Spiegel, US
Alvan D. Spiegel, Washington, PA US
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20140317990 | Fishing Rod Holder - A fishing rod holder for shore-based fishing, comprising a base having two or more recesses, each recess adapted to receive a rod having a fishing rod receiving end at its top end. Mating hook and loop closures on the base and rod shafts allow the rods to be stowed against the base in a storage or transit position. A handle on one long side of the base allows easy transport. Each pair of rods features rods of two lengths: a shorter rod approximately two thirds the length of the longer rod. When the shorter rod is placed closer to the water's edge relative to the longer rod, this orientation is typically used for carp or catfish fishing. When the rod position is reversed, this orientation is suitable for bass or bluegill fishing. A second embodiment allowing multiple rods to be held at the same time is also provided. | 10-30-2014 |
Bill Spiegel, Arcadia, FL US
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20140373719 | Air Filtration Apparatus - An air filtration apparatus operable to be coupled with an air return of a conventional HVAC system wherein the air filtration apparatus is configured to supply a continuous supply of unused air filtration media. The air filtration apparatus further includes a frame having four sides and an opening configured to accommodate any size air return. A first media receptacle and a second media receptacle are mounted on the frame. Disposed within said first media receptacle and said second media receptacle is an air filtration media, wherein the air filtration media is substantially disposed within the first media receptacle in its first position and is disposed within the second media receptacle in its second position. A drive assembly and fan are operably coupled to the air filtration media operable to transition the air filtration media intermediate its first position and second position as a result of airflow through the air return. | 12-25-2014 |
Brad A. Spiegel, Lake Forest, IL US
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20090005247 | Dispenser and Methods for Dispensing Custom Garden Products - An apparatus for diagnosing a plant ailment and providing a formulation to address the plant ailment is shown and described along with a method of identifying a plant ailment, dispensing a formulation for the ailment and for applying the formulation to the plant are disclosed. The formulation dispenser is a multiple-component liquid and powder material dispenser with multiple pump types and reservoirs or canisters. All of the pumps are controlled by a central controller which also preferably includes substantial memory for a database containing a library of formulations associated with particular plant ailments. Samples of the sick plants may be scanned or digital photographs downloaded into the memory for diagnosis. Experts can be consulted over the internet or telephone for assistance in identifying an appropriate formulation. A limited quantity of the formulation is prepared for a single application and deposited in a recyclable container. The entire formulation is intended to be applied and the container disposed of thereby eliminating the presence of hazardous materials in the consumer's garage or garden shed. The dispensed formulations may be in granular, liquid or concentrate form. | 01-01-2009 |
Chris Spiegel, Richland, WA US
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20150301847 | Environment Virtualization - An environment virtualization infrastructure (EVI) is made up of storage, network, and compute elements which are virtualized in a virtual platform that is implemented on a hardware platform. In some embodiments, the EVI is dynamic and is expressed as a collection of downloadable data structures. The virtual platform can include an EVI with a definable topology and an emulator that configures various components of the EVI automatically. In some embodiments, the emulator is invoked via an Application Programming Interface. The EVI can be implemented as a Software as a Service. In some embodiments, the EVI includes virtual environments that have routers, switches, operating systems, and software applications. | 10-22-2015 |
David Spiegel, New Haven, CT US
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20110201563 | CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS - The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule. | 08-18-2011 |
20120034295 | CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS - The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule. | 02-09-2012 |
20120269766 | BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS - The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-H′ function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-H's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. | 10-25-2012 |
20130245040 | BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS - The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-HI's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-HI's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. | 09-19-2013 |
20150018395 | CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS - The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule. | 01-15-2015 |
20150087609 | CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE - The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein. | 03-26-2015 |
20150099260 | Crosslink Breakers for Preservation of Biological Substances - A preservative for body fluids, proteins, cells and tissues comprising an effective amount of an AGE crosslink breaker for preventing formation of advanced glycation end products. The AGE crosslink breaker comprises a compound of Structure (1): | 04-09-2015 |
20150110742 | TLR-AGONIST-CONJUGATED ANTIBODY RECRUITING MOLECULES (TLR-ARMS) - The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule. | 04-23-2015 |
20160082102 | BIFUNCTIONAL MOLECULES WITH ANTIBODY-RECRUITING AND ENTRY INHIBITORY ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS - The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as ARM-H's, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by recruiting anti-DNP antibodies to gp120-expressing cells, thereby preventing cell infection and spread of HIV. It has been shown that ARM-H's bind to gp120 and gp-120 expressing cells competitively with CD4, thereby decreasing viral infectivity as shown by an MT-2 cell assay, the binding leading to formation of a ternary complex by recruiting anti-DNP antibodies to bind thereto, the antibodies present in the ternary complex promoting the complement-dependent destruction of the gp120-expressing cells. Compounds and methods are described herein. | 03-24-2016 |
David A. Spiegel, New Haven, CT US
