Soper, US
Bryan R. Soper, San Francisco, CA US
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20100070186 | METHODS OF SCREENING FOR AND MAPPING PHENOTYPIC AND GENOTYPIC VARIATIONS IN CELLS - Described herein are methods of mapping in cultured cells a recessive genotypic or phenotypic variation to a region of a genetic sequence, methods of screening cells in. cell culture for genotypic or phenotypic variations, methods of mutagenizing cells, and methods of using genetic sequences identified by one or more methods described herein. | 03-18-2010 |
David Soper, Gastonia, NC US
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20130220939 | Method of Controlling Addition Rate of an Odor Control Chemical - The invention concerns a method of controlling addition rate of an odor control chemical to a wastewater line comprising means for adding odor control chemical to the wastewater. The method comprises measuring a level of dissolved sulfides in the wastewater line using a sulfide probe placed in said wastewater line, transferring data on the level of dissolved sulfides to a computing unit, determining a required odor control chemical addition rate in said computing unit based on said level of dissolved sulfides, and instructing the means for adding odor control chemical to add the odor control chemical at said required addition rate. The invention allows for accurate on-line control of the level of H | 08-29-2013 |
20150246834 | Method and system for control of an addition rate of a hexavalent chromium control chemical to water - The invention describes a method and system for controlling the addition rate of a contaminant control chemical to a water or wastewater line. The level of hexavalent chromium as a contaminant in the water or wastewater is measured using a spectro-photometric probe placed in the line. Data representative of the level of measured hexavalent chromium content is read into a computing unit, which determines a required contaminant control chemical addition rate based on said level of hexavalent chromium content. The contaminant control chemical is then added at the required addition rate to reduce the amount of hexavalent chromium to a predetermined level. | 09-03-2015 |
David Soper, San Francisco, CA US
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20100240542 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 09-23-2010 |
20120276558 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 11-01-2012 |
David M. Soper, San Francisco, CA US
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20100042351 | METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS - In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied. | 02-18-2010 |
20120215481 | METHODS AND APPARATUS RELATED TO MANAGEMENT OF EXPERIMENTS - In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied. | 08-23-2012 |
20140031308 | BENCHMARKS FOR NORMAL CELL IDENTIFICATION - Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample. | 01-30-2014 |
David M. Soper, Stevenson Ranch, CA US
Patent application number | Description | Published |
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20150119288 | KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS - As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a plurality of binding elements for cell surface markers, and a plurality of binding elements for state-specific intracellular markers. The kits can further comprise a plurality of modulators directed for the particular cell function or signaling pathways. The kits can further include fixatives, permeabilizing agent, buffers, containers, instructions, and software for data analysis/compilation. | 04-30-2015 |
Ian Soper, Washington, DC US
Patent application number | Description | Published |
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20140244292 | Method for Helping Patients Find Treatments Based on Similar Patients' Experiences - This disclosure describes, among other things, a method for recommending treatments for a condition (e.g., a medical condition). The method may include generating ranking treatments for a condition based on patient information. The patient information may identify one or more characteristics of a patient. The patient information may include clinical and/or non-clinical information. The treatments may be ranked based on a prediction of the degree to which the patient will be satisfied with the treatment. The prediction may be based on the degree to which other patients were satisfied with the treatment. | 08-28-2014 |
James Soper, Cambridge, MA US
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20120329877 | Cycloalkyl-dione Derivatives And Methods Of Their Use - The present invention is directed to compounds of formula I: | 12-27-2012 |
John G. Soper, Mt.zion, IL US
