Patent application number | Description | Published |
20110164031 | NOVEL IMPLEMENTATION OF TOTAL VARIATION (TV) MINIMIZATION ITERATIVE RECONSTRUCTION ALGORITHM SUITABLE FOR PARALLEL COMPUTATION - The CT imaging system optimizes its image generation by frequently updating an image and adaptively minimizing the total variation in an iterative reconstruction algorithm using many or sparse views under both normal and interior reconstructions. The projection data is grouped into N subsets, and after each of the N subsets is processed by the ordered subsets simultaneous algebraic reconstruction technique (OSSART), the image volume is updated. During the OSSART, no coefficients is cached in the system matrix. This approach is intrinsically parallel and can be implemented with a GPU card. Due to the more frequent image update and the variable step value, an image quality has improved. | 07-07-2011 |
20120128265 | METHOD AND SYSTEM UTILIZING ITERATIVE RECONSTRUCTION WITH ADAPTIVE PARAMETERS FOR COMPUTER TOMOGRAPHY (CT) IMAGES - The CT imaging system optimizes its image generation by adaptively weighting certain parameters during the iterations in an iterative reconstruction algorithm. The projection data is grouped into N subsets, and after each of the N subsets is processed by the ordered subsets simultaneous algebraic reconstruction technique (OSSART), the image undergoes total variation (TV) minimization process. During the iterative reconstruction algorithm, a combination of the parameters such as a total variation, a relaxation parameter and a step size parameter is assigned a respective value based upon the current value of the iteration. | 05-24-2012 |
20130016805 | METHOD AND SYSTEM FOR ACQUIRING SPARSE CHANNEL DATA AND FOR IMAGE PROCESSING UTILIZING ITERATIVE RECONSTRUCTION ALGORITHMSAANM SILVER; Michael D.AACI NORTHBROOKAAST ILAACO USAAGP SILVER; Michael D. NORTHBROOK IL USAANM SHI; DaxinAACI VERNON HILLSAAST ILAACO USAAGP SHI; Daxin VERNON HILLS IL US - The current invention is generally related to a data acquisition and or image processing method and system for acquiring and or processing sparse channel data. The sparse channel is implemented in a data acquisition system having a predetermined wider pitch between the adjacent detector cells than that in the currently available imaging systems at least in one predetermined channel direction. The sparse channel is also defined to encompass various imaging modalities including CT, positron emission tomography (PET) and positron emission tomography-computed tomography (PET/CT). The sparse channel data is acquired by the sparse channel data acquisition system, and an image is reconstructed from the sparse channel data according to a predetermined iterative reconstruction technique. | 01-17-2013 |
20130094735 | METHOD AND SYSTEM FOR EXPANDING AXIAL COVERAGE IN ITERATIVE RECONSTRUCTION IN COMPUTER TOMOGRAPHY (CT) - The image generation method and system generates an image using a predetermined iterative reconstruction technique from cone beam data that has been expanded by adding additional data, and an instance of the iteration process is weighted according to a corresponding validation weight during the reconstruction. Optionally, an instance of the iteration process is weighted according to a combination of weights during the reconstruction. The predetermined combination of the weights includes axial weights based upon a validity value of the expanded data and statistical weights. | 04-18-2013 |
20130101190 | COMBINATION WEIGHT APPLIED TO ITERATIVE RECONSTRUCTION IN IMAGE RECONSTRUCTION - The image generation method and system generates an image using a predetermined iterative reconstruction technique, and an instance of the iteration process is weighted according to a predetermined combination of weights during the reconstruction. The predetermined combination of the weights includes weights based upon a predetermined noise model and a predetermined window function to improve image quality. | 04-25-2013 |
20130101191 | METHOD AND SYSTEM FOR SUPPLEMENTING DETAIL IMAGE IN SUCCESSIVE MULTI-SCALE RECONSTRUCTION - The image reconstruction method and system reconstructs a multi-scale image using a set of predetermined nested 3D grids, and a zoomed image is reconstructed without losing details. The multiple steps uses a decreasing grid size to reconstruct an ultimately zoomed image in region of interest without degrading image quality. | 04-25-2013 |
20130177225 | SPATIAL RESOLUTION IMPROVEMENT IN COMPUTER TOMOGRAPHY (CT) USING ITERATIVE RECONSTRUCTION - Spatial resolution is substantially improved by simulating a system blur kernel including an angle variable in the forward projection during a predetermined iterative reconstruction technique. The iterative reconstruction acts as a deconvolution, which overcomes certain restrictions of system optics. In general, resolution is substantially improved with cone beam and helical data without a large increase in noise. | 07-11-2013 |
