Singh, CT
Ajaib Singh, Shelton, CT US
Patent application number | Description | Published |
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20090076239 | HIGH PERFORMANCE POLYURETHANE ELASTOMERS FROM MDI PREPOLYMERS WITH REDUCED CONTENT OF FREE MDI MONOMER - Polyurethane prepolymers having a reduced amount of unreacted monomeric diisocyanate, particularly diphenylmethane diisocyanate (MDI), prepared by distilling the prepolymer reaction product in the presence of at least one inert solvent whose boiling point is slightly below that of the monomeric diisocyanate; and to high performance cast polyurethane elastomers from the thus obtained prepolymers using diamine and/or diol chain extenders. | 03-19-2009 |
Bhupindar Singh, West Hartford, CT US
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20150097580 | TIP CLEARANCE MEASUREMENT SYSTEM - A tip clearance measurement system (TCMS) includes a probe and sensing circuitry. The probe directs microwave signals toward a turbine blade and receives microwave signals reflected by the turbine blade. The sensing circuitry includes a switch having a first state in which a main frequency is provided at an output of the switch and a second state in which a reference frequency is provided at an output of the switch. The sensing circuitry further includes a first conditioning circuit that receives a frequency provided at the output of the switch and provides a conditioned frequency to the probe and a second conditioning circuit that receives both the conditioned frequency provided by the first conditioning circuit and a reflected frequency received by the probe, and provides a conditioned output based on the conditioned frequency and reflected frequency. | 04-09-2015 |
Harjit Singh, Woodbridge, CT US
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20090162489 | EFFERVESCENT TABLET FOR USE AS AN ADDITIVE IN HOT COFFEE OR HOT WATER AND METHOD OF MAKING SAME - An effervescent tablet for direct use as an additive in hot coffee or hot water includes one or more creamer additives, pH stabilizing agents, effervescence agents, and solubility agents. In one embodiment, the tablet includes dry coffee and, in another embodiment, the tablet excludes it. The creamer additive(s) may be dairy and/or non-dairy. The effervescence agent(s) includes sufficient effervescence to separate the tablet upon placement of the tablet in the hot coffee or water and, in one embodiment, to further create foam on the surface of the coffee so as to yield an instant frothy latte or cappuccino. The pH stabilizing agent(s) stabilizes a pH of the coffee and the solubility agent(s) facilitates expeditious dissolution of the tablet in the coffee or water. Various other ingredients and agents may be included in the tablet to enhance flavor, improve mouth feel, enhance foam production, or achieve other desired characteristics or results. | 06-25-2009 |
20100021613 | Powdered Dairy Additive and Mixture Designed for Use in a Vending Machine and Vended Consumable Beverage Made Therewith - A soluble, dairy additive designed specifically for use in a vending machine that produces consumable beverages includes or consists of agglomerated dry milk powder formulated specifically for use in the vending machine. The agglomerated dry milk powder consists of dairy ingredients only (e.g., dried milk) and has a scorched particle mass not greater than fifteen milligrams and a particle bulk density in the range of 0.25 g/cc to 0.34 g/cc. The powder may be combined with coffee and/or other ingredients, either prior to being placed in the vending machine or upon demand within the vending machine, to vend a consumable beverage from the vending machine. Accordingly, the agglomerated dry milk powder may be pre-mixed with one or more independent flavoring ingredients, such as coffee, sugar, or cocoa powder, to provide a mixture formulated specifically for use in the vending machine. | 01-28-2010 |
20120082769 | EFFERVESCENT TABLET FOR USE AS AN ADDITIVE IN HOT COFFEE OR HOT WATER AND METHOD OF MAKING SAME - An effervescent tablet for direct use as an additive in hot coffee or hot water includes one or more creamer additives, pH stabilizing agents, effervescence agents, and solubility agents. In one embodiment, the tablet includes dry coffee and, in another embodiment, the tablet excludes it. The creamer additive(s) may be dairy and/or non-dairy. The effervescence agent(s) includes sufficient effervescence to separate the tablet upon placement of the tablet in the hot coffee or water and, in one embodiment, to further create foam on the surface of the coffee so as to yield an instant frothy latte or cappuccino. The pH stabilizing agent(s) stabilizes a pH of the coffee and the solubility agent(s) facilitates expeditious dissolution of the tablet in the coffee or water. Various other ingredients and agents may be included in the tablet to enhance flavor, improve mouth feel, enhance foam production, or achieve other desired characteristics or results. | 04-05-2012 |
Jai R. Singh, Shelton, CT US