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20140039224 | METHODS FOR PRODUCING BIODERIVED PROPYLENE GLYCOL - In the process of distilling a polyol product mixture including one or both of a biobased propylene glycol and a biobased ethylene glycol from the reaction of hydrogen with a biobased feed, it has been discovered that undesirable epoxides can form, and the present invention provides means for guarding against their formation, for removing epoxides which do form by particular methods of distilling, and for removing the epoxides from a finished, otherwise commercially acceptable biobased glycol product. | 02-06-2014 |
20140256991 | METHODS FOR PRODUCING BIODERIVED PROPYLENE GLYCOL - In the process of distilling a polyol product mixture including one or both of a biobased propylene glycol and a biobased ethylene glycol from the reaction of hydrogen with a biobased feed, it has been discovered that undesirable epoxides can form, and the present invention provides means for guarding against their formation, for removing epoxides which do form by particular methods of distilling, and for removing the epoxides from a finished, otherwise commercially acceptable biobased glycol product. | 09-11-2014 |
20150152031 | METHODS FOR PRODUCING BIODERIVED PROPYLENE GLYCOL - In the process of distilling a polyol product mixture including one or both of a biobased propylene glycol and a biobased ethylene glycol from the reaction of hydrogen with a biobased feed, it has been discovered that undesirable epoxides can form, and the present invention provides means for guarding against their formation, for removing epoxides which do form by particular methods of distilling, and for removing the epoxides from a finished, otherwise commercially acceptable biobased glycol product. | 06-04-2015 |
John G. Soper, Mt. Zion, IL US
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20090120878 | SEPARATION OF A MIXTURE OF POLYHYDRIC ALCOHOLS - The present invention provides methods of separating at butanediol compound from a mixture containing polyhydric alcohols and butanediol compounds. The mixture of polyhydric alcohols typically contains propylene glycol and ethylene glycol in addition to the butanediol contaminants. Butanediol contaminants are removed by contacting the mixture with a chromatographic matrix. Either the butanediol compounds or the non-butanediol compounds adsorb to the chromatographic matrix. If desired, the adsorbed compounds may be eluted from the matrix, purified and used in products. | 05-14-2009 |
20100093530 | METHOD OF PREPARING A COMPOSITION USING ARGENTATION CHROMATOGRAPHY - The present invention is directed to a method of preparing compositions enriched in compounds containing carbon chains of varying degrees of unsaturation using argentation chromatography. The present method utilizes an argentized cationic resin or a conditioned argentized alumina to separate compounds containing saturated or mono-unsaturated carbon chains from compounds having polyunsaturated carbon chains present in a starting composition. The invention is particularly useful for preparing a composition enriched in polyunsaturated fatty acid alkyl esters from mixtures of fatty acid esters in a starting composition derived from vegetable oils. The present invention is also directed to a method of preparing a conditioned argentized alumina adsorbent having increased selectivity for compounds containing one or more polyunsaturated carbon chains. | 04-15-2010 |
20150158803 | PURIFICATION OF SUCCINIC ACID FROM FERMENTATION BROTH ON NON-FUNCTIONALIZED CHROMATOGRAPHIC RESIN - A process for purifying a filtered fermentation broth of succinic acid is described. The process involves separating succinic acid from the other organic acids and salts in a raw filtered broth using a non-functionalized chromatographic resin. The operation can be run either as an isocratic elution to yield free succinic acid, or as a gradient or binary elution to produce succinate salt. | 06-11-2015 |
20150218069 | REMOVAL OF ORGANIC SALTS FROM BIO-DERIVED GLYCOL PRODUCTS OF POLYOL HYDROGENOLYSIS - A method for reducing contaminants in the production of a bio-derived glycol product of polyol hydro-genolysis is described. The method involves subjecting an aqueous, polyol product mixture (from the hydrogenolysis conversion of biologically-derived carbohydrate feedstock) to ion-exclusion chromatography to separate and reduce impurities from an eluant fraction containing a desired product, and distilling the eluant fraction to yield the desired product (e.g., propylene glycol or ethylene glycol). The reaction product mixture can be introduced into a continuous ion-exclusion chromatography system to reduce the impurities and produce in a high-throughput manner a finished otherwise commercially acceptable glycol product. | 08-06-2015 |
John Glenn Soper, Mt. Zion, IL US
