Patent application number | Description | Published |
20140243403 | TREATING COLORECTAL, PANCREATIC, AND LUNG CANCER - The invention relates to methods of determining an appropriate chemotherapy for a subject based on expression levels of a TAK1 biomarker, such as one or more TAK1 biomarkers listed in Table 1, or any subset or combination thereof, e.g., a set of biomarkers consisting of or comprising GGH, BMP7, BAMBI, MBOAT2, HSPA12A, FYN, NAV2, RGL1, SYK and RUNX1 genes, optionally with one or both of INHBB and/or BMPR1A. In some embodiments, the biomarkers include one, two, three, or all of BMP7, BAMBI, BMPR1A, and INHBB. Kits useful for the methods are also provided. | 08-28-2014 |
Patent application number | Description | Published |
20140171760 | SYSTEMS AND METHODS FOR REDUCING OR PREVENTING BACKFLOW IN A DELIVERY SYSTEM - Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. | 06-19-2014 |
20140171902 | SYSTEMS AND METHODS FOR REDUCING OR PREVENTING BACKFLOW IN A DELIVERY SYSTEM - Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid. | 06-19-2014 |
20140207043 | SYSTEMS AND METHODS FOR SHUNTING FLUID - Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. | 07-24-2014 |
20140207045 | SYSTEMS AND METHODS FOR SHUNTING FLUID - Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system. | 07-24-2014 |
20140371711 | METHODS AND DEVICES FOR PROTECTING CATHETER TIPS AND STEREOTACTIC FIXTURES FOR MICROCATHETERS - Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips. | 12-18-2014 |
20150038949 | SYSTEMS AND METHODS FOR DRUG DELIVERY, TREATMENT, AND MONITORING - Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. | 02-05-2015 |
Patent application number | Description | Published |
20120045189 | MEDIA COMPOSITION SYSTEM WITH REMOTE CONNECTION - Computer-based methods for time-based media composition of programs that include secondary material. The methods involve searching for secondary media available from secondary material providers over a wide-area network, selecting secondary material, receiving metadata pertaining to the selected secondary material, inserting a representation of the selected secondary media into a media composition, playing back a sequence of the media composition that includes the secondary media, wherein playback of the secondary media involves playing an evaluation version of the secondary media streamed to a media composition system over the wide area network, and displaying metadata pertaining to the selected secondary material. The media composition system facilitates purchasing and transfer, and re-linking of the secondary media for inclusion within the media composition. In-context previewing of secondary media facilitates selection of the optimal secondary material, accelerated workflows, and improved media cost control. | 02-23-2012 |
20120257877 | MEDIA COMPOSITION SYSTEM WITH REMOTE CONNECTION - Computer-based methods for time-based media composition of programs that include secondary material. The methods involve searching for secondary media available from secondary material providers over a wide-area network, selecting secondary material, receiving metadata pertaining to the selected secondary material, inserting a representation of the selected secondary media into a media composition, playing back a sequence of the media composition that includes the secondary media, wherein playback of the secondary media involves playing an evaluation version of the secondary media streamed to a media composition system over the wide area network, and displaying metadata pertaining to the selected secondary material. The media composition system facilitates purchasing and transfer, and re-linking of the secondary media for inclusion within the media composition. In-context previewing of secondary media facilitates selection of the optimal secondary material, accelerated workflows, and improved media cost control. | 10-11-2012 |
Patent application number | Description | Published |
20080298277 | NEIGHBOR DISCOVERY PROXY WITH DISTRIBUTED PACKET INSPECTION SCHEME - A network device is to receive traffic including neighbor discovery messages from requesting customer devices, and can detect the neighbor discovery messages within the traffic according to a distributed inspection scheme that includes the network device and a remote component. The network device is to then examine the neighbor discovery messages to determine if the neighbor discovery message should be forwarded to other of the customer devices, and respond to the requesting customer devices. | 12-04-2008 |
20090125957 | STATEFUL DHCPv6 RELAY AGENT IN A CABLE MODEM TERMINATION SYSTEM - A CMTS or other data aggregation component having a DHCPv6 relay agent extracts a Media Access Control (MAC) address of an end device from a data packet received from an end device. A DHCPv6 data frame is created for transmission to a DHCPv6 server. The MAC address may be inserted into a specific option of the DHCPv6 data frame, where data in the option may not be processed by the server and are echoed back to the aggregation component or CMTS. The DHCPv6 data frame is transmitted to the DHCPv6 server. The component receives a response message from the server that may contain the MAC address or similar client hardware address as it was sent to the server by the network component. The network component may determine an outgoing port interface from which the response message should be sent, utilizing the MAC address and an interface bundling table. In this manner, interface bundling may be enabled. | 05-14-2009 |
20100309813 | DETECTION AND SUPPORT OF A DUAL-STACK CAPABLE HOST - A network processing device is configured to receive a configuration message from a host device and forward the configuration message to a server. The configuration message can be configured to request the server assign an Internet Protocol (IP) address to the host device. The network processing device can be configured to send at least one probe message to the host device responsive to receiving the configuration message. The network processing device can be configured to determine whether the host device intends to continue utilizing a previously assigned IP address in addition to the IP address requested by the configuration message based, at least in part, on any responses to the at least one probe message received from the host device. | 12-09-2010 |
