Patent application number | Description | Published |
20120273090 | PROCESS AND MATERIAL SOLUTION TO REDUCE METAL ION RELEASE FOR IMPLANTABLE MEDICAL DEVICE APPLICATION - The invention describes a method and compositions where the presence of cobalt and or nickel have been depleted from the surface layer(s) of a cobalt, chromium, nickel containing alloy. | 11-01-2012 |
20130126474 | SURFACE IMPROVEMENT ON ELECTRIC DISCHARGE MACHINED TITANIUM ALLOY MINIATURE PARTS FOR IMPLANTABLE MEDICAL DEVICE - The invention describes a process to remove a recast layer and/or burrs from machining processes to provide a surface of a titanium medical device without dissipation of copper or zinc from the surface of the medical device. | 05-23-2013 |
20140277316 | MEDICAL LEADS AND TECHNIQUES FOR MANUFACTURING THE SAME - In some examples, the disclosure relates to a medical device comprising a lead including an electrically conductive lead wire; and an electrode electrically coupled to the lead wire, the electrode including a first portion and a second portion, wherein the first portion defines an exposed outer surface of the electrode and is electrically coupled to the second portion along a first interface, wherein the second portion is electrically coupled to the lead wire along a second interface different from the first interface via welding to couple the lead wire to the electrode, wherein an electrical signal may be transferred between the lead wire and exposed outer surface of the first portion via the second portion, and wherein the first portion is formed from a first material having a first composition, and the second portion is formed from a second material having a second composition different from the first composition. | 09-18-2014 |
20140343644 | MEDICAL LEADS AND TECHNIQUES FOR MANUFACTURING THE SAME - In some examples, the disclosure relates to a medical device comprising a lead including an electrically conductive lead wire; and an electrode electrically coupled to the lead wire, the electrode including a substrate and a coating on an outer surface of the substrate, wherein the lead wire is formed of a composition comprising titanium or titanium alloys, wherein the substrate is formed of a composition comprising one or more of titanium, tantalum, niobium, and alloys thereof, wherein the coating comprises at least one of Pt, TiN, IrOx, and poly(dioctyl-bithiophene) (PDOT). In some examples, the lead wire may be coupled to the lead wire via a weld, such as, e.g., a laser weld. | 11-20-2014 |
Patent application number | Description | Published |
20120305573 | Self-Righting Containers - An open self-righting container comprising a shell with a bottom truncated non-spherical Gomboc-like surface and a wall projecting upwardly therefrom, an interior cavity, a bottom rest surface at a stable equilibrium point of the shell, and a top opening opposite the rest surface where the interior of the shell may include a meltable solid fuel fitted with a wick. | 12-06-2012 |
20120305574 | Self-Righting Container - An open self-righting container comprising a convex shell with an outer truncated non-spherical Gomboc-like surface, an interior cavity, a rest surface at a stable equilibrium point of the shell, and an opening opposite the rest surface where the interior cavity may include a meltable fuel fitted with a wick. | 12-06-2012 |
20130323292 | Clog Resistant Insect Control Formulations Containing Pyrethrin, An Acetylenic Compound, And A Hydrocarbon Diene - Disclosed are pyrethrin-based insect control formulations which have been formulated to reduce wick clogging in dispensers which use heaters to drive an insect control active from the wick. Pyrethrum extract is mixed with an acetylenic compound, such as prallethrin or 3,5-dimethylhex-1-yn-3-ol, and a terminal diene compound such as myrcene or 1,3 hexadiene. Wick clogging side effects from using the pyrethrum are thereby suppressed. | 12-05-2013 |
20140027530 | Dispensing Device - A dispensing device for release of an air treatment material includes a semi-permeable substrate having a mesh size between about 15 strands per cm to about 79 strands per cm and a support component for supporting the semi-permeable substrate. The dispensing device releases the air treatment material at a rate of at least about 0.05 mg/hr at about 25° C. | 01-30-2014 |
20150075445 | Portable Area Repellent Device - A device for dispensing an air treatment chemical includes a housing having an inlet for permitting air to enter into an interior space of the housing and an outlet for permitting air mixed with an air treatment chemical to exit the interior space of the housing. A substrate positioned within the housing bears an air treatment chemical. A power supply mounted within the housing powers a motor within the housing. The motor is connected to a fan mounted within the housing. The fan moves air from the inlet adjacent to the substrate to mix the air treatment chemical into the moving air and deliver the mixture of air and air treatment chemical through the outlet to the outside of the housing. | 03-19-2015 |
20150078921 | AIR TREATMENT CHEMICAL DISPENSER HAVING ANGLED DISPERSION OF CHEMICALS - A device for dispensing an air treatment chemical includes a housing having an inlet for permitting air to enter into an interior space of the housing and an outlet for permitting air mixed with air treatment chemical to exit the interior space of the housing. A substrate positioned within the housing bears the air treatment chemical. A power supply mounted within the housing powers a motor mounted within the housing. The motor is connected to an impeller mounted within the housing. The impeller moves air from the inlet adjacent the substrate to mix the air treatment chemical into the moving air and deliver the mixture of air and air treatment chemical through the outlet to outside of the housing. The housing includes a transitional body defining a convergent-divergent channel for compressing the mixture at the converging section and expanding the mixture at the diverging section. | 03-19-2015 |
Patent application number | Description | Published |
20080268190 | DEGRADABLE, SOFT-FEEL NETTING - The present invention provides degradable extruded netting. The netting comprises a plurality of oriented interconnected strands that intersect during extrusion. At least some of the strands include a degradable composition comprising a stiffening agent, a degradable material and a crystallinity inhibiting agent. In some embodiments, the stiffening agent comprises a polylactic acid polymer, the degradable material comprises a polyester degradable plasticizer, and the crystallinity inhibiting agent comprises a starch-based polymer. In certain embodiments, the degradable composition may comprise 10 to 70 weight percent polylactic acid polymer, 15 to 75 weight percent polyester degradable plasticizer, and 5 to 30 weight percent starch-based polymer. In other embodiments, the degradable composition may further comprise a friction reducing additive. | 10-30-2008 |
