Patent application number | Description | Published |
20090012607 | METHOD FOR THE PREPARATION OF TUBE-TYPE POROUS BIODEGRADABLE SCAFFOLD HAVING DOUBLE-LAYERED STRUCTURE FOR VASCULAR GRAFT - Disclosed herein are a tube-type porous scaffold having a double-layered structure for use as an artificial vascular graft and a preparation method thereof. The method comprises (1) dissolving a biodegradable polymer in an organic solvent and mixing the polymer with a porogen so as to provide a polymer/porogen mixture; (2) coating a cylindrical shaft with the polymer/porogen mixture so as to form an inner porous coating layer; (3) preparing a biodegradable polymer gel by dissolving a biodegradable polymer in an organic solvent; (4) spinning down the biodegradable polymer gel in a non-solvent coagulation bath in which the cylindrical shaft having the inner porous coating layer, obtained at step (2), is immersed and rotated to form gel-phase fibers and allowing the gel-phase fibers to wind around the inner porous coating layer of the rotating shaft so as to form an outer polymer fibrous layer; and (5) separating the double-layered porous scaffold, formed on the shaft, from the shaft and removing the organic solvent and the porogen from the scaffold. Since the porous scaffold has a double-layered structure consisting of an inner porous coating layer containing micropores and a gel-phase outer polymer fibrous layer, it has high pore interconnectivity and mechanical strength, which effectively prevents the leakage of blood, and has high cell seeding and proliferation efficiencies, thereby being useful as a tissue-engineered artificial vascular graft. | 01-08-2009 |
20090017619 | METHOD FOR MANUFACTURING METAL SILICIDE LAYER IN A SEMICONDUCTOR DEVICE - A metal suicide layer is fabricated in a semiconductor device. A first metal layer is deposited on a silicon substrate formed with an S interlayer dielectric having a contact hole through PVD. A second metal layer is deposited on the first metal layer through any one of CVD and ALD. Annealing is performed on the silicon substrate which is formed with the first and second metal layers to form the metal silicide. The portions of the second metal layer and the first metal layer which have not reacted during annealing are removed. | 01-15-2009 |
20090200672 | METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE - Disclosed is a method for manufacturing a semiconductor device. This method includes the step of forming a diffusion barrier film, which is interposed between a silicon film and a metal film and functions to prevent diffusion between the silicon and metal films. The diffusion barrier film is formed of a WSixNy film or a WSix film by using an ALD process. | 08-13-2009 |
20100028950 | METHOD FOR THE IMMOBILIZATION OF BIOLOGICALLY ACTIVE POLYPEPTIDES BY USING MALTOSE BINDING PROTEIN - The present invention relates to a method for immobilization of a biologically active polypeptide using maltose binding protein (MBP) and a biologically active solid substrate on which a biologically active polypeptide is immobilized by the above method. More particularly, the present invention relates to a method for immobilization of a biologically active polypeptide comprising the following steps; 1) preparing a fusion protein by linking a biologically active polypeptide to carboxyl terminal of maltose binding protein (MBP); and 2) immobilizing the fusion protein on the hydrophobic surface by physical adsorption of amino terminal containing hydrophobic domain exposed on the surface of maltose binding protein on the hydrophobic surface of a solid substrate, and a biologically active solid substrate on which a biologically active polypeptide is immobilized by the said method. | 02-04-2010 |
20100038788 | MULTI-LAYERED METAL LINE OF SEMICONDUCTOR DEVICE FOR PREVENTING DIFFUSION BETWEEN METAL LINES AND METHOD FOR FORMING THE SAME - A multi-layered metal line of a semiconductor device includes a semiconductor substrate; a lower metal line formed on the semiconductor substrate and recessed on a surface thereof; an insulation layer formed on the semiconductor substrate including the lower metal line and having a damascene pattern for exposing a recessed portion of the lower metal line and for delimiting an upper metal line forming region; a glue layer formed on a surface of the recessed portion of the lower metal line; a first diffusion barrier formed on the glue layer to fill the recessed portion of the lower metal line; a second diffusion barrier formed on the glue layer and the first diffusion barrier; a third diffusion barrier formed on the second diffusion barrier and a surface of the damascene pattern; and an upper metal line formed on the third diffusion barrier to fill the damascene pattern. | 02-18-2010 |
20100081638 | COMPOSITIONS COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTING AND TREATING CANCER DISEASES - The present invention relates to an anoikis-inducing agent comprising a | 04-01-2010 |