20110182295 | AUTOMATICALLY IDENTIFYING AN EDGE-FACING ROUTER - Techniques for automatically identifying an edge-facing router in a network are provided. | 07-28-2011 |
20120151085 | Hot Standby Neighbor Discovery Protocol for Internet Protocol Version 6 - Techniques are provided herein for receiving synchronization messages at a second network device that is in a hot standby configuration from a first network device that is maintaining Internet Protocol version 6 (IPv6) state machines for one or more neighbor devices. The synchronization messages are configured to indicate an IPv6 state for each state machine maintained in the first network device. An IPv6 state for corresponding state machines is updated in the second network device based on the synchronization messages such that the IPv6 states in the second network device allows the second network device to actively process IPv6 traffic for the one or more neighbor devices upon traffic switchover from the first network device to the second network device without restarting the corresponding IPv6 state machine associated with each of the one or more neighbor devices in the second network device. The roles of the first and second device with respect to active and standby state are reversed after a switchover. | 06-14-2012 |
20140044012 | AUTOMATICALLY IDENTIFYING AN EDGE-FACING ROUTER - Techniques for automatically identifying an edge-facing router in a network are provided. In one technique, a DHCP message is obtained at a router of a subscriber network. An options field of the DHCP message is identified. The options field of the DHCP message is analyzed to determine whether data in the options field indicates that first router is SP-facing. If it is determined that the router is an SP-facing router, then identification data that identifies the router as an SP-facing router is stored. | 02-13-2014 |
20140215091 | RECOVERING LOST DEVICE INFORMATION IN CABLE NETWORKS - In one embodiment, methods are described for recovering lost customer premises equipment (CPE) information on a cable modem termination system (CMTS) in the presence of only Dynamic Host Control Protocol Version 6 (DHCPv6) CONFIRM. A CMTS purges routing information for an Internet Protocol Version 6 (IPv6) node, such as a CPE router, in response to detecting an interface reset for the IPv6 node. IPv6 addresses and prefixes information for the IPv6 node is gleaned from a DHCPv6 CONFIRM message received from the IPv6 node. By sending portions of the IPv6 addresses and prefixes information within a DHCPv6 LEASEQUERY message, a DHCPv6 CONFIRM message with an embedded DHCPv6 LEASEQUERY message, or a DHCPv6 CONFIRM message with an Interface-ID option, a reply message can be received that contains the purged routing information for the IPv6 node. | 07-31-2014 |
Patent application number | Description | Published |
20100087511 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 04-08-2010 |
20120165394 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 06-28-2012 |
20140066492 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 03-06-2014 |
Patent application number | Description | Published |
20140354650 | ATTRIBUTE-BASED STACKING FOR DIAGRAMS - A system and method for facilitating adjusting a displayed representation of a visualization. An example method includes displaying a first visualization that includes plural nodes; providing a first user option to specify a first node attribute; and stacking nodes of the first visualization based on the first node attribute, resulting in display of one or more stacks of nodes. In a more specific embodiment, one or more links connect one or more of the plural nodes to one or more other nodes of the plural nodes. The method further includes adjusting the first visualization to illustrate the one or more stacks of nodes, while preserving any links, resulting in display of a second visualization in response thereto. The step of adjusting further includes animating a transition between display of the first visualization and display of the second visualization. | 12-04-2014 |
20150029215 | INTERACTIVE INTERSECTION AREAS - A system that generates interactive intersection areas receives a graphic diagram that includes a plurality of intersecting shapes and intersection areas. The system then creates or receives a definition for each of the shapes and determines a number of possible intersection areas for the diagram. The system defines a clipping path for each possible intersection area and defines a mask for each possible intersection area. The system then draws each intersection area using the defined clipping paths and masks | 01-29-2015 |
20150077433 | ALGORITHM FOR IMPROVED ZOOMING IN DATA VISUALIZATION COMPONENTS - Example embodiments reduce the processing required to zoom on graphical data visualizations by transforming only graphic elements visible in the zooming viewport. In one example embodiment, a grid overlays the component image. Prior to zooming, grid elements covered by the zooming viewport are determined and only graphic objects bounded by those grid elements are transformed during zooming. | 03-19-2015 |
20150084961 | MAP PERFORMANCE BY DYNAMICALLY REDUCING MAP DETAIL - Example embodiments dynamically generate lower resolution maps from high precision vector for use on desktops. Lower resolution maps are dynamically generated on the client side by decreasing coordinate and path precision. | 03-26-2015 |
Patent application number | Description | Published |