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20090011211 | Metal matrix composite bodies, and methods for making same - A metal matrix composite (MMC) material that is castable, or can be rendered castable, is melted and cast into a mold or crucible, and at least a portion of the plurality of reinforcement bodies is permitted to at least partially settle out of their suspension in the molten matrix metal. The casting is solidified, and the sparsely loaded supernatant is separated from the zone of the casting containing the sediment—either by cutting, sawing, etc., or by decanting the supernatant when the casting was still in a molten condition. In a preferred embodiment, during the settling and/or the solidification process, mechanical energy, such as in the form of oscillations, is applied to the MMC melt. The applied energy permits the reinforcement bodies to nestle and pack more efficiently, thereby increasing their volumetric loading in the cast composite. | 01-08-2009 |
Manpreet Singh, Ellington, CT US
Patent application number | Description | Published |
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20110033032 | DETECTING FALSE ANSWER SUPERVISION - A method and corresponding apparatus are provided to detect false answer supervision by determining false answer supervision as either as a function of a number of completed calls of short duration or as a function of a distribution of differences between timestamps of alert signals and timestamps of connect signals used to complete calls, detecting false answer supervision based on the indicator of false answer supervision determined by either functions separately or in combination, and affecting a decision in response to the detecting. | 02-10-2011 |
20120140903 | DETECTING FALSE ANSWER SUPERVISION - A method and corresponding apparatus are provided to detect false answer supervision by determining false answer supervision as either as a function of a number of completed calls of short duration or as a function of a distribution of differences between timestamps of alert signals and timestamps of connect signals used to complete calls, detecting false answer supervision based on the indicator of false answer supervision determined by either functions separately or in combination, and affecting a decision in response to the detecting. | 06-07-2012 |
20140269681 | Method And System For Call Routing - In an embodiment, a method and corresponding apparatus of managing call routing includes sending a first message by a session border controller (SBC) to a routing engine, the first message including event information indicative of an event related to a call, the event being associated with a second message received by the SBC; receiving a response message including call managing information related to the call, the call managing information being determined based on at least part of the event information, the call managing information to be returned to the routing engine in a subsequent message related to the call; and maintaining the call managing information received in the response message, the call managing information to be returned to the routing engine in a subsequent message related to the call. | 09-18-2014 |
Moninder Singh, Middletown, CT US
Patent application number | Description | Published |
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20080307491 | SECURE SYSTEM AND METHOD FOR ENFORCEMENT OF PRIVACY POLICY AND PROTECTION OF CONFIDENTIALITY - The invention includes various systems, architectures, frameworks and methodologies that can securely enforce a privacy policy. A method is included for securely guaranteeing a privacy policy between two enterprises, comprising: creating a message at a first enterprise, wherein the message includes a request for data concerning a third party and a privacy policy of the first enterprise; signing and certifying the message that the first enterprise has a tamper-proof system with a privacy rules engine and that the privacy policy of the first entity will be enforced by the privacy rules engine of the first enterprise; sending the message to a second enterprise; and running a privacy rules engine at the second enterprise to compare the privacy policy of the first enterprise with a set of privacy rules for the third party. | 12-11-2008 |
20090006870 | METHOD, SYSTEM, AND APPARATUS FOR DYNAMIC DATA-DRIVEN PRIVACY POLICY PROTECTION AND DATA SHARING - A method of sharing telematics data for a vehicle with service providers can include receiving the telematics data for the vehicle, where the telematics data dynamically changes over time, and comparing the telematics data with a privacy policy associated with the vehicle. The privacy policy can specify rules for selectively releasing items of the telematics data to one or more service providers. Data items of the telematics data can be selectively provided to the service providers according to the comparing step. | 01-01-2009 |