20130188847 | METHOD AND SYSTEM FOR IMAGE DENOISING USING DISCRETE TOTAL VARIATION (TV) MINIMIZATION WITH ONE-DIRECTION CONDITION - In the CT imaging system, a one-direction condition improves noise uniformity in the denoised images and avoids over smoothing in the low noise regions in an image, assuming that the image originally has an unequal noise distribution. On the other hand, the discrete gradients of total variation (DTV) minimization results in an improved edge preserving effects in comparison to the conventional total variation (TV) minimization. Using DTV, the pixel values on an edge will not be substantially affected after a certain denoising treatment. The difference between the DTV minimization and the conventional TV minimization is substantially negligible for strong edges while the DTV minimization substantially improves in preserving the weak edges. DTV keeps the original values while TV slightly smoothes the values for the pixel near the bottom and top of edges. | 07-25-2013 |
20130336561 | CONCURRENT UPDATE ITERATIVE RECONSTRUCTION (IR) METHOD AND SYSTEM - The CT imaging system optimizes its image generation by updating an image with the current application of a data fidelity update and a regularization update together in a single step in an iterative reconstruction algorithm. The iterative reconstruction algorithm includes the ordered subsets simultaneous algebraic reconstruction technique (OS SART) and the simultaneous algebraic reconstruction technique (SART). The data fidelity update and the regularization update are independently obtained using some predetermined statistical information such as noise and or error in matching the real data. | 12-19-2013 |
20130336562 | ADAPTIVELY DETERMINED PARAMETER VALUES IN ITERATIVE RECONSTRUCTION METHOD AND SYSTEM - The CT imaging system optimizes its image generation by adaptively changing parameters in an iterative reconstruction algorithm based upon certain information such as statistical information. The coefficients for the parameters include at least a first coefficient for a predetermined data fidelity process and a second coefficient for a predetermined regularization process in an iterative reconstruction algorithm. The iterative reconstruction algorithm includes the ordered subsets simultaneous algebraic reconstruction technique (OSSART) and the simultaneous algebraic reconstruction technique (SART). The first coefficient and the second coefficient are independently determined using some predetermined statistical information such as noise and or error in matching the real data. | 12-19-2013 |
20140219529 | ALTERATIVE NOISE MAP ESTIMATION METHODS FOR CT IMAGES - Noise map for CT images have been estimated by generalizing the prior art even-and-odd views approach. One example is to estimate a noise map from images reconstructed from three sets of independent views. A second example is to estimate a noise map from images reconstructed by using two sets of correlated views. A third example is to estimate a noise map from noise map from two images reconstructed from two sets of independent views while the number of views in each set is unequal. Physical phantom data were employed to validate our proposed noise map estimation methods. In comparison to the existing method, our alternative methods yield reasonably accurate noise map estimation. | 08-07-2014 |
20160063694 | ITERATIVE RECONSTRUCTION SCHEME FOR PHASE CONTRAST TOMOGRAPHY - A method of tomographic imaging the real part of the refractive index of the internal structure of an image volume and a corresponding apparatus for performing the method. The method includes a two-step process of first retrieving phase projections of an image volume from projective intensity measurements through the image volume. The second step of the method includes iterative image reconstruction of an image of the image volume using phase projections taken at multiple projection angles. The first step of intensity measurements and subsequent phase retrieval can use one of many possible phase retrieval methods including the Bronnikov phase retrieval method. The second step of iterative image reconstruction can be performed using the total variation minimization method, the algebraic reconstruction technique method, or any other iterative image reconstruction method. | 03-03-2016 |
Patent application number | Description | Published |
20130107584 | Dynamic Mosfet Gate Drivers | 05-02-2013 |