20110055767 | System and Method for Providing Graphical User Interface Displaying Muiltiple Views - Embodiments of the present invention provide techniques for displaying hierarchy information. In one embodiment, a graphical user interface (“GUI”) is provided that displays hierarchy information, the displayed information comprising multiple nodes and hierarchical relationships between the nodes. Different sets of information may be associated with one or more of the displayed nodes. Techniques are provided to enable a user to individually change the set of information displayed in one or more of the displayed nodes. In this manner, a user is able to change the set and/or category of information displayed for one or more selected nodes. More specifically, different sets and/or categories of information contained in the nodes are displayed based on the view selected by the user. In an embodiment, a user is able to choose which nodes need to change the view levels. There are other features in the graphical interface as well. | 03-03-2011 |
20110055768 | METHOD AND SYSTEM FOR PROVIDING GRAPHICAL USER INTERFACE WITH CONTEXTUAL VIEW - A method and system for providing a graphical user interface with contextual views. In various embodiments, the present invention provides a graphical user interface that allows the changing contents of a global menu in the graphical display based upon the selected nodes that belong to a hierarchical chart. Only those actions applicable (contextual) to the selected nodes will be determined and displayed in the menu. Accordingly, the contents of the selectable options are updated based upon the selected nodes. When more than one node is selected, the displayed selectable actions are an intersection of the actions permitted for each selected node. In a specific embodiment, a comparison menu is provided to allow the user to be able to compare unique corresponding properties of selected nodes. | 03-03-2011 |
20110055771 | METHOD AND SYSTEM FOR PROVIDING USER INTERFACE REPRESENTING ORGANIZATION HIERARCHY - Method and system for providing graphical user interface for displaying hierarchical charts. According to various embodiments, the present invention provides a graphical user interface where relational data are displayed as one or more hierarchical charts. A hierarchical chart includes a plurality of nodes that are organized according to the hierarchical chart. Each of the nodes is associated with a data record that contains multiple level of information. At different view level, different amount of information for the nodes are displayed. A view control function is provided for the graphical user interface. If none (or all) of the nodes are selected, each nodes display the same level of information based associated with a particular view level. If only few of the nodes are selected, only the selected nodes responds changes in view level when being displayed. | 03-03-2011 |
20120174040 | METHOD AND SYSTEM FOR PROVIDING USER INTERFACE REPRESENTING ORGANIZATION HIERARCHY - Method and system for providing graphical user interface for displaying hierarchical charts. According to various embodiments, the present invention provides a graphical user interface where relational data are displayed as one or more hierarchical charts. A hierarchical chart includes a plurality of nodes that are organized according to the hierarchical chart. Each of the nodes is associated with a data record that contains multiple level of information. At different view level, different amount of information for the nodes are displayed. A view control function is provided for the graphical user interface. If none (or all) of the nodes are selected, each nodes display the same level of information based associated with a particular view level. If only few of the nodes are selected, only the selected nodes responds changes in view level when being displayed. | 07-05-2012 |
20120198351 | Automatically Testing a Web Application That Has Independent Display Trees - An automatic testing application is provided that can simulate a user interaction with a web application. The automatic testing application can determine that the web application has been completely displayed within a graphical user interface of a web browser using a consistent global page state. The automatic testing application can test that the web application has been correctly displayed by verifying a state of a visualization component of the web application using a communication component. Subsequently, the automatic testing application can transmit an event to the web application that can modify the state of the visualization component using the communication component. Once the automatic testing application has determined that the web application has been completely re-displayed, using the consistent global page state, the automatic testing application can test that the web application has been correctly re-displayed by verifying a modified state of the visualization component using the communication component. | 08-02-2012 |
20120198374 | DRAG AND DROP INTERACTION BETWEEN COMPONENTS OF A WEB APPLICATION - A user of a web application can perform a drag and drop operation from a first component of the web application to a second component of the web application. The drag and drop operation can include three actions. The first action can be initializing a drag of an object within a first component of a web application. The second action can be dragging the object from within the first component over a drop target located within a second component of the web application. The third action can be dropping the object onto the drop target located within the second component of the web application. One of the first and second components can be a web component, and the other component can be a visualization component. The first and second components of the web application can communicate with each other using a communication component of the web application. | 08-02-2012 |