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20090018352 | Method for purifying hydroxymethylfurfural using non-functional polymeric resins - Disclosed are methods of at least partially purifying HMF from an aqueous mixture containing reactants and products of HMF synthesis from fructose that relies on use of non-functional polymeric resins. A first type of non-functional polymeric resin preferentially adsorbs HMF relative to fructose and is used to remove a majority of fructose from the reaction mixture. HMF is desorbed from the first non-functional polymeric resin with an organic solvent such as acetone. A second type of non-functional polymeric resin preferential adsorbs furfural from an aqueous reaction mixture allowing HMF to pass through. In one embodiment, these non-functional polymeric resins may be used alone in combination with each other to obtain HMF of high purity. In other embodiments, one or more of the foregoing non-functional polymeric resin resins is used in combination with cation exchange chromatography to still further purify the HMF. | 01-15-2009 |
Karin N. Soper, Rindge, NH US
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20110265312 | FILTER MEDIA WITH IMPROVED CONDUCTIVITY - Filter media are provided having improved conductivity to enhance filtration efficiency and/or dissipate static charge, and methods for making the same. In one exemplary embodiment, the filter media can include a filtration substrate, and at least one conductive coating disposed on at least a portion of the filtration substrate. In use, the conductive coating is coupled to an energy source and it is effective to emit ions when energy is delivered thereto to increase the efficiency of the filtration substrate and/or to dissipate or eliminate static charge generated during filtration. | 11-03-2011 |
20140190353 | FILTER MEDIA WITH IMPROVED CONDUCTIVITY - Filter media are provided having improved conductivity to enhance filtration efficiency and/or dissipate static charge, and methods for making the same. In one exemplary embodiment, the filter media can include a filtration substrate, and at least one conductive coating disposed on at least a portion of the filtration substrate. In use, the conductive coating is coupled to an energy source and it is effective to emit ions when energy is delivered thereto to increase the efficiency of the filtration substrate and/or to dissipate or eliminate static charge generated during filtration. | 07-10-2014 |
Matthew Soper, Clayton, NC US
Patent application number | Description | Published |
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20100314513 | METHOD AND APPARATUS FOR OVERHEAD EQUIPMENT MOUNTING - A method and apparatus for overhead equipment mounting is provided. In accordance with at least one embodiment, the apparatus comprises a support tube and a flange. The support tube defines a longitudinal cable access slot and a plurality of support tube perforations. The flange comprises a collar defining a plurality of first collar perforations. At least one of the plurality of first collar perforations is adapted to align with at least one of the plurality of support tube perforations. In accordance with at least one embodiment, the plurality of support tube perforations and the plurality of first collar perforations are spaced so as to allow adjustment of an equipment mounting height with fine resolution. In accordance with at least one embodiment, a cable access slot cover is adaptable to cover at least a portion of the longitudinal cable access slot. | 12-16-2010 |
20110006146 | CABLE RETRACTOR - A cable retractor is provided. In accordance with at least one embodiment, the cable retractor is articulate, comprising an articulate housing which comprises a cable stop housing pivotably coupled to a pulley housing. In accordance with at least one embodiment, the cable retractor also comprises a first pulley assembly coupled to the pulley housing, an end cap coupled to the pulley housing, a spring coupled to the end cap, and a second pulley assembly coupled to the spring. In accordance with at least one embodiment, the first pulley assembly and the second pulley assembly are disposed within the pulley housing. In accordance with at least one embodiment, a cable stop assembly is coupled to the cable stop housing. In accordance with at least one embodiment, several of the parts are separable to facilitate installation or replacement of a cable. | 01-13-2011 |
20140151487 | SPEED CONTROL FOR CABLE RETRACTOR - The present invention is a speed control for a cable retractor. The cable retractor with which the speed control is used comprises a pulley that engages a cable that may be extended and retracted. A friction element configured to adjustably contact the cable adjacent to the pulley is attached to a movable linkage. The movement of the linkage is constrained to move along a predetermined path such that movement of the linkage along the path alters the distance between the friction element and the pulley. In one or more embodiments a cantilevered spring is attached to the linkage. An adjustable control, for example a thumbscrew, is configured to move the spring in relation to the linkage in a manner that alters the position of the friction element with respect to the cable and/or the pressure exerted by the friction element on the cable. | 06-05-2014 |
