Patent application number | Description | Published |
20090105119 | ASPARAGINE-10-SUBSTITUTED NONADEPSIPEPTIDES - The invention relates to nonadepsipeptides and methods for their preparation, as well as to their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases. | 04-23-2009 |
20090163696 | METHOD FOR PREPARING LYSOBACTIN DERIVATIVES - Method for preparing cyclic depsipeptides having the following formula (I) | 06-25-2009 |
20090203582 | LYSOBACTIN AMIDES - The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases. | 08-13-2009 |
20110034433 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE - The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system. | 02-10-2011 |
20140045802 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND THEIR USE - The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system. | 02-13-2014 |
20150045344 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF - The present invention relates to novel 4-(4-cyano-2-thioaryl)dihydropyrimidin-2-one derivatives, to processes for their preparation, to their use alone or in combination for the treatment and/or prevention of diseases and also to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of disorders of the lung and the cardiovascular system. | 02-12-2015 |
Patent application number | Description | Published |
20110027714 | TONER COMPOSITIONS - Toner particles are provided which may, in embodiments, include an additive package possessing both a silica that has been treated with polydimethyl siloxane and a titanium dioxide that has been subjected to a fluorine treatment. The silica that has been treated with polydimethyl siloxane has low levels of free polydimethyl siloxane. The combined additives provide toners with excellent charging characteristics and good blocking performance. | 02-03-2011 |
20110223525 | TONER HAVING POLYESTER RESIN - Embodiments include a toner having a polyester resin derived from diacids and diesters, in combination with at least one diol, in embodiments a cycloaliphatic diol, an optional crystalline resin, an optional colorant, and an optional wax. | 09-15-2011 |
20120156607 | TONER COMPOSITIONS AND PROCESSES - Environmentally friendly toner particles are provided which may include a bio-based amorphous polyester resin, optionally in combination with another amorphous resin and/or a crystalline resin. Methods for providing these toners are also provided. In embodiments, the bio-based amorphous polyester resin is modified with a multi-functional bio-based acid, thereby providing acid-functionalized polyesters, which can be readily emulsified in emulsion aggregation processes for toner fabrication. | 06-21-2012 |
20120156610 | TONER COMPOSITIONS AND PROCESSES - Processes for producing toners are provided. The processes include determining the desired gloss for a given toner, and determining the desired amount of aluminum in the toner to obtain that gloss. Utilizing the processes of the present disclosure, the solids content of an emulsion utilized to produce such a toner, as well as the mixing speed utilized in the aggregation process and the temperature at which aggregation of the toner particles occurs, may then be selected to obtain toner particles possessing the desired amount of aluminum, and thus the desired gloss. | 06-21-2012 |
20120258393 | CO-EMULSIFICATION OF INSOLUBLE COMPOUNDS WITH TONER RESINS - A process for making a latex emulsion suitable for use in a toner composition includes co-emulsifying a bio-based resin with an insoluble component, such as a pigment or wax, whereby the resin encapsulates the insoluble component. The resulting latex, including the insoluble component encapsulated in the resin, may then be utilized to form a toner. The insoluble component may thus be included in toner particles, which might otherwise be difficult to achieve, using emulsion aggregation processes. | 10-11-2012 |
20120258397 | CO-EMULSIFICATION OF INSOLUBLE COMPOUNDS WITH TONER RESINS - A process for making a latex emulsion suitable for use in a toner composition includes co-emulsifying a bio-based resin with an insoluble component, such as a pigment or wax, whereby the resin encapsulates the insoluble component. The resulting latex, including the insoluble component encapsulated in the resin, may then be utilized to form a toner. The insoluble component may thus be included in toner particles, which might otherwise be difficult to achieve, using emulsion aggregation processes. | 10-11-2012 |
20130164668 | TONER COMPOSITIONS OF BIODEGRADABLE AMORPHOUS POLYESTER RESINS - Disclosed is a toner that includes a mixture of a bio-based amorphous polyester resin, a crystalline polyester resin, and a colorant. | 06-27-2013 |
20140170547 | Polyester EA Toner Comprising Furan - The present disclosure provides a bio-based polyester resin comprising a polyacidic furan, including the manufacture of such polyester resin, which resin may be used in manufacturing toner for imaging devices. | 06-19-2014 |
20140322642 | Biophenols for Polyester Toner Resins - The present disclosure provides a polyester toner resin comprising a natural phenol used in manufacturing a toner for imaging devices. | 10-30-2014 |