20120293516 | KEYBOARD NAVIGATION AMONG VISUAL ELEMENTS IN A USER INTERFACE - A system navigates among visual elements of a user interface. The system receives a keystroke indicating navigating from a current visual element in a first direction, determines a next visual element that is substantially near the current visual element and in the first direction, and navigates to the next visual element. | 11-22-2012 |
20120297327 | INTERACTIVE CUSTOM REGIONS - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include receiving a selection of built-in interactive regions provided by a visualization component, aggregating the selected set of regions, and creating one or more custom regions from the aggregation of the selected set of regions. | 11-22-2012 |
20120311497 | System for business portfolio modeling and analysis - A system and method for facilitating integrating enterprise data from multiple sources for display via in a common interface. An example method includes displaying, via a first user interface display screen, a first set of one or more personnel icons representative of one or more enterprise personnel, and providing a first user option to select one or more of the personnel icons. A second user interface display screen may be displayed in response to or after selection of one or more of the personnel icons. The second user interface display screen presents a first type of data. The second user interface display screen further provides a second user option to select one or more user interface features associated with the first type of data, and to then trigger display of a third user interface display screen. The third user interface display presents a second type of data that is associated with the first type of data. | 12-06-2012 |
20130038628 | AUTOMATED BOUNDING BOX GENERATION WITHIN THE BOUNDARIES OF ARBITRARY SHAPES - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include sampling a plurality of points that lie within the interior of an arbitrary shape, drawing one or more rectangles from each of the points, gradually increasing the length and width of the rectangles until the rectangles no longer falls within the interior of the arbitrary shape, and assigning the largest of the increased rectangles as the interior bounding box. | 02-14-2013 |
20130083056 | INTERACTIVE DISPLAY ELEMENTS IN A VISUALIZATION COMPONENT - One embodiment is directed to a computer program, embodied on a computer readable medium. The computer program is configured to control a processor to execute instructions. The instructions include receiving one or more files as input. The files may each include descriptions of different shapes. The instructions may further include interpreting each of the files as a layer of shapes, converting each of the shapes into an interactive element, layering the converted shapes onto one another to create a custom interactive display, and displaying the custom interactive display. | 04-04-2013 |
20130147834 | MAGNIFYING TOOL FOR VIEWING AND INTERACTING WITH DATA VISUALIZATION ON MOBILE DEVICES - In accordance with various embodiments, a magnifying tool is provided in a user interface for magnifying content displayed on a mobile device and any other device with a restricted or limited viewing screen. A mobile device, including a magnifying tool for magnifying content displayed on the mobile device, can comprise a computer readable storage medium and processor. The mobile device can include a touchscreen operable to receive input from a user and display content. When the mobile device receives a selection of a location on the touchscreen, the mobile device determines a position of the location on the screen, determines a portion of the screen to magnify, and magnifies the portion of the screen and overlays the magnified portion on the screen. | 06-13-2013 |
20130187923 | LEGEND INDICATOR FOR SELECTING AN ACTIVE GRAPH SERIES - Various arrangements for identifying and selected a data value of a dataset presented on a graph are described. The graph may be presented, wherein the graph illustrates a plurality of datasets and a legend that identifies each of the plurality of datasets. A selection of the dataset may be received via the legend of the graph. An input of a point on the graph may be received. A value of a data point from the dataset that corresponds to the input of the point on the graph may be presented. | 07-25-2013 |
20130187948 | 2D LINE DATA CURSOR - Various arrangements for displaying a value of a data point on a graph are presented. The graph that illustrates a plurality of datasets may be presented. Input may be received from a user that indicates a point on the graph. Along a line parallel to an axis that extends through the point on the graph indicated by the user input, a dataset from the plurality of datasets may be identified. The value for the data point of the dataset that corresponds to an intersection of the line parallel to the axis and the visual representation of the dataset may be determined. The value for the data point may be displayed. | 07-25-2013 |
Patent application number | Description | Published |
20090274713 | CROSS-LINKERS AND THEIR USES - Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same. | 11-05-2009 |
20100129314 | POTENT CONJUGATES AND HYDROPHILIC LINKERS - Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided. | 05-27-2010 |
20110003969 | CONJUGATION METHODS - This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues | 01-06-2011 |
20120226026 | POTENT CONJUGATES AND HYDROPHILIC LINKERS - Linkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment. A method for preparing maytansinoids bearing a thioether moiety and a reactive group which allows the maytansinoid to be linked to a cell-binding agent in essentially a single step is also provided. | 09-06-2012 |
20120238731 | METHODS OF PREPARATION OF CONJUGATES - The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents. | 09-20-2012 |
20130011419 | CROSS-LINKERS AND THEIR USES - Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same. | 01-10-2013 |
