Patent application number | Description | Published |
20080199964 | SITE-SPECIFIC INSTALLATION OF METHYL-LYSINE ANALOGUES INTO RECOMBINANT HISTONES - The present invention provides reagents and methods for the introduction of analogues of methyl or acetyl lysine into histone proteins. | 08-21-2008 |
20080213900 | Engineered Protein Kinases Which Can Utilize Modified Nucleotide Triphosphate Substrates - Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified substrates to identify which protein substrates the kinases act upon, to measure the extent of such action, and to determine if test compounds can modulate such action. Also Engineered forms of multi-substrate enzymes which covalently attach part or all of at least one (donor) substrate to at least one other (recipient) substrate, which engineered forms will accept modified substrates that are not as readily utilized by the wild-type forms of those enzymes. Methods for making and using such engineered enzymes. Modified substrates and methods of making and using them. Methods for using such engineered enzymes and such modified substrates to identify the recipient substrates the enzymes act upon, to measure the extent of such action, and to measure whether test compounds modulate such action. | 09-04-2008 |
20120322814 | METHODS OF INHIBITING IRE1 - Disclosed herein are, inter alia, methods for inhibiting Ire1 activity. | 12-20-2012 |
20150051193 | PI-kinase Inhibitors with Broad Spectrum Anti-Infective Activity - Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like. | 02-19-2015 |
Patent application number | Description | Published |
20080261821 | Mechanism-Based Crosslinkers - The present invention provides novel mechanism-based crosslinkers useful in covalently linking a kinase and an interactor. | 10-23-2008 |
20090124638 | ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES - The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition. | 05-14-2009 |
20090270426 | P13 Kinase Antagonists - The present invention provides novel PI3-Kinase antagonists and methods of use thereof. | 10-29-2009 |
20100009963 | KINASE ANTAGONISTS - The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase. | 01-14-2010 |
20110144134 | Anti-Inflammatory Pyrazolopyrimndines - The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition. | 06-16-2011 |
20110224223 | MTOR Modulators and Uses Thereof - The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications. | 09-15-2011 |
20110275651 | FUSED RING HETEROARYL KINASE INHIBITORS - Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states. | 11-10-2011 |
20110301144 | Kinase Antagonists - The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase. | 12-08-2011 |
20110319436 | Methods and Compositions for Modulating IRE1, SRC, and ABL Activity - Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl. | 12-29-2011 |
20120065154 | Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof - This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof. | 03-15-2012 |
20130137708 | METHODS AND COMPOSITIONS FOR KINASE INHIBITION - The present invention sets forth a new chemical genetic approach for engineering kinase enzymes with a cysteine gatekeeper residue as well as for developing electrophilic inhibitors thereto. The present invention also provides a Src proto-oncogenic tyrosine kinase with a cysteine gatekeeper that recapitulates wild type activity and can be irreversibly inhibited both in vitro and in cells. The present invention also provides methods and compositions for modulating kinases and for treating kinase-associated diseases. | 05-30-2013 |
20140243357 | SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF - Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers. | 08-28-2014 |
20140288096 | P13 KINASE ANTAGONISTS - The present invention provides novel PI3-Kinase antagonists and methods of use thereof. | 09-25-2014 |
20140288097 | USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT - The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein. | 09-25-2014 |
20150031881 | PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF - This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof. | 01-29-2015 |
20150087628 | COMPOSITIONS AND METHODS FOR TREATING CANCER - K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer. | 03-26-2015 |