Patent application number | Description | Published |
20100263915 | CIRCUIT BOARD STRUCTURE HAVING MEASURES AGAINST HEAT - To achieve efficient heat spreading and heat releasing by using a metal core of a circuit board, a terminal block includes an insulating block body and terminals. At least one of the terminals is provided with terminal portions for a connection with a circuit board. The terminal portions are inserted into respective through holes of the circuit board, the circuit board having a pattern circuit at a surface layer thereof and a conductive metal core at an intermediate portion in a thickness direction, so that heat of the metal core or of both the metal core and the pattern circuit is absorbed and transferred to the terminals. A bus-bar block includes an insulating block body and several parallel bus-bars with different lengths. Terminal portions at a tip end of the bus-bars are inserted, near heat-generating component on the circuit board, into the through holes of the circuit board. | 10-21-2010 |
20100317241 | PLATE-LIKE TERMINALS MOUNTING STRUCTURE - A plate-like terminal mounting structure is configured to attach a plurality of plate-like terminals in multiple tiers to a terminal holder for facilitated and effective positioning of the terminals in the terminal holder and prevention of undesirable impacts of the terminals upon a connection between the terminals and a circuit board. The terminal holder includes a plurality of ribs tapering toward their tips and parallel to each other. The terminal includes a recessed portions or holes for engaging the plate-like terminals with the ribs in a regular mounting position without gap left therebetween. The rib includes sloping surfaces on its four sides (front, rear, right, and left sides). The terminal holder includes a partition wall separating the terminals from each other, the partition wall being in one piece with the ribs. The plate-like terminals are arranged in multiple tiers in a height direction of the ribs. The recessed portion or the hole of the terminal in a lower tier is large, and the recessed portion or the hole of the terminal in the upper tier is small depending on tapering of the ribs. | 12-16-2010 |
20100328908 | BUSBAR-BLOCK MOUNTING STRUCTURE - In order to readily and securely mount, for example, a fuse block to a cover and readily accommodate increase in the number of circuits, bus bars each having on one side a terminal portion for connection of an electrical component and on the other side a terminal portion for connection of circuit board are provided in an insulating block body parallel to each other to constitute a busbar block. The bus bars are prevented from uplifting by virtue of a rib integral with the block body. Recessed portions for positioning are provided in an insulating cover corresponding to the ribs, and at the same time as the busbar block is attached to the cover, the ribs are brought into engagement with the recessed portions to provide positioning of the busbar block. Terminal block constructed by terminals each having on one end thereof a terminal portion for connection of an electrical component and on the other side thereof a terminal portion for connection of circuit board | 12-30-2010 |
20110043969 | JUNCTION BLOCK - The present invention provides a junction block adapted for a variety grade of vehicles without increase of cost. The junction block includes a circuit board | 02-24-2011 |
20140085831 | CIRCUIT BOARD STRUCTURE HAVING MEASURES AGAINST HEAT - To achieve efficient heat spreading and heat releasing by using a metal core of a circuit board, a terminal block includes an insulating block body and terminals. At least one of the terminals is provided with terminal portions for a connection with a circuit board. The terminal portions are inserted into respective through holes of the circuit board, the circuit board having a pattern circuit at a surface layer thereof and a conductive metal core at an intermediate portion in a thickness direction, so that heat of the metal core or of both the metal core and the pattern circuit is absorbed and transferred to the terminals. A bus-bar block includes an insulating block body and several parallel bus-bars with different lengths. Terminal portions at a tip end of the bus-bars are inserted, near heat-generating component on the circuit board, into the through holes of the circuit board. | 03-27-2014 |
Patent application number | Description | Published |
20110180318 | Electric junction box - There is provided an electric junction box ( | 07-28-2011 |