20090055342 | METHOD AND KNOWLEDGE STRUCTURES FOR REASONING ABOUT CONCEPTS, RELATIONS, AND RULES - A system and method for reasoning about concepts, relations and rules having a semantic network comprising at least one node from a predetermined set of node types, at least one link from a predetermined set of link types, and zero or more rules from a predetermined set of rule types, a subset of the rule types being matching rule types, each node and each link being associated with a set of zero or more rules; a network reasoning data structure having a reasoning type database having at least one regular expression, each of the regular expressions being a class of sequences having at least three node types and two link types, wherein the network reasoning data structure further has a context being a set of rules; and a reasoning engine having an activator for activating one or more activated paths in the semantic network, the set of activated paths having a common starting node in the semantic network, wherein the reasoning engine further has a validator for selecting a subset of the activated paths being valid paths, each rule from the set of rule matching types that is associated with one or more path elements on each valid path being matched by one or more rules in the context and wherein the reasoning engine further has a legal inferencer for selecting a subset of the set of valid paths being legal and valid paths, the legal and valid paths matching at least one of the regular expressions. | 02-26-2009 |
20130124420 | SECURE SYSTEM AND METHOD FOR ENFORCEMENT OF PRIVACY POLICY AND PROTECTION OF CONFIDENTIALITY - The invention includes various systems, architectures, frameworks and methodologies that can securely enforce a privacy policy. A method is included for securely guaranteeing a privacy policy between two enterprises, comprising: creating a message at a first enterprise, wherein the message includes a request for data concerning a third party and a privacy policy of the first enterprise; signing and certifying the message that the first enterprise has a tamper-proof system with a privacy rules engine and that the privacy policy of the first entity will be enforced by the privacy rules engine of the first enterprise; sending the message to a second enterprise; and running a privacy rules engine at the second enterprise to compare the privacy policy of the first enterprise with a set of privacy rules for the third party. | 05-16-2013 |
Moninder Singh, Farmington, CT US
Patent application number | Description | Published |
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20080215511 | SYSTEM AND METHOD FOR AUTOMATED PART-NUMBER MAPPING - Automated mapping of part numbers associated with parts in a bill of materials (BOM) submitted by a BOM originator to internal part numbers assigned to those parts by a BOM receiver is performed by one or more computers connected to one or more networks through one or more network interfaces. A first receive component receives one or more data sets containing historical data on bills of materials received in the past by the BOM receiver. A second receive component receives one or more data sets containing known mappings between internal part numbers used by the BOM receiver, and part numbers used by various BOM originators. A third receive component receives one or more data sets containing information of various parameters and their values describing the parts to which the BOM receiver has assigned internal part numbers. A fourth receive component receives one or more methods of automatically learning models for predicting internal part numbers from the above mentioned historical BOM data, mapping data and part parametric data. A learning component learns the models from the data. A fifth receive component receives a BOM from a requesting process. The BOM has one or more parts with a missing internal part number. A mapping component applies the learned models to the received BOM to automatically determine internal part numbers for all unmapped BOM originator part numbers. A release process assigns internal part numbers to all unmapped parts in the BOM and releases the BOM to the requesting process. | 09-04-2008 |
20100145961 | System and method for adaptive categorization for use with dynamic taxonomies - A system, method and computer program product provides a solution to a class of categorization problems using a semi-supervised clustering approach, the method employing performing a Soft Seeded k-means algorithm, which makes effective use of the side information provided by seeds with a wide range of confidence levels, even when they do not provide complete coverage of the pre-defined categories. The semi-supervised clustering is achieved through the introductions of a seed re-assignment penalty measure and model selection measure. | 06-10-2010 |
Prabhakar Singh, Storrs, CT US
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20130287663 | SYSTEM, SORBENTS, AND PROCESSES FOR CAPTURE AND RELEASE OF CO2 - A system, sorbent formulations, methods of preparation, and methods are described that provide selective sorption and release of CO | 10-31-2013 |
Prabhjyot Singh, Stratford, CT US
Patent application number | Description | Published |
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20090312223 | Method of Controlling Structure and Rheology of Low Active Liquid Cleansers by Selecting Perfume Components - The invention relates to method of enhancing viscosity of low active liquid cleanser by adding perfumes individual perfume components or mixtures of components. | 12-17-2009 |