20140265753 | MODULAR SURFACE MOUNTABLE ENCLOSURE - A modular, customizable, versatile, easy to use, easy to install, aesthetically pleasing surface mountable enclosure is presented. In one or more embodiments, the enclosure includes a modular housing that is configured to be gangable with one or more other housings to provide a range of sizes and configurations. In one or more embodiments, the modular housing of the invention is configured to accept a variety of interchangeable cassettes or modules that provide a variety of cable and power connections or other resources. In one or more embodiments, the modular housing of the invention includes an articulating lid mechanism that is configured to smoothly open and slide neatly out of the way while occupying a reduced volume than the lid mechanisms of the prior art. In one or more embodiments, the enclosure includes cam driven mounting clamps that allow the enclosure to be quickly and easily secured to a table top or other mounting surface. | 09-18-2014 |
20140319263 | CABLE RETRACTOR - A cable retractor is provided. In accordance with at least one embodiment, the cable retractor is articulate, comprising an articulate housing which comprises a cable stop housing pivotably coupled to a pulley housing. In accordance with at least one embodiment, the cable retractor also comprises a first pulley assembly coupled to the pulley housing, an end cap coupled to the pulley housing, a spring coupled to the end cap, and a second pulley assembly coupled to the spring. In accordance with at least one embodiment, the first pulley assembly and the second pulley assembly are disposed within the pulley housing. In accordance with at least one embodiment, a cable stop assembly is coupled to the cable stop housing. In accordance with at least one embodiment, the cable retractor is configured to be mountable to a cable access enclosure in a plurality of orientations. | 10-30-2014 |
Nathaniel J. Soper, Chicago, IL US
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20120100515 | Fluoroscopy Simulator - An apparatus and machine for more realistically simulating fluoroscopy is disclosed. The apparatus includes a light source, cameras, an artificial lumen, and an access port. The artificial lumen can be comprised of an anterior side and a posterior side. The anterior side of the artificial lumen is opaque to the light source such that light reflects off the anterior side of the artificial lumen to a camera to provide a real-time extra-luminal view of an artificial lumen. The posterior side of the artificial lumen is transparent to the light source such that light passes through it, reflects off the opaque anterior side of the artificial lumen, back through the transparent posterior side of the artificial lumen to a camera to provide a real-time intra-luminal view of an artificial lumen. The cameras can be in electronic communication with video monitors to display the real-time extra-luminal and intra-luminal views. | 04-26-2012 |
Peter C. Soper, Berkeley, CA US
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20090238383 | LOUDSPEAKER SYSTEM AND METHOD FOR PRODUCING SYNTHESIZED DIRECTIONAL SOUND BEAM - A loudspeaker system has a plurality of relatively small transducer elements configured in a closely spaced transducer array such that their acoustic outputs combine to produce a focused beam of sound in front of the array that is substantially uniform about the beams radiation axis. The transducer array lies in a plane and has a perimeter that approximates a circle, and will have fill-factor with respect to a circle circumscribing the array of at least approximately 70%. In one variation of the loudspeaker system, the transducer array is constructed in smaller transducer array modules that are operatively fitted together to produce a larger array. | 09-24-2009 |
Robert Soper, Plano, TX US
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20090146259 | Sub-Resolution Assist Feature To Improve Symmetry for Contact Hole Lithography - A method of making a mask design having optical proximity correction features is provided. The method can include obtaining a target pattern comprising a plurality of target pattern features corresponding to a plurality of features to be imaged on a substrate. The method can also comprise generating a mask design comprising mask features corresponding to the plurality of features to be imaged on the substrate and controlling the aspect ratio of at least one of the features of the plurality of features to be imaged on the substrate by positioning a sub-resolution assist feature proximate to the corresponding mask feature. | 06-11-2009 |
Robert Randall Soper, Alexandria, VA US
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20100227519 | POLYMER-FILM-LAMINATED ACTIVATED-CARBON PAPER - A product and method of manufacture is described for a highly filled activated carbon material with a polymer surface layer for strength. | 09-09-2010 |