20100120149 | CELL AGGREGATE-HYDROGEL-POLYMER SCAFFOLD COMPLEX FOR CARTILAGE REGENERATION, METHOD FOR THE PREPARATION THEREOF AND COMPOSITION COMPRISING THE SAME - The present invention relates to a cell aggregate-hydrogel-polymer scaffold complex useful for cartilage regeneration which has a structure in which cell aggregates of differentiated chondrocytes are evenly dispersed in a hydrogel matrix, and the resulting hydrogel matrix is immobilized onto the surface of a polymer scaffold while filling up the pores thereof. Since the cell aggregate-hydrogel-polymer scaffold complex according to the present invention can efficiently induce the regeneration of cartilage tissue similar to natural cartilage and retain high mechanical strength, flexibility, and uniform morphology during the cartilage regeneration, it can be effectively used as a cartilage therapeutic agent for the repair of cartilage defects and injuries. | 05-13-2010 |
20100124570 | HIGHLY RESILIENT COPOLYMER WITH SHAPE RECOVERY FORCE AND FLEXIBILITY AND THE USE THEREOF FOR THE REPAIR OF ARTICULAR CARTILAGE DEFECTS - The present invention relates to a highly resilient (lactide/glycolide)/ε-caprolactone copolymer with good shape recovery force, flexibility, and biodegradability and a use of such copolymer for the repair of articular cartilage defects. The highly resilient (lactide/glycolide)/ε-caprolactone copolymer of the present invention is capable of rapidly and efficiently inducing cartilage regeneration, can be easily deformed and almost completely restored to its original form after deformation. Further, the highly resilient copolymer of the present invention can be safely and conveniently transplanted to a patient by using an arthroscope without causing economic, physical, and mental burden. Thus, the highly resilient copolymer of the present invention can be effectively used as a polymer scaffold for the repair of cartilage defects. | 05-20-2010 |
20100193956 | MULTI-LAYER METAL WIRING OF SEMICONDUCTOR DEVICE PREVENTING MUTUAL METAL DIFFUSION BETWEEN METAL WIRINGS AND METHOD FOR FORMING THE SAME - A multi-layer metal wiring of a semiconductor device and a method for forming the same are disclosed. The multi-layer metal wiring of the semiconductor device includes a lower Cu wiring, and an upper Al wiring formed to be contacted with the lower Cu wiring, and a diffusion barrier layer interposed between the lower Cu wiring and the upper Al wiring. The diffusion barrier layer is formed of a W-based layer. | 08-05-2010 |
20100323495 | RECESSED GATE ELECTRODE MOS TRANSISTOR AND METHOD FOR FABRICATING THE SAME - Disclosed are a transistor and a method for fabricating the same capable of increasing a threshold voltage and a driving current of the transistor. The method includes the steps of forming a first etch mask on a silicon substrate, forming a trench by etching the exposed isolation area, forming a first insulation layer in the trench and the first etch mask, forming a second insulation layer on the first insulation layer, removing the second insulation layer and the first insulation layer until the first etch mask is exposed, forming a trench type isolation layer on the isolation area, forming a second etch mask on an entire surface of the silicon substrate, etching the exposed channel area, performing an etching process with respect to a resultant substrate structure, and forming a gate in the recess. | 12-23-2010 |
20110201710 | METHOD FOR PREPARING BIODEGRADABLE POLYMER STEREOCOMPLEXES USING A SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM AND STEREOCOMPLEXES PREPARED BY THE SAME - The present invention relates to methods for preparing biodegradable polymer stereocomplexes using a supercritical fluid-organic solvent system and polymer stereocomplexes prepared by such methods. The method of the present invention involves introducing two types of homopolymers having different stereostructures and a small amount of organic solvent into a reactor, adding a supercritical fluid thereto, followed by applying a specific temperature and pressure to form a polymer stereocomplex having a crystalline structure. According to the method of the present invention, biodegradable polymer stereocomplexes in the form of powder or porous foam having excellent thermal and mechanical stabilities can be prepared in a simple, economical and environmentally-friendly manner in a single process. | 08-18-2011 |
20120007240 | METAL WIRE FOR A SEMICONDUCTOR DEVICE FORMED WITH A METAL LAYER WITHOUT VOIDS THEREIN AND A METHOD FOR FORMING THE SAME - A metal wiring of a semiconductor device includes a semiconductor substrate; an insulating layer provided with a damascene pattern formed over the semiconductor substrate; a diffusion barrier layer which contains a RuO | 01-12-2012 |
