Siegel, PA
Dennis C. Siegel, Alverton, PA US
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20120276616 | METHOD AND SYSTEM FOR METHANE SEPARATION AND PURIFICATION FROM A BIOGAS - The method and system for methane separation and purification from a biogas includes collecting a raw Biogas gas stream having methane, carbon dioxide, water, sulfur compounds and non-methane organic compound (NMOC) constituents. The Biogas stream is fed into the intake of a liquid sulfur scrubber or a sulfur adsorber unit where the Biogas is separated into a main gas stream routed downstream in the system and a sulfur compounds stream removed from the system. The main gas stream is then processed by an NMOC absorber and further downstream, by an NMOC adsorber. NMOC produced by both NMOC processes is liquefied, removed from the system and stored. Upstream from the NMOC processes, the main gas stream is processed by at least one CO | 11-01-2012 |
Donald Siegel, Lansdale, PA US
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20120294799 | ANTI-TEM1 ANTIBODIES AND USES THEREOF - The invention relates to Anti-TEM 1 anti-bodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same. | 11-22-2012 |
Donald Siegel, Philadelphia, PA US
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20100015595 | Phage Particle Diagnostic Reagents - The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the “receptor”) is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the “ligand” or “target”). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a red blood cell, using antibody-displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage. | 01-21-2010 |
Donald L. Siegel, Lansdale, PA US
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20090123475 | Compositions and methods for detection of antibody binding to cells - The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included. | 05-14-2009 |
20100135948 | Anti-Autoimmune Antibodies for Treatment of Pemphigus - This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for both pemphigus vulgaris and pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody. | 06-03-2010 |
20110091449 | Isolation of Anti-Desmoglein 1 Antibodies by Phage Display of Pemphigus Foliaceus Autoantibodies - This invention relates to compositions and methods for the use of anti-autoimmune reagents that specifically bind to anti-desmoglein antibodies, which are responsible for pemphigus foliaceus. In addition, the invention relates to methods and compositions for inhibiting the expression or function of a variable region of an anti-desmoglein (anti-Dsg) pathogenic autoantibody. | 04-21-2011 |
20110091960 | Compositions and Methods for Detection of Antibody Binding to Cells - The invention includes Rh(D) binding proteins, including antibodies, and DNA encoding such proteins. Methods of generating such proteins and DNAs are also included. | 04-21-2011 |
20110200601 | Drug Delivery to Human Tissues by Single Chain Variable Region Antibody Fragments Cloned by Phage Display - The present invention relates to the use of non-pathogenic antibodies to deliver biologically-active proteins to specific cellular and sub-cellular sites. The invention also relates to the use of non-pathogenic antibodies to deliver biologically-active, non-protein molecules to specific cellular and sub-cellular sites. | 08-18-2011 |
Fred Siegel, Philadelphia, PA US
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20120233938 | Modular System - A modular tile adapted for mounting onto a flat surface, comprising an edge connector; an edge receiver configured to accommodate the connector; and a plurality of flat units, wherein each unit comprises a central opening with two dimensions with a first dimension smaller than a second dimension. The modular tiles are connected by releasably securing an edge connector of a first modular tile to an edge receiver of a second modular tile. | 09-20-2012 |
John D. Siegel, Malvern, PA US
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20140157696 | AIR INFILTRATION REDUCTION SYSTEM, INSULATING PANEL ASSEMBLY, MOUNTING ASSEMBLY, AND METHOD OF INSTALLING THE SAME - An airflow reduction system includes an insulating panel assembly for sealing a window within a jamb. The insulating panel assembly has a frame configured to fit within the jamb and a glazing panel in the frame coated with a low-emissivity or solar control coating or film. The frame may include one or more cavities extending along its length. The assembly may also include a blind stop and/or a trim stop installed on either side of the frame within the jamb. A compressible seal around the external perimeter of the frame bears against the jamb to form a first barrier impeding the flow of air, and the blind stop or the trim stop forms a second barrier impeding the flow of air. Also disclosed is a mounting assembly including an insulating panel assembly and at least one bracket and a method of installing the same. | 06-12-2014 |
Marvin Siegel, Blue Bell, PA US