20150302954 | INSERT BUS BAR PLATE AND METHOD FOR MANUFACTURING THE SAME - An insert bus bar plate includes a plate-shaped resin material and a plurality of metal bus bars that are embedded within the resin material by insert molding and have a terminal part exposed to a mounting surface that is one of principal faces of the resin material. The bus bars are formed, before the insert molding, as a bus bar assembly before molding the one ends different from the terminal part of which are coupled to each other by a carrier to be cut after the insert molding. The insert bus bar plate (a substrate main body) is formed by the insert molding performed by oppositely arranging two bus bar assemblies before molding of the same shape so that two terminal parts are positioned in between two carriers. | 10-22-2015 |
20150303669 | ELECTRONIC COMPONENT UNIT AND WIRE HARNESS - An electronic component unit includes a plate made of a resin material configured to embed metallic bus bars in the resin material and mount electronic components thereon, and a supporting member to which the plate is assembled. The plate has a plurality of exposed ends at which the bus bars are partially exposed on edge surfaces of the plate. The supporting member includes protrusions that are formed on opposed surfaces facing the edge surfaces of the plate such that the protrusions face the edge surfaces of the plate, protrude from the opposed surfaces toward the edge surface sides of the plate, and are each located between the adjacent exposed ends in an arrangement direction of the multiple exposed ends. | 10-22-2015 |
20150305181 | ELECTRONIC COMPONENT UNIT - An electronic component unit includes a housing. The housing includes a housing space that houses an electronic component. The housing space is divided into a plurality of divided spaces by a central wall-shaped part protruding from a bottom of the housing space. The bottom defines a lower side of the housing space in the vertical direction. The central wall-shaped part has a connecting portion-fitting part to which a connecting part of an electric wire is fitted. For each of the divided spaces, the bottom has a short side direction tilted surface that is tilted from the central wall-shaped part toward the lower side in the vertical direction in a state where the housing is installed at an installation position, and a drain hole formed at a lower end of the short side direction tilted surface in the vertical direction. | 10-22-2015 |
20150305184 | LOCKING STRUCTURE BETWEEN MEMBER TO BE SUPPORTED AND SUPPORTING BODY - A locking structure between a member to be supported and a supporting body includes an electronic component unit as a member to be supported, an electronic component unit housing part of an electrical connection box as a supporting body, a lock mechanism for upper insertion fitting (an engagement claw and a lock arm) that, when the electronic component unit is fitted to the electronic component unit housing part from an upper-side opening, locks the electronic component unit to the electronic component unit housing part to prevent the electronic component unit from escaping toward the upper-side opening, and a lock mechanism for lower insertion fitting (an engagement claw and a lock arm) that, when the electronic component unit is fitted to the electronic component unit housing part from a lower-side opening, locks the electronic component unit to the electronic component unit housing part to prevent from escaping toward the lower-side opening. | 10-22-2015 |
Patent application number | Description | Published |
20100239577 | ANTI-GLYPICAN-3 ANTIBODY HAVING IMPROVED KINETICS IN PLASMA - A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient. | 09-23-2010 |
20100298542 | Modified Antibody Constant Region - The present inventors succeeded in improving the antibody constant region to have increased stability under acid conditions, reduced heterogeneity originated from disulfide bonds in the hinge region, reduced heterogeneity originated from the H chain C terminus, and increased stability at high concentrations as well as in discovering novel constant region sequences having reduced Fcγ receptor-binding, while minimizing the generation of novel T-cell epitope peptides. As a result, the present inventors successfully discovered antibody constant regions with improved physicochemical properties (stability and homogeneity), immunogenicity, safety, and pharmacokinetics. | 11-25-2010 |
20110098450 | Antibody Molecules - The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions. | 04-28-2011 |
20110129459 | ANTI-NR10 ANTIBODY AND USE THEREOF - The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases. | 06-02-2011 |
20110229459 | ANTI-NR10 ANTIBODY AND USE THEREOF - The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases. | 09-22-2011 |
20110245473 | Anti-IL-6 Receptor Antibody - The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations. | 10-06-2011 |
