performing PCR with primers with blocked 3′-ends that are unblocked when these primers anneal to the template. The multiplexed PCR can be used as real-time qPCR, for end-point detection or as enrichment method for next generation sequencing (NGS). Also described herein are methods and compositions to improve sensitivity of mutation-specific PCR when targeting closely-spaced mutations. | 11-06-2014 |
20150038336 | METHOD FOR RELATIVE QUANTIFICATION OF NUCLEIC ACID SEQUENCE, EXPRESSION, OR COPY CHANGES, USING COMBINED NUCLEASE, LIGATION, AND POLYMERASE REACTIONS - The present invention is directed to methods for identifying the presence of one or more target nucleotide sequences in a sample that involve a nuclease-ligation reaction. In some embodiments, the ligation products formed in the nuclease-ligation process of the present invention are subsequently amplified using a polymerase chain reaction. The ligated product sequences or extension products thereof are detected, and the presence of one or more target nucleotide sequences in the sample is identified based on the detection. | 02-05-2015 |
Eugene G. Spier, Palo Alto, CA US
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20080248469 | Methods for Identifying Nucleotides of Interest in Target Polynucleotides - In some embodiments, the present teachings provide a method of identifying a nucleotide of interest in a target polynucleotide. In some embodiments, the method can comprise forming an amplification strand, wherein the amplification strand comprises a hairpinning end region; hybridizing the hairpinning end region of the amplification strand with a hairpinning region of a target polynucleotide, to form a self-complementary amplification product. After performing an extension reaction, wherein the hairpinning end region of the amplification strand is extended, an extended reaction product is formed. Detection of the extended reaction product can result in the identification of a nucleotide of interest in the target polynucleotide. Additional methods, as well as kits, are also provided. | 10-09-2008 |
20110033845 | Methods For Amplification of Nucleic Acids Using Spanning Primers - The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences. | 02-10-2011 |
Eugene G. Spier, Los Altos, CA US
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20100209932 | MicroRNA and Messenger RNA Detection On Arrays - The present teachings provide methods for reverse transcribing, and detecting, a plurality of small nucleic acids such as micro RNAs, from the same reaction mixture as a plurality of messenger RNAs. High levels of multiplexing are provided by the use of a plurality of zip-coded stem-loop reverse transcription primers, along with an oligo-dT-promoter-containing reverse transcription primer, in the same reverse transcription reaction mixture. The resulting products can be amplified in an in vitro transcription reaction, and detected on a solid support such as an array. The present teachings also provide compositions, kits, and devices for performing and detecting the reverse transcription reactions described herein. | 08-19-2010 |
20120303472 | METHODS FOR PLACING, ACCEPTING, AND FILLING ORDERS FOR PRODUCTS AND SERVICES - Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer. | 11-29-2012 |
Harm-Jan Spier, Orlando, FL US
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20110046956 | System And Method For Improved Dynamic Allocation Of Application Resources - A self-help application platform such as one hosting an interactive voice response (IVR) has a browser that executes application scripts to implement the self-help application. The execution of the application scripts is performed by utilizing various application resources, such as media conversions from text to speech (TTS) and speech to text (automatic speech recognition ASR) and other media servers. The platform is provided with a dynamic resource selection mechanism in which the application is executed with an updated optimum set of application resources distributed over different locations. The selection is based on the profiles of the browser, users, route, and quality of service. The selection is further modulated by the browser's previous experiences with the individual resources. The selection is made dynamically during the executing of the application script. | 02-24-2011 |
20110046960 | Multi-Channel Interactive Self-Help Application Platform and Method - An interactive voice response (IVR) platform running a voice application for use with a voice client is extended to support text messaging clients and other clients of other media types on other channels. An application-to-text messaging interface interfaces with text messaging clients via a text messaging protocol transport and interfaces with the IVR via an API. It includes a user/application manager to handle user and application accounts and a state/session manager to handle state information required by the text messaging operations and to handle sessions maintained by the IVR. Text modules are implemented having text synthesis and text recognition with a dictionary/grammar. These allow voice-specific application scripts to be interpreted in a text channel. The extended multi-channel platform supports an open source text messaging network and also through a transport gateways to other types of text messaging clients. | 02-24-2011 |
Laurence Spier, Roslyn, NY US
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20140122324 | System and Method for Online Gift and Donation Exchange - An online method for facilitating the exchange of monetary or non-monetary gifts comprising, providing a computer data transfer server communicatively linked to a wide area network, connecting a gift exchange server communicatively to the computer data transfer server, giving access to the computer data transfer server to at least one user, registering the at least one user as a gift exchange user, accepting a monetary transfer or gift purchase for a exchangeable gift from the at least one user, storing data in the gift exchange server identifiably linked to the at least one user that is associated with the exchangeable gift; and transferring the exchangeable gift from one user to another user. | 05-01-2014 |
Martin Spier, Mainz DE
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20140305929 | GLASS CERAMIC COOKING PLATE WITH LOCALLY INCREASED TRANSMISSION AND METHOD FOR PRODUCING SUCH A GLASS CERAMIC COOKING PLATE - A volume-colored monolithic glass ceramic cooking plate is provided. The plate includes a first zone in which the coloration of the glass ceramic differs from that of a second, adjacent zone, so that an absorption coefficient of the first zone is lower than the absorption coefficient of the second, adjacent zone and so that integral light transmission in the visible spectral range is greater in the first zone than the integral light transmission of the second, adjacent zone. The light scattering in the glass ceramic of the first zone differs from light scattering in the glass ceramic of the second zone by not more than 20 percentage points, preferably by not more than 5 percentage points. | 10-16-2014 |
Petra Spier, Bad Blankenburg DE
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20110220467 | Conveyor Belt for Transporting Hot Material - A conveyor belt has a reinforcement insert and is provided to transport hot materials at higher temperatures. The core of the conveyor belt is protected against the high temperatures by an additional textile layer made of basalt fibers arranged above the reinforcement insert in the rubber cover layer defining the load-carrying side of the conveyor belt. | 09-15-2011 |
Travis Spier, Sioux Falls, SD US
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20120315612 | MOBILE MEDICAL TRAINING PLATFORM AND METHOD OF USE - A mobile medical simulation platform for training medical emergency personnel comprises a mobile base movable between remote geographical locations. The mobile base may include a main enclosure having a forward end and a rearward end and defining an interior space. The base may also include medical equipment in the interior space of the main enclosure and usable in medical simulation training for treating a human patient, and simulation apparatus configured to provide simulation of medical events and conditions of a human patient. The interior space is separated into an ambulance simulation area and an emergency room simulation area contained in the main enclosure to permit simultaneous simulation training exercises to occur in each of the simulation areas. A method of utilizing the platform may include conducting training at a first location, moving the platform to a second location, and conducting training at the second location. | 12-13-2012 |
Wolfgang Spier, Porta Westfalica DE
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20110297601 | PHYSICAL WATER PURIFIER - A physical water purifier includes a tubular housing and permanent magnets arranged at a specific distance from one another in the tubular housing in a region of the tubular housing facing a water connection. The permanent magnets are arranged so as to form a pumping and eddying effect. The permanent magnets are produced from an anisotropic magnetic material. | 12-08-2011 |