20100120308 | OXO-BIODEGRADABLE NETTING - The present invention provides a degradable extruded netting. The netting comprises a plurality of interconnected strands with at least some of the strands comprising a degradable composition comprising a polyolefin and a metal carboxylate. The present invention also relates to a method for making degradable extruded netting. The method comprises extruding strands of polymeric material to form a netting wherein at least some of the strands are formed of the degradable composition. | 05-13-2010 |
20110252747 | Wrapping Material For Use With An Automated Packing Machine And Methods Of Manufacture And Use - In at least one embodiment, a wrapping material for use in covering an article on an automated packing machine includes an interconnected network of a plurality of machine-direction strands being integrally joined to a plurality of cross-direction strands to form a netting. A first film segment is situated overlapping and bonded to the netting to form a first machine-direction seal. A second film segment being spaced apart from the first film segment is situated overlapping and bonded to the netting to form a second machine-direction seal. The first or the second seal has a wave height maximum, crest-to-trough, of less than | 10-20-2011 |
20120208417 | Netting With High Friction Surface And Method of Manufacture - In at least one embodiment, a netting comprising an interconnected network including a plurality of coextruded strands integrally joined, the coextruded strands having a first layer including a first thermoplastic composition and a second layer bonded to the first thermoplastic layer and including a second thermoplastic composition. The netting also includes a third layer bonded to the second layer and spaced apart from the first layer. The third layer includes a third thermoplastic composition. The netting has a friction angle ranging from 10 degrees to 40 degrees. | 08-16-2012 |
20120322331 | MULTIFUNCTIONAL MAT AND METHOD OF MANUFACTURE - In at least one embodiment, a multifunctional mat is provided comprising an interconnected network including a plurality of coextruded integrally joined strands forming a netting and a film bonded to the netting. The coextruded strands have at least three layers having three different compositions. The netting has an average kinetic coefficient ranging from 0.006 to 2.4 when measured according to ASTM D-1894 and a minimum absolute difference in adhesion temperature between the second thermoplastic composition and the other two thermoplastic compositions ranges from 10° C. to 120° C. | 12-20-2012 |
Patent application number | Description | Published |
20090264306 | DNA METHYLATION BIOMARKERS IN LYMPHOID AND HEMATOPOIETIC MALIGNANCIES - Differential Methylation Hybridization (DMH) was used to identify novel methylation markers and methylation profiles for hematopoieetic malignancies, leukemia, lymphomas, etc. (e.g., non-Hodgkin's lymphomas (NHL), small B-cell lymphomas (SBCL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), mantle cell lymphoma (MCL), B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL), chronic lymphocytic leukemia (CLL), multiple myeloma (MM), acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL), etc.). Particular aspects provide novel biomarkers for NHL and subtypes thereof (e.g., MCL, B-CLL/SLL, FL, DLBCL, etc.), AML, ALL and MM, and further provide non-invasive tests (e.g. blood tests) for lymphomas and leukemias. Additional aspects provide markers for diagnosis, prognosis, monitoring responses to therapies, relapse, etc., and further provide targets and methods for therapeutic demethylating treatments. Further aspects provide cancer staging markers, and expression assays and approaches comprising idealized methylation and/or patterns” (IMP and/or IEP) and fusion of gene rankings. | 10-22-2009 |
20100248228 | Method for detecting DNA methylation in cancer cells - The present invention provides a detecting method of detecting malignant cells in a patient's specimen or a biological sample. Specifically, the inventive method includes the steps of extracting a genomic DNA, digesting said genomic DNA with one or multiple methylation sensitive restriction enzymes, and amplifying by PCR with one or multiple selected primers. The PCR can be performed in a conventional or a real-time platform. The inventive method can detect leukemia cells in 90% ALL patients at a sensitivity of up to 10 | 09-30-2010 |
Patent application number | Description | Published |
20080312258 | METABOLITES OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE - The present invention provides active metablites of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases. | 12-18-2008 |
20110082159 | METABOLITES OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYL- PROPANENITRILE - The present invention provides active metabolites of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases. | 04-07-2011 |
Patent application number | Description | Published |
20130042156 | UTILIZING MULTIPLE STORAGE DEVICES TO REDUCE WRITE LATENCY FOR DATABASE LOGGING - Methods, computer-readable media, and computer systems are provided for initiating storage of data on multiple storage devices and confirming storage of the data after the data has been stored on one but not necessarily all of the devices. A storage server receives, from a client, a request to store data. In response to the request, the storage server initiates, in parallel, storage of the data on multiple storage systems. The storage server detects that the data has been stored on any one of the storage systems, such as an auxiliary system, and, in response, indicates, to the client, that the data has been stored. The storage server may flush or discard data on the auxiliary storage system upon detecting that the data has been successfully stored on a target storage system, where the data persists. | 02-14-2013 |
20130086330 | Write-Back Storage Cache Based On Fast Persistent Memory - A storage device uses non-volatile memory devices for caching. The storage device operates in a mode referred to herein as write-back mode. In write-back mode, a storage device responds to a request to write data by persistently writing the data to a cache in a non-volatile memory device and acknowledges to the requestor that the data is written persistently in the storage device. The acknowledgement is sent without necessarily having written the data that was requested to be written to primary storage. Instead, the data is written to primary storage later. | 04-04-2013 |
20130262937 | NODE DEATH DETECTION BY QUERYING - Systems, methods, and other embodiments associated with detecting a node death in a clustered distributed system are described. In one embodiment, a method includes transmitting a ping message to a peer node in the network. If a reply to the ping message is not received from the peer node, a query is sent to table of port identifiers that lists ports in the cluster. In one embodiment, the query includes a port identifier associated with the peer node. The peer node is declared as inactive/dead when the query fails to locate a match in the table for the port identifier. When the query locates a match in the table for the port identifier, another ping message is periodically transmitted to the peer node. | 10-03-2013 |