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20140308342 | REPROGRAMMING UROKINASE INTO AN ANTIBODY-RECRUITING ANTICANCER AGENT - The present invention relates to chimeric (preferably, bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds preferably covalently bind to the urokinase receptor and recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and/or antibody-dependent cellular cytotoxicity (ADCC) against a large number and variety of cancers, thus providing cancer cell death and/or an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer. | 10-16-2014 |
20160082112 | SYNTHETIC ANTIBODY MIMETIC COMPOUNDS (SYAMS) TARGETING CANCER, ESPECIALLY PROSTATE CANCER - The present invention relates to compounds which function as antibody mimetic compounds. These compounds are bifunctional/multifunctional compounds which contain at least one cancer cell binding moiety which selectively binds to prostate specific membrane antigen (PSMA) and a FC receptor binding moiety which modulates an FC immune receptor, preferably a FcγRI receptor. Compounds according to the present invention bind selectively to cancer cells which upregulate PSMA and through that interaction, place the Fc receptor binding moiety of the compound in proximity to a Fc receptor, preferably a FcγRI receptor, which can modulate (preferably, upregulate) a humoral response in a patient to cancer cells. Through this biological action of the compounds according to the present invention, cancer cells, including metastatic cancer cells, especially prostate cancer cells can be immune regulated, resulting in the favorable therapy of cancer in a patient. Methods of using these compounds to treat cancer and/or reduce the likelihood of metastatis of cancer are additional aspects of the present invention. | 03-24-2016 |
David D. Spiegel, Stamford, CT US
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20110091841 | Diet dinnerware - A dieting aid having an alternating timed red and green light. A spoon, fork, and table model have a push button and flashing or alternating red and green lights. A red light turns on or flashes for a first predetermined time, preferably twenty-five seconds indicating a time to rest without eating. After the red light, a green light goes on for forty seconds indicating a time to eat. The alternating red and green lights acts as a reminder to control and slow down eating, thereby controlling weight gain easily and simply. | 04-21-2011 |
Erin K. Spiegel, Aurora, CO US
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20100120155 | CONSTRUCTION OF FULLY-DELETED ADENOVIRUS-BASED GENE DELIVERY VECTORS AND USES THEREOF - The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector includes (a) providing an Adenovirus packaging cell line; (b) transfecting a fully-deleted Adenoviral vector construct into the cell line; and optionally (c) transfecting a packaging construct into the cell line, wherein the fully-deleted Adenoviral vector construct and optionally the packaging construct can transfect the Adenovirus packaging cell line resulting in the encapsidation of a fully-deleted Adenoviral vector independent of helper Adenovirus. In an embodiment, a target cell is transduced with the encapsidated fully-deleted Adenoviral vector for treating a condition, disease or a disorder. | 05-13-2010 |
20150093831 | CONSTRUCTION OF FULLY-DELETED ADENOVIRUS-BASED GENE DELIVERY VECTORS AND USES THEREOF - The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and more particularly to their use in gene therapy for gene and protein expression, vaccine development, and immunosuppressive therapy for allogeneic transplantation. In an embodiment, a method for propagating an adenoviral vector includes (a) providing an Adenovirus packaging cell line; (b) transfecting a fully-deleted Adenoviral vector construct into the cell line; and optionally (c) transfecting a packaging construct into the cell line, wherein the fully-deleted Adenoviral vector construct and optionally the packaging construct can transfect the Adenovirus packaging cell line resulting in the encapsidation of a fully-deleted Adenoviral vector independent of helper Adenovirus. In an embodiment, a target cell is transduced with the encapsidated fully-deleted Adenoviral vector for treating a condition, disease or a disorder. | 04-02-2015 |
Evan Scott Spiegel, Las Vegas, NV US
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20120031154 | EVERYDAY SAFE - An everyday safe bag has a dual lock design. A cable is fixed at one end to a first end of the dual lock. The everyday safe bag has a plurality of small openings located at the open end of the bag that receive the cable there through. A fixed ball is affixed to the cable a first distance from the first end of the dual lock. A channel at a second end of the dual lock receives the fixed ball in a locked position, forming a first loop that cinches the bag closed. A lock fob channel located in a second end of the dual lock receives a lock fob on the other end of the cable in a locked position, forming a larger second loop, which may encompass a fixed object. Dials in the dual lock establish an unlock position or combination that secures and releases the cable. | 02-09-2012 |
Gregory S. Spiegel, Land Of Lakes, FL US
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20110232586 | Animal cooling device and method therefor - An animal cooling device includes a housing with front, rear, top, and bottom portions, a fluid container removably positioned adjacent the bottom portion of the housing, a nozzle disposed adjacent or remotely from the cooling device for dispensing a fluid adjacent an animal, a length of tubing connecting the nozzle with the cooling device, and a pump for pressurizing the fluid. The housing includes a handle with a trigger for dispensing the fluid from the container. | 09-29-2011 |
20110232587 | Animal cooling device and method therefor - An animal cooling device includes a housing with front, rear, top, and bottom portions, a fluid container removably positioned adjacent the top portion of the housing, a nozzle disposed remotely from the cooling device for dispensing a fluid adjacent an animal, a length of tubing connecting the nozzle with the cooling device, and a pump for pressurizing the fluid. The housing includes a handle with a trigger for dispensing the fluid from the container. | 09-29-2011 |
20110239392 | Brush with a variable edge - A brush with a variable edge includes a handle with proximal and distal end portions, a bristle pack extending outwardly from an opening in the distal end portion and including individual sets of bristles of a predetermined width that together form a continuous edge, and a slide mechanism for adjusting the length of each individual set of bristles so as to vary the shape of the edge. | 10-06-2011 |
H. Jay Spiegel, Mount Vernon, VA US
