Smith, Hertfordshire
Clifford L. Smith, Hertfordshire GB
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20090274623 | IN VIVO IMAGING AGENTS FOR MET RECEPTOR TYROSINE KINASE - Provided are in vivo imaging agents comprising muteins of hTLc having detectable binding affinity for c-Met or a domain thereof, coupled to a signal generator, and the mutein coupled to a signal generator is disposed in a pharmaceutically acceptable carrier. Also provided are diagnostic methods using in vivo imaging agents comprising muteins of hTLc having detectable binding affinity for c-Met or a domain thereof. | 11-05-2009 |
Howard Smith, Hertfordshire GB
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20100248674 | Switchable Mode Filter for Overlaid Signal Extraction in Noise - A method of extracting predetermined narrowband microwave signals having common transmission center frequency is presented through the teachings of the invention. In an embodiment of the invention a software based signal processing approach is employed to identify the microwave signals present and control an adaptive bandwidth filter to provide an approximately optimal transmission bandwidth of the adaptive bandwidth filter for the selected microwave signal and minimized noise into the correlation process. | 09-30-2010 |
Ian Edward David Smith, Hertfordshire DE
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20080221108 | Anthranilic Acid Derivatives As Hm74A Receptor Agonists - Therapeutically active anthranilic acid derivatives of Formula (I) wherein R | 09-11-2008 |
Ian Edward David Smith, Hertfordshire GB
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20080242666 | 1-6-Substituted (3R,6R)-3-(2,3-Dihydro-1H-Inden-2-Yl)-2,5-Piperazinedione Derivatives as Oxytocin Receptor Antagonists For the Treatment of Preterm Labour, Dysmenorrhea and Endometriosis - The present invention relates to Compound S of Formula (I). | 10-02-2008 |
20100099690 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS - The present invention relates to compounds which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing the active compounds and the use of the compounds in therapy, for example, in the treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial. | 04-22-2010 |
20100179128 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS - The present invention relates to compounds of formula (I) which are xanthine derivatives, processes for the manufacture of said derivatives, pharmaceutical formulations containing these active compounds and the use of the compounds in therapy, for example, in the treatment of diseases where under-activation of the HM74A receptor contributes to the disease or where activation of the receptor will be beneficial | 07-15-2010 |
Kathryn Jane Smith, Hertfordshire GB
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20100120804 | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors - A process for the preparation of a compound of formula (I) | 05-13-2010 |
Nell Michael Smith, Hertfordshire GB
Nigel Smith, Hertfordshire GB
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20140322288 | METHOD OF FORMING AND THE RESULTING MEMBRANE COMPOSITION FOR SURGICAL SITE PRESERVATION - A method of forming and the resulting membrane composition for securement to a patient's bone or tissue to reduce the formation of tissue adhesions following a surgical procedure comprises a first component and a second component. The first component comprises a hydrogel including at least one crosslinked polymer. The second component comprises a textile component. The composition has a thickness between about two tenths of a millimeter (0.2 mm) to about six tenths of a millimeter (0.6 mm), a suture retention strength between about one Newton (1 N) to about thirteen Newtons (13 N), a static coefficient of friction between about one hundredth (0.01) and about one-half (0.5), a kinetic coefficient of friction between about one hundredth (0.01) and about one-half (0.5) and a flexibility of less than thirty millimeters (30 mm) bend length. A method of reducing the occurrence of tissue adhesions following surgery comprises applying the membrane composition to a surgical site. | 10-30-2014 |
Nigel G. Smith, Hertfordshire GB
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20100272672 | CROSSLINKED HYDROGELS - The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer. | 10-28-2010 |
20100286786 | BIOADHESIVE HYDROGELS - A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient. | 11-11-2010 |
Paul Clifford Smith, Hertfordshire GB
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20090014075 | Dispenser Tap with Two Stage Valve - A dispenser for delivering beverages (e.g. beer) including a main body ( | 01-15-2009 |
Richard Anthony Godwin Smith, Hertfordshire GB
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20100286367 | CONJUGATES OF SOLUBLE PEPTIDIC COMPOUNDS WITH MEMBRANE-BINDING AGENTS - The present invention provides, among other things, soluble derivatives of soluble polypeptides that incorporate membrane binding elements. Methods of making these soluble derivatives, and methods of using these soluble derivatives also are provided. | 11-11-2010 |
Stephen Allan Smith, Hertfordshire GB
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20100120799 | PURINE DERIVATIVES AS IMMUNOMODULATORS - Compounds of formula (I): | 05-13-2010 |
20110144136 | NOVEL ADENINE DERIVATIVES - The present invention relates to compounds of formula (I): | 06-16-2011 |
20110229500 | PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES - The present invention relates to compounds of formula (I): | 09-22-2011 |
20140024664 | NOVEL ADENINE DERIVATIVES - Compounds of formula (I): | 01-23-2014 |