20120065379 | Antibody Constant Region Variant - By means of amino acid sequence alterations, the present inventors succeeded in providing constant regions that can confer antibodies with favorable properties, particularly as pharmaceuticals. The variants of the constant regions provided by the present invention will remarkably reduce heterogeneity when applied to antibody production. That is, homogeneity of antibodies can be maintained at a high level by introducing the alterations provided by the present invention into the antibody heavy chain constant regions. More specifically, decrease in homogeneity caused by —SS— bond linkage differences in the heavy chains of antibody molecules can be prevented. Furthermore, in a preferred embodiment of the present invention, pharmacokinetics of antibodies can be improved and decrease in homogeneity caused by deletion of the C terminus in the antibody constant region can be ameliorated. | 03-15-2012 |
20120071634 | Antibody Constant Region Variant - By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region. | 03-22-2012 |
20120121587 | ANTI-AXL ANTIBODY - An objective of the present invention is to decrease the immunogenicity of mouse-derived anti-AXL antibodies in humans by humanizing them. The present invention provides antibodies that can bind to a specific region in Anexelekto (AXL) and humanized antibodies that are produced based on such antibodies. The anti-AXL antibodies of the present invention have high antitumor activity, and are useful as agents for decreasing the AXL expression level, antitumor agents, and diagnostic agents for cancer. | 05-17-2012 |
20120253016 | ANTIBODY MOLECULES THAT BIND TO IL-6 RECEPTOR - The present invention provides pharmaceutical compositions comprising second-generation molecules that are superior than TOCILIZUMAB, by altering the amino acid sequences of the variable and constant regions of TOCILIZUMAB, which is a humanized anti-IL-6 receptor IgG1 antibody, to enhance the antigen-neutralizing ability and increase the pharmacokinetics, so that the therapeutic effect is exerted with a less frequency of administration, and the immunogenicity, safety and physicochemical properties (stability and homogeneity) are improved. The present invention also provides methods for producing these pharmaceutical compositions. The present inventors have successfully generated second-generation molecules that are superior to TOCILIZUMAB by appropriately combining amino acid sequence alterations in the CDR domains, variable regions, and constant regions. | 10-04-2012 |
20130295612 | ANTI-GLYPICAN-3 ANTIBODY HAVING IMPROVED KINETICS IN PLASMA - A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient. | 11-07-2013 |
20130317203 | Anti-IL-6 Receptor Antibody - The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations. | 11-28-2013 |
20140039165 | ANTI-NR10 ANTIBODY AND USE THEREOF - The present inventors successfully obtained anti-NR | 02-06-2014 |
20140199294 | HETERODIMERIZED POLYPEPTIDE - The present inventors produced a heterodimerized polypeptide having an Fc region formed from two polypeptides with different amino acid sequences (a first polypeptide and a second polypeptide), and succeeded in producing a heterodimerized polypeptide containing an Fc region with improved Fc region function compared to that of a homodimer in which the Fc region is composed of only the first polypeptide or only the second polypeptide by conventional technology. | 07-17-2014 |
20150110793 | Humanized Anti-Epiregulin Antibody, and Cancer Therapeutic Agent Comprising Said Antibody as Active Ingredient - The inventors successfully produced anti-Epiregulin antibodies showing cross-species reactivity between cynomolgus monkey (non-human animals) and human, anti-Epiregulin antibodies with suppressed chemical degradation, anti-Epiregulin antibodies with lowered isoelectric point, anti-Epiregulin antibodies with increased thermal denaturation midpoint temperature, and anti-Epiregulin antibodies with reduced amount of aggregate by performing appropriate amino acid residue substitutions in the variable-region sequences of the humanized EP27 antibody which inhibits growth of cancer cells by exhibiting cytotoxic activity and neutralizing activity against human Epiregulin-expressing cancer cells. | 04-23-2015 |
20150175704 | ANTI-NR10 ANTIBODY AND USE THEREOF - The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases. | 06-25-2015 |
20150274809 | ANTIBODY CONSTANT REGION VARIANT - By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region. | 10-01-2015 |
Patent application number | Description | Published |
20120287552 | SUBSTRATE TEMPERATURE ADJUSTING-FIXING DEVICE - A disclosed substrate temperature adjusting-fixing device includes an electro static chuck attracting and holding an attractable object onto a base body having a built-in electrode by applying a voltage to the electrode, a base plate fixing the electro static chuck via an adhesive layer, a power supplying portion electrically connected to the electrode, and a retaining portion holding the power supplying portion, wherein the retaining portion includes a main body and a sealing portion, the main body is fixed to the base plate and has recesses opened on an opposite side of the adhesive layer and a through hole penetrating through the main body, the power supplying portion includes an electrode pin and an electric wire, the electric wire is wired inside the adhesive layer, the through hole and the recesses to electrically connect the electrode with the electrode pin, and the sealing portion fills the recesses. | 11-15-2012 |