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20080216755 | Efficiency promoting water drinking container for animals - A first embodiment of the present invention contemplates a rectangular cubic container including five sub-chambers generally separated from one another by parallel partitions, with each partition having a small weep hole near its bottom. The weep holes are designed to facilitate equalization of water level in each sub-chamber. Each sub-chamber has an elongated length dimension and a width that is relatively narrow and designed to approximate the width of an animal's tongue. When an animal is drinking water from one of the sub-chambers of this embodiment, as the tongue is lapping, the sides of the tongue are close to the inner walls of the sub-chamber, thereby precluding some of the water resting on the tongue from falling off the tongue as the water is lifted into the animal's mouth. In this way, the efficiency of drinking using the lapping technique is enhanced. The inventive device may be made with sub-chambers having differing widths to accommodate to animals of different sizes and different tongue widths. In a further embodiment, a second sub-chamber provides a reservoir for replenishing the first sub-chamber as it drains down through a small weep hole near the bottom of a common wall between the sub-chambers. The second sub-chamber may be designed to receive an inverted bottle filled with water so that continuous replenishment of the drinking sub-chamber through a weep hole connecting the supply sub-chamber may be accomplished. | 09-11-2008 |
20100236488 | Method of promoting efficient water drinking by animals - A method of promoting efficient water drinking by animals uses any one of a number of container embodiments. A first embodiment of container contemplates five sub-chambers separated from one another by parallel partitions, with each partition having a small weep hole near its bottom to equalize water level in each sub-chamber. Each sub-chamber has an elongated length dimension and a width that is relatively narrow and designed to approximate the width of an animal's tongue. When an animal is drinking water from one of the sub-chambers of this embodiment, as the tongue is lapping, the sides of the tongue are close to the inner walls of the sub-chamber, thereby precluding some of the water resting on the tongue from falling off the tongue as the water is lifted into the animal's mouth. In this way, the efficiency of drinking using the lapping technique is enhanced. In a further embodiment, a second sub-chamber provides a reservoir for replenishing the first sub-chamber as it drains down through a small weep hole near the bottom of a common wall between the sub-chambers. The second sub-chamber may be designed to receive an inverted bottle filled with water so that continuous replenishment of the drinking sub-chamber through a weep hole connecting the supply sub-chamber may be accomplished. | 09-23-2010 |
20120058841 | Football tee with multiple ball supporting modes - A tee includes a ball receiving recess shaped like the outer surface of the tip of a football so that the bottom portion of that tip may be supported within the recess. The recess is discontinuous consisting of two laterally opposed recess portions with a rearwardly facing opening and forward ribs. The opening permits the kicker to see the entirety of the football down to the tip. Textured surfaces are provided that extend forward to a downwardly depending shoulder. The textured surfaces are devised so that a football can be supported horizontally on the textured surfaces for squib kicks. The facing terminations of the recess portions are sized and configured to allow a football to be leaned against the tee engaging those terminations to allow the ball to be supported with its tip on a ground surface for onside kicks. | 03-08-2012 |
20120329582 | Multi-purpose football tees - A football tee combines three ball receiving recesses into a single tee. The ball receiving recesses include a first ball receiving recess for conventional kicks, a second ball receiving recess for squib kicks, and a third ball receiving recess for onside kicks. In a first embodiment, the first ball receiving recess consists of a plurality of elongated arcuate lines with each line conforming to the shape of the surface of the football near the tip. In a second embodiment, the lines are replaced by a similar number of arcuate narrow bands, each of which conforms to the shape of the football above the tip. In a third embodiment, a series of semi-spherical projections are provided, each of which engages the football in a point contact. The bottom of the first recess is open to reduce surface area of ball contact. | 12-27-2012 |
20130274036 | LACROSSE STICK WITH IMPROVED BALL SCOOPING - The inventive lacrosse stick has a head with a distal end which features a pivotable distal plate. The distal edge of the distal plate is recessed proximally of the distal end of the head so that movements of the plate do not in any way change the fixed length of the stick defined by portions of the head distal of the distal edge of the plate. The distal plate may be made in one of two ways. First, the plate may be made of a separate piece coupled to the lacrosse head and pivotable with respect thereto. In this embodiment, a spring is provided that acts to pivot the distal plate downwardly and to be restored to that orientation whenever it is pivoted upwardly. In a second embodiment, the plate is integrally molded with the head to include a living hinge pivoted upwardly. | 10-17-2013 |
20130276713 | METHOD OF PROMOTING EFFICIENT WATER DRINKING BY ANIMALS - A method of promoting efficient water drinking by animals uses any one of a number of container embodiments. A first embodiment of container contemplates five sub-chambers separated from one another by parallel partitions, with each partition having a small weep hole near its bottom to equalize water level in each sub-chamber. Each sub-chamber has an elongated length dimension and a width that is relatively narrow and designed to approximate the width of an animal's tongue. When an animal is drinking water from one of the sub-chambers of this embodiment, as the tongue is lapping, the sides of the tongue are close to the inner walls of the sub-chamber, thereby precluding some of the water resting on the tongue from falling off the tongue as the water is lifted into the animal's mouth. In this way, the efficiency of drinking using the lapping technique is enhanced. In a further embodiment, a second sub-chamber provides a reservoir for replenishing the first sub-chamber as it drains down through a small weep hole near the bottom of a common wall between the sub-chambers. The second sub-chamber may be designed to receive an inverted bottle filled with water so that continuous replenishment of the drinking sub-chamber through a weep hole connecting the supply sub-chamber may be accomplished. | 10-24-2013 |
20130331207 | MULTI-PURPOSE FOOTBALL TEES - A football tee combines three ball receiving recesses into a single tee. The ball receiving recesses include a first ball receiving recess for conventional kicks, a second ball receiving recess for squib kicks, and a third ball receiving recess for onside kicks. In a first embodiment, the first ball receiving recess consists of a plurality of elongated arcuate lines with each line conforming to the shape of the surface of the football near the tip. In a second embodiment, the lines are replaced by a similar number of arcuate narrow bands, each of which conforms to the shape of the football above the tip. In a third embodiment, a series of semi-spherical projections are provided, each of which engages the football in a point contact. The bottom of the first recess is open to reduce surface area of ball contact. | 12-12-2013 |