20140354730 | UNDERCOAT COMPOSITION FOR INK JET PRINTING - An ink jettable underprint composition includes a reversible polymer material, which can reversibly transition between a liquid state and a solid state by reversible cycloaddition reactions, wherein upon cooling, the reversible polymer material transitions from a liquid state to a solid state by reversible cycloaddition reactions within a time period of less than about 10 seconds. | 12-04-2014 |
20140354742 | OVERCOAT COMPOSITION FOR INK JET PRINTING - An ink jettable overprint composition includes a reversible polymer material, which can reversibly transition between a liquid state and a solid state by reversible cycloaddition reactions, wherein upon cooling, the reversible polymer material transitions from a liquid state to a solid state by reversible cycloaddition reactions within a time period of less than about 10 seconds. | 12-04-2014 |
20140357783 | REVERSIBLE POLYMER COMPOSITION - A composition includes a reversible polymer material, which can reversibly transition between a liquid state and a solid state by reversible cycloaddition reactions, wherein upon cooling, the reversible polymer material transitions from a liquid state to a solid state by reversible cycloaddition reactions within a time period of less than about 10 seconds. | 12-04-2014 |
20150086922 | LATEX FORMING PROCESS COMPRISING CONCURRENT STEAM INJECTION EMULSIFICATION AND SOLVENT DISTILLATION - A process includes dissolving a polymer in an organic solvent to form a polymer solution and forming a latex from the polymer solution by contacting the polymer solution with steam while substantially simultaneously distilling the organic solvent. | 03-26-2015 |
Patent application number | Description | Published |
20100035971 | Methods and Means Related to Diseases - The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibility to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and follow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti-CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL. | 02-11-2010 |
20100143907 | METHODS AND USES INVOLVING GENETIC ABNORMALITIES AT CHROMOSOME 12 - The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial origin. The present invention further relates to a novel method of identifying an individual with potential for developing carcinoma, the method comprising detection of genetic abnormalities. The present invention also relates to a method of predicting the progression of carcinomas and the transformation thereof to an aggressive variant, the method comprising detection of genetic abnormalities, which indicate the probability to develop carcinoma. The present invention also relates to a use of specific chromosomal region, a gene or a fragment thereof, and/or genetic markers for predicting tumor initiation, tumor progression and/or carcinoma. The present invention also relates to a use of specific chromosomal region or a gene or a fragment thereof in therapy, for the development of therapy, and for the preparation of a medicament for treating tumors of epithelial origin. | 06-10-2010 |
20130029337 | METHODS AND USES INVOLVING GENETIC ABNORMALITIES AT CHROMOSOME 12 - The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial origin. The present invention further relates to a novel method of identifying an individual with potential for developing carcinoma, the method comprising detection of genetic abnormalities. The present invention also relates to a method of predicting the progression of carcinomas and the transformation thereof to an aggressive variant, the method comprising detection of genetic abnormalities, which indicate the probability to develop carcinoma. The present invention also relates to a use of specific chromosomal region, a gene or a fragment thereof, and/or genetic markers for predicting tumor initiation, tumor progression and/or carcinoma. The present invention also relates to a use of specific chromosomal region or a gene or a fragment thereof in therapy, for the development of therapy, and for the preparation of a medicament for treating tumors of epithelial origin. | 01-31-2013 |
Patent application number | Description | Published |
20120077907 | STYRENE-BUTADIENE BASED REDISPERSIBLE POLYMER POWDERS WITH IMPROVED STABILITY IN CEMENT APPLICATIONS - A water redispersible polymer powder is produced by drying an aqueous mixture of a carboxylated styrene butadiene polymer and a colloidal stabilizer which includes a polyvinyl alcohol modified with an alkyl end chain. The alkyl modified polyvinyl alcohol provides excellent redispersibility of the redispersible polymer powder without adversely affecting spray drying. Cement compositions such as mortars, which contain the redispersible polymer powder with the alkyl modified polyvinyl alcohol exhibit unexpectedly superior stability and an unexpectedly lower rate of mortar viscosity buildup which is advantageous for workability or troweling. | 03-29-2012 |
20130092056 | CELLULOSE ETHER AND MICROCRYSTALLINE CELLULOSE IN INORGANIC BINDER COMPOSITIONS - A new water-based inorganic binder composition includes inorganic binder, cellulose ether and microcrystalline cellulose. A new additive for water-based inorganic binder compositions includes cellulose ether and microcrystalline cellulose. A method for improving the properties of water-based inorganic binder compositions includes blending a combination of cellulose ether and microcrystalline cellulose in the water-based binder composition. | 04-18-2013 |