20130121032 | POWER SUPPLY REGULATION FOR ULTRA-LOW LOAD AND NO-LOAD OPERATION - A controller of a switching power converter employs a dynamically adaptive power supply regulation approach that improves low-load and no-load regulation to achieve ultra-low standby power in a switching power converter. Under ultra-low load conditions when a deep-deep pulse width modulation (DDPWM) is applied, the controller decreases the actual on-time of the power switch of the switching power converter by decreasing the “on” duration of the control signal used to turn on or off the power switch, until the “on” duration of the control signal reaches a minimum value. To further reduce the on-time of the power switch, the controller reduces the power applied to the power switch to turn on the switch more slowly, while maintaining the “on” duration of the control signal at a minimum value. The minimum value of the “on” duration of the control signal and the minimum power applied to the switch are dynamically controlled. | 05-16-2013 |
20130121044 | Power Converter Controller IC Having Pins with Multiple Functions - A controller integrated circuit (IC) for controlling a power converter uses one or more IC pins having plurality of functions such as configuration of a parameter supported by the controller IC and shutdown protection. Several different functions may be supported by a single IC pin, thereby reducing the number of pins required in the controller IC and also reducing the cost of manufacturing the controller IC. The controller IC may also share a comparison circuit among different pins and the different functions provided by those pins. Use of a shared comparison circuit further reduces the cost of manufacturing the controller IC without sacrificing the performance of the IC. | 05-16-2013 |
20130121049 | EMI Frequency Spreading Method for Switching Power Converter - A controller of a switching power converter sets an actual turn-on time of a switch in the switching power converter in each switching cycle by selecting one of a plurality of valley points of the output voltage of the switching power converter occurring subsequent to the desired turn-on time of the switch. The desired turn-on time of the switch may be calculated according to the regulation scheme employed by the switching power converter. The controller selects one of the plurality of valley points randomly from switching cycle to switching cycle. The controller generates a control signal to turn on the switching power converter at the selected one of the plurality of valley points of the output voltage occurring subsequent to the desired turn-on time. | 05-16-2013 |
20140015447 | THERMAL DE-RATING POWER SUPPLY FOR LED LOADS - Embodiments disclosed herein describe the use of a power supply to provide power to an LED load. The power supply provides a present output current to the LED, and receives a temperature signal representing the operating temperature of the LED. A target output current is determined, for instance based on the temperature signal. An output current rate of change is determined, and the power supply adjusts the output current to the LED at the determined rate of change until the output current is substantially equal to the target current. | 01-16-2014 |
20140016376 | CONFIGURABLE POWER CONTROLLER WITH COMBINATION INPUT - Embodiments described herein describe a power supply configured to provide power to an output load via a power supply transformer. The power supply includes a controller configured to operate in a configuration state and an operating state. During the configuration state, the controller receives a configuration signal from a sense circuit coupled to the controller and selects one of a plurality of operating modes from the configuration signal. During the operating state, the controller controls a switch coupled to the transformer based on the selected operating mode and a sense signal received from the sense circuit representative of the power provided to the output load by the power supply. When the switch is closed, current flows from a power source through the transformer, and when the switch is open, current is prevented from flowing from the power source through the transformer. | 01-16-2014 |
20140022829 | Hybrid Adaptive Power Factor Correction Schemes For Switching Power Converters - The embodiments disclosed herein describe a method of a controller of a switching power converter that provides a configurable power factor control method for the switching power converter. In one embodiment, the controller combines power regulation control methods of constant on-time control and constant power control to adjust the power factor of the switching power converter. | 01-23-2014 |