20090312224 | Method of Reducing Viscosity of Concentrated Liquid Cleansers by Selection of Perfume Components - The invention relates to method of reducing viscosity of high active liquid concentrate cleanser by adding perfumes, individual perfume components, or mixtures of components. | 12-17-2009 |
20100009891 | Liquid cleansing compositions comprising microfibrous cellulose suspending polymers - The present invention relates to personal care liquid cleansing compositions comprising bacterially produced microfibrous cellulose (MFC) suspending polymers which have not previously been used in personal care compositions. | 01-14-2010 |
20120009127 | FOAM ENHANCEMENT OF FATTY ACYL GLYCINATE SURFACTANTS - A personal care cleansing composition is provided which includes a C | 01-12-2012 |
20120145171 | PERSONAL CARE IMPLEMENT WITH LOW ACTIVE CLEANSING COMPOSITION - A personal care implement is disclosed having a water insoluble absorbent/adsorbent layer attached to a water insoluble scrubbing layer and a mild, low active, low viscosity cleansing composition contained in the absorbent/adsorbent layer. A sufficient quantity of the composition is transferred on demand to the scrubbing layer by squeezing the implement. The implement produces copious quantities of lather foam and mild cleansing. | 06-14-2012 |
Rajvir Singh, New Haven, CT US
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20100292306 | Compositions And Methods For The Treatment Of Muscular Dystrophy - Compositions and methods for treatment of individuals diagnosed with a dystrophin deficiency are disclosed. In particular, inhibitors of NFκB transactivation and/or inhibitors that suppress p65 expression are used to prevent and/or reverse muscle damage in animals or humans lacking dystrophin. Such compositions and methods are useful in the treatment of individuals with muscular dystrophy. | 11-18-2010 |
Rama N. Singh, Bethel, CT US
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20090171644 | CA RESISTANCE VARIABILITY PREDICTION METHODOLOGY - A methodology for obtaining improved prediction of CA resistance in electronic circuits and, particularly, an improved CA resistance model adapted to capture larger than anticipated “out of spec” regime. In one embodiment, a novel bucketization scheme is implemented that is codified to provide a circuit designer with considerably better design options for handling large CA variability as seen through the design manual. The tools developed for modeling the impact of CA variable resistance phenomena provide developers with a resistance model, such as conventionally known, modified with a new CA model Basis including a novel CA intrinsic resistance model, and, a novel CA layout bucketization model. | 07-02-2009 |
20090204930 | IPHYSICAL DESIGN SYSTEM AND METHOD - A design system for designing complex integrated circuits (ICs), a method of IC design and program product therefor. A layout unit receives a circuit description representing portions in a grid and glyph format. A checking unit checks grid and glyph portions of the design. An elaboration unit generates a target layout from the checked design. A data prep unit prepares the target layout for mask making. A pattern caching unit selectively replaces portions of the design with previously cached results for improved design efficiency. | 08-13-2009 |
20120167029 | PHYSICAL DESIGN SYSTEM AND METHOD - A design system for designing complex integrated circuits (ICs), a method of IC design and program product therefor. A layout unit receives a circuit description representing portions in a grid and glyph format. A checking unit checks grid and glyph portions of the design. An elaboration unit generates a target layout from the checked design. A data prep unit prepares the target layout for mask making. A pattern caching unit selectively replaces portions of the design with previously cached results for improved design efficiency. | 06-28-2012 |
20130185045 | ANALYZING A PATTERNING PROCESS USING A MODEL OF YIELD - Techniques are presented that include accessing results of forward simulations of circuit yield, the results including at least circuit yield results including simulated device shapes. Using the circuit yield results, high-level traits of at least the simulated device shapes are determined. Based on the determined high-level traits and using the circuit yield results, a compact model for predicted yield is constructed, the compact model including a plurality of adjustable parameters, and the constructing the compact model for predicted yield including adjusting the adjustable parameters until at least one first predetermined criterion is met. An optimization problem is constructed including at least the compact model for yield, an objective, and a plurality of constraints. Using the optimization problem, the objective is modified subject to the plurality of constraints until at least one second predetermined criterion is met. | 07-18-2013 |