Shari Joy Soper, Mason, OH US
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20080280805 | Process for manufacturing liquid detergent containing methyl ester sulfonate - Process for manufacturing stable liquid laundry detergent compositions containing sulfonated fatty acid alkyl ester surfactants and compositions resulting therefrom. | 11-13-2008 |
20110209291 | DUAL-USAGE LIQUID LAUNDRY DETERGENTS - Dual-usage aqueous liquid detergent compositions having suds compatability and improved cleaning, said composition containing from about 1% to about 60%, by weight of the composition, of a surfactant system wherein said surfactant system contains at least 35%, by weight of the surfactant system, of alkylethoxysulfate; from 0% to about 10%, by weight of the surfactant system, of nonionic surfactant; from 0% to about 10%, by weight of the surfactant system, of soap; further contains from about 0.001% to about 4.0%, by weight of the composition, of an anti-foam selected from organomodified silicone polymers with aryl or alkylaryl substituents combined with silicone resin and the primary filler is modified silica; and mixtures thereof; and contains from about 0.01% to about 2.5%, by weight of the composition, of a structurant. | 09-01-2011 |
20130276243 | LIQUID LAUNDRY DETERGENTS COMPRISING A SILICONE ANTI-FOAM - Dual-usage aqueous liquid detergent compositions having suds compatability and improved cleaning, said composition containing from about 1% to about 60%, by weight of the composition, of a surfactant system wherein said surfactant system contains at least 35%, by weight of the surfactant system, of alkylethoxysulfate; from 0% to about 10%, by weight of the surfactant system, of nonionic surfactant; from 0% to about 10%, by weight of the surfactant system, of soap; further contains from about 0.001% to about 4.0%, by weight of the composition, of an anti-foam selected from organomodified silicone polymers with aryl or alkylaryl substituents combined with silicone resin and the primary filler is modified silica; and mixtures thereof; and contains from about 0.01% to about 2.5%, by weight of the composition, of a structurant. | 10-24-2013 |
20140289969 | LIQUID LAUNDRY DETERGENTS COMPRISING A SILICONE ANTI-FOAM - Dual-usage aqueous liquid detergent compositions having suds compatibility and improved cleaning, said composition containing from about 1% to about 60%, by weight of the composition, of a surfactant system wherein said surfactant system contains at least 35%, by weight of the surfactant system, of alkylethoxysulfate; from 0% to about 10%, by weight of the surfactant system, of nonionic surfactant; from 0% to about 10%, by weight of the surfactant system, of soap; further contains from about 0.001% to about 4.0%, by weight of the composition, of an anti-foam selected from organomodified silicone polymers with aryl or alkylaryl substituents combined with silicone resin and the primary filler is modified silica; and mixtures thereof; and contains from about 0.01% to about 2.5%, by weight of the composition, of a structurant. | 10-02-2014 |
Steven Soper, Baton Rouge, LA US
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20140134646 | VITRO CAPTURE AND ANALYSIS OF CIRCULATING TUMOR CELLS - This invention provides methods and compositions for capturing circulating tumor cells (CTCs) as well as various divergent CTC phenotypes using seprase-specific affinity reagents. Methods of analyzing CTCs and assessing their metastatic potential in vivo and in vitro are also disclosed. | 05-15-2014 |
Steven Soper, Glendale, AZ US
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20080303957 | Modular Entertainment and Data System - A modular, reconfigurable entertainment and data system provides data to at least one user. A cabinet is provided which contains a plurality of module receiving rails therein. A power supply module is positioned on a first one of the rails and provides an operating potential. An entertainment/data module is positioned on a second rail and a control module is positioned on a third one of the module receiving rails and provides an interface between the user and the entertainment/data module. | 12-11-2008 |
Steven A. Soper, Baton Rouge, LA US
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20090068596 | Negative-tone,Ultraviolet Photoresists for Fabricating High Aspect Ratio Microstructures - UV photoresist materials are disclosed, based on EPON 154 or EPON 165. Preferred embodiments, based on a composite of EPON 154 and EPON 165, spread evenly into a flat, uniform layer, even without spin-coating. The preferred embodiments bond strongly to all substrates, and are resistant to cracking and debonding following exposure and development. The preferred embodiments have high UV transmittance, which promotes uniform photopolymerization throughout a thick layer. Structures may be produced by UV lithography that have a sidewall quality that has previously been attainable only by photolithography with a collimated x-ray source. | 03-12-2009 |