20140275307 | POLYURETHANE POWDER BLEND WITH REDISPERSIBLE POLYMER POWDER FOR CEMENT COMPOSITIONS - Powdered polyurethane flexible foams, preferably powdered recycled polyurethane flexible foams are used with a redispersible polymer powder (RDP), preferably as a preblended additive, in hydraulic binders or cementitious compositions to improve performance of cementitious compositions or mortar, in applications such as cement based tile adhesives (CBTA), or external thermal insulating composite systems (ETICS). The use of the powdered polyurethane flexible foam as a partial replacement for an RDP unexpectedly provides an increase in wet mortar density while maintaining excellent workability and quick open time, quicker setting times, improved impact resistance, and increased adhesion after water immersion. | 09-18-2014 |
20140288202 | USE OF POLYURETHANE POWDER AS INNER ADDITIVE OF REDISPERSIBLE POLYMER POWDER - A powdered polyurethane, preferably a powdered recycled polyurethane rigid foam is co-dried with a water insoluble film-forming polymer to obtain a redispersible polymer powder composite for use in hydraulic binders or cementitious compositions to improve performance of cementitious compositions or mortar, in applications such as cement based the adhesives (CBTA), or external thermal insulating composite systems (ETICS). | 09-25-2014 |
20140336306 | METHOD FOR PROVIDING MODIFIED CEMENT COMPOSITIONS, DRY MORTARS AND CEMENT-FREE MIXTURES - The present invention relates to methods for providing modified cement compositions having increased slip resistance and/or a decreased setting time in comparison to cement compositions comprising from 1 to 10 weight percent redispersible polymer powder (RDP) and water soluble cellulose ether in a specific amount from 0.1 to 1.0 weight percent, based on the total dry weight of said composition. Also provided are dry mortars comprising cement, RDP, water soluble cellulose ether and one or more additives selected from gelatin, bentonite and combinations thereof for use in such methods, and cement-free mixtures comprising water soluble cellulose ether and one or more additives selected from gelatin, bentonite and combinations thereof which may be added to cement binder for use a for use in such methods. | 11-13-2014 |
20150087751 | DRY MIX FORMULATIONS CONTAINING CARBOXYLATED STYRENE-BUTADIENE REDISPERSIBLE POLYMER POWDERS AND ALUMINA RICH CONTAINING CEMENTS - Dry mix formulations containing a redispersible polymer powder (RDP) made of a low carboxylation, large particle size water-insoluble film—forming styrene butadiene polymer having at least one ethylenically unsaturated dicarboxylic acid monomer, and a high alumina content cement such as a calcium aluminate cement (CAC) or a calcium sulfoaluminate cement (CSA) provides cement compositions having unexpectedly superior water immersion shear strength and set time for a cement containing tile adhesive (CBTA or CTA), superior adhesion properties in water proofing mortars or mortar applications, and superior flexural and compressive strength in grout applications. | 03-26-2015 |
Patent application number | Description | Published |
20100195070 | PROJECTION OBJECTIVE FOR MICROLITHOGRAPHY, PROJECTION EXPOSURE APPARATUS, PROJECTION EXPOSURE METHOD AND OPTICAL CORRECTION PLATE - A projection objective is disclosed. The projection objective can include a plurality of optical elements arranged to image a pattern from an object field in an object surface of the projection objective to an image field in an image surface of the projection objective with electromagnetic operating radiation from a wavelength band around an operating wavelength λ. The plurality of optical elements can include an optical correction plate that includes a body comprising a material transparent to the operating radiation, the body having a first optical surface, a second optical surface, a plate normal substantially perpendicular to the first and second optical surfaces, and a thickness profile defined as a distance between the first and second optical surfaces measured parallel to the plate normal. The first optical surface can have a non-rotationally symmetric aspheric first surface profile with a first peak-to-valley value PV | 08-05-2010 |
20130188246 | Imaging Optical System for Microlithography - An imaging optical system, in particular a projection objective, for microlithography, includes optical elements to guide electromagnetic radiation with a wavelength in a path to image an object field into an image plane. The imaging optical system includes a pupil, having coordinates (p, q), which, together with the image field, having coordinates (x, y) of the optical system, spans an extended 4-dimensional pupil space, having coordinates (x, y, p, q), as a function of which a wavefront W(x, y, p, q) of the radiation passing through the optical system is defined. The wavefront W can therefore be defined in the pupil plane as a function of an extended 4-dimensional pupil space spanned by the image field (x, y) and the pupil (p, q) as W(x, y, p, q)=W(t), with t=(x, y, p, q). | 07-25-2013 |