20130185046 | Analyzing A Patterning Process Using A Model Of Yield - Techniques are presented that include accessing results of forward simulations of circuit yield, the results including at least circuit yield results including simulated device shapes. Using the circuit yield results, high-level traits of at least the simulated device shapes are determined. Based on the determined high-level traits and using the circuit yield results, a compact model for predicted yield is constructed, the compact model including a plurality of adjustable parameters, and the constructing the compact model for predicted yield including adjusting the adjustable parameters until at least one first predetermined criterion is met. An optimization problem is constructed including at least the compact model for yield, an objective, and a plurality of constraints. Using the optimization problem, the objective is modified subject to the plurality of constraints until at least one second predetermined criterion is met. | 07-18-2013 |
Rama Nand Singh, Bethel, CT US
Patent application number | Description | Published |
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20080301624 | SYSTEM AND METHOD FOR EMPLOYING PATTERNING PROCESS STATISTICS FOR GROUND RULES WAIVERS AND OPTIMIZATION - A system and method of employing patterning process statistics to evaluate layouts for intersect area analysis includes applying Optical Proximity Correction (OPC) to the layout, simulating images formed by the mask and applying patterning process variation distributions to influence and determine corrective actions taken to improve and optimize the rules for compliance by the layout. The process variation distributions are mapped to an intersect area distribution by creating a histogram based upon a plurality of processes for an intersect area. The intersect area is analyzed using the histogram to provide ground rule waivers and optimization. | 12-04-2008 |
20090089726 | Layout Quality Gauge for Integrated Circuit Design - A method for layout design includes steps or acts of: receiving a layout for design of an integrated circuit chip; designing mask shapes for the layout; transmitting the mask shapes to a litho simulator for generating wafer shapes; receiving the wafer shapes; calculating electrically equivalent gate lengths for the wafer shapes; analyzing the gate lengths to check for conformity against a threshold value, wherein the threshold value represents a desired value of electrically equivalent gate lengths; placing markers on the layout at those locations where the gate length violates the threshold value; and generating a histogram of gate lengths for comparing layouts for electrically equivalent gate lengths for layout quality. | 04-02-2009 |
20110173577 | Techniques for Pattern Process Tuning and Design Optimization for Maximizing Process-Sensitive Circuit Yields - Techniques for improving circuit design and production are provided. In one aspect, a method for virtual fabrication of a process-sensitive circuit is provided. The method comprises the following steps. Based on a physical layout diagram of the circuit, a virtual representation of the fabricated circuit is obtained that accounts for one or more variations that can occur during a circuit production process. A quality-based metric is used to project a production yield for the virtual representation of the fabricated circuit. The physical layout diagram and/or the production process are modified. The obtaining, using and modifying steps are repeated until a desired projected production yield is attained. | 07-14-2011 |
Ripudaman Singh, Cromwell, CT US
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20150343560 | APPARATUS AND METHOD FOR CONTROLLED LASER HEATING - The invention pertains to an apparatus and method for controlled laser heating of a body. An optical integrating chamber, with an opening adjacent to the surface of the body, has a first and second aperture. A laser source, produces a beam of known power which is directed through the first aperture and the chamber opening onto the surface. A portion of the power of the laser beam is absorbed by the body, thereby heating it locally, and the remaining portion is substantially reflected back into the chamber. A photodetector samples the reflected light accumulated within the chamber through the second aperture, thereby discerning the total power of the reflected light, and enabling the computation of the absorbed power imparted as heat to the body. This computation is performed by a computer or controller, which also serves as a control feedback mechanism, by which the application of the laser is controlled based on the absorbed power imparted to the body during the heating process. Several embodiments are described, useful for a wide range of potential applications in processing and evaluation of organic and inorganic materials and structures. | 12-03-2015 |
Samir Singh, Stamford, CT US
Patent application number | Description | Published |