20130326152 | Rapid Recovery From Loss Of Storage Device Cache - Dirty data in a storage device is made current through rapid re-silvering, which uses a mirrored and up-to-date version of the dirty data from another storage device to recover the data. Because under rapid re-silvering cache metadata in volatile memory survives the failure of the cache, the cache metadata is used to determine which subset of data from the other storage device needs to be copied to the storage device being re-silvered. During re-silvering, cache metadata is used to determine which I/O requests from clients are requests for data that is not stale. | 12-05-2013 |
20140281272 | Rapid Recovery From Downtime Of Mirrored Storage Device - No-loss rapid recovery performs resynchronization efficiently while concurrently allowing availability to mirrored data on the storage device. No-loss rapid recovery has two stages and involves storage devices that have both a non-volatile cache and primary storage and that operate as mirror buddies. The first stage is referred to herein as the buddy-retention stage. During the buddy-retention stage, writes to mirrored data are not performed on the offline mirror buddy but are performed on the online mirror buddy. The mirrored data changed in the online mirrored buddy is retained in the non-volatile cache of the retention buddy. The next stage is referred to herein as the rapid resynchronization stage. In this stage, the changed mirrored data retained by the retention buddy for no-loss rapid recovery is used to resynchronize the offline buddy. The storage device is resynchronized using the changed mirrored data retained in the cache of the mirror buddy. | 09-18-2014 |
20150088805 | AUTOMATIC CACHING OF SCAN AND RANDOM ACCESS DATA IN COMPUTING SYSTEMS - Approaches, techniques, and mechanisms are disclosed for improved caching in database systems that deal with multiple data access patterns, such as in database systems that interface with both OLTP and Data Warehouse clients. A cache is deployed between a database server and a storage system that stores data units. Some of the data units accessed by the database server are buffered within the cache. The data units may be associated with data access patterns, such as a random data access pattern or a scan data access pattern, in accordance with which the database server is or appears to be accessing the data units. A processor selects when to cache data units accessed by the database server, based at least on the associated data access patterns. Recent access counts may also be stored for the data units, and may further be utilized to select when to cache data units. | 03-26-2015 |
20150089008 | INTELLIGENT NETWORK RESOURCE MANAGER - A method and apparatus for intelligent network resource manager for distributed computing systems is provided. A first priority is assigned to a first virtual channel set that includes at least two virtual channels of a plurality of virtual channels associated with a physical communication channel. A second priority is assigned to a second virtual channel set that includes at least one virtual channel of the plurality of virtual channels. The first virtual channel set has more virtual channels than the second virtual channel set. Outbound messages of the first priority are directed to virtual channels of the first virtual channel set. Outbound messages of the second priority are directed to virtual channels of the second virtual channel set. The virtual channels are processed in a round-robin order, where processing includes sending the outbound messages over the physical communication channel. | 03-26-2015 |
20150089138 | Fast Data Initialization - A method and system for fast file initialization is provided. An initialization request to create or extend a file is received. The initialization request comprises or identifies file template metadata. A set of allocation units are allocated, the set of allocation units comprising at least one allocation unit for the file on a primary storage medium without initializing at least a portion of the file on the primary storage medium. The file template metadata is stored in a cache. The cache resides in at least one of volatile memory and persistent flash storage. A second request is received corresponding to a particular allocation unit of the set of allocation units. Particular file template metadata associated with the particular allocation unit is obtained. In response to the second request, at least a portion of a new allocation unit is generated. | 03-26-2015 |
20150089140 | Movement Offload To Storage Systems - In a write by-peer-reference, a storage device client writes a data block to a target storage device in the storage system by sending a write request to the target storage device, the write request specifying information used to obtain the data block from a source storage device in the storage system. The target storage device sends a read request to the source storage device for the data block. The source storage device sends the data block to the target storage device, which then writes the data block to the target storage device. The data block is thus written to the target storage device without the storage device client transmitting the data block itself to the target storage device. | 03-26-2015 |
Patent application number | Description | Published |
20120091204 | Real-time barcode recognition using general cameras - A method, apparatus, and system for decoding and recognizing barcode information by using a general camera such as one in a mobile device is disclosed. The invention uses a set of compact point spread functions (PSF) with a squared-shape distribution to restore blurred barcode image for quick and efficient decoding and recognition. Image pre-processing methods are applied to reduce noise and normalize pixel grayscale. On each normalized image, the invention checks if the image contains barcode lines. If there is a barcode, the invention tries to identify the beginning and ending positions of the barcode. The invention selectively decodes multiple scan lines across the barcode and match against predefined barcode models. The best matched barcodes are saved in the history buffer. | 04-19-2012 |
20120165658 | SYSTEM, ARTICLE OF MANUFACTURE, AND METHOD FOR CHARACTERIZING A MEDICAL DEVICE AND/OR ONE OR MORE SENSORS MOUNTED THEREON - Systems and methods for characterizing a medical device and/or the sensors thereof are provided. A system comprises an electronic control unit (ECU) configured to acquire first and second configurations of the device. The ECU is configured to process the configurations to calculate an index used to characterize the device and/or the sensors thereof. An article of manufacture comprises a computer-readable storage medium having a computer program encoded thereon for characterizing the device and/or the sensor thereof. The program includes code for acquiring first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof. A method for characterizing the device and/or the sensors thereof comprises providing an ECU, acquiring, by the ECU, first and second configurations of the device, and processing them together to calculate an index used to characterize the device and/or the sensors thereof. | 06-28-2012 |
