Patent application number | Description | Published |
20100003687 | System and method for detection of HIV tropism variants - An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species, wherein each first amplicon comprises a plurality of amplified copies and is amplified with a pair of nucleic acid primers that define a locus of the first amplicon; clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons wherein a plurality of the second amplicons comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition of the substantially identical copies from at least 100 of the immobilized populations in parallel on a single substrate; and detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the at least 100 immobilized populations; and correlating the detected sequence variants with variation associated with HIV tropism. | 01-07-2010 |
20100136516 | System and method for detection of HIV integrase variants - An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with integrase is described that comprises the steps of: (a) generating a cDNA species from a plurality of RNA molecules in an HIV sample population; (b) amplifying a plurality of first amplicons from the cDNA species, wherein each first amplicon is amplified with a pair of nucleic acid primers; (c) clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons; (d) determining a nucleic acid sequence composition of the second amplicons; (e) detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the second amplicons; and (f) correlating the detected sequence variants with variation associated with HIV integrase. | 06-03-2010 |
20100203497 | SYSTEM AND METHOD FOR DETECTION OF HIV DRUG RESISTANT VARIANTS - In one embodiment of the invention a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is describe that comprises generating cDNA species from RNA molecules in an HIV sample population; amplifying first amplicons from the cDNA species, wherein each amplicon comprises amplified copies and is amplified with a pair of nucleic acid primers that define a locus; clonally amplifying the amplified copies of the first amplicons to produce second amplicons that comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition from at least 100 of the immobilized populations in parallel on a single instrument; detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the at least 100 immobilized populations; and correlating the detected sequence variants with variation associated with HIV drug resistance. | 08-12-2010 |
20110165556 | SYSTEM AND METHOD FOR DETECTION OF HIV TROPISM VARIANTS - An embodiment of a method for detecting low frequency occurrence of one or more HIV sequence variants associated with drug resistance is described that comprises the steps of: generating cDNA species from each RNA molecule in an HIV sample population; amplifying at least one first amplicon from the cDNA species, wherein each first amplicon comprises a plurality of amplified copies and is amplified with a pair of nucleic acid primers that define a locus of the first amplicon; clonally amplifying the amplified copies of the first amplicons to produce a plurality of second amplicons wherein a plurality of the second amplicons comprise an immobilized population of substantially identical copies from one of the amplified copies of first amplicons; determining a nucleic acid sequence composition of the substantially identical copies from at least 100 of the immobilized populations in parallel on a single substrate; and detecting one or more sequence variants that occur at a frequency of 5% or less in the nucleic acid sequence composition of the at least 100 immobilized populations; and correlating the detected sequence variants with variation associated with HIV tropism. | 07-07-2011 |
Patent application number | Description | Published |
20130227118 | SYSTEM AND METHOD FOR PROVIDING ACCESS TO PRESENCE STATUS FOR MOBILE DEVICES - A system and method are provided for enabling access to presence status for mobile devices. The method comprises receiving, via an application programming interface, an application inquiry, the application inquiry requesting a presence data for at least one mobile device; responsive to receiving said inquiry, obtaining network data from one or more network infrastructure nodes associated with providing service to the at least one mobile device; determining a response to the application inquiry based upon the network data; and providing the response via the application programming interface. | 08-29-2013 |
20130227119 | SYSTEM AND METHOD FOR PROVIDING ACCESS TO PRESENCE STATUS FOR MOBILE DEVICES - A system and method are provided for enabling access to presence status for mobile devices. The method comprises receiving, via an application programming interface, a subscription request, the subscription request requesting a presence data for at least one mobile device; registering a subscription for a subscriber device according to the subscription request; obtaining network data from one or more network infrastructure nodes associated with providing service to the at least one mobile device; determining that at least a portion of the network data is associated with the subscription; and providing the at least a portion of the network data to the subscriber device via the application programming interface. | 08-29-2013 |
20140043967 | METHOD AND APPARATUS FOR MANAGING LOAD IN A COMMUNICATION NETWORK - A method and apparatus for managing load in a communication network are provided. At a processor of a relay device, a number of messages is determined that are one or more of currently queued for relay via a communication interface of the relay device and previously relayed within a given time period, the communication interface and the processor of the relay device for relaying the messages, via the communication interface, between a plurality of devices and a network infrastructure. At the processor, a rate at which the plurality of devices establishes communications with the network infrastructure is controlled, wherein there is an inverse relationship between the rate and the number of messages. | 02-13-2014 |
20140043968 | METHOD AND APPARATUS FOR MANAGING LOAD ON SERVICE DEVICES IN A COMMUNICATION NETWORK - A method, system and apparatus for managing load on service devices in a communication network are provided. At a processor of a relay device, it is determined that the service devices are available after being unavailable, the relay device comprising a communication interface and a processor for relaying messages, via the communication interface, between a communication device and the service devices. In response, the processor blocks incoming messages associated with a subset of the service devices, the incoming messages from the at least one communication device. | 02-13-2014 |