20150182832 | FOOTBALL TEE WITH ANGULARLY ADJUSTABLE BALL SUPPORT - The present invention includes a ball receiving recess carried by a pivotable support structure. This support structure may be pivoted to the left or right to allow the ball receiving recess to be angulated with respect to vertical. The sides of the support structure include openings and elongated slots are formed within the football tee base aligned with the side openings in the support structure. An arm includes an elongated rod receivable within either opening in the football tee base, but rotatable with respect thereto. The arm includes an arcuate portion and an end distal from the rod including a wedge-like end having a narrow edge engaging within a seam of a football. The slots interengage with the rod of the arm to provide a limit stop mechanism, limiting the degree of lateral pivoting of the support structure. | 07-02-2015 |
20150301151 | EXTENDED LIFE, TIMED PINGER FOR AIRCRAFT - A system monitors geographical information for location of an aircraft and supplies that information to a sunrise/sunset calculator that feeds location and sunrise/sunset data to a controller. The controller controls operation of a pinger, limiting its hours of operation to save battery power and extend the time period within which the pinger is audible. The hours of operation are pre-programmed to consist of a time range from sunrise to sunset or from a time after sunrise to a time before sunset. | 10-22-2015 |
Jason Spiegel, Austin, TX US
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20140248403 | APPARATUS FOR DELIVERING MULTIPLE COMESTIBLE COMPONENTS IN A SIMULTANEOUS AND ORGANOLEPTICALLY PLEASING MANNER - An apparatus for delivering a multi-state or multi-component comestible, comprising a sealed pouch or tube containing one component of the comestible which surrounds, either fully or on multiple sides, one or more other components, housed in one or more separated tubes or compartments. The apparatus' unique delivery, wherein one component surrounds the other component(s) as it is expulsed into the consumer's mouth, greatly enhances the consumer's organoleptic experience. The consumer's organoleptic experience may be further enhanced by the shape and/or location of the tubes/pouches of the apparatus, which, based on the specific comestible being delivered, can be modified to speed up or slow down delivery of individual comestible components into the consumer's mouth, and to provide greater control over the outflow of individual components of the multi-component comestible. | 09-04-2014 |
Joan E. Spiegel, Natick, MA US
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20120078223 | WARMING GARMENT AND METHOD FOR PROMOTING VASODILATION - A warming garment and method of making and using are provided. The warming garment may have an inner lining and an outer lining which may form an annular space in which an exothermic composition that is activated upon exposure to oxygen may be disposed. When worn, the warming garment may aid in inducing vasodilation upon a subject's limb through the emanation of heat from the exothermic composition. Once vasodilation is achieved, venipuncture or catheter insertion procedures may be properly initiated. | 03-29-2012 |
20140311474 | Warming Garment and Method for Promoting Vasodilation - A warming garment and method of making and using are provided. The warming garment may have an inner lining and an outer lining which may form an annular space in which an exothermic composition that is activated upon exposure to oxygen may be disposed. When worn, the warming garment may aid in inducing vasodilation upon a subject's limb through the emanation of heat from the exothermic composition. Once vasodilation is achieved, venipuncture or catheter insertion procedures may be properly initiated. | 10-23-2014 |
Joan E. Spiegel, Boston, MA US
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20100179488 | PRESSURE MEASURING SYRINGE - A syringe having an internal pressure gauge comprises a syringe barrel; a piston within the barrel; a spring coupled to the piston at a first position of the spring, the spring having a second portion that is movable in response to fluid pressure within a syringe cavity; and a pressure gauge having an indicator correlated to a plurality of positions of the second portion of the spring to indicate a pressure of a fluid. The spring can be a bellows. The first portion of the spring can be coupled to the piston to form a sliding seal with an inner wall of the syringe, and the second portion of the spring can move longitudinally within the syringe without sealing contact. The syringe can indicate fluid pressures within a range of at least about 5 to 35 cm H | 07-15-2010 |
20120312300 | PRESSURE MEASURING SYRINGE - A syringe having an internal pressure gauge comprises a syringe barrel; a piston within the barrel; a spring coupled to the piston at a first position of the spring, the spring having a second portion that is movable in response to fluid pressure within a syringe cavity; and a pressure gauge having an indicator correlated to a plurality of positions of the second portion of the spring to indicate a pressure of a fluid. The spring can be a bellows. The first portion of the spring can be coupled to the piston to form a sliding seal with an inner wall of the syringe, and the second portion of the spring can move longitudinally within the syringe without sealing contact. | 12-13-2012 |
Joel R. Spiegel, Woodinville, WA US
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20080262964 | NETWORK BASED USER-TO-USER PAYMENT SERVICE - A network-based payment service and site provides various features for facilitating user-to-user payments. One such feature enables users of the payment service to create pay boxes, or other types of payment objects, that can be incorporated into externally hosted web pages and used to make payments. In some embodiments, the payment objects enable users to make payments directly from the externally hosted web pages. | 10-23-2008 |
20090281877 | IDENTIFYING ASSOCIATIONS BETWEEN ITEMS AND EMAIL-ADDRESS-BASED USER COMMUNITIES - A computer-implemented service analyzes collected data reflective of actions of users of an interactive system to identify items that are significantly more popular in specific user communities than in a general user population. The communities may, for example, include email-based communities (e.g., all users with email addresses associated with a particular company or other organization), shipping address based communities (e.g., all users with shipping addresses in Seattle), and/or communities based on other types of user attributes. The results of the analysis may be exposed to users to assist users in making item selection decisions, and/or may be used to provide item recommendations to users. | 11-12-2009 |