20130167208 | Smart Phone Login Using QR Code - Systems and methods are disclosed for a user to use a mobile device such as a smart phone to scan a QR (Quick Response) code displayed on a login webpage of a website. The QR code may encode a server URL of the website. The mobile device decodes the QR code and transmits a device ID and other decoded information to a service provider. The service provider locates login credentials of the user linked to the device ID and communicates the login credentials to a website server for user authentication. Alternatively, the mobile device may transmit its device ID to the website server for the website server to locate a user account linked to the device ID for user login. Alternatively, the mobile device may transmit stored login credentials to the website server. Advantageously, a user may access a website without the need to provide any login credentials. | 06-27-2013 |
20130274582 | System and Method for Diagnosing Arrhythmias and Directing Catheter Therapies - An efficient system for diagnosing arrhythmias and directing catheter therapies may allow for measuring, classifying, analyzing, and mapping spatial electrophysiological (EP) patterns within a body. The efficient system may further guide arrhythmia therapy and update maps as treatment is delivered. The efficient system may use a medical device having a high density of sensors with a known spatial configuration for collecting EP data and positioning data. Further, the efficient system may also use an electronic control system (ECU) for computing and providing the user with a variety of metrics, derivative metrics, high definition (HD) maps, HD composite maps, and general visual aids for association with a geometrical anatomical model shown on a display device. | 10-17-2013 |
Patent application number | Description | Published |
20110186467 | WATER-SOLUBLE FILM HAVING IMPROVED DISSOLUTION AND STRESS PROPERTIES, AND PACKETS MADE THEREFROM - Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325. | 08-04-2011 |
20110186468 | WATER-SOLUBLE FILM HAVING IMPROVED DISSOLUTION AND STRESS PROPERTIES, AND PACKETS MADE THEREFROM - Disclosed is a pouch having at least one sealed compartment containing a first composition. At least one wall of the at least one sealed compartment is made from a water-soluble film having any suitable thickness. The water-soluble film comprises PVOH polymer such that when the film has a thickness of about 76 microns the film is characterized by a Dissolution Index of about 620 to about 920, or of about 665 to about 920, or about 710 to about 920; and a Stress Index of about 145 to about 626, or about 155 to about 480, or about 165 to about 325. | 08-04-2011 |
20110188784 | WATER-SOLUBLE FILM HAVING BLEND OF PVOH POLYMERS, AND PACKETS MADE THEREFROM - Disclosed are plasticized, water-soluble films having favorable cold-water solubility, wet handling, and thermoforming characteristics, and which can include a PVOH resin made up of blend of two or more PVOH polymers each having a monomodal molecular weight distribution, and the PVOH resin characterized by a viscosity in a range of about 13.5 cP to about 20 cP (or a corresponding weight average molecular weight), a degree of hydrolysis of about 84% to about 92%, a polydispersity index value in a range of about 1 to about 5, a residual water content of about 4 wt. % to about 10 wt. %, and a Resin Selection Index value in a range of 0.255 to 0.315; methods of making the films; compositions including PVOH resins for making the films; and pouch and packet articles made from the films. | 08-04-2011 |
20110189413 | WATER-SOLUBLE FILM HAVING BLEND OF PVOH POLYMERS, AND PACKETS MADE THEREFROM - Disclosed are plasticized, water-soluble films having favorable cold-water solubility, wet handling, and thermoforming characteristics, and which can include a PVOH resin made up of blend of two or more PVOH polymers each having a monomodal molecular weight distribution, and the PVOH resin characterized by a viscosity in a range of about 13.5 cP to about 20 cP (or a corresponding weight average molecular weight), a degree of hydrolysis of about 84% to about 92%, a polydispersity index value in a range of about 1 to about 5, a residual water content of about 4 wt. % to about 10 wt. %, and a Resin Selection Index value in a range of 0.255 to 0.315; methods of making the films; compositions including PVOH resins for making the films; and pouch and packet articles made from the films. | 08-04-2011 |
20130310300 | Inverse Dispersion Comprising a Cationic Polymer and a Stabilizing Agent - An inverse dispersion comprising
| 11-21-2013 |
Patent application number | Description | Published |
20120021294 | Graphite or carbon particulates for the lithium ion battery anode - This invention provides a graphite or graphite-carbon particulate for use as a lithium secondary battery anode material having a high-rate capability. The particulate is formed of a core carbon or graphite particle and a plurality of satellite carbon or graphite particles that are each separately bonded to the core particle wherein the core particle is spherical in shape, slightly elongate in shape with a major axis-to-minor axis ratio less than 2, or fibril in shape, and wherein the satellite particles are disc-, platelet-, or flake-like particles each containing a graphite crystallite with a crystallographic c-axis dimension Lc and a lateral dimension. Preferably, Lc is less than 100 nm and the flake/platelet lateral dimension is less than 1 μm. The core particle may be selected from natural graphite, artificial graphite, spherical graphite, graphitic coke, meso-carbon micro-bead, soft carbon, hard carbon, graphitic fibril, carbon nano-fiber, carbon fiber, or graphite fiber. Preferably, the flat-shaped particles are randomly oriented with respect to one another. | 01-26-2012 |
20120058397 | Graphene-Enhanced cathode materials for lithium batteries - A nano graphene-enhanced particulate for use as a lithium battery cathode active material, wherein the particulate is formed of a single or a plurality of graphene sheets and a plurality of fine cathode active material particles with a size smaller than 10 μm (preferably sub-micron or nano-scaled), and the graphene sheets and the particles are mutually bonded or agglomerated into an individual discrete particulate with at least a graphene sheet embracing the cathode active material particles, and wherein the particulate has an electrical conductivity no less than 10 | 03-08-2012 |
20120064409 | Graphene-enhanced anode particulates for lithium ion batteries - A nano graphene-enhanced particulate for use as a lithium-ion battery anode active material, wherein the particulate is formed of a single sheet of graphene or a plurality of graphene sheets and a plurality of fine anode active material particles with a size smaller than 10 μm. The graphene sheets and the particles are mutually bonded or agglomerated into the particulate with at least a graphene sheet embracing the anode active material particles. The amount of graphene is at least 0.01% by weight and the amount of the anode active material is at least 0.1% by weight, all based on the total weight of the particulate. A lithium-ion battery having an anode containing these graphene-enhanced particulates exhibits a stable charge and discharge cycling response, a high specific capacity per unit mass, a high first-cycle efficiency, a high capacity per electrode volume, and a long cycle life. | 03-15-2012 |
Patent application number | Description | Published |