20120122156 | RECOMBINANT PROTEIN OF FIBROBLAST GROWTH FACTOR HAVING ADHESIVE ACTIVITY FOR STEM CELLS AND METHOD FOR CULTURING STEM CELLS USING THE SAME - The present invention relates to a recombinant protein of a fibroblast growth factor (FGF) having an adhesive activity for stem cells and a method for culturing stem cells using the same. More particularly, the present invention relates to a recombinant protein having an adhesive activity for stem cells by fusion of a polypeptide linker at amino terminal of FGF, and a method for culturing stem cells using immobilized FGF comprising: fixing the recombinant protein in a culture vessel with a hydrophobic surface using amino terminal of the polypeptide linker, adhering stem cells on the recombinant protein-fixed culture vessel, and culturing the stem cells. | 05-17-2012 |
20120134965 | METHOD FOR DIFFERENTIATION OF STEM CELLS INTO VASCULAR CELLS AND THE INDUCTION OF ANGIOGENESIS USING THE SAME - The present invention relates to a method for differentiating stem cells into vascular cells by culturing them in the form of a three-dimensional cell cluster and the use of the three-dimensional cell cluster for angiogenesis. Specifically, the present invention teaches a method for differentiating stem cells into vascular cells comprising culturing stem cells by adhering them onto a culture plate with a surface having a hydrophobic property or a culture plate onto which a growth factor is immobilized, wherein the cultured stem cells are later detached from the culture plate as their density increases to form a three-dimensional cell cluster and grown in the form of a three-dimensional cell cluster while differentiating into vascular cells. Also disclosed is the use of a three-dimensional cell cluster composed of the vascular cells differentiated from stem cells by the above method as a cell therapy agent for angiogenesis. | 05-31-2012 |
20120289618 | PREPARATION METHOD OF CLAY/POLYMER COMPOSITE USING SUPERCRITICAL FLUID-ORGANIC SOLVENT SYSTEM - The present invention relates to a method for preparing a clay/polymer composite having a predetermined form such as powder or porous foam with an enhanced thermal and mechanical stability using a simple, economical and eco-friendly supercritical fluid-organic solvent system, and more particularly, to a method for preparing a clay/biodegradable polymer stereoisomeric nanocomposite and a clay/polymer composite prepared by the method thereof. The method of preparing a clay/polymer composite according to the present invention may include (a) introducing a clay, a biodegradable single-phase D-type/L-type stereoisomeric polymer and an organic solvent into a reactor, (b) introducing a supercritical fluid into the reactor to form a stereoisomeric composite, and forming a clay/polymer composite dispersed with the clay on the stereoisomeric composite, and (c) collecting the clay/polymer composite, and the clay/polymer composite of the present invention is a clay/polymer composite prepared by the preparation method. | 11-15-2012 |
20130035449 | METHOD FOR PREPARING BIODEGRADABLE POLYMER MATERIALS, BIODEGRADABLE POLYMER MATERIALS AND PRODUCT FOR FIXING BONE - Disclosed are a method for preparing biodegradable polymer materials, biodegradable polymer materials, and a product for fixing bone. The method includes a complex preparing step of preparing polylactide stereoisomeric complex by using a polymer having weight-average molecular weight more than 100,000 g/mol; a molding step of compression-molding the complex; a cooling step of cooling the compression-molded complex; and an extruding step of solid state extruding the cooled complex. Biodegradable polymer materials prepared by the method may be applied to a product for fixing bone or spine requiring high strength. Biodegradable polymer materials may have no corrosion in the body, may require no additional operation for removal after healing bones and tissues, and may prevent stress shielding. | 02-07-2013 |
20130053464 | PREPARATION METHOD OF FLEXIBLE POLYLACTIDE STEREOCOMPLEX AND THE COMPOUND THEREOF - Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, | 02-28-2013 |
20140012311 | BIO-IMPLANTABLE DEVICES HAVING SUPER-HYDROPHOBIC SURFACE AND METHOD FOR MANUFACTURING THEREOF - The present disclosure relates to a bioimplantable device having a superhydrophobic surface and a method for manufacturing the same. The bioimplantable device, which includes a biocompatible substrate and a superhydrophobic nanostructure formed on the surface of the biocompatible substrate, is capable of preventing blood clot formation by blocking contact with proteins, water, blood platelets, etc. when used for blood vessels. | 01-09-2014 |
20150057385 | PREPARATION METHOD OF FLEXIBLE POLYLACTIDE STEREOCOMPLEX AND THE COMPOUND THEREOF - Disclosed are a polylactide stereocomplex with improved thermal stability and thus improved processability and a method for preparing the same. In order to confer flexibility to polymer chains, | 02-26-2015 |