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20080275798 | Evergreen contract billing & in life contract management system and method - The present invention provides an improved billing and contract management method and a computerized enterprise resource management system for processing and management of rent-producing financial products, such as contracts and leases that are past the initial end term date, and that have not been renegotiated or extended, or, in other words, that have entered the “evergreen” period. Among other things, the method and computerized system of the present invention integrate processing of the “evergreen” contracts with a proprietary generalized ERP software product/solution such as Oracle™ E-Business suite's Lease Management system, and supplement the processing of regular contracts with the “evergreen” contract authoring and booking, processing, validation, billing, accounting, collections, modification and audit trailing of the changes made to the “evergreen” contract terms. | 11-06-2008 |
Sanjaya Singh, Sandy Hook, CT US
Patent application number | Description | Published |
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20080226621 | ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 09-18-2008 |
20090214523 | Novel anti-IL13 antibodies and uses thereof - The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 08-27-2009 |
20100111971 | ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 05-06-2010 |
20110014199 | NOVEL ANTI-IL 13 ANTIBODIES AND USES THEREOF - The present invention relates to anti IL13 antibodies that hind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 01-20-2011 |
20110064725 | HIGH AFFINITY, ANTI-HUMAN IGE ANTIBODIES - The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 03-17-2011 |
20110123528 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 05-26-2011 |
20110165622 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 07-07-2011 |
20110206675 | ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 08-25-2011 |
20110223155 | ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 09-15-2011 |
20110243932 | ANTI-CD40 ANTIBODIES - The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 10-06-2011 |
20120027780 | ANTICOAGULANT ANTIDOTES - The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants. | 02-02-2012 |
20120114644 | ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 05-10-2012 |
20120156203 | NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF - The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 06-21-2012 |
20120164144 | NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF - The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 06-28-2012 |
20120213785 | ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 08-23-2012 |
20120214971 | NOVEL ANTI-IL13 ANTIBODIES AND USES THEREOF - The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 08-23-2012 |
20120230985 | HUMANIZED ANTI-FACTOR D ANTIBODIES AND USES THEREOF - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 09-13-2012 |
20120276123 | ANTICOAGULANT ANTIDOTES - The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants. | 11-01-2012 |
20120282269 | Anti-IL-23 Antibodies - The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 11-08-2012 |
20130011391 | ANTI-PSGL-1 ANTIBODIES AND USES THEREOF - Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein. | 01-10-2013 |
20130084288 | ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 04-04-2013 |
20130144040 | ANTAGONIST ANTI-NOTCH3 ANTIBODIES AND THEIR USE IN THE PREVENTION AND TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 06-06-2013 |
20130171070 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 07-04-2013 |
20130195881 | POTENT, STABLE AND NON-IMMUNOSUPPRESSIVE ANTI-CD4 ANTIBODIES - Novel antibodies and their fragments are disclosed that specifically bind to CD4. Anti-CD4 antibodies are disclosed having amino acid substitutions in the hinge region that prevent intrachain disulfide bond formation resulting in antibody molecules with surprisingly improved bivalent stability. Increased stability facilitates manufacturing and provides increased in vivo stability. Antibodies are also disclosed that have amino acid substitutions that reduce binding to Fc receptor and ADCC activity that also result in a surprising effect on CD4 internalization. In addition, genes for such antibodies are disclosed that have been modified such that they have increased expression over their unmodified counterparts. | 08-01-2013 |
20130209449 | ANTI-PSGL-1 ANTIBODIES AND USES THEREOF - Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein. | 08-15-2013 |
20130224224 | CX3CR1-BINDING POLYPEPTIDES - The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes. | 08-29-2013 |
20130251708 | ANTI-PSGL-1 ANTIBODIES AND USES THEREOF - Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein. | 09-26-2013 |
20130289248 | ANTICOAGULANT ANTIDOTES - The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants. | 10-31-2013 |
20140093889 | ANTI-NOTCH3 AGONIST ANTIBODIES AND THEIR USE IN THE TREATMENT OF NOTCH3-RELATED DISEASES - The present invention relates to agonist antibodies that specifically bind to Notch 3 and activate signaling. The present invention includes antibodies binding to an epitope comprising the first Lin12 domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders. | 04-03-2014 |