20140023662 | NON-ANTAGONISTIC EGFR-BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF - Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided. | 01-23-2014 |
20140178416 | CROSS-LINKERS AND THEIR USES - Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same. | 06-26-2014 |
20140179906 | CONJUGATION METHODS - This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues | 06-26-2014 |
Patent application number | Description | Published |
20090155165 | ANTI-IGF-I RECEPTOR ANTIBODY - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I and are substantially devoid of agonist activity toward the insulin-like growth factor-I receptor. These molecules can be conjugated to cytotoxic agents for use in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer. These molecules can also be labeled for in vitro and in vivo diagnostic uses, such as in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor. | 06-18-2009 |
20090162284 | ANTI-IGF-I RECEPTOR ANTIBODY - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I and are substantially devoid of agonist activity toward the insulin-like growth factor-I receptor. These molecules can be conjugated to cytotoxic agents for use in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer. These molecules can also be labeled for in vitro and in vivo diagnostic uses, such as in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor. | 06-25-2009 |
20100260678 | ANTI-IGF-I RECEPTOR ANTIBODIES - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I and are substantially devoid of agonist activity toward the insulin-like growth factor-I receptor. These molecules can be conjugated to cytotoxic agents for use in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma, prostate cancer and pancreatic cancer. These molecules can also be labeled for in vitro and in vivo diagnostic uses, such as in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor. | 10-14-2010 |
20130295050 | ANTI-IGF-I RECEPTOR ANTIBODIES, DNAS, VECTORS, HOST CELLS AND GENETIC CONSTRUCTS - DNAs, vectors, host cells and genetic constructs of antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these molecules with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I and are substantially devoid of agonist activity toward the insulin-like growth factor-I receptor. These molecules can be conjugated to cytotoxic agents for use in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer. These molecules can also be labeled for in vitro and in vivo diagnostic uses, such as in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor. | 11-07-2013 |
Patent application number | Description | Published |
20100087511 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 04-08-2010 |
20120165394 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 06-28-2012 |
20140066492 | SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES - The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the SMN2 ISS-N1 site in the SMN2 pre-mRNA, thereby modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript. The ISS-N1 blocking agents of the invention cause elevated expression of SMN protein, thus compensating for the loss of SMN protein expression commonly observed in subjects with spinal muscular atrophy (SMA). | 03-06-2014 |
Patent application number | Description | Published |
20120066331 | SYSTEMS AND METHODS FOR ORGANIZING CONTENT FOR MOBILE MEDIA SERVICES - In embodiments of the present invention, systems and methods for organizing content for media services may comprise organizing content from a plurality of data sources having information relevant to a channel, transforming the content into short messages suitable for delivery to a user via at least two of SMS, MMS, WAP, e-mail, and the Internet, and managing a script of such messages, wherein the next short message in a series is based on a user response to a prior short message in the series. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 03-15-2012 |
20150094044 | SYSTEMS AND METHODS FOR ORGANIZING CONTENT FOR MOBILE MEDIA SERVICES - In embodiments of the present invention, systems and methods for organizing content for media services may comprise organizing content from a plurality of data sources having information relevant to a channel, transforming the content into short messages suitable for delivery to a user via at least two of SMS, MMS, WAP, e-mail, and the Internet, and managing a script of such messages, wherein the next short message in a series is based on a user response to a prior short message in the series. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 04-02-2015 |
Patent application number | Description | Published |
20080248788 | SYSTEMS AND METHODS FOR MULTI-MODAL MOBILE MEDIA SERVICES - In embodiments of the present invention, systems and methods for a method for multi-modal mobile media services may comprise delivering a message comprising content to a user handset, associating an offer for related content with the message, associating at least one request for response with the offer, wherein the request for response is associated with a mode for accessing the related content, and transmitting the related content via the mode indicated by the response. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 10-09-2008 |
20080248819 | SYSTEMS AND METHODS FOR MOBILE MEDIA SERVICES UTILIZING A SHORT FORM COMMAND STRUCTURE - In embodiments of the present invention, systems and methods for media services may comprise transmitting a message comprising content to a handset, soliciting a response message, wherein the solicitation indicates a short form command structure for the response, receiving a response from the handset comprising a short form command, and processing the response using the short form command. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 10-09-2008 |