20110035370 | IDENTIFYING RELATED SEARCH TERMS BASED ON SEARCH BEHAVIORS OF USERS - A system is disclosed that identifies related search terms by performing a term co-occurrence analysis of search query submissions of users. The system may give different amounts of weight to different search query submissions based, for example, on whether subsequent user actions reveal that particular searches were successful. The system may use the identified related search terms to correct spelling errors in search queries received from users. | 02-10-2011 |
20110060664 | SERVICES FOR ENABLING USERS TO SHARE INFORMATION REGARDING E-COMMERCE TRANSACTIONS - Various computer-implemented services are disclosed for assisting users in selecting items from an electronic catalog, and for selecting merchants with which to conduct transactions. One such service enables users to share information about their respective purchases with other users. Another service enables users to share information regarding the merchants with which they have conducted transactions. | 03-10-2011 |
20120072363 | Method And System For Anticipatory Package Shipping - A method and system for anticipatory package shipping are disclosed. According to one embodiment, a method may include packaging one or more items as a package for eventual shipment to a delivery address, selecting a destination geographical area to which to ship the package, shipping the package to the destination geographical area without completely specifying the delivery address at time of shipment, and while the package is in transit, completely specifying the delivery address for the package. | 03-22-2012 |
20120278317 | MINING OF USER EVENT DATA TO IDENTIFY USERS WITH COMMON INTEREST - A computer-implemented matching service matches users to other users, and/or to user communities, based at least in part on a computer analysis of event data reflective of user behaviors. The event data may, for example, evidence user affinities for particular items represented in an electronic catalog, such as book titles, music titles, movie titles, and/or other types of items that tend to reflect the traits of users. Event data reflective of other types of user actions, such as item-detail-page viewing events, browse node visits, search query submissions, and/or web browsing patterns may additionally or alternatively be considered. By taking such event data into consideration, the matching service reduces the burden on users to explicitly supply personal profile information, and reduces poor results caused by exaggerations and other inaccuracies in such profile information. | 11-01-2012 |
20120303713 | PLAYLIST-BASED DETECTION OF SIMILAR DIGITAL WORKS AND WORK CREATORS - A computer-implemented service recommends digital works (and/or creators of works) to a user based on works currently or previously played or downloaded by the user on a player device or based on playlists stored on the player device. The works may be, for example, music files, video files, electronic books, or other digital content for playing by users. A user may thus obtain personalized recommendations that are based on works obtained from sources (web sites, physical CDs, etc.) that are independent of the recommendations system. In one embodiment, the service identifies pairs of works (and/or work creators) that are similar to each other by virtue of the relatively high frequency with which they co-occur on playlists or within play histories of users. The resulting mappings are used to provide recommendations to users. | 11-29-2012 |
20120323645 | METHOD AND SYSTEM FOR ANTICIPATORY PACKAGE SHIPPING - A method and system for anticipatory package shipping are disclosed. According to one embodiment, a method may include packaging one or more items as a package for eventual shipment to a delivery address, selecting a destination geographical area to which to ship the package, shipping the package to the destination geographical area without completely specifying the delivery address at time of shipment, and while the package is in transit, completely specifying the delivery address for the package. | 12-20-2012 |
20130085896 | Placing a Purchase Order via a Communications Network - An order is placed by a purchaser in which a server system receives an identification of the purchaser, payment information, and shipment information from a client system. The server system assigns a client identifier to the client system and associates the identifier with the purchaser information. The server system sends to the client system the identifier and a document identifying an item to be purchased and including an order button. The client system receives and stores the identifier and receives and displays the document. In response to the selection of the order button, the client system sends to the server system a request to purchase the identified item. The server system receives the request and combines the purchaser information associated with the client identifier to generate an order to purchase the item in accordance with the billing and shipment information. | 04-04-2013 |
20130254065 | PLAY HISTORY BASED DETECTION OF SIMILAR DIGITAL WORKS OR WORK CREATORS - A computer-implemented service recommends digital works (and/or creators of works) to a user based on works currently or previously played or downloaded by the user on a player device or based on playlists stored on the player device. The works may be, for example, music files, video files, electronic books, or other digital content for playing by users. A user may thus obtain personalized recommendations that are based on works obtained from sources (web sites, physical CDs, etc.) that are independent of the recommendations system. In one embodiment, the service identifies pairs of works (and/or work creators) that are similar to each other by virtue of the relatively high frequency with which they co-occur on playlists or within play histories of users. The resulting mappings are used to provide recommendations to users. | 09-26-2013 |
20130346186 | METHOD AND SYSTEM FOR ALLOCATING DISPLAY SPACE - Display space on web page may be allocated by bids. In one embodiment, the display space system receives bids indicating a bid amount and an advertisement. When providing a web page with the display space, the display space system selects a bid. The display space system adds the advertisement of the selected bid to the web page. The bid may specify web pages on which the advertisement may be placed, the users to whom the advertisement may be presented, and time when the advertisement may be placed. The bid amount may be in an established currency or in advertising points. Activities for which advertising points may be awarded may include listing an auction, auction bidding, or purchasing of an item. When a user advertisement is placed, the display space system reduces user advertising points. The display space system may also place bids for display space on behalf of the user. | 12-26-2013 |