20140185024 | PROJECTION OBJECTIVE OF A MICROLITHOGRAPHIC PROJECTION EXPOSURE APPARATUS - A projection objective of a microlithographic projection exposure apparatus comprises a wavefront correction device comprising a refractive optical element that has two opposite optical surfaces, through which projection light passes, and a circumferential rim surface extending between the two optical surfaces. A first and a second optical system are configured to direct first and second heating light to different portions of the rim surface such that at least a portion of the first and second heating light enters the refractive optical element. A temperature distribution caused by a partial absorption of the heating light results in a refractive index distribution inside the refractive optical element that corrects a wavefront error. At least the first optical system comprises a focusing optical element that focuses the first heating light in a focal area such that the first heating light emerging from the focal area impinges on the rim surface. | 07-03-2014 |
20140239192 | ILLUMINATION AND DISPLACEMENT DEVICE FOR A PROJECTION EXPOSURE APPARATUS - An illumination and displacement device for a projection exposure apparatus comprises an illumination optical unit for illuminating an illumination field. An object holder serves for mounting an object in such a way that at least one part of the object can be arranged in the illumination field. An object holder drive serves for displacing the object during illumination in an object displacement direction. A correction device serves for the spatially resolved influencing of an intensity of the illumination at least of sections of the illumination field, wherein there is a spatial resolution of the influencing of the intensity of the illumination of the illumination field at least along the object displacement direction. This results in an illumination and displacement device in which field-dependent imaging aberrations which are present during the projection exposure do not undesirably affect a projection result. | 08-28-2014 |
20140347721 | Projection Lens for EUV Microlithography, Film Element and Method for Producing a Projection Lens Comprising a Film Element - A film element of an EUV-transmitting wavefront correction device is arranged in a beam path and includes a first layer of first layer material having a first complex refractive index n | 11-27-2014 |
Patent application number | Description | Published |
20080200530 | Diaryl and Arylheteroaryl Urea Derivatives as Modulators of 5-Ht2a Serotonin Receptor Useful for the Prophylaxis or Treatment of Progressive Multifocal Leukoencephalopathy - The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the prophylaxis or treatment of progressive multifocal leukoencephalopathy. | 08-21-2008 |
20090186895 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together. | 07-23-2009 |
20100004264 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 01-07-2010 |
20110105456 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 05-05-2011 |
20120295938 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, blood clot formation, asthma or symptoms thereof, agitation or a symptom thereof, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together. | 11-22-2012 |
20130217700 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 08-22-2013 |
20130237540 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 09-12-2013 |
Patent application number | Description | Published |
20120214766 | CANNABINOID RECEPTOR MODULATORS - The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease. | 08-23-2012 |
20130165412 | CANNABINOID RECEPTOR MODULATORS - The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, migraine and other headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis, and Parkinson's disease. | 06-27-2013 |
20130237541 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 09-12-2013 |
20140163032 | ETHERS, SECONDARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT 2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention pertains to certain compounds of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 06-12-2014 |
20140206649 | CANNABINOID RECEPTOR MODULATORS - Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB | 07-24-2014 |
20150073141 | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT | 03-12-2015 |
Patent application number | Description | Published |
20120238639 | PHARMACEUTICAL COMPOSITION COMPRISING PROPOFOL - The invention provides novel pharmaceutical compositions comprising the active ingredient propofol. Preferably, propofol is dissolved in at least one semifluorinated alkane. The compositions, which are preferably liquid or gel-like, may optionally comprise further excipients. They may be used as fill material in capsules, as buccal or nasal sprays, or as aerosols for pulmonary administration. They are particularly useful for the transmucosal administration of propofol. | 09-20-2012 |
20120244177 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DRY EYE SYNDROME - The invention provides novel pharmaceutical compositions for the treatment of keratoconjunctivitis sicca comprising liquid vehicles which include one or more semifluorinated alkanes. The compositions incorporate an active ingredient selected from the group of macrolide immunosuppressants. They can be administered topically into the eye. The invention further provides kits comprising such compositions. | 09-27-2012 |