20130048217 | ELECTROSTATIC CHUCK AND SEMICONDUCTOR/LIQUID CRYSTAL MANUFACTURING EQUIPMENT - An electrostatic chuck includes, a chuck function portion including a plurality of chuck regions on which an attractable object is placed respectively, and a concave surface portion provided in an outer region of the chuck regions, and electrodes arranged in an inner part of the chuck function portion corresponding to the chuck regions and an inner part of the chuck function portion corresponding to the concave surface portion, respectively. | 02-28-2013 |
20130308244 | ELECTROSTATIC CHUCK AND METHOD FOR MANUFACTURING THE ELECTROSTATIC CHUCK - An electrostatic chuck includes a pedestal part formed of metal and including a gas passage, an insulation substrate mounted on the pedestal part and including a first surface facing the pedestal part and a second surface on an opposite side of the first surface, the first surface including a first hole part communicating with the gas passage, the second surface including a second hole part having a bore diameter less than that of the first hole part and communicating with the first hole part, and an insulation flow part formed of an insulating material and including a first end provided in the first hole part and a second end provided in the gas passage. The insulation flow part is configured to allow a gas supplied from the gas passage to flow into the second hole part. | 11-21-2013 |
20140103612 | DIELECTRIC LAYER FOR ELECTROSTATIC CHUCK AND ELECTROSTATIC CHUCK - A dielectric layer for an electrostatic chuck is formed of a ceramic material having a first phase including aluminum oxide and a second phase including composite carbonitride (Ti, Me)(C, N) that contains titanium as fine grains. The Me represents a transition element and metals of Group 4 to Group 6 such as Mo and W. The ceramic material that includes the second phase by 0.05 vol % to 2.5 vol % has a volume resistivity value of about 10 | 04-17-2014 |
20140254061 | ELECTROSTATIC CHUCK APPARATUS - An electrostatic chuck apparatus includes a pedestal part including a side surface, an electrostatic chuck including a side surface and provided on the pedestal part, an adhesive part including a side surface and provided between the pedestal part and the electrostatic chuck, the adhesive part containing a resin adhesive agent that adheres the pedestal part and the electrostatic chuck together, a recess part provided in a portion of the side surface of the pedestal part and a portion of the side surface of the electrostatic chuck, the recess part being provided in an area that includes a side surface of the adhesive part, the recess part being provided along an outer periphery of the pedestal part, an outer periphery of the adhesive part, and an outer periphery of the electrostatic chuck, and a focus ring engaged with the recess part and covering the side surface of the adhesive part. | 09-11-2014 |
Patent application number | Description | Published |
20090093313 | Data management apparatus and data distribution system - Ghost data used for reproducing a game process having been executed in accordance with operations performed by users are transmitted, as necessary, from a plurality of game apparatuses to a data management apparatus. The data management apparatus stores the ghost data received from the plurality of game apparatuses, in accordance with a definition of a database in which a plurality of score sections are defined based on a value represented by score data, and a maximum registration allowable number of users for which the ghost data are registered is defined for each of the plurality of score sections, or is defined so as to be the same among the plurality of score sections. The data management apparatus transmits, when a ghost data distribution request is received from a one of the plurality of game apparatuses, the ghost data for at least one user for which the ghost data is registered so as to be associated with one of the plurality of score sections, the one of the plurality of scores sections being associated with the score data included in the ghost data distribution request, to the one of the plurality of game apparatuses. Thus, it is possible to limit the total capacity for storing the ghost data in a server to a predetermined range of capacity, and allow each player to obtain the ghost data in accordance with a skill of the player. | 04-09-2009 |