20080320613 | MODULATING MYO-INOSITOL CATABOLISM IN PLANTS - Compositions and methods for modulating MIOX activity are provided. Such compositions include nucleotide sequences for novel MIOX sequences obtained from maize, amino acid sequences for the proteins encoded by the nucleotide sequences of the invention, and variants and fragments thereof. Methods of the invention involve introducing into a plant a nucleotide construct comprising a MIOX nucleotide sequence operably linked to a promoter that drives expression in a plant. Expression of the novel nucleotide sequences disclosed herein confers advantageous agronomic properties on a plant. Transformed plants, plant cells, and seeds are additionally provided. | 12-25-2008 |
20090081354 | Phytate Polynucleotides and Methods of Use - This invention relates to newly identified polynucleotides and polypeptides in the phytic acid biosynthetic pathway, fragments, variants and derivatives of same; methods for making the polynucleotides, polypeptides, fragments, variants, derivatives and antagonists. In particular the invention relates to polynucleotides and polypeptides of the inositol 1,3,4-trisphosphate 5/6-kinase gene family. In particular this invention relates to using the newly identified polynucleotides and polypeptides to modulate the phytic acid biosynthesis in such a way as to decrease phytate and/or increase non-phytate phosphorous, especially in corn or soy animal feedstuffs. | 03-26-2009 |
20100218276 | MAIZE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN POLYNUCLEOTIDES AND METHODS OF USE - Compositions and methods are provided for modulating the level of phytate in plants. More specifically, the invention relates to methods of modulating the level of phytate utilizing nucleic acids comprising multidrug resistance-associated protein (MRP) nucleotide sequences to modulate the expression of MRP(s) in a plant of interest. The compositions and methods of the invention find use in agriculture for improving the nutritional quality of food and feed by reducing the levels of phytate and/or increasing the levels of non-phytate phosphorus in food and feed. The invention also finds use in reducing the environmental impact of animal waste. | 08-26-2010 |
20100281569 | MAIZE 17KD OLEOSIN SEED-PREFERRED REGULATORY ELEMENT - The present invention provides compositions and methods for regulating expression of nucleotide sequences of interest in a plant. Compositions are novel nucleotide sequences for a seed-preferred promoter associated with the maize 17 KD OLE (17 kilodalton oleosin) coding region. A method for expressing a nucleotide sequence of interest in a plant using the regulatory sequence disclosed herein is provided. | 11-04-2010 |
20100281570 | MAIZE 18KD OLEOSIN SEED-PREFERRED REGULATORY ELEMENT - The present invention provides compositions and methods for regulating expression of nucleotide sequences of interest in a plant. Compositions are novel nucleotide sequences for a seed-preferred promoter associated with the maize 18 KD OLE (18 kilodalton oleosin) coding region. A method for expressing a nucleotide sequence of interest in a plant using the regulatory sequence disclosed herein is provided. | 11-04-2010 |
20120058244 | MAIZE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN POLYNUCLEOTIDES AND METHODS OF USE - Compositions and methods are provided for modulating the level of phytate in plants. More specifically, the invention relates to methods of modulating the level of phytate utilizing nucleic acids comprising multidrug resistance-associated protein (MRP) nucleotide sequences to modulate the expression of MRP(s) in a plant of interest. The compositions and methods of the invention find use in agriculture for improving the nutritional quality of food and feed by reducing the levels of phytate and/or increasing the levels of non-phytate phosphorus in food and feed. The invention also finds use in reducing the environmental impact of animal waste. | 03-08-2012 |
20150082478 | PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE - Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ a guide RNA/Cas endonuclease system to provide an effective system for modifying or altering target sites within the genome of a plant, plant cell or seed. Also provided are compositions and methods employing a guide polynucleotide/Cas endonuclease system for genome modification of a nucleotide sequence in the genome of a cell or organism, for gene editing, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a cell or organism. Once a genomic target site is identified, a variety of methods can be employed to further modify the target sites such that they contain a variety of polynucleotides of interest. Breeding methods and methods for selecting plants utilizing a two component RNA guide and Cas endonuclease system are also disclosed. Compositions and methods are also provided for editing a nucleotide sequence in the genome of a cell. | 03-19-2015 |
Patent application number | Description | Published |
20090247201 | DYNAMIC ALLOCATION OF SPECTRUM SENSING RESOURCES IN COGNITIVE RADIO NETWORKS - A method, wireless controller, and information processing system are provided to dynamically allocate spectrum sensing resources. A first input ( | 10-01-2009 |
20100081387 | SIGNAL DETECTION IN COGNITIVE RADIO SYSTEMS - A cognitive radio wireless device ( | 04-01-2010 |
20100197332 | TARGETED GROUP SCALING FOR ENHANCED DISTRIBUTED SPECTRUM SENSING - A method, wireless device, and information processing system dynamically update spectrum sensing groups in a wireless communication system. A set of wireless devices ( | 08-05-2010 |
20110142027 | METHOD OF SIGNAL TO TIME-SPECTRUM CHANNEL RESOURCE MAPPING FOR WIRELESS COMMUNICATION SYSTEM - A communication device and method of allocating spectrum resources in a communication system to protect data to be transmitted are disclosed. The communication channel resource is divided temporally to form regions. Data to be transmitted is separated into data portions. Each data portion is able to be transmitted over one of the regions. The data portions are prioritized based on the importance of the data portion. The regions are ranked based on the transmission reliability thereon. The prioritized data portions are mapped to the ranked regions such that more important data portions are mapped to more reliable regions and less important data portions are mapped to less reliable regions. The prioritized data is output temporally in order of importance to enable the mapping of the prioritized data. | 06-16-2011 |
20130083786 | METHOD AND APPARATUS FOR SYNCHRONIZATION IN A DYNAMIC SPECTRUM ACCESS (DSA) COGNITIVE RADIO SYSTEM - A method and apparatus for synchronization in a dynamic spectrum access system is provided herein. During operation a transmitter will vary a known sequence to generate a preamble for each radio frame. The variation of the known sequence is based on what particular subcarriers are currently being used by the transmitter. In one embodiment, the preamble is coupled to the filterbank multicarrier synthesis to generate an over-the-air preamble for use in synchronizing a receiver. | 04-04-2013 |