20140085938 | PRIMARY FEEDBACK SWITCHING POWER CONVERTER CONTROLLER WITH INTELLIGENT DETERMINATION OF AND RESPONSE TO OUTPUT VOLTAGE DROPS DUE TO DYNAMIC LOAD CONDITIONS - The embodiments herein include a primary-side controller for a switching power converter that is capable of receiving a detection signal from a secondary-side detection circuit indicating that an output voltage has reached a condition. The controller determines the appropriate action once a detection signal has been received by distinguishing whether a dynamic load condition has been placed on the power supply versus other operating conditions. | 03-27-2014 |
20140085941 | AC-DC POWER SUPPLY INPUT VOLTAGE DETECTION AND MONITORING - A power converter includes a transformer with a primary and a secondary winding and a switch. A controller of the power converter at the primary winding side of the transformer generates a control signal to turn on or turn off the switch, the switch being turned on responsive to the control signal being in a first state and the switch being turned off responsive to the control signal being in a second state. The controller determines current through the primary winding generated while the switch is turned on and indirectly detects an input voltage to the power converter based on the current through the primary winding generated while the switch is turned on. The controller in turn may detect conditions such as a loss of power or brown out at the input of the power converter based on the indirectly detected input voltage. | 03-27-2014 |
20140362612 | SWITCHING POWER CONVERTER WITH PRIMARY-SIDE DYNAMIC LOAD DETECTION AND PRIMARY-SIDE FEEDBACK AND CONTROL - A switching power converter provides regulated voltage to a load. The switching power converter comprises a transformer including a first primary winding coupled to an input voltage, a second primary winding, a secondary winding coupled to an output of the switching power converter, and an auxiliary winding, a first switch coupled to the first primary winding, and a second switch coupled to the secondary primary winding. A controller generates a first control signal to turn the first switch on or off at a first switching frequency, and a second control signal to turn the second switch on or off at a second switching frequency that is higher than the first frequency. During off cycles of the switches, feedback voltage representing the output voltage of the power converter is generated across the auxiliary winding. The controller controls switching of the first switch to regulate the output voltage based on the feedback. | 12-11-2014 |
20140376280 | PRECISE OUTPUT POWER DETECTION - A switching power converter provides regulated output power to a load. The switching power converter comprises a transformer including a primary winding coupled to an input voltage, a secondary winding coupled to an output of the switching power converter, an auxiliary winding on a primary side of the transformer, and a switch coupled to the primary winding of the transformer. Output voltage across the secondary winding is reflected as a feedback voltage across the auxiliary winding. The switching power converter detects output current based on a reset time of the transformer. Based on the detected output power, the switching power converter controls switching of the switch to provide regulated output power. | 12-25-2014 |
Patent application number | Description | Published |
20110021263 | CONTROLLING EVENT-DRIVEN BEHAVIOR OF WAGERING GAME OBJECTS - A behavior controller system and its operations are described herein. In embodiments, the operations can include detecting one or more events that occur within a wagering game. The wagering game can feature a wagering game object that can automatically (e.g., intelligently) respond to the one or more events. The behavior controller system can use event-driven behavior controllers, such as a behavior tree. The behavior controller system can determine, and activate, tasks on the behavior tree that cause the wagering game object to respond to the one or more events. In some embodiments, the behavior controller system can also prioritize tasks that may be performed by behavior trees to prevent conflicts between wagering game objects during a wagering game. | 01-27-2011 |
20110045895 | PRESENTING PRIMARY AND SECONDARY WAGERING GAMES - An apparatus for presenting primary and secondary wagering game content is described herein. In one embodiment, the apparatus includes a primary wagering game unit configured to determine results for a first group of primary wagering games in a first wagering game session. The first wagering game session can be associated with a player identifier. The primary wagering game unit can be further configured to determine results for a second group of primary wagering games in a second wagering game session that is associated with the player identifier. The apparatus can also include a secondary wagering game unit configured to, after certain of the results in the first wagering game session, cause presentation a first episode of a group of episodes, and to, after certain of the results in the second wagering game session, cause presentation a second episode of the group of episodes. | 02-24-2011 |