20130142866 | COMPOSITIONS AND METHODS FOR IMPROVED ORGAN TRANSPLANT PRESERVATION AND ACCEPTANCE - The invention provides a novel aqueous composition for the storage and preservation of transplants, such as organ or tissue allografts. The composition comprises the compound N-octanoyl dopamine in solubilised form. The composition may also be administered as a pre-treatment of transplant donors. Moreover, it may be used in transplant recipients, optionally in combination with immunosuppressants. | 06-06-2013 |
20130266652 | LIQUID PHARMACEUTICAL COMPOSITION FOR THE DELIVERY OF ACTIVE INGREDIENTS - The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions. | 10-10-2013 |
20140004197 | O/W-EMULSIONS COMPRISING SEMIFLUORINATED ALKANES | 01-02-2014 |
20140100180 | TOPICAL PHARMACEUTICAL COMPOSITION BASED ON SEMIFLUORINATED ALKANES - The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids. | 04-10-2014 |
20140140942 | PHARMACEUTICAL COMPOSITION FOR ADMINISTRATION TO NAILS - The invention provides semi-solid or liquid pharmaceutical compositions for topical administration to a finger- or toenail of a human. The compositions are useful for the delivery of active ingredients deep into the nail. Various active ingredients may be incorporated, such as antifungal agents, anti-infectives, anti-inflammatory agents, immunosuppressants, local anaesthetics, and retinoids. | 05-22-2014 |
20140221485 | LIPOPHILIC DOPAMINE DERIVATIVES AND THEIR USE - The invention provides novel lipophilic dopamine derivatives with improved stability and physiological half-life. The compounds may be used for organ and tissue preservation during storage and transport, or in the pre-treatment of organ and tissue donor or recipients. Moreover, they may be used as therapeutic agents for the prevention or treatment of ischaemia-related pathological conditions. | 08-07-2014 |
20140369993 | STABILISED PROTEIN COMPOSITIONS BASED ON SEMIFLUORINATED ALKANES - The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route. | 12-18-2014 |
Patent application number | Description | Published |
20110173797 | Method of Loosely Prefixing at Least Two Components That are to be Firmly Connected With One Another - A method of fixing, particularly loosely prefixing, at least two components that are to be firmly connected with one another, especially two body parts of a vehicle body that are to be firmly connected with one another, includes the steps of providing a first component on which at least one first form-locking element projecting from the first component is provided, providing a second component which has at least one second form-locking element that interacts with the first form-locking element of the first component, and loosely prefixing the two components by placing them together such that the form-locking elements interlock with one another. As a result, the components are held relative to one another at least in one direction. The at least one first form-locking element is a separate part that differs from the first component and that is connected with the first component only after the manufacture of the first component. | 07-21-2011 |
20140143989 | Method of Connecting Two Components as Well as a Component Connection - A method of connecting a first component having a first hole with a second component having a second hole includes the acts of placing together the two components so that the holes are situated above one another, and fixing the two components on one another. The fixing occurs by pushing a connection element projecting beyond the two components through the two components, the connection element having at least one clamping head which projects beyond a side of the first component facing away from the second component, and clipping a clamping element onto the clamping head, so that the clamping element is supported on a side of the first component facing away from the second component and exercises a clamping force onto the connection element which clamps together the two components. | 05-29-2014 |
20140147195 | Connecting Element - A connection element is provided for connecting at least two components. The connection element has at least two spherical, sphere-shaped or sphere-type or sphere-like sections, wherein a first section of the at least two sections is provided for the connection with a first component, and the second section of the at least two sections is provided for the connection with a second component. | 05-29-2014 |
Patent application number | Description | Published |
20090313243 | METHOD AND APPARATUS FOR PROCESSING SEMANTIC DATA RESOURCES - A semantic data resource of a domain is processed by calculating relevance scores for terms which occur in domain corpora and weighting the semantic data resource depending on the relevance scores calculated for these terms. The semantic data resource may include domain-specific terms and relations, such as a domain ontology, a domain terminology and a domain classification. The domain ontology may include a domain-specific-hierarchy of terms assigned to nodes which are connected by edges and may be encoded in a web ontology language. The relevance scores may be chi-square scores which are calculated depending on a frequency of a term in the domain corpora and an expected frequency of the term. | 12-17-2009 |