20140105897 | Novel Anti-IL13 Antibodies and Uses Thereof - The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis. | 04-17-2014 |
20140179907 | ANTI-CD40 ANTIBODIES - The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 06-26-2014 |
20140295494 | HIGH AFFINITY, ANTI-HUMAN IgE ANTIBODIES - The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 10-02-2014 |
20140303355 | Humanized Anti-Factor D Antibodies And Uses Thereof - The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease. | 10-09-2014 |
20140363444 | Anti-IL-23 Antibodies - The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 12-11-2014 |
20140377265 | ANTICOAGULANT ANTIDOTES - The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants. | 12-25-2014 |
20150056133 | CX3CR1-TARGETING IMAGING AGENTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF DISEASE - The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis. | 02-26-2015 |
20150210778 | ANTICOAGULANT ANTIDOTES - The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants. | 07-30-2015 |
20150218267 | NOVEL ANTI-BAFF ANTIBODIES - The present invention relates to anti-BAFF antibody molecules, including novel humanized anti-BAFF antibodies, therapeutic and diagnostic methods and compositions for using the same. | 08-06-2015 |
20150239971 | CX3CR1-BINDING POLYPEPTIDES - The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes. | 08-27-2015 |
20150315282 | ANTI-CD40 ANTIBODIES - The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same. | 11-05-2015 |
Sanjaya Singh, Ridgefield, CT US
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20120093814 | Fusion Proteins Comprising Canine FC Portions - The present invention relates to therapeutic peptides and proteins fused to a canine antibody Fc domain. Methods and compositions of using the same are described. | 04-19-2012 |
Sanjeev K. Singh, Danbury, CT US
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20100238016 | Automotive Brake Lighting - A method and an apparatus are provided for controllably illuminating automotive brake lights. In one embodiment, an automotive brake lighting system comprises a brake light including first and second light sources, a sensor to sense a level of an operating condition associated with at least one of a brake assembly or a brake pedal of a motor vehicle for illuminating the brake light, and a controller configured to monitor information provided by the sensor. The controller, in response to the level of the operating condition, selectively powers the at least one of the first or second light sources of the brake light based at least in part on the monitored information to generate a variable visual indication relating to braking of the motor vehicle from the brake light over a range of at least two different visual indications that indicate a variable braking rate of the motor vehicle over a corresponding range of at least two different braking rates. | 09-23-2010 |
20100238017 | Automotive Brake Lighting - A method and an apparatus are provided for controllably illuminating automotive brake lights. In one embodiment, an automotive brake lighting system comprises a brake light including first and second light sources, a sensor to sense a level of an operating condition associated with at least one of a brake assembly or a brake pedal of a motor vehicle for illuminating the brake light, and a controller configured to monitor information provided by the sensor. The controller, in response to the level of the operating condition, selectively powers the at least one of the first or second light sources of the brake light based at least in part on the monitored information to generate a variable visual indication relating to braking of the motor vehicle from the brake light over a range of at least two different visual indications that indicate a variable braking rate of the motor vehicle over a corresponding range of at least two different braking rates. | 09-23-2010 |
20120058802 | FORMING A GEOMETRIC STRUCTURE IN A DEVICE HOUSING TO EXTERNALLY PROVIDE A HARDWARE ELEMENT OF A MOBILE TELECOMMUNICATION DEVICE - In one illustrative embodiment, a functional device hardware element of a mobile telecommunication device is provided externally by forming a dual geometric structure in an exterior surface of at least two device side edges of a device housing. The device housing has first and second grooves being substantially disposed from the front surface to the back surface across the side circumferential surface of first and second device edges of at least four device side edges, respectively, such that a combination of the first and second grooves is configured to jointly define at least one of a shape and a size of a predefined geometric structure that is selected to externally form a functional device hardware element of the mobile telecommunication device from the device housing of the device body. | 03-08-2012 |
