Patent application number | Description | Published |
20140162305 | Patient In Vivo Gut Diagnostic and Treatment Tool - An orally ingestible capsule device with monitoring and control instruments is provided for practicing physicians to use in patient examining rooms. The Capsule is part of an in vivo gut healthcare system with capabilities of delivering medications to any point in the gut, administering them at any time, or autonomously based upon onboard measurements, and simultaneously measuring results, along with extra body function measurements. It is capable of delivering gut medications or autoimmune perturbation substances and simultaneously measuring responses and sample gut substances/microbes at application points. Objectives, as part of patient diagnosis, include determining microbe roles in the patient's digestion process, along with toxic substances contributing to illnesses or diseases, such as gluten sensitivities. Capsule embodiments include a belt with pockets for substance delivery or sampling, lab-on-a-chip devices, chip-based logic, sensor/transducer, and control circuits, and data reduction and storage, for efficient, cost-effective diagnostics and treatment in minimal time. | 06-12-2014 |
20140163416 | In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases - An orally ingested capsule has capabilities of sampling gut substances and microbes before, during and after delivery of system perturbation substances, to the gut at any point or time. Sensors are provided to simultaneously measure, monitor, record, and transmit data in real time obtained within the exact vicinity of substance deployment and microbial assisted digestive processes occur. In vivo collected samples are collected and preserved for extensive in vitro analysis. Digestive processes and dysfunctions involving proteins that result in “gluten sensitivities” and dozens of gut-based diseases that develop in stages, and have been mysteries for over 2,000 years, can be analyzed. The capabilities were developed to permit research within the heretofore inaccessible and important regions of the small intestine where villi functions are compromised, and in the upper colon. Special focus includes determining roles microbes and their byproduct substances in cascade play in autoimmune system responses and diseases. | 06-12-2014 |
Patent application number | Description | Published |
20140241883 | GAS TURBINE ENGINE COMPONENT - Embodiments are disclosed of a turbomachinery component having an outer part that is captured between a cap and a base of the component. In one form, the outer part is placed in compression between the cap and the base. The outer part can be formed prior to being placed between the cap and the base. In some forms, the outer part can be formed partially or completely while engaged with the component. A fugitive spacer can be placed between the outer part and an extension of the component. In various embodiments, the extension can reach into an opening of the outer part and the cap can be coupled with the extension. | 08-28-2014 |
20140255620 | SONIC GRAIN REFINEMENT OF LASER DEPOSITS - A metal additive method includes directing sonic and/or ultrasonic energy from a probe that is directed toward a melt pool during solidification of the melt pool and formation of a layer, wherein a solid portion of an object on which the pool is positioned at least partially surrounds the melt pool. | 09-11-2014 |
20140263195 | VARIABLE WORKING DISTANCE FOR LASER DEPOSITION - A method of applying a laser metal formed build layer on a surface of an article is disclosed. A laser deposition head including a light source and a nozzle is positioned relative to the surface of the article by a distance that is about normal to the surface. The surface of the article is melted locally using the laser light source to form a melt pool. Powdered metal is injected into the melt pool using the nozzle. The melt pool is solidified to form the build layer having a desired microstructure on the surface of the article. | 09-18-2014 |
20150084240 | METHOD AND APPARATUS FOR FORMING THREE-DIMENSIONAL ARTICLES - The present disclosure relates to a method and apparatus for forming a three-dimensional article. The method includes establishing control commands effective to form a three-dimensional article and dispensing a first layer of particulate material onto a build platform. The method also includes irradiating the first layer of particulate material with microwaves and guiding a directed energy, according to the control commands, at the first layer of particulate material to form a first consolidated layer of the three-dimensional article. | 03-26-2015 |
Patent application number | Description | Published |
20120160375 | HEAT TREATING AND BRAZING OF AN OBJECT - One embodiment of the present invention is a unique method for brazing an assembly. Another embodiment is a unique method of heat treating an object. Other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for heat treating and/or brazing. Further embodiments, forms, features, aspects, benefits, and advantages of the present application will become apparent from the description and figures provided herewith. | 06-28-2012 |
20120160443 | GAS TURBINE ENGINE COMPONENT MATERIAL ADDITION PROCESS - A material addition process is described that includes coupling a plate to a gas turbine engine component and adding material to the plate. In one embodiment the gas turbine engine component can be processed by removing a portion that is damaged, such as a portion that includes a crack. A material can be deposited on the plate and built up in layers to replace the removed portion. The material can be layered upon the plate such that its thickness through the layers is smaller than a reach of the layers in a direction of the layer. The plate can be removed in whole or in part after a material has been added. In one form the material can be added by direct laser deposition. In one embodiment a metal powder is fused using a laser. Excess buildup can be removed to reveal a net shape article. | 06-28-2012 |
20120164349 | SYSTEM AND METHOD FOR DEPOSITING MATERIAL IN A SUBSTRATE - One embodiment of the present invention is a unique method for depositing materials in a substrate. Another embodiment is a unique system for depositing materials in a substrate. Other embodiments include apparatuses, systems, devices, hardware, methods, and combinations for depositing materials within a substrate. Further embodiments, forms, features, aspects, benefits, and advantages of the present application will become apparent from the description and figures provided herewith. | 06-28-2012 |
20140230212 | WELD REPAIR OF A COMPONENT - A method for repairing a component may include machining a depression into the component. A size and a shape of the depression may be configured to remove a damaged portion of the component; and wherein the depression forms a repair volume. The method also may include depositing a plurality of continuous additive weld layers, each continuous additive weld layer of the plurality of continuous additive weld layers having a beginning point and an ending point. The beginning point and the ending point of a first continuous additive weld layer of the plurality of additive weld layers may be formed at or beyond an outer boundary of the repair volume. The beginning points and the ending points of the remainder of the plurality of continuous additive weld layers may be formed at or beyond the outer boundary of the repair volume. | 08-21-2014 |
20140238097 | LAMINATED CAVITY TOOLING - In some examples, a laminated tooling die may include multiple sheets or plates used in conjunction in any of a number of forming operations such as, for example, hydroforming, compression molding, and stamping. The sheets or plates can include an open interior that, when used in conjunction with neighboring sheets, produce a cavity into which a deformable workpiece can be placed and subjected to the forming operation. In some examples, one or more sheets can be coupled with a heat exchanger to impart a heat transfer with the workpiece. | 08-28-2014 |
Patent application number | Description | Published |
20130028989 | MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF - Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a protein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment. | 01-31-2013 |
20140370121 | MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF - Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a protein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment. | 12-18-2014 |