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20110142873 | BIOACTIVE PURIFIED HSPE7 COMPOSITIONS - A method of treating or preventing a condition related to an HPV infection is provided. The method comprises administering to a subject a composition comprising a purified Hsp65-E7 fusion protein (HspE7) admixed with an immune stimulant selected from the group consisting of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, mono-phosphoryl-lipid A (MPL), MPL-trehalose 6,6′-dimycolate (MPL-TDM), and anti-CD40. A composition comprising HspE7 and one or more than one of CpG, a TLR3 agonist such as PolyI:C, PolyICLC, MPL, MPL-TDM, and anti-CD40, and method of reducing a tumor or virus development in a mammal or subject in need thereof by using the composition are also provided. | 06-16-2011 |
Marvin I. Siegel, Blue Bell, PA US
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20080311145 | PROTEIN CAGE IMMUNOTHERAPEUTICS - The present invention provides compositions of heat shock protein cages for use in therapeutic vaccines. The heat shock protein cages of the invention have attached antigen, located either on the interior or exterior of the protein cage, and optionally an adjuvant. | 12-18-2008 |
20090035389 | TARGETED PROTEIN CAGES - The present invention provides targeted protein cages for the specific delivery of a variety of agents to cells and tissues and methods of use. The targeted protein cages have exterior targeting moieties and therapeutic or imaging agents which are encapsulated within the protein cages or are located on the exterior surfaces of the protein cages. | 02-05-2009 |
Mei Siegel, Pittsburgh, PA US
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20090234206 | MEDICAL DEVICE FOR DIAGNOSING PRESSURE ULCERS - Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the patient and collects the optical reflectance data. The controller processes the data to determine whether there exists a pressure ulcer and, if there is one, its depth. The tip may also include a pressure sensor for sensing the pressure at which the tip is applied to the patient's skin. | 09-17-2009 |
20120130255 | MEDICAL DEVICE FOR DIAGNOSING PRESSURE ULCERS - Medical device or instrument for diagnosing pressure ulcers using optical reflectance spectroscopy. The device may comprise a tip and a controller. The tip is pressed against the skin of the patient and collects the optical reflectance data. The controller processes the data to determine whether there exists a pressure ulcer and, if there is one, its depth. The tip may also include a pressure sensor for sensing the pressure at which the tip is applied to the patient's skin. | 05-24-2012 |
Mel Siegel, Pittsburgh, PA US
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20090246404 | Enhanced projection screen - An apparatus and method for producing a screen is provided. The method includes propelling a quantity of paint comprising metallic flakes, such as aluminum flakes, toward the screen. The method also includes applying at least one magnetic field in a vicinity of the screen, wherein applying the at least one magnetic field causes at least one metallic flake in the quantity of paint to be oriented relative to the screen in a substantially preferred orientation, thereby producing a screen exhibiting beneficial projection qualities, such as brightness. The magnetic field(s) applied may be unsymmetric in the time domain of, for example, an AC component of the magnetic field. | 10-01-2009 |
Nathan P. Siegel, Lewisburg, PA US
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20140102912 | HYBRID METAL OXIDE CYCLE WATER SPLITTING - Hybrid thermochemical water splitting cycles are provided in which thermally reduced metal oxides particles are used to displace some but not all of the electrical requirements in a water splitting electrolytic cell. In these hybrid cycles, the thermal reduction temperature is significantly reduced compared to two-step metal-oxide thermochemical cycles in which only thermal energy is required to produce hydrogen from water. Also, unlike the conventional higher temperature cycles where the reduction step must be carried out under reduced oxygen pressure, the reduction step in the proposed hybrid cycles can be carried out in air, allowing for thermal input by a solar power tower with a windowless, cavity receiver. | 04-17-2014 |
Richard Siegel, Horsham, PA US
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20100028904 | WAY TO OBTAIN HIGH EXPRESSION CLONES OF MAMMALIAN CELLS USING A METHYLCELLULOSE WITH FLUORESCENT PROTEIN A OR G AND FLUORESCENT SCREENING METHOD - The invention provides a genetic screening method for identifying a transfected cell expressing the polypeptide of interest. The methods allows for high throughput screening of recombinant cells for elevated levels of expression of the polypeptide of interest using methylcellulose comprising fluorescent protein A or G to improve detection and cloning. The invention also provides capture media, formulations and methods of making and using thereof. | 02-04-2010 |
Stanley M. Siegel, West Newton, PA US
Patent application number | Description | Published |