20110065496 | AUGMENTED REALITY MECHANISM FOR WAGERING GAME SYSTEMS - A wagering game system and its operations are described herein. In some embodiments, the operations can include detecting, at a gaming machine, a fiducial marker in one or more images captured by an image capture device of the gaming machine, determining an orientation of the fiducial marker, and detecting a fiducial code embedded within the fiducial marker. The operations can also include providing, via a network, fiducial code information and fiducial marker orientation information to a wagering game server to identify an augmented reality object associated with the fiducial code and determine attributes of the augmented reality object. The operations can further include receiving, at the gaming machine, wagering game content and the augmented reality object from the wagering game server, incorporating the augmented reality object within the wagering game content, and presenting the wagering game content comprising the augmented reality object on a display device of the gaming machine. | 03-17-2011 |
20110111840 | Methods of Receiving Electronic Wagers in a Wagering Game Via a Handheld Electronic Wager Input Device - A gaming system for conducting a multi-player wagering game includes a multi-touch table surface that is touched by a handheld electronic wager input device (EWID) carried by a player for placing wagers on a wagering game displayed on the multi-touch table surface. Each EWID carried by a player has an associated unique identification code, linked to the respective player's account. Players indicate an amount to be wagered by touching the EWID to designated wager amount areas, then place the wager by touching the EWID to a designated wagering area. Because each EWID is uniquely associable with distinct player accounts, the gaming system can support any number of players placing wagers. The funds remain safe in the player account and no funds are stored on the EWID. Only the identification code is detected, which is compared with the associated player account before allowing that player to place wagers. | 05-12-2011 |
20110207531 | OPTICAL MACHINE-READABLE DATA REPRESENTATION IMAGE - Club cards and tickets can be eliminated by providing an application that allows a player's mobile phone to process an image of an optical machine-readable representation of data. At the end of a wagering session on a WGM, the WGM can display a barcode representing a player's winnings, an achievement, game status, etc. The player takes a picture of the barcode with his or her mobile phone. The application on the phone processes the barcode image and automatically updates an account of the player in accordance with the data represented or carried by the barcode. For instance, the mobile phone sends a request to a wagering account server to electronically deposit the winnings, as represented by the barcode, in a wagering account associated with the player's club profile. | 08-25-2011 |
20110250948 | VIDEO COMPRESSION IN GAMING MACHINES - Based on the characteristics of a reel-spinning video, a video encoder/decoder can rely on image date from a preceding video frame to reconstruct a current area of a current frame of the reel-spinning video. The video encoder can record some indication of the current area (e.g., number of dropped blocks or boundary values of the area). The video encoder can rely on motion information (e.g., a motion vector) of a preceding area within the current frame, or encode motion information with the indication of the current area. The video encoder then transmits the indication of the current area, perhaps with a subsequent area, without image data of the current area. The video decoder can then reconstruct the current area with image data from a matching area in the preceding frame based on the motion information. | 10-13-2011 |
20120329553 | Methods of Receiving Electronic Wagers in a Wagering Game Via a Handheld Electronic Wager Input Device - A gaming system for conducting a multi-player wagering game includes a multi-touch table surface that is touched by a handheld electronic wager input device (EWID) carried by a player for placing wagers on a wagering game displayed on the multi-touch table surface. Each EWID carried by a player has an associated unique identification code, which is linked to the respective player's account. Players indicate an amount to be wagered by touching the EWID to designated wager amount areas, then place the wager by touching the EWID to a designated wagering area. Because each EWID is uniquely associable with distinct player accounts, the gaming system can support any number of players placing wagers. The funds remain safe in the player account and no funds are stored on the EWID. Only the identification code is detected, which is compared with the associated player account before allowing that player to place wagers. | 12-27-2012 |