20130337761 | METHOD AND APPARATUS FOR IN-CHANNEL INTERFERENCE CANCELLATION - A communication device includes a receiver that is capable of canceling in-channel interference. The receiver includes an antenna for receiving a wireless signal comprising in-channel components and an out-of-channel component, wherein the in-channel components comprise a desired component and an in-channel interference component. A first filter of the receiver filters the wireless signal by blocking at least a portion of the out-of-channel component to produce a first signal comprising the in-channel components, and at least a second filter of the receiver filters the wireless signal by blocking at least a portion of the in-channel components to produce a second signal comprising the out-of-channel component. An in-channel interference estimator of the receiver generates an in-channel interference estimation signal based on the second signal. And a combiner of the filter combines the first signal and the second signal to at least partially cancel the in-channel interference component of the first signal. | 12-19-2013 |
20140064405 | METHOD AND APPARATUS FOR OUT-OF-CHANNEL EMISSION SUPPRESSION - A wireless communication device is provided that is capable of suppressing out-of-channel emissions. The wireless communication device includes an upsampled broadband multicarrier signal generator and multiple upsampled sidelobe signal generators. The upsampled broadband multicarrier signal generator receives a symbol stream and, based on the symbol stream, generates a broadband multicarrier signal comprising an in-channel signal and a first multiple out-of-channel sidelobes. Each upsampled sidelobe signal generator of the multiple upsampled sidelobe signal generators receives at least a portion of the symbol stream and, based on at least a portion of the symbol stream, generates an out-of-channel sidelobes to produce a second multiple out-of-channel sidelobes. The wireless communication device further includes a combiner that combines the broadband multicarrier signal and the second multiple out-of-channel sidelobes to at least partially suppress first multiple out-of-channel sidelobes of the broadband multicarrier signal. | 03-06-2014 |
Patent application number | Description | Published |
20110170820 | EO POLYMER-BASED DUAL SLOT WAVEGUIDE MODULATORS - Electro-optic modulators are disclosed. An electro-optic modulator comprises an electro-optic polymer layer, semiconductor layers, ferroelectric material layers, and electrodes. The semiconductor layers are positioned on each surface of the electro-optic polymer layer. The refractive index of the semiconductor layers in the optical and RF domains is higher than the refractive index of the electro-optic polymer layer in the optical and RF domains. The ferroelectric material layers are positioned on each semiconductor layer opposite the electro-optic polymer layer. The refractive index of the ferroelectric material layers in the RF domain is higher than the refractive indices of both the electro-optic polymer layer and the semiconductor layers in the RF domain. The refractive index of the ferroelectric material layers in the optical domain is lower than the refractive index of the semiconductor layer in the optical domain. The electrodes are positioned on each ferroelectric material layer opposite the semiconductor layer. | 07-14-2011 |
20110203663 | PHOTONIC CRYSTAL ENHANCED LIGHT TRAPPING SOLAR CELL - This invention relates to a high efficiency solar cell comprising: (a) a top surface of an anti-reflective coating layer; (b) an engineered photonic crystal material layer, (c) an active photovoltaic layer; (d) a photonic crystals with an integrated diffraction grating; (e) a metallic diffraction grating reflective layer, and (f) a metallic back reflector;
| 08-25-2011 |
20130140723 | METHOD OF FABRICATING AN OPTICAL GRATING - According to embodiments of the invention, the design and fabrication of a binary superimposed grating (BSG) results in better performing devices that may be fabricated using existing technology. The fabrication process includes forming grating features based upon repeating features of the desired superposition function. The design process also relaxes the processing requirement for equivalently performing devices. | 06-06-2013 |
20140192161 | THREE-DIMENSIONAL RECONSTRUCTION OF A MILLIMETER-WAVE SCENE BY OPTICAL UP-CONVERSION AND CROSS-CORRELATION DETECTION - An apparatus and method may be used to create images, e.g., three-dimensional images, based on received radio-frequency (RP), e.g., millimeter wave, signals carrying image data. The RF signals may be modulated onto optical carrier signals, and the resulting modulated optical signals may be cross-correlated. The resulting cross-correlations may be used to extract image data that may be used to generate three-dimensional images. | 07-10-2014 |
Patent application number | Description | Published |
20080262055 | Macrocyclic Acyl Guanidines as Beta-Secretase Inhibitors - There is provided a series of heterocyclic-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, | 10-23-2008 |
20120238539 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS - A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: | 09-20-2012 |
20120245176 | NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS - A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof: | 09-27-2012 |
20140011700 | THREE-DIMENSIONAL STRUCTURE OF H1N1 NUCLEOPROTEIN IN COMPLEX WITH ANTIVIRAL COMPOUNDS - The binding mode of the antiviral compounds have been characterized through a variety of biophysical and structural studies, elaborating on the proposed aggregation mechanism of action. We demonstrate the direct binding of these antiviral compounds to NP using thermal shift enhancement assay (TSE) and NMR. In addition, we have completed a detailed analysis of the oligomerization mechanism of action using dynamic light scattering, analytical ultracentrifugation, and surface plasmon resonance (SPR). Structure determination using x-ray crystallography confirmed the proposed compound-induced oligomerization mechanism of action. The co-crystal structure revealed that two compounds bound in an anti-parallel fashion bridging two NP monomers, inducing a novel non-native NP oligomer. Taken together, our data suggest a complex binding mode in which the compounds bind NP specifically in stoichiometric fashion inducing the formation of an NP oligomer without obstructing the RNA binding pocket or interfering with the native NP homo-oligomerization. | 01-09-2014 |
Patent application number | Description | Published |
20090056991 | Methods of Treating a Surface to Promote Binding of Molecule(s) of Interest, Coatings and Devices Formed Therefrom - The present invention generally relates to methods of treating a surface of a substrate, and to the use of the method and resulting films, coatings and devices formed therefrom in various applications including but not limited to electronics manufacturing, printed circuit board manufacturing, metal electroplating, the protection of surfaces against chemical attack, the manufacture of localized conductive coatings, the manufacture of chemical sensors, for example in the fields of chemistry and molecular biology, the manufacture of biomedical equipment, and the like. In another aspect, the present invention provides a printed circuit board, a printed circuit board, comprising: at least one metal layer; a layer of organic molecules attached to the at least one metal layer; and an epoxy layer atop said layer of organic molecules. | 03-05-2009 |