20080250035 | SYSTEMS AND METHODS FOR ORGANIZING CONTENT FOR MOBILE MEDIA SERVICES - In embodiments of the present invention, systems and methods for organizing content for media services may comprise organizing content from a plurality of data sources having information relevant to a channel, transforming the content into short messages suitable for delivery to a user via at least two of SMS, MMS, WAP, e-mail, and the Internet, and managing a script of such messages, wherein the next short message in a series is based on a user response to a prior short message in the series. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 10-09-2008 |
20120270527 | SYSTEMS AND METHODS FOR MOBILE MEDIA SERVICES UTILIZING A SHORT FORM COMMAND STRUCTURE - In embodiments of the present invention, systems and methods for mobile media services media services may comprise content delivery via a mobile platform. User engagement may be facilitated by developing locally produced, personalized channels for delivery of relevant content. The mobile platform may enable building mobile-oriented communities around original content. Content may be local, authentic, relevant, insider, original, aggregated, a multi-modal mash-up, and the like. | 10-25-2012 |
Patent application number | Description | Published |
20120011084 | SEMANTIC ENTITY MANIPULATION USING INPUT-OUTPUT EXAMPLES - Semantic entity manipulation technique embodiments are presented that generate a probabilistic program capable of manipulating character strings representing semantic entities based on input-output examples. The program can then be used to produce a desired output consistent with the input-output examples from inputs of a type included in the examples. The probabilistic program is generated based on the output of parsing, transform and formatting modules. The parsing module employs a probabilistic approach to parsing the input-output examples. The transform module identifies a weighted set of transforms that are capable of producing the output item from the input items of an input-output example to a likelihood specified by their assigned weight. The formatting module generates formatting instructions that transform selected output parts into a form specified by the output items in the input-output examples. | 01-12-2012 |
20120192051 | FORMATTING DATA BY EXAMPLE - Data formatting rules to convert data from one form to another form are automatically determined based on a user's edits. A machine learning heuristic is applied to a user's edits to determine a data formatting rule that may be applied to data. For example, a user may make edits that add/remove characters from data, concatenate data, extract data, rename data, and the like. The machine learning heuristic may be automatically triggered in response to an event (e.g. after a predetermined number of edits are made to a same type of data) or manually triggered (e.g. selecting a user interface option). The data formatting rule may be applied to other data and the results of the formatting reviewable by the user. Based on further edits/reviews, the data formatting rule may be updated. The data formatting rules may be stored for later use. | 07-26-2012 |
20130144902 | INDUCTIVE SYNTHESIS OF TABLE-BASED STRING TRANSFORMATIONS - Inductive synthesis and combination framework technique embodiments are presented that generally perform string transformations involving lookup operations in one or more relational tables, either alone or in combination with other non-lookup operations. More particularly, a semantic string lookup transformation language is presented, which can be used to generate an inductive synthesis procedure that synthesizes a set of transformations involving lookup operations that are consistent with the given set of input-output examples. In addition, a combination framework for combining the lookup transformation language and its synthesis procedure, with other transformation languages and their associated synthesis procedures, is presented. The resulting combined synthesis procedures enable the combination framework to synthesize transformations on a rich variety of data-types. | 06-06-2013 |
20130326475 | EXPEDITED TECHNIQUES FOR GENERATING STRING MANIPULATION PROGRAMS - A program creation system is described which generates sets of subprograms for respective input-output examples. The program creation system then groups the sets into partitions by performing an intersection operation. According to one aspect, the program creation system generates subprograms so as to exclude tokens that are not represented by the input strings of the input-output examples. According to another aspect, the program creation system first generates the subprograms without attempting to generate loop-type expressions. If this operation produces unsatisfactory results, the program creation system repeats its processing, this time including loop-type expressions. According to another aspect, the program creation system performs the grouping operation using an expedited graph-intersection operation. According to another aspect, the program creation system ranks programs (which are created based on the results of the grouping operation) based on the presence of preferred features found in the programs. | 12-05-2013 |
20140108305 | RANKING FOR INDUCTIVE SYNTHESIS OF STRING TRANSFORMATIONS - Ranking technique embodiments are presented that use statistical and machine learning techniques to learn the desired ranking function for use in inductive program synthesis for the domain of string transformations. This generally involves automatically creating a training dataset of positive and negative examples from a given set of training tasks, each including multiple input-output examples. From the training dataset, a ranking function is learned that assigns an expression in a program in the domain specific language to a likelihood measure. This ranking function is then used to compute likelihoods of learnt programs from a very small number of input-output examples for a new task. | 04-17-2014 |
Patent application number | Description | Published |