20100094874 | Method and an apparatus for retrieving additional information regarding a patient record - A method and an apparatus retrieve additional information regarding a patient record. Applying the subject-matter of the present invention clinical experts, such as doctors, can be provided with domain specific background knowledge, and can, hence, be supported in making decisions regarding the treatment of patients. Said additional information can be structured and visualised, which makes the retrieved information understandable also for persons without advanced knowledge regarding data processing. The retrieval of additional information is accomplished by a comparison of data being stored in the patient record and data being stored in a predefined textual resource, such as a ontology, and an identification of further terms describing attributes of the patient record. This finds application in supporting the diagnosis of patients and healthcare related information retrieval tasks. | 04-15-2010 |
20110016130 | Method and an apparatus for providing at least one configuration data ontology module - A method and an apparatus provide at least one configuration data ontology module. Modules are extracted from an ontology under consideration of the semantics of the ontology. Therefore, individual concepts are selected from the ontology which are in a subsequent step connected by relations. The method and apparatus are used in ontology modularization, and especially in biomedical application domains. | 01-20-2011 |
20140297230 | SYSTEM AND METHOD FOR HANDLING PLANT ENGINEERING DATA - Methods for modeling a physical facility and corresponding systems and computer-readable mediums. A method includes receiving a plant concept model of a physical facility including a plurality of metamodel entities and receiving a plurality of plant foundational models corresponding to the plant concept model, each plant foundational model addressing a different engineering aspect of the physical facility. The method includes integrating the plurality of plant foundational models and defining a plurality of plant type models each corresponding to a respective plant foundational model. The method includes defining a plurality of plant instance models each corresponding to a respective plant type model and creating an integrated model that provides a user view that combines the plant foundational models and plant instance models. The method includes storing the integrated model. | 10-02-2014 |
Patent application number | Description | Published |
20080201280 | MEDICAL ONTOLOGIES FOR MACHINE LEARNING AND DECISION SUPPORT - A medical ontology may be used for computer assisted clinical decision support. Multi-level and/or semantically grouped medical ontology is incorporated into a machine learning algorithm. The resulting machine-learnt algorithm outputs information to assist in clinical decisions. For example, a patient record is input to the algorithm. Based on the incorporated medical ontology, similarities are aggregated in different groups. An aggregate similarity of at least one group is a function of an aggregate similarity of at least another group. One or more similar patients and/or outcomes are identified based on similarity. Probability based outputs may be provided. | 08-21-2008 |
20110295790 | SYSTEM AND METHOD FOR PROVIDING INSTANCE INFORMATION DATA OF AN INSTANCE - A method and system for providing instance information data of at least one instance. The method has the steps of generating a semantic representation of the instance on the basis of at least one instance data source, providing a semantic representation of a domain on the basis of at least one structured domain data source, performing an integration of the semantic instance and domain representations to provide an integrated semantic representation and deriving automatically instance information data from the provided integrated semantic representation. The method and system allow to provide efficiently instance information data of a wide range of instances with technical entities and persons, in a particular patients in different domains such as radiology or anatomy. | 12-01-2011 |
20120296910 | METHOD AND SYSTEM FOR RETRIEVING INFORMATION - A method of retrieving information regarding an information resource, has the steps of: providing an information resource with a plurality of information instances from a first memory unit; providing a knowledge model with a plurality of type categories and a relationship between at least two type categories from a second memory unit; providing a multi-dimensional context model with a plurality of context categories and a number of dimensions corresponding to a number of the context categories from a third memory unit; annotating an information instance by one of the type categories; mapping at least one type category and/or annotating at least one information instance by one of the context categories; and; assigning a context variable to one of the context categories, the context variable determining a value of a context distance between the context category and the information instance mapped to the context category. | 11-22-2012 |
20120330974 | METHOD OF COMPOSING AN ONTOLOGY ALIGNMENT - A modular method of composing an ontology alignment provides a set of correspondences between at least two ontologies thereby allowing a composition of an optimal alignment by balancing a recall value and a precision of the alignment. A two-fold strategy is followed. By means of mapping functions a set of alignment correspondences is determined. Depending on a particular mapping function a recall value of the alignment can be improved by an extension of the set of correspondences. By filtering functions particularities of the domain are reflected and incorrect mappings are avoided. Depending on a particular filtering function a precision value of the alignment can be improved by restricting the set of correspondences. | 12-27-2012 |