20130023337 | PLAYER HEAD TRACKING FOR WAGERING GAME CONTROL - A wagering game system and its operations are described herein. In some embodiments, the operations can include presenting a wagering game on a display device of a wagering game machine. The operations can also include detecting head movements and facial gestures of a player of the wagering game via a video capture device of the wagering game machine, and generating player input data based on the head movements and facial gestures of the player. The operations can further include modifying wagering game content based on the player input data associated with the head movements and facial gestures of the player, and presenting results of the wagering game on the display device of the wagering game machine. | 01-24-2013 |
20130130779 | USING CODED IDENTIFIERS FOR ADAPTIVE GAMING - A wagering game system and its operations are described herein. In some embodiments, the operations can include initiating a wagering game session for presentation of wagering game content. The operations can further include scanning a coded identifier during the wagering game session. The coded identifier indicates a characteristic associated with activity, events, achievements, etc. performed or attained prior to initiation of the wagering game session. For instance, the coded identifier can be a two-dimensional barcode generated in response to online activity (e.g., in response to progress attained in an online game). In some embodiments, the characteristics indicate information about the activity. The operations can further include adapting the wagering game content during the wagering game session based, at least in part, on the characteristic indicated in the coded identifier, such as providing gaming rewards and bonus games, adding funds, unlocking content, modifying wagering game content, etc. | 05-23-2013 |
20130196750 | TRANSFERRING AWARDS VIA OPTICAL MACHINE READABLE DATA REPRESENTATION IMAGES - Club cards and tickets can be eliminated by providing an application that allows a player's mobile phone to process an image of an optical machine-readable representation of data. At the end of a wagering session on a WGM, the WGM can display a barcode representing a player's winnings, an achievement, game status, etc. The player takes a picture of the barcode with his or her mobile phone. The application on the phone processes the barcode image and automatically updates an account of the player in accordance with the data represented or carried by the barcode. For instance, the mobile phone sends a request to a wagering account server to electronically deposit the winnings, as represented by the barcode, in a wagering account associated with the player's club profile. | 08-01-2013 |
20140248934 | CONTROLLING EVENT-DRIVEN BEHAVIOR OF WAGERING GAME OBJECTS - A behavior controller system and its operations are described herein. In embodiments, the operations can include detecting one or more events that occur within a wagering game. The wagering game can feature a wagering game object that can automatically (e.g., intelligently) respond to the one or more events. The behavior controller system can use event-driven behavior controllers, such as a behavior tree. The behavior controller system can determine, and activate, tasks on the behavior tree that cause the wagering game object to respond to the one or more events. In some embodiments, the behavior controller system can also prioritize tasks that may be performed by behavior trees to prevent conflicts between wagering game objects during a wagering game. | 09-04-2014 |
20150094136 | TRANSFERRING AWARDS VIA OPTICAL MACHINE READABLE DATA REPRESENTATION IMAGES - Club cards and tickets can be eliminated by providing an application that allows a player's mobile phone to process an image of an optical machine-readable representation of data. At the end of a wagering session on a WGM, the WGM can display a barcode representing a player's winnings, an achievement, game status, etc. The player takes a picture of the barcode with his or her mobile phone. The application on the phone processes the barcode image and automatically updates an account of the player in accordance with the data represented or carried by the barcode. For instance, the mobile phone sends a request to a wagering account server to electronically deposit the winnings, as represented by the barcode, in a wagering account associated with the player's club profile. | 04-02-2015 |