20090326384 | Device With Integrated Multi-Fiber Optical Probe and Methods of Use - Biopsy instruments are integrated with a multi-fiber optical probe adapted to perform diagnostic measurements. In addition to being able to analyze, treat or remove tissue, such integrated devices characterize tissue by measuring the amount of scattering and absorption of light transmitted into the tissue. Each fiberoptic probe has an illuminating fiber that provides a broadband light source for transmission into tissue, and a collecting fiber that collects the light scattered by the tissue and transmits the collected light to a spectrometer. One embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a multi-fiber optical probe which is conveyed through a hollow central channel. Another embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a plurality of multi-fiber optical probes. Yet another embodiment is an endoscopic polypectomy-type snare catheter with a multi-fiber optical probe located at the tip. | 12-31-2009 |
20100203521 | METHOD FOR BACTERIAL LYSIS - The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes. The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria. In some embodiments, the microfluidic devices of the present invention can also optionally comprise other modules enabling further processing of the biological sample, for example isolation, purification and detection of biomolecules released from the lysed cells, such as but not limited to nucleic acids or proteins or peptides from the lysed cells, providing a complete Lab-on-a-Chip analysis system for biomolecules released from difficult to lyse microorganisms in a single step or process. The microfluidic devices of the present invention can also be adapted and are useful to methods to enrich for microorganisms in a biological sample, for example enrich for a desired type of bacteria within a biological sample. The microfluidic devices and methods of the present invention can be adapted to perform highly efficient lysis of microorganisms within a biological sample for diagnostic tests, for example for diagnosis of infectious agents and pathogens, such as bacteria, viruses or parasites. | 08-12-2010 |
20110060188 | LOW COST DISPOSABLE MEDICAL FORCEPS TO ENABLE A HOLLOW CENTRAL CHANNEL FOR VARIOUS FUNCTIONALITIES - The present invention relates to an endoscopic biopsy forceps ( | 03-10-2011 |
Patent application number | Description | Published |
20090149549 | PREPARATION OF CHIRAL AMIDES AND AMINES - This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure. | 06-11-2009 |
20120095106 | PREPARATION OF CHIRAL AMIDES AND AMINES - This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure. | 04-19-2012 |
20140057990 | PREPARATION OF CHIRAL AMIDES AND AMINES - This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure. | 02-27-2014 |
Patent application number | Description | Published |
20080293726 | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders - One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders. | 11-27-2008 |
20120123164 | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders - One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders. | 05-17-2012 |
20130065904 | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders - One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders. | 03-14-2013 |
20130116332 | FORMULATIONS, SALTS AND POLYMORPHS OF TRANSNORSERTRALINE AND USES THEREOF - Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression. | 05-09-2013 |
20140315910 | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders - One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders. | 10-23-2014 |
Patent application number | Description | Published |
20110249905 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA FROM ELECTRONIC DOCUMENTS INCLUDING TABLES - A method of automatically extracting data from an electronic document including tables is provided. The method includes: automatically identifying rows of the table using gaps in horizontal projections of the plurality of image sections, wherein at least some of the identified rows in close proximity are collected to form table formations; and automatically identifying columns of the table using at least some of the plurality of image sections that are vertically aligned, wherein the identified columns are grown in each of the table formations using gaps in vertical projections of the plurality of image sections until an obstruction is reached. The method further includes automatically identifying labels in the plurality of corresponding image sections to associate the identified labels with at least one of the identified columns and the identified rows; and automatically extracting data from cells of the table formed by the identified rows and columns. | 10-13-2011 |
20110255782 | SYSTEMS AND METHODS FOR AUTOMATICALLY PROCESSING ELECTRONIC DOCUMENTS USING MULTIPLE IMAGE TRANSFORMATION ALGORITHMS - In a document analysis system that receives and processes jobs from a plurality of users, in which each job may contain multiple electronic documents, to extract data from the electronic documents, a method of automatically pre-processing each received electronic document using a plurality of image transformation algorithms to improve subsequent data extraction from said document is provided. The method includes: electronically partitioning each received electronic document page into pieces; automatically processing each piece of the received electronic document page using each of a plurality of image pre-processing algorithms to produce a plurality of image variations of each piece; and analyzing the outputs of subsequent processing and data extraction, on each of the image variations of the pieces to determine which output is best, from the plurality of outputs for each piece. | 10-20-2011 |