20090056994 | Methods of Treating a Surface to Promote Metal Plating and Devices Formed - Embodiments of the present invention provide methods of treating a surface of a substrate. In one particular aspect, embodiments of the present invention provide methods of treating a surface of a substrate that promote binding of one or more metal elements to the surface. According to some embodiments of the invention, films are formed on any conducting, semiconductive or non-conductive surface, by thermal reaction of molecules containing reactive groups in an organic solvent or in aqueous solution. The thermal reaction may be produced under a variety of conditions. In another aspect, the present invention provides a printed circuit board, comprising: at least one substrate; a layer of organic molecules attached to the at least one substrate; and a metal layer atop said layer of organic molecules. | 03-05-2009 |
20100071938 | METHODS OF TREATING A SURFACE TO PROMOTE METAL PLATING AND DEVICES FORMED - Embodiments of the present invention provide methods of treating a surface of a substrate. In one particular aspect, embodiments of the present invention provide methods of treating a surface of a substrate that promote binding of one or more metal elements to the surface. According to some embodiments of the invention, films are formed on any conducting, semiconductive or non-conductive surface, by thermal reaction of molecules containing reactive groups in an organic solvent or in aqueous solution. The thermal reaction may be produced under a variety of conditions. In another aspect, the present invention provides a printed circuit board, comprising: at least one substrate; a layer of organic molecules attached to the at least one substrate; and a metal layer atop said layer of organic molecules. | 03-25-2010 |
20100075427 | METHODS OF TREATING A SURFACE TO PROMOTE METAL PLATING AND DEVICES FORMED - Embodiments of the present invention provide methods of treating a surface of a substrate. In one embodiment a kit for carrying out the binding of metals to a substrate is provided, comprising: a container comprising a heat-resistant organic molecule derivatized with an attachment group Y and a binding group X, the binding group X promotes binding of metals; and instructional materials teaching coupling the organic molecule to the substrate by heating the molecule and/or the surface to a temperature of at least 25° C. | 03-25-2010 |
20120125514 | Methods Of Treating Copper Surfaces For Enhancing Adhesion To Organic Substrates For Use In Printed Circuit Boards - Embodiments of the present invention relates generally to the manufacture of printed circuit boards (PCB's) or printed wiring boards (PWB's), and particularly to methods for treating smooth copper surfaces to increase the adhesion between a copper surface and an organic substrate. More particularly, embodiments of the present invention related to methods of achieving improved bonding strength of PCBs without roughening the topography of the copper surface. The bonding interface between the treated copper and the resin layer of the PCB exhibits excellent resistance to heat, moisture, and chemicals involved in post-lamination process steps. | 05-24-2012 |
Patent application number | Description | Published |
20110152513 | CONVERSION OF CARBOHYDRATES TO HYDROCARBONS - Materials and processes for the conversion of carbohydrates and polyols to gasoline boiling range hydrocarbons. Carbohydrates and polyols are reacted in the presence of modified zeolite catalysts to form a reaction product containing non-aromatic and aromatic gasoline boiling range hydrocarbons. | 06-23-2011 |
20110263916 | CARBOHYDRATES UPGRADING AND HYDROTREATING TO HYDROCARBONS - Technologies to convert biomass to liquid hydrocarbon fuels are currently being developed to decrease our carbon footprint and increase use of renewable fuels. Since sugars/sugar derivatives from biomass have high oxygen content and low hydrogen content, coke becomes an issue during zeolite upgrading to liquid hydrocarbon fuels. A process was designed to reduce the coke by co-feeding sugars/sugar derivatives with a saturated recycle stream containing hydrogenated products. | 10-27-2011 |
20120023810 | METAL IMPURITY AND HIGH MOLECULAR WEIGHT COMPONENTS REMOVAL OF BIOMASS DERIVED BIOCRUDE - This invention relates to a process for production of transportation fuels from biomass. More particularly, this invention relates to a process for using solvent to remove metal impurities and high molecular weight components from biomass derived biocrude to prevent potential catalyst poisoning and catalyst bed plugging in biocrude-to-transportation fuel upgrading process. | 02-02-2012 |
20120095274 | COMBINATION OF ZEOLITE UPGRADING WITH HYDROGENATION UPGRADING TO PRODUCE RENEWABLE GASOLINE FROM BIOMASS - Technologies to convert biomass to liquid hydrocarbon fuels are currently being developed to decrease our carbon footprint and increase use of renewable fuels. Since sugars/sugar derivatives from biomass have high oxygen content and low hydrogen content, coke becomes an issue during zeolite upgrading to liquid hydrocarbon fuels. A self-sustainable process was designed to reduce the coke by co-feeding sugars/sugar derivatives with the paraffin products from hydrogenation of sugars/sugar derivatives. Paraffins without complete conversion result in products with less aromatics and relatively low density compared with the products directly from zeolite upgrading. Thus, the process is more economically favorable. | 04-19-2012 |
20130219778 | CONVERTING GLYCOLS TO ALCOHOLS - The conversion of diols to mono-alcohols as fuel blendstocks. In one embodiment hydrotreating processes are described that selectively convert glycols to mono-alcohols that can be blended as biofuels. Both NiMo and CoMo catalysts are active for the reaction and reaction conditions can also impact the selectivity of mono-alcohols. | 08-29-2013 |
20130237728 | TRANSPORTATION FUELS FROM BIOMASS OXYGENATES - Oxygenate feedstocks derived from biomass are converted to a variety of fuels including gas, jet, and diesel fuel range hydrocarbons. General methods are provided including hydrolysis, dehydration, hydrogenation, condensation, oligomerization, and/or a polishing hydrotreating. | 09-12-2013 |
20140316176 | Deep Deoxygenation of Biocrudes Utilizing Fluidized Catalytic Cracking Co-Processing with Hydrocarbon Feedstocks - A system and method produce hydrocarbons from biomass by fluid catalytic cracking. In one embodiment, the system is a fluid catalytic cracking system. The system includes a riser. The riser contains a catalyst. The system also includes a biological feed comprising biomass-derived liquid for the riser. In addition, the system includes a hydrocarbon feed comprising hydrocarbons for the riser. The biological feed and the hydrocarbons react in the riser in the presence of the catalyst to convert at least a portion of the biological feed and the hydrocarbons to hydrocarbon products. The hydrocarbon products comprise a concentration of oxygen from about 0.005 wt. % to about 6 wt. %. | 10-23-2014 |
