Patent application number | Description | Published |
20130019327 | METHOD FOR SEARCHING AND SCREENING FOR TARGET OF ANTI-CANCER AGENT USING NON-HUMAN ANIMAL MODEL HAVING NOG ESTABLISHED CANCER CELL LINE TRANSPLANTED THEREINAANM Suzuki; MasamiAACI ShizuokaAACO JPAAGP Suzuki; Masami Shizuoka JPAANM Matsubara; KoichiAACI HeliosAACO SGAAGP Matsubara; Koichi Helios SGAANM Kato; AtsuhikoAACI ShizuokaAACO JPAAGP Kato; Atsuhiko Shizuoka JPAANM Kato; ChieAACI ShizuokaAACO JPAAGP Kato; Chie Shizuoka JPAANM Kobayashi; ShintaAACI HeliosAACO SGAAGP Kobayashi; Shinta Helios SGAANM Chen; Yu JauAACI HeliosAACO SGAAGP Chen; Yu Jau Helios SGAANM Yamazaki; MasakiAACI HeliosAACO SGAAGP Yamazaki; Masaki Helios SG - An objective of the present invention is to provide non-human animal models of cancer pathology, which mimic the hierarchical organization, cancer progression process, or biological property of human cancer tissues, and uses thereof. To achieve the objective described above, first, the present inventors transplanted cells of NOG-established cancer lines into NOG mice and morphologically observed the resulting tissue organization. As a result, the non-human animal models were demonstrated to exhibit pathologies (the hierarchical organization, cancer progression process, or biological properties of the cancer cells) similar to that of human cancer. Specifically, the present inventors succeeded in preparing non-human animal models exhibiting pathologies more similar to a human cancer, and cell culture systems using NOG-established cancer cell lines where the in vitro cell morphology is more similar to that of human cancer. | 01-17-2013 |
20130288248 | CANCER STEM CELL MASS AND PROCESS FOR PRODUCTION THEREOF - The purpose of the present invention is to provide: a cancer stem cell mass from which cells incapable of forming cancer are substantially removed and which has a characteristic property of reproducing a layered structure of a cancer tissue; a process for producing the cancer stem cell mass; and use of the cancer stem cell mass. For achieving the purpose, the present inventors grew a human cancer tissue repeatedly in a NOG mouse, separated cancer cells from the grown cancer tissue, and made a comparison of various cancer cell culture processes with each other. As a result, a cancer stem cell composition which is homogeneous and is substantially free of the coexistence of cells capable of forming cancer and cells incapable of forming cancer in a mixed state can be produced successively by employing an attached culture process using a serum-free stem cell culture medium rather than a generally employed floating culture process, and consequently the present invention has been accomplished. | 10-31-2013 |
20140302511 | CANCER STEM CELL-SPECIFIC MOLECULE - An objective of the present invention is to obtain two types of substantively homogeneous cancer stem cell populations which can be characterized using the cell surface marker Lgr5, and to provide cancer therapeutics using an antibody against a cell membrane molecule specifically expressed in these cancer stem cells by identifying said cell membrane molecule. A further objective of the present invention is to provide, using an antibody against a cell membrane molecule specifically expressed in cancer stem cells, a reagent for detecting cancer stem cells, and a method for diagnosing and sorting cancer patients. The present inventors discovered that highly pure large intestine cancer stem cells (CSC) can be obtained in a large quantity, and identified the two types of conditions of large intestine CSCs distinguishable through Lgr5 expression. Moreover, the present inventors discovered that an antibody against a cell membrane molecule specifically expressed in said cancer stem cells can damage said cells. | 10-09-2014 |
20140314675 | CANCER STEM CELL ISOLATION - An objective of the present invention is to provide: a cancer stem cell isolated using a cell marker; a substantively homogeneous cancer stem cell population including said cancer stem cell; and a method of preparing said cancer stem cell population. Another objective of the present invention is to provide: a method for separating cancer stem cells with a high proliferative potential and those with a low proliferative potential; a method for inducing cancer stem cells to have a different proliferative potential; and cancer stem cells separated or induced by these separation or induction methods. A further objective of the present invention is to provide: a method of screening for pharmaceuticals using said cancer stem cell or cancer stem cell population; a method for detecting the presence of said cancer stem cell or cancer stem cell population and for identifying or quantifying the same. The present inventors discovered that highly pure colon cancer stem cells (CSC) can be obtained in a large quantity, and identified two types of states of colon CSCs distinguishable through Lgr5 expression. | 10-23-2014 |
Patent application number | Description | Published |
20110202970 | Secure Access In A Communication Network - A method of providing secure access to a remote communication network via a local communication network for a terminal device. A gateway node located outside the local communication network allocates an IP address to the terminal device. The gateway node subsequently receives a request to establish a secure tunnel between the gateway node and the terminal device. It identifies the terminal device as the same terminal device to which an IP address is allocated, and allocates the same IP address for use by the terminal device as both an inner IP address and an outer IP address for packets sent via the secure tunnel. This ensures that there are no issues as described above in selecting the IP address for use in the secure tunnel, and reduces the risk of a successful man-in-the-middle attack. | 08-18-2011 |
20130124710 | MEDIATION SERVER, CONTROL METHOD THEREFOR, COMMUNICATION DEVICE, CONTROL METHOD THEREFOR, ACCOUNT PROVISIONING SERVER, AND CONTROL METHOD THEREFOR - In the first embodiment, the mobile phone | 05-16-2013 |
20140075532 | Authentication Server and Communication Device - There is provided an authentication server. The server includes a receiving unit configured to receive a request from a network apparatus. The request includes a subscription identity. The server further includes a determination unit configured to determine whether the received subscription identity is a predetermined subscription identity and an obtaining unit configured to obtain, when it is determined that the received subscription identity is the predetermined subscription identity, a key and a subscription identity. The key is derived by applying a key derivation function to a random number and a key associated with the predetermined subscription identity. The server further includes a storage unit configured to store the obtained key and the obtained subscription identity and a response unit configured to send a response including the random number and an authentication token to the network apparatus. The authentication token includes the obtained subscription identity. | 03-13-2014 |