20090074637 | Optimized Modular Microfluidic Devices - Passively aligned modular microfluidic devices, and a method for fabricating such passively aligned polymeric modular microfluidic devices have been reported. The modular units fabricated are plurality of integrated microdevices. Also reported are microfluidic devices wherein isolated temperature zones exist so that the temperature within each zone may be distinctly and accurately controlled, and a method for fabricating such microfluidic devices wherein there are isolated temperature zones so that the temperature within each zone may be distinctly and accurately controlled. Such devices allow one to define constant temperature zones along a microfluidic channel where different reactions or stages of reactions occur. | 03-19-2009 |
20090155894 | Electrokinetic Thermal Cycler and Reactor - Microfluidic devices are disclosed for carrying out cyclic or iterated reactions such as PCR, LDR, and other cyclic or iterated reactions. A microchannel forms a closed loop, through which a reaction mixture may be thermally cycled an arbitrary number of times. Flow is preferably mediated primarily by electrokinetics. Multiple temperature zones may be employed along the course of a single microchannel loop, for example for PCR. Embodiments may be compact, automated, fast, and operable in continuous-flow mode. Real-time reaction monitoring may optionally be used. | 06-18-2009 |
20090215105 | Tetraazaporphyrin-Based Compounds and Their Uses - Asymmetrically substituted metal-phthalocyanine compounds are disclosed. These compounds and other phthalo-cyanine-derivatives are used in bioimaging, bioanalysis, FRET and quenching techniques, photodynamic therapy, DNA analysis for cells, proteins, tissues and other biological entities, and other applications. Near-infrared fluorescence minimizes matrix effects typically seen in other methods of analyzing biochemical entities in cells, proteins, tissues and other biological entities. | 08-27-2009 |
20120100521 | Microfluidic Isolation of Tumor Cells or Other Rare Cells from Whole Blood or Other Liquids - Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple parallel meandering channels having a width on the order of 1-2 cell diameters. The microdevices can be produced at low-cost, may readily be automated, and in many instances may be used without pre-processing of the sample. They may be used to isolate and enumerate rare cells, including for example the detection and diagnosis of cancers, cancer staging, or evaluating the effectiveness of a therapeutic intervention, or detecting pathogenic bacteria. The device may optionally be used to nondestructively capture and later to release target cells. | 04-26-2012 |
20150099642 | METHODS AND DEVICES FOR DNA SEQUENCING AND MOLECULAR DIAGNOSTICS - The present invention is directed to methods for capturing, amplifying and identifying one or more of a plurality of target nucleotide sequences in a sample. The present invention is further directed to a device comprising a solid support having a plurality of wells or pillars and a plurality of oligonucleotides attached to the wells or pillars. Other aspects of the invention are directed to methods of making such devices. | 04-09-2015 |
Steven A. Soper, Baton Rogue, LA US
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20100108519 | Polymeric Nanopillars and Nanotubes, Their Manufacture and Uses - A method is disclosed for fabricating free-standing polymeric nanopillars or nanotubes with remarkably high aspect ratios. The nanopillars and nanotubes may be used, for example, in integrated microfluidic systems for rapid, automated, high-capacity analysis or separation of complex protein mixtures or their enzyme digest products. One embodiment, preferably fabricated entirely from polymer substrates, comprises a cell lysis unit; a solid-phase extraction unit with free-standing, polymeric nanostructures; a multi-dimensional electrophoretic separation unit with high peak capacity; a solid-phase nanoreactor for the proteolytic digestion of isolated proteins; and a chromatographic unit for the separation of peptide fragments from the digestion of proteins. The nanopillars and nanotubes may also be used to increase surface area for reaction with a solid phase, for example, with immobilized enzymes or other catalysts within a microchannel, or as a solid support for capillary electrochromatography-based separations of proteins or peptides. | 05-06-2010 |
Tammy Soper, Wilmington, MA US