Patent application number | Description | Published |
20090131693 | Process for Selective Oxidation of Olefins to Epoxides - A process for the selective oxidation of olefins to epoxides comprising the step of contacting the olefin (propylene or ethylene) with an oxidant (hydrogen peroxide) in the presence of a Lewis acid oxidation catalyst (MTO), organic base (pyridine or its N-oxide), in a solvent system comprising an organic water-miscible solvent (methanol). The system is pressurized using either the olefin itself or by adding an inert pressurizing gas (nitrogen) to increase the pressure between 230 and 700 psi at a temperature between 0.7 and 1.3 times the critical temperature of the olefin. The resulting increased solubility of the olefin in the organic solvent system increases the selectivity and yield of the desired epoxide (propylene oxide or ethylene oxide). | 05-21-2009 |
20130144089 | PYROLYSIS OIL UPGRADING TO GASOLINE RANGE LIQUIDS - This invention is a method for converting biomass derived pyrolysis oil (bio-oil) into materials that will be more useful for transportation fuels including the following two steps: 1) solubilizing and extracting bio-oil oxygenates, and 2) zeolite catalyzed hydrogenation of the oxygenates into renewable fuel range materials. | 06-06-2013 |
20140069010 | GENERATING DEOXYGENATED PYROLYSIS VAPORS - The present disclosure relates generally to novel biomass pyrolysis processes and systems that decrease entrainment of char and other contaminants with the pyrolysis vapors. In certain embodiments, the present disclosure provides methods and systems to prevent entrainment of particles of char and heat carrier with pyrolysis vapors leaving a reactor, while allowing rapid upgrading of the vapors by catalyst(s) that are held in a an upgrading reactor and protected from contact with the char. | 03-13-2014 |
20140073823 | GENERATING DEOXYGENATED PYROLYSIS VAPORS - The present disclosure relates generally to novel biomass pyrolysis processes and systems that decrease entrainment of char and other contaminants with the pyrolysis vapors. | 03-13-2014 |
Patent application number | Description | Published |
20110195860 | FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAME - Biofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated with nickel or may be directly linked to the histidine-tagged protein e.g., histidine-tagged streptococcal IgG-binding protein, protein G, protein G3T, GFP or RFP. The resulting biofunctionalized fibers can be assembled into protein fiber assemblies by a variety of biofabrication methods. The fiber assemblies, e.g., in the form of woven fabrics, are useful for (i) antigen capture; (ii) immunoanalysis, and/or (iii) multiplexed analysis. In one fabrication, each fiber of a fiber assembly presents a specific antibody, and mixing and matching of fibers, for example by weaving of fabrics from various antibody-presenting fibers, allows for multiple antigens to be captured simultaneously for multiplexed analysis. | 08-11-2011 |
20110217785 | CHITOSAN-COATED WIRES FOR BIOSENSING - A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electro-depositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like. | 09-08-2011 |
20120103822 | ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERS - Methods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroaddressable to a location within the hydrogel and where the cells of the cell populations are entrapped by the hydrogel and are capable of expansion within the hydrogel and may be releasable from the hydrogel. Further provided are electroaddressable polysaccharide blends for the in-film expansion of a cell population, allowing probing of the cells and formation of immunocomplexes. Further provided are methods of using hydrogels containing electroaddressed or electroaddressable cell populations in in-film bioprocessing methods such as cell-based biosensing, protein-based biosensing, and in studies of cell signaling. | 05-03-2012 |
Patent application number | Description | Published |
20100124776 | ALLOGRAFTS COMBINED WITH TISSUE DERIVED STEM CELLS FOR BONE HEALING - There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose issue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed. | 05-20-2010 |
20140024115 | METHODS OF COMBINING MESENCHYMAL STEM CELLS AND CARTILAGE CONTAINING ALLOGRAFTS, AND PRODUCTS OF COMBINED MESENCHYMAL STEM CELLS AND CARTILAGE CONTAINING ALLOGRAFTS - There is disclosed a method of combining mesenchymal stem cells (MSCs) with an osteochondral allograft. In an embodiment, the method includes obtaining adipose tissue having MSCs with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The suspension is added to seed the allograft. The MSCs are allowed to attach to the allograft. There is disclosed an allograft product including MSCs with an osteochondral allograft. There is disclosed a method of combining MSCs with decellularized, morselized cartilage. In an embodiment, the method includes obtaining adipose tissue having MSCs with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The suspension is added to seed the cartilage. The MSCs are allowed to attach to the cartilage to. There is disclosed an allograft product including MSCs with morselized cartilage. Other embodiments are also disclosed. | 01-23-2014 |
20140134212 | MINCED CARTILAGE SYSTEMS AND METHODS - Compositions comprising a plurality of cartilage particles from a human adult cadaveric donor, wherein the cartilage particles comprise viable chondrocytes, and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a plurality of cartilage particles from a human adult cadaveric donor are also provided. | 05-15-2014 |
20140243993 | CARTILAGE MOSAIC COMPOSITIONS AND METHODS - Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided. | 08-28-2014 |
20140255489 | CONSISTENT CALCIUM CONTENT BONE ALLOGRAFT SYSTEMS AND METHODS - Embodiments of the present invention provides bone graft compositions, and methods for their use and manufacture. A bone graft composition may include a first amount of non-demineralized cancellous bone. The composition may further include a second amount of demineralized cancellous bone. The composition may also include a third amount of demineralized cortical bone. The non-demineralized cancellous bone, the demineralized cancellous bone, and the demineralized cortical bone may be obtained from the same cadaveric donor. | 09-11-2014 |
20140271570 | PERFORATED OSTEOCHONDRAL ALLOGRAFT COMPOSITIONS - Osteochondral graft composition comprising a cartilage component and a bone component, and further comprising one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using osteochondral graft compositions comprising one or more perforations in the bone component and/or the cartilage component are also provided. | 09-18-2014 |
20140286911 | CELL REPOPULATED COLLAGEN MATRIX FOR SOFT TISSUE REPAIR AND REGENERATION - The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided. | 09-25-2014 |
Patent application number | Description | Published |
20090203635 | HXAAA01 Polynucleotides - The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins. | 08-13-2009 |
20100291033 | Albumin Fusion Proteins - The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention. | 11-18-2010 |