20140108427 | MINING OF USER EVENT DATA TO IDENTIFY USERS WITH COMMON INTERESTS - A computer-implemented matching service matches users to other users, and/or to user communities, based at least in part on a computer analysis of event data reflective of user behaviors. The event data may, for example, evidence user affinities for particular items represented in an electronic catalog, such as book titles, music titles, movie titles, and/or other types of items that tend to reflect the traits of users. Event data reflective of other types of user actions, such as item-detail-page viewing events, browse node visits, search query submissions, and/or web browsing patterns may additionally or alternatively be considered. By taking such event data into consideration, the matching service reduces the burden on users to explicitly supply personal profile information, and reduces poor results caused by exaggerations and other inaccuracies in such profile information. | 04-17-2014 |
20140222615 | SERVICES FOR ENABLING USERS TO SHARE INFORMATION REGARDING E-COMMERCE TRANSACTIONS - Various computer-implemented services are disclosed for assisting users in selecting items from an electronic catalog, and for selecting merchants with which to conduct transactions. One such service enables users to share information about their respective purchases with other users. Another service enables users to share information regarding the merchants with which they have conducted transactions. | 08-07-2014 |
20140222803 | IDENTIFYING ITEMS RELEVANT TO A CURRENT QUERY BASED ON ITEMS ACCESSED IN CONNECTION WITH SIMILAR QUERIES - The present invention provides a software facility for identifying the items most relevant to a current query based on items selected in connection with similar queries. In preferred embodiments of the invention, the facility receives a query specifying one or more query terms. In response, the facility generates a query result identifying a plurality of items that satisfy the query. The facility then produces a ranking value for at least a portion of the items identified in the query result by combining the relative frequencies with which users selected that item from the query results generated from queries specifying each of the terms specified by the query. The facility identifies as most relevant those items having the highest ranking values. | 08-07-2014 |
20150026089 | DELIVERING ORDERED ITEMS TO AN APPROPRIATE ADDRESS - A method, system, and computer-readable medium for automatically determining appropriate delivery information for one or more items of an order or potential order is described. A variety of types of information can be considered when determining what delivery information is appropriate for one or more items, such as a type of the items, the particular items, relationships of the items to other items, information about the purchaser, and/or information about the recipient. In addition, the automatic determination of an appropriate address for an item being ordered or potentially ordered by a user can be made in a variety of ways, such as based on inferences from past behavior when ordering items, on inferences from information about the item and from available delivery information for the user, and/or on previous explicit indications from the user. | 01-22-2015 |
20150066791 | MINING OF USER EVENT DATA TO IDENTIFY USERS WITH COMMON INTERESTS - A computer-implemented matching service matches users to other users, and/or to user communities, based at least in part on a computer analysis of event data reflective of user behaviors. The event data may, for example, evidence user affinities for particular items represented in an electronic catalog, such as book titles, music titles, movie titles, and/or other types of items that tend to reflect the traits of users. Event data reflective of other types of user actions, such as item-detail-page viewing events, browse node visits, search query submissions, and/or web browsing patterns may additionally or alternatively be considered. By taking such event data into consideration, the matching service reduces the burden on users to explicitly supply personal profile information, and reduces poor results caused by exaggerations and other inaccuracies in such profile information. | 03-05-2015 |
20150379648 | MINING OF USER EVENT DATA TO IDENTIFY USERS WITH COMMON INTERESTS - A computer-implemented matching service matches users to other users, and/or to user communities, based at least in part on a computer analysis of event data reflective of user behaviors. The event data may, for example, evidence user affinities for particular items represented in an electronic catalog, such as book titles, music titles, movie titles, and/or other types of items that tend to reflect the traits of users. Event data reflective of other types of user actions, such as item-detail-page viewing events, browse node visits, search query submissions, and/or web browsing patterns may additionally or alternatively be considered. By taking such event data into consideration, the matching service reduces the burden on users to explicitly supply personal profile information, and reduces poor results caused by exaggerations and other inaccuracies in such profile information. | 12-31-2015 |
Joel R. Spiegel, Woodlinville, WA US
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20120047150 | MINING OF USER EVENT DATA TO IDENTIFY USERS WITH COMMON INTERESTS - A computer-implemented matching service matches users to other users, and/or to user communities, based at least in part on a computer analysis of event data reflective of user behaviors. The event data may, for example, evidence user affinities for particular items represented in an electronic catalog, such as book titles, music titles, movie titles, and/or other types of items that tend to reflect the traits of users. Event data reflective of other types of user actions, such as item-detail-page viewing events, browse node visits, search query submissions, and/or web browsing patterns may additionally or alternatively be considered. By taking such event data into consideration, the matching service reduces the burden on users to explicitly supply personal profile information, and reduces poor results caused by exaggerations and other inaccuracies in such profile information. | 02-23-2012 |
Jonathan Spiegel, Aurora, CO US
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20140130657 | HIGH STRENGTH, LIGHT WEIGHT COMPOSITE STRUCTURE, METHOD OF MANUFACTURE AND USE THEREOF - A composite structure ( | 05-15-2014 |
20140284855 | HIGH STRENGTH, LIGHT WEIGHT COMPOSITE LEAF SPRING AND METHOD OF MAKING - A composite leaf spring comprising a thermoplastic matrix material reinforced with fibers embedded and aligned in the matrix of the composite leaf spring. | 09-25-2014 |