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20120111817 | LOW-CLEARANCE RACK MOUNT ADAPTER - The invention relates to systems and processes for securably retaining a device within an equipment rack. A device carrier is configured to retain the device having a maximum height, such that a combined height of the device carrier and the device retained therein is not substantially greater than the maximum height of the device. A rack-mountable tray includes an aperture to accommodate the device carrier with a device retained therein. The device carrier is securable to the rack-mountable tray, such that the device retained therein can be securably retained to the equipment rack by a combination of the device carrier and the rack-mountable tray. Beneficially, a combined height of the device, the device carrier and the rack-mountable tray is not substantially greater than the maximum height of the device. | 05-10-2012 |
Timothy Soper, Sunnyvale, CA US
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20150265368 | Systems and Methods for Anatomic Motion Compensation - A method of modeling a cyclic anatomical motion comprises receiving a pose dataset for an identified point on an interventional instrument retained within and in compliant movement with a cyclically moving patient anatomy for a plurality of time parameters. The method also includes determining a set of pose differentials for the identified point with respect to a reference point at each of the plurality of time parameters and identifying a periodic signal for the cyclic anatomical motion from the set of pose differentials. | 09-24-2015 |
Timothy D. Soper, Seattle, WA US
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20130158346 | Catheterscope 3D Guidance and Interface System - Visual-assisted guidance of an ultra-thin flexible endoscope to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity-identified by non-invasive imaging methods, such as high-resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor on the flexible endoscope indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display also includes windows depicting a virtual fly-through perspective and real-time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account. | 06-20-2013 |
Timothy D. Soper, Sunnyvale, CA US
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20150208904 | IMAGE-BASED FEEDBACK ENDOSCOPY SYSTEM - The image-based feedback endoscopy system includes a steering apparatus having a base platform, a pair of servomotors, a rigid tube, and a biasing member. A flexion member has a tether member and a ball screw, the tether member being in communication with the biasing member. The image-based feedback endoscopy system further includes an endoscope having a tip. The endoscope is positioned through the concentric spring such that the tip extends from the biasing member. The endoscope is in communication with the flexion member such that the endoscope is selectively movable by the pair of servomotors selectively controlling the flexion member. The endoscope includes a piezo actuator, a scanning fiber, a lens assembly, and collection fibers. The image-based feedback endoscopy system also includes an image based feedback algorithm, which selectively controls the operation of the pair of servo motors. | 07-30-2015 |
Timothy D. Soper, San Jose, CA US
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20150216398 | MULTISPECTRAL WIDE-FIELD ENDOSCOPIC IMAGING OF FLUORESCENCE - Improved methods, systems and apparatus relating to wide field fluorescence and reflectance imaging are provided, including improved methods, systems and apparatus relating to removal of background signals such as autofluorescence and/or fluorophore emission cross-talk; distance compensation of fluorescent signals; and co-registration of multiple signals emitted from three dimensional tissues. | 08-06-2015 |
Vera N. Soper, Cincinnati, OH US
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20150025482 | SYSTEMS AND METHODS FOR APPLYING REDUCED PRESSURE THERAPY - Embodiments of a reduced pressure system and methods for operating the system are disclosed. In some embodiments, the system can include one or more processors responsible for various functions associated with various levels of responsiveness, such as interfacing with a user, controlling a vacuum pump, providing network connectivity, etc. The system can present GUI screens for controlling and monitoring its operation. The system can be configured to determine and monitor flow of fluid in the system by utilizing one or more of the following: monitoring the speed of a pump motor, monitoring flow of fluid in a portion of a fluid flow path by using a calibrated fluid flow restrictor, and monitoring one or more characteristics of the pressure pulses. The system can be configured to provide external connectivity for accomplishing various activities, such as location tracking of the system, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc. | 01-22-2015 |
William Wayne Soper, Bay City, MI US
Patent application number | Description | Published |
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20090078651 | Mung Water Treatment Method - A water treatment method for reducing/eliminating and preventing biofilm buildup in recirculating water systems. The method includes providing both NuTowerâ„¢ and a biocide in a recirculating water system. | 03-26-2009 |