20090102847 | Computer-readable storage medium having distribution chart display program stored therein, information processing apparatus, and distribution chart display system - A distribution chart representing a distribution of accomplishment times included in a plurality of pieces of result data is generated based on the plurality of pieces of result data including the accomplishment times of a racing game. Icons for identifying the plurality of pieces of result data are displayed on the distribution chart. When one of the icons displayed on the distribution chart is selected by a user, a process associated with the result data represented by the one of the icons having been selected is executed. Therefore, the distribution chart which includes a plurality of pieces of data as elements and is based on a predetermined index is displayed, and an interactive operation using the distribution chart can be realized. | 04-23-2009 |
20090197682 | Game network construction method and game network system - After a star peer-to-peer network is constructed, a network game is started. While the network game is executed, a mesh peer-to-peer network is gradually constructed by establishing connections between client terminals which have been connected to the star peer-to-peer network. After the network game is started, while the mesh peer-to-peer network is constructed, client terminals which have established connections therebetween transmit and receive game data to and from each other without passing via a host terminal, and client terminals which have not established connections therebetween yet transmit and receive game data to and from each other via the host terminal. Thus, a game network system can be realized, in which a time during which players wait for the network game to start is short and in which processing burdens are not concentrated on a specific user terminal. | 08-06-2009 |
20110157013 | COMPUTER-READABLE STORAGE MEDIUM HAVING INFORMATION PROCESSING PROGRAM STORED THEREIN, INFORMATION PROCESSING SYSTEM, AND INFORMATION PROCESSING METHOD - A free direction input area, a lateral direction input area, and a longitudinal direction input area are provided on an input surface of a touch panel. When a user performs a slide operation whose starting point is within the free direction input area, movement of a virtual camera is controlled based on a change amount of a touch position with respect to X- and Y-axis directions. When the user performs a slide operation whose starting point is within the lateral direction input area, movement of the virtual camera is controlled based on a change amount of a touch position only with respect to the X-axis direction. When the user performs a slide operation whose starting point is within the longitudinal direction input area, movement of the virtual camera is controlled based on a change amount of a touch position only with respect to the Y-axis direction. | 06-30-2011 |
20120116551 | DATA MANAGEMENT APPARATUS AND DATA DISTRIBUTION SYSTEM - Ghost data used for reproducing a game process executed by user operations are transmitted from game apparatuses to a data management apparatus. The data management apparatus stores the received ghost data, according to a definition of a database in which score sections are defined based on a value represented by score data, and a maximum registration allowable number of users for which the ghost data are registered is defined for each of the score sections, or is defined so as to be the same among the score sections. The data management apparatus transmits, when a ghost data distribution request is received, the ghost data for at least one user for which the ghost data is registered so as to be associated with one of the score sections, the scores section being associated with the score data included in the ghost data distribution request, to the one of the game apparatuses. | 05-10-2012 |
20120176384 | COMPUTER-READABLE STORAGE MEDIUM HAVING DISTRIBUTION CHART DISPLAY PROGRAM STOREDTHEREIN, INFORMATION PROCESSING APPARATUS, AND DISTRIBUTION CHART DISPLAY SYSTEM - A distribution chart representing a distribution of accomplishment times included in a plurality of pieces of result data is generated based on the plurality of pieces of result data including the accomplishment times of a racing game. Icons for identifying the plurality of pieces of result data are displayed on the distribution chart. When one of the icons displayed on the distribution chart is selected by a user, a process associated with the result data represented by the one of the icons having been selected is executed. Therefore, the distribution chart which includes a plurality of pieces of data as elements and is based on a predetermined index is displayed, and an interactive operation using the distribution chart can be realized. | 07-12-2012 |