20140360344 | HIGH PERFORMANCE THERMOPLASTIC COMPOSITE LAMINATES AND COMPOSITE STRUCTURES MADE THEREFROM - A fire resistant composite laminate includes a thermoplastic matrix material reinforced with fibers embedded in the matrix of the composite laminate, wherein the thermoplastic matrix material of the fire resistant composite laminate includes polyvinylidene fluoride (PVDF). | 12-11-2014 |
20150343875 | SUSPENSION SUB-ASSEMBLY - A suspension sub-assembly includes a fiber reinforced polymeric (FRP) thermoplastic composite upper control arm/spring assembly having a control arm portion and a spring member portion. The suspension sub-assembly can tune roll stiffness of a vehicle during cornering. The FRP thermoplastic composite upper control arm/spring assembly comprises a thermoplastic matrix material reinforced with fibers embedded and aligned in the matrix of the assembly. | 12-03-2015 |
Joshua Spiegel, St. Louis, MO US
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20160070694 | PARALLEL XML PARSER - An XML document is stored in a file that is divided into file partitions. Each file partition is assigned to a process of a set processes to search for one or more separate target elements. The target elements are identified by a target element name. Each process scans an assigned file partition for the beginning of a target element. When a target element is found, an XML parser is invoked to parse the target element. | 03-10-2016 |
Joshua Spiegel, Madison, AL US
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20150300172 | SYSTEM AND METHOD FOR DETERMINING WHEN TO TURN OFF ENGINES - Systems and methods for determining when to turn off an engine are described. The systems and methods may identify when an amount of carboxyhemoglobin exceeds a predetermined threshold; and monitor the amount of carboxyhemoglobin for a period of time. The systems and methods may determine when the amount of carboxyhemoglobin exceeds the predetermined threshold during the time period; and turn off the engine when the amount of carboxyhemoglobin exceeds the predetermined threshold during the time period. | 10-22-2015 |
Joshua Jeffrey Spiegel, St. Louis, MO US
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20150278314 | DYNAMIC GENERATION OF DATABASE VIEWS AND CLASS OBJECTS FOR PROVIDING ACCESS TO REPOSITORY DATA - Techniques for dynamically generating database views and class objects for allowing access to domain data stored in a repository are provided. A computer-implemented method, a system, and/or a machine-readable medium storing instructions executable by one or more processors may include generating a database view and a class object using metadata included in a domain model, and retrieving domain data from a repository using the database view and the class object. For example, a method may include obtaining a domain model from a repository, the domain model including metadata corresponding to a set of domain data stored in the repository, generating a database view of a subset of the set of domain data using the metadata, generating a class object for the subset using the metadata, generating mapping information, and retrieving the subset of domain data from the repository using the database view, the class object, and the mapping information. | 10-01-2015 |
Judy Spiegel, Englewood, NJ US
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20150242585 | Method and Apparatus for Monitoring a User and Providing a Schedule for a User - A multipurpose device and/or application running on a smartphone device or the like that allows a user to be reached with discreet reminders and maintain an accurate schedule. Also disclosed is an application for patients, particularly Alzheimer patients. Preferably, the application adapts as the user condition declines. A caregiver application and/or assisted living application is disclosed and depicted as well | 08-27-2015 |
Marko Spiegel, Lafox, IL US
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20120240501 | FRAME UNIT AND METHOD - An insulated frame unit for enclosing a wall to provide a highly insulated and airtight wall is provided. The frame unit includes a panel that is formed from a rigid insulated composition such as an expanded foam composition. The panels can be mounted to a wall frame in rows and columns to enclose the wall, and may include outwardly extending flanges that can cooperate with a flange of an adjacent frame unit to provide a stud-receiving opening into which a stud is inserted when mounting the frame units to the frame of the building. The frame unit is mountable to the frame with the interior side of the stud extending from the inner side of the frame unit so that adequate space is provided between the inner side of the frame unit and an interior finish member mounted to the interior side of the studs. | 09-27-2012 |
Michael Spiegel, Miami Beach, FL US
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20080287730 | Apparatus for Creating Therapeutic Charge Transfer in Tissue - An apparatus for creating therapeutic charge transfer in tissue includes a coil. The coil generates a changing magnetic field to induct an electric field in the tissue exceeding 10 mV/cm when the coil is 5 cm from the tissue. Preferably, the magnetic field has a growth phase and a decay phase and a duration of the growth phase is at least ten times a duration of the decay phase. The apparatus can include a control circuit to control a current fed to the coil. The control circuit includes two subcircuits and a switch for switching between a first of the subcircuits and a second of the subcircuits; preferably, a λ of the second subcircuit is at least ten times a λ of the first subcircuit. To generate the therapeutic effect, the coil should have a duty cycle of at least ten percent. | 11-20-2008 |
Michael D. Spiegel, Elmwood Park, NJ US
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20140051798 | CATIONIC WATER BASED POLYMERS FOR INKJET INKS - The present invention provides a durable, external surfactant free, cationic, water based jet ink polymer which when formulated into an ink jet ink results in a printing that has an excellent adhesion to metal or plastic substrates. Such a jet ink polymer is suitable performance replacement of solvent soluble polymers currently in commercial use. The hybridized copolymer comprises a hydrophobic functional polymeric backbone comprised of a polysiloxane polymer, a polyolefin polymer, or a functional polyvinyl polymer. The hybridized copolymer also comprises a plurality of copolymeric side chains attached to the backbone, comprising a polymerizable amine-containing unsaturated monomer, and a polymerizable unsaturated monomer. The use of the inks of the present invention enhances performance criteria such as print-head open time, ink stability, and resistance to typical water based cleaners. | 02-20-2014 |