20130005265 | Hand-Held, Portable Electronic Device With Retainer Port For Receiving Retainable Wireless Accessory For Use Therewith - A hand-held, portable electronic device is provided with a retainer port that defines an accessory retaining structure formed in an exterior periphery of a device housing for removably retaining a retainable wireless accessory in a cavity of the accessory retaining structure. In one embodiment of the present invention, the hand-held, portable electronic device includes a first transceiver adapted to communicate with the retainable wireless accessory over a short-range wireless communication link. The retainable wireless accessory may include a second transceiver adapted to communicate with the hand-held, portable electronic device using the short-range wireless communication link. | 01-03-2013 |
Shreya Singh, Danbury, CT US
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20130221180 | Portable Document or Notebook Holder for use with Portable Computers such as Netbook or Laptop - A holder such as a portable document/notebook holder is provided for use with a portable computer such as a netbook or a laptop computer to locate a document or a notebook in a front space relative to a user by mounting the holder on to the portable computer and attaching the document or notebook to that holder. Connectors such as clips may be coupled to ends of two arms that are movably coupled to each other on the other ends. For example, a first arm may fold against a second arm in a closed position and the first arm may maintain an open position when the first arm is either partially folded or not folded. For reading hand written notes, instead of repetitive turning of the neck sideways only upward and downward movement of eyeballs is sufficient which avoids straining of neck or back, making the typing much faster and a comfortable task. | 08-29-2013 |
Vinayck K. Singh, Litchfield, CT US
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20100088249 | Trade Risk Management - Disclosed herein is a computer implemented method and system for managing financial risk involved in trading of multiple financial instruments between multiple counterparties. A risk profile is determined for each of the counterparties based on transaction data provided by the counterparties. The transaction data relates to trading of the financial instruments. Individual prices for multiple predefined maturity periods of the financial instruments are provided by the counterparties based on the risk profile. A consensus price is created for each of the predefined maturity periods based on the individual prices. The created consensus price is compared with each of the individual prices provided by each of the counterparties. The financial risk is computed for each of the counterparties based on multiple predefined parameters and the comparison. The computed financial risk of each of the counterparties is modified by each of the counterparties for the management of the financial risk. | 04-08-2010 |
Vinayek K. Singh, Litchfield, CT US
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20110131126 | Trade Management System For Reducing Securities Positions - A computer implemented method and system is provided for reducing the number of securities positions of multiple counterparties. Securities positions are acquired from the counterparties. A price is obtained for each of the acquired securities positions from each of the counterparties. A consensus price is created for each of the acquired securities positions based on the obtained price of each of the acquired securities positions. The created consensus price for each of the acquired securities positions is displayed to the counterparties. The counterparties perform acceptance or rejection of the created consensus price of each of the acquired securities positions. The acquired securities positions are allocated at the created consensus price to one or more counterparties who accept the consensus price, using a sorting algorithm. The number of securities positions of the counterparties is reduced by trading the allocated securities positions to the associated counterparties. | 06-02-2011 |
20110131127 | Distribution Of Financial Instruments Among Counterparties - A computer implemented method and system is provided for distributing aggregated financial instruments among counterparties. The counterparties' financial instrument positions are acquired along with risk measures. The financial instrument positions are weighted using the risk measures to obtain risk weighted positions. An aggregate risk is computed by aggregating the risk weighted positions of the financial instruments. A position risk is computed by aggregating the risk weighted positions of the counterparties. A financial instrument with highest aggregate risk is allocated to a counterparty with highest position risk based on predefined rules. The position risks are recomputed by aggregating the risk weighted positions modified due to the allocation. An unallocated financial instrument with highest aggregate risk is allocated to a counterparty with highest change in position risk after the recomputation. Recomputation of the position risk and allocation of the unallocated financial instruments are performed until the financial instruments are completely allocated. | 06-02-2011 |