20150126267 | Methods Of Receiving Electronic Wagers In A Wagering Game Via A Handheld Electronic Wager Input Device - A gaming system for conducting a multi-player wagering game includes a multi-touch table surface that is touched by a handheld electronic wager input device (EWID) carried by a player for placing wagers on a wagering game displayed on the multi-touch table surface. Each EWID carried by a player has an associated unique identification code, which is linked to the respective player's account. Players indicate an amount to be wagered by touching the EWID to designated wager amount areas, then place the wager by touching the EWID to a designated wagering area. Because each EWID is uniquely associable with distinct player accounts, the gaming system can support any number of players placing wagers. The funds remain safe in the player account and no funds are stored on the EWID. Only the identification code is detected, which is compared with the associated player account before allowing that player to place wagers. | 05-07-2015 |
20160027253 | METHODS OF RECEIVING ELECTRONIC WAGERS IN A WAGERING GAME VIA A HANDHELD ELECTRONIC WAGER INPUT DEVICE - A gaming system for conducting a multi-player wagering game includes a multi-touch table surface that is touched by a handheld electronic wager input device (EWID) carried by a player for placing wagers on a wagering game displayed on the multi-touch table surface. Each EWID carried by a player has an associated unique identification code, which is linked to the respective player's account. Players indicate an amount to be wagered by touching the EWID to designated wager amount areas, then place the wager by touching the EWID to a designated wagering area. Because each EWID is uniquely associable with distinct player accounts, the gaming system can support any number of players placing wagers. The funds remain safe in the player account and no funds are stored on the EWID. Only the identification code is detected, which is compared with the associated player account before allowing that player to place wagers. | 01-28-2016 |
Patent application number | Description | Published |
20090110679 | Methods and compositions for pulmonary administration of a TNFa inhibitor - The invention describes methods of pulmonary delivery of a TNFα inhibitor to a subject having a disorder in which TNFα is detrimental, such that the disorder is treated. Also included is a method of achieving systemic circulation of a TNFα inhibitor in a subject comprising administering the TNFα inhibitor to the central lung region or the peripheral lung region of the subject via inhalation, such that systemic circulation of the TNFα inhibitor is achieved. | 04-30-2009 |
20100278921 | SOLID ORAL FORMULATION OF ABT-263 - An orally deliverable pharmaceutical composition comprises (a) a pharmaceutically acceptable acid addition salt of ABT-263 in solid particulate form, and (b) a plurality of pharmaceutically acceptable excipients including at least a solid diluent and a solid disintegrant; wherein the salt is formed from more than one equivalent of acid per equivalent of ABT-263. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer. | 11-04-2010 |
20100297194 | FORMULATION FOR ORAL ADMINISTRATION OF APOPTOSIS PROMOTER - An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer. | 11-25-2010 |
20100323020 | STABLE NANOPARTICULATE DRUG SUSPENSION - A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bc1-2 family protein inhibitory compound such as ABT-263, having a D | 12-23-2010 |
20140113921 | FORMULATIONS OF PYRIMIDINEDIONE DERIVATIVE COMPOUNDS - The present disclosure relates to pharmaceutical compositions of pyrimidinedione derivative compounds and methods of preparing and uses thereof. The disclosure also relates to methods of enhancing bioavailability of pyrimidinedione derivative compounds in pharmaceutical compositions administered to a subject and methods of reducing the amount of a pyrimidinedione derivative compound in a pharmaceutical composition while achieving the same bioavailability in a subject. | 04-24-2014 |
20150126545 | COMPOSITIONS CONTAINING KINASE INHIBITORS - A composition comprises a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea, in a mixture comprising (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. The composition is suitable for dilution with an IV solution for administration to a subject in need thereof for treatment of a cancer. | 05-07-2015 |
20150258093 | SOLID ANTIVIRAL DOSAGE FORMS - The present disclosure relates to solid dosage forms comprising antiviral compounds and methods of using such dosage forms to treat antiviral infection. | 09-17-2015 |