20120331014 | METHOD OF ADMINISTERING A KNOWLEDGE REPOSITORY - The method of administering a knowledge repository described herein establishes combining data input with concurrent data analytics in order to improve the quality and relevance of data entries. | 12-27-2012 |
20130011027 | SYSTEM AND METHOD FOR COMPOSING A MEDICAL IMAGE ANALYSIS - A method composing a medical image analysis, includes the steps of: retrieving anatomical findings captured in a medical report by an information extraction module; providing at least one anatomical knowledge model including a plurality of concepts and a plurality of relationship between the plurality of concepts; mapping at least one anatomical finding of the medical re-port by at least one of the plurality of concepts by a mapping component, thereby locating the anatomical findings in the context of the anatomical knowledge model; and; representing the anatomical findings in the context of the anatomical knowledge model within an anatomical model by a visualization component. | 01-10-2013 |
20130310653 | METHOD AND SYSTEM FOR SUPPORTING A CLINICAL DIAGNOSIS - Methods and systems may support conclusions of a clinician by enabling the clinician to arbitrarily define the symptoms according to the patient's record. The method may comprise: (a) determining a plurality of symptoms representing a patient and including characteristics of the patient, the symptoms being categorized as present symptoms, absent symptoms or open symptoms; (b) establishing a multi-tier relationship between said symptoms and a plurality of diseases based on a knowledge model; (c) adjusting weighting factor(s) for at least one multi-tier relationship based on said knowledge model; (d) optionally adjusting at least one weighting factor of step (c) by an expert; and (e) building a ranking of diseases from said multi-tier relationship based on said weighting factors. The method may provide an efficient ranking of disease information, thereby supporting a clinical diagnosis that may consider multiple symptoms while emphasizing particular symptoms in view of the clinician's expertise. | 11-21-2013 |
20140081623 | METHOD FOR PROCESSING MEDICAL REPORTS - A method for processing medical reports is disclosed. An initial segmentation textual contents of a medical report into information units is performed using natural language processing methods, thereby addressing the challenge of identifying information units, such as text fragments, sentences or text passages, covered within medical reports that are of relevance for a particular context. The information units are then classified into at least one context class to determine their appropriate context classes for a particular situation or application. The context classifications are created using a grammar, e.g., a context-free grammar, and can then be used for automatically assigning each information unit to an appropriate context meta-information. The medical report is then annotated by assigning at least one of said information units to at least one context meta-information determined by said context class. The context meta-information may be then used by other applications. | 03-20-2014 |
20140288964 | Method And System For Supporting An Acquisition Of Clinical Data - A method for supporting an acquisition of clinical data may include the steps of: receiving, by an input component, an identifier characterizing a health state of a patient; accessing a diagnose process model associated to said identifier, the diagnose process model specifying a sequence of clinical treatments whereby each of said clinical treatments includes at least one information model; sequentially activating information models from at least one of said clinical treatments by said process model; requesting, by each of said activated information models, at least one data unit; extracting an information unit by applying an information extraction method to said data unit and interpreting the information unit by reasoning and mapping the information unit to at least one knowledge model; and sequentially instantiating at least one information model by a plurality of said information units. | 09-25-2014 |
20150081648 | Method of Composing an Integrated Ontology - A method of composing an integrated ontology is provided. The method makes use of feature models for the process of modular development of ontologies. The feature models are adapted to assist the user in the process of selection of appropriate and combinable ontologies from an ontology repository for a given use case scenario. The usage of a feature model provides a view of all possible combinations, i.e. all combinations that do not result in an inconsistent ontology. The feature model is specifying dependencies between different ontologies thereby expediting the selection of appropriate ontologies. The usage of reasoning techniques provides for an in-situ consideration of restrictions for the selection of ontologies. | 03-19-2015 |