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20120276616 | METHOD AND SYSTEM FOR METHANE SEPARATION AND PURIFICATION FROM A BIOGAS - The method and system for methane separation and purification from a biogas includes collecting a raw Biogas gas stream having methane, carbon dioxide, water, sulfur compounds and non-methane organic compound (NMOC) constituents. The Biogas stream is fed into the intake of a liquid sulfur scrubber or a sulfur adsorber unit where the Biogas is separated into a main gas stream routed downstream in the system and a sulfur compounds stream removed from the system. The main gas stream is then processed by an NMOC absorber and further downstream, by an NMOC adsorber. NMOC produced by both NMOC processes is liquefied, removed from the system and stored. Upstream from the NMOC processes, the main gas stream is processed by at least one CO | 11-01-2012 |
Steven Siegel, Berwyn, PA US
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20080305140 | Long-Term Delivery Formulations and Methods of Use Thereof - The present invention provides a method, a kit and compositions for long-term release of a drug at a constant therapeutically effective level for nervous system disorders where adherence to therapeutic regimen is problematic. In particular, to the therapy of psychotic disorders. | 12-11-2008 |
20090297572 | Drug-Containing Implants And Methods of Use Thereof - The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention. | 12-03-2009 |
20130064773 | DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF - The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention. | 03-14-2013 |
20140249184 | POLYMER-BASED SURGICALLY IMPLATABLE HALOPERIDOL DELIVERY SYSTEMS AND METHODS FOR THEIR PRODUCTION AND USE - Surgically implantable drug delivery systems for long-term delivery of haloperidol containing a biodegradable polymer and haloperidol fabricated into the surgically implantable drug delivery systems via solvent casting and compression molding are provided. Also provided are methods for producing the surgically implantable drug delivery systems and methods for using these systems in the treatment of psychotic disorders such as schizophrenia. | 09-04-2014 |
20140343080 | DRUG-CONTAINING IMPLANTS AND METHODS OF USE THEREOF - The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention. | 11-20-2014 |
Steven J. Siegel, Berwyn, PA US
Patent application number | Description | Published |
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20100104618 | POLYMER-BASED SURGICALLY IMPLANTABLE HALOPERIDOL DELIVERY SYSTEMS AND METHODS FOR THEIR PRODUCTION AND USE - Surgically implantable drug delivery systems for long-term delivery of haloperidol containing a biodegradable polymer and haloperidol fabricated into the surgically implantable drug delivery systems via solvent casting and compression molding are provided. Also provided are methods for producing the surgically implantable drug delivery systems and methods for using these systems in the treatment of psychotic disorders such as schizophrenia. | 04-29-2010 |
20110159066 | Methods For Treating Parkinson's Disease - Methods for restoring normal patterns of activity in a subject suffering from Parkinson's Disease are disclosed that include administering an effective steady state concentration of a dopamine modulating compound continuously for a prolonged period of time such that normal patterns of activity are substantially restored in the subject. | 06-30-2011 |
20140147486 | IMPLANTS FOR THE TREATMENT OF DOPAMINE ASSOCIATED STATES - Biodegradable implants comprising dopamine modulating compounds are described. | 05-29-2014 |
20140178449 | METHODS FOR TREATING PARKINSON'S DISEASE - Methods for restoring normal patterns of activity in a subject suffering from Parkinson's Disease are disclosed that include administering an effective steady state concentration of a dopamine modulating compound continuously for a prolonged period of time such that normal patterns of activity are substantially restored in the subject. | 06-26-2014 |
20140221451 | IMPLANTS FOR THE TREATMENT OF DOPAMINE ASSOCIATED STATES - Biodegradable implants comprising dopamine modulating compounds are described. | 08-07-2014 |
William L. Siegel, Mercersburg, PA US
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20150159552 | INTEGRATED ELECTRICAL POWER AND THERMAL MANAGEMENT SYSTEM - An electrical power and thermal management system may include a power plant operable to provide power to an electrical generation device. The system may include at least one conversion/distribution assembly configured to provide electrical power to a first electrical bus. The system may also include a thermal management system configured to circulate coolant to at least one heat source. A controller may be in communication with the power plant, the electrical generation device, the conversion/distribution assembly, the electrical power bus, and the thermal management system. The controller may be configured to integrally manage electrical and thermal steady and transient demands, wherein the controller is operable to selectively distribute power to the electrical power bus and regulate produced thermal energy in response to electrical and thermal demands, respectively. | 06-11-2015 |