20140113990 | WATER BASED ANIONIC POLYMERS FOR INKJET INKS - The present invention provides a durable, external surfactant free, anionic, water based jet ink polymer which when formulated into an ink jet ink results in a printing that has an excellent adhesion to metal or plastic substrates. Such a jet ink polymer is suitable performance replacement of solvent soluble polymers currently in commercial use. The hybridized copolymer comprises a hydrophobic functional polymeric backbone comprised of a polysiloxane polymer, a polyolefin polymer, or a functional polyvinyl polymer. The hybridized copolymer also comprises a plurality of copolymeric side chains attached to the backbone, comprising a polymerizable acid-containing unsaturated monomer, and a polymerizable unsaturated monomer. The use of the inks of the present invention enhances performance criteria such as print-head open time, ink stability, and resistance to typical water based cleaners. | 04-24-2014 |
Murray Spiegel, Roseland, NJ US
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20130110511 | System, Method and Program for Customized Voice Communication | 05-02-2013 |
Sarah Spiegel, Richmond, VA US
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20100035959 | Novel sphingosine kinase type 1 inhibitors, compositions and processes for using same - Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis. | 02-11-2010 |
20100278741 | Novel compositions including sphingosine kinase type 1 inhibitors, and processes for using same - Provided are novel compositions and analogs which are useful in a number of applications, indications and diseases, as well as for monitoring pharmakinetics and patient management. These compounds and analogs are applicable to treating tumors of the central nervous system, e.g., glioblastoma (GBM). | 11-04-2010 |
20120237448 | SPHINGOSINE KINASE TYPE 1 INHIBITORS, AND PROCESSES FOR USING SAME - Provided are novel compositions and analogs which are useful in a number of applications, indications and diseases, as well as for monitoring pharmakinetics and patient management. These compounds and analogs are applicable to treating tumors of the central nervous system, e.g., glioblastoma (GBM). | 09-20-2012 |
20130245321 | SPHINGOSINE KINASE TYPE 1 INHIBITORS - Provided are novel compositions and analogs which are useful in a number of applications, indications and diseases, as well as for monitoring pharmakinetics and patient management. These compounds and analogs are applicable to treating tumors of the central nervous system, e.g., glioblastoma (GBM). | 09-19-2013 |
Sarah Spiegel, Mclean, VA US
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20090169555 | Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof - Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing peptides or antibodies to peptides encoded by such nucleic acids. | 07-02-2009 |
20120107833 | Antibody specific for a mammalian sphingosine kinase type 2 isoform protein and methods of use thereof - Polyclonal or monoclonal antibodies which are specific for a mammalian sphingosine kinase type 2 isoform protein and methods for detecting the presence of sphingosine kinase type 2 isoform using the antibodies. | 05-03-2012 |
Sylvia C. Spiegel, Stamford, CT US
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20110091841 | Diet dinnerware - A dieting aid having an alternating timed red and green light. A spoon, fork, and table model have a push button and flashing or alternating red and green lights. A red light turns on or flashes for a first predetermined time, preferably twenty-five seconds indicating a time to rest without eating. After the red light, a green light goes on for forty seconds indicating a time to eat. The alternating red and green lights acts as a reminder to control and slow down eating, thereby controlling weight gain easily and simply. | 04-21-2011 |
Wes Spiegel, Richardson, TX US
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20110098590 | METHODS AND APPARATUSES FOR DETECTING ANALYTES - An apparatus for measuring a quantity of an analyte, such as an aldehyde, contained in a breath sample includes a breath collection device and a measurement device. The breath collection device includes a breath inlet area, a breath outlet area, and a reaction chamber. The reaction chamber can include a reagent that is colorimetrically reactive with one or more aldehydes. The measurement device includes a light emitting device and a light measuring device and is configured to provide a quantitative value indicative of the amount of aldehydes present in the breath sample. | 04-28-2011 |
Wesley Spiegel, Richardson, TX US
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20080234553 | NON-INVASIVE HUMAN-HEALTH-MEASUREMENT SYSTEM AND METHOD - Methods and hand-held devices non-invasively measure a health parameter in an individual or a plurality of individuals. Plural hand-held devices may be provided to plural individuals. Each device may compute a score based on the assayed health parameter in the individual. A server on a computer network may receive the scores and determine a pattern based on the scores. The hand-held devices may be further configured to receive additional data from the individuals regarding activities that may affect the individuals' scores. The server may receive the additional data from the devices and determine additional patterns. | 09-25-2008 |
20100178662 | NON-INVASIVE HUMAN-HEALTH-MEASUREMENT SYSTEM AND METHOD - Methods and hand-held devices non-invasively measure a health parameter in an individual or a plurality of individuals. Plural hand-held devices may be provided to plural individuals. Each device may compute a score based on the assayed health parameter in the individual. A server on a computer network may receive the scores and determine a pattern based on the scores. The hand-held devices may be further configured to receive additional data from the individuals regarding activities that may affect the individuals' scores. The server may receive the additional data from the devices and determine additional patterns. | 07-15-2010 |
Wesley F. Spiegel, Richardson, TX US
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20110110507 | System And Method For Communication Account Management - According to one embodiment, a method includes receiving a notification of a first communication number from a first prime provider of a first institution. The method also includes determining a first account associated with the first communication number. The method also includes determining whether the first account includes sufficient funding for a first communication session involving the first communication number. The method includes sending a first message to the first prime provider indicating that the first account comprises sufficient funding for the first communication session. Further, the method includes receiving a notification of a second communication number from the first prime provider of the first institution. The method also includes determining that the second communication number is associated with the first account. The method also includes sending a second message to the first prime provider indicating that a communication session to the second communication number may proceed. | 05-12-2011 |