20110255784 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA FROM ELETRONIC DOCUMENTS USING MULTIPLE CHARACTER RECOGNITION ENGINES - In a document analysis system that receives and processes jobs from a plurality of users, in which each job may contain multiple electronic documents, to extract data from the electronic documents, a method of automatically extracting data from each received electronic document using a plurality of character recognition engines is provided. The method includes: automatically processing each received electronic document page using each of a plurality of recognition engines to extract data; comparing quality of data extracted from each of the recognition engines to assign a confidence score to the extracted data; and selecting extracted data having highest confidence score as the correct extracted data. | 10-20-2011 |
20110255789 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA FROM ELECTRONIC DOCUMENTS CONTAINING MULTIPLE LAYOUT FEATURES - A method of automatically extracting data from an electronic document containing a plurality of layout features through progressive refinement is provided. The method includes: analyzing each document to automatically extract images and text features wherein each document includes at least two features that are related to each other, and wherein said analyzing compares extracted features with a first search space of candidate features to try and recognize the extracted features; if one of the at least two related features is not recognized and at least one feature is recognized, selecting a second search space of candidate features in response thereto and in response to predefined rules about the relationship between the two features; and comparing the unrecognized feature with said selected second search space. | 10-20-2011 |
20110255794 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA BY NARROWING DATA SEARCH SCOPE USING CONTOUR MATCHING - A method of extracting data by narrowing a scope of data search using contour matching of select elements in a document is provided. The method includes: analyzing each document to automatically extract images and text features wherein said analyzing compares extracted features with a first search space of candidate features to try and recognize the extracted features; automatically processing each unrecognized feature using a contour recognition engine to generate a contour of the unrecognized feature; automatically selecting a second search space of candidate features through contour matching using the contour of the unrecognized feature, wherein the second search space of candidate features is narrower than the first search space of candidate features; and comparing the unrecognized feature with said second search space to identify the previously unrecognized feature. | 10-20-2011 |
20110258150 | SYSTEMS AND METHODS FOR TRAINING DOCUMENT ANALYSIS SYSTEM FOR AUTOMATICALLY EXTRACTING DATA FROM DOCUMENTS - A method of training a document analysis system to extract data from documents is provided. The method includes: automatically analyzing images and text features extracted from a document to associate the document with a corresponding document category; comparing the extracted text features with a set of text features associated with corresponding category of the document, in which the set of text features includes a set of characters, words, and phrases; if the extracted features are found to consist of the characters, words, and phrases belonging to the set of text features associated with the corresponding document category, storing the extracted text features as the data contained in the corresponding document; and, if the extracted text features are found to include at least one text feature that does not belong to the set of text features associated with the corresponding document category, submitting the unrecognized text features to a training phase. | 10-20-2011 |
20110258182 | SYSTEMS AND METHODS FOR AUTOMATICALLY EXTRACTING DATA FROM ELECTRONIC DOCUMENT PAGE INCLUDING MULTIPLE COPIES OF A FORM - In a document analysis system that receives and processes jobs from a plurality of users, in which each job may contain multiple electronic documents, to extract data from the electronic documents, a method of extracting data from a received electronic document page that includes multiple copies of a form is provided. The method comprising: automatically processing a received electronic document page that includes multiple copies of a form to group the multiple copies into corresponding number of records; automatically extracting data from each of the multiple copies of the form and saving the extracted data into the corresponding record; automatically comparing the extracted data in the records to determine which copy of the extracted data to select; if all extracted data instances are identical, assigning a high confidence score to the extracted data; and, if all extracted data instances are not identical, flagging the extracted data for a further processing. | 10-20-2011 |
20110258195 | Systems and methods for automatically reducing data search space and improving data extraction accuracy using known constraints in a layout of extracted data elements - A method of automatically narrowing data search space and improving accuracy of data extraction using known constraints in a layout of extracted data elements for classified documented is provided. The method includes: analyzing each document to classify it within a document category, each category having a corresponding set of expected layouts; analyzing each electronic document to automatically extract images and text features; automatically constructing a data structure including a layout of the extracted features and layout relationships amongst the extracted features, wherein each of the extracted features in the layout maintains a reference to neighboring features and wherein closely related features are merged to form a combined feature; automatically narrowing data search space by detecting and removing parts of the layout that are not associated with any data elements using the data structure; and automatically detecting data using the extracted feature layout and the layout relationships amongst the extracted features. | 10-20-2011 |