Patent application number | Description | Published |
20090246791 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING - Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleic acid synthesis reactions. | 10-01-2009 |
20090325260 | CIS REACTIVE OXYGEN QUENCHERS INTEGRATED INTO LINKERS - The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates. | 12-31-2009 |
20100136592 | Photo-Induced Damage Mitigating Agents and Preparation and Methods of Use Thereof - Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photo-induced damage mitigating agents to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period. | 06-03-2010 |
20100255488 | FRET-LABELED COMPOUNDS AND USES THEREFOR - FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions. | 10-07-2010 |
20120028248 | ENGINEERED FLUORESCENT DYE LABELED NUCLEOTIDE ANALOGS FOR DNA SEQUENCING - Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the nucleotide analogs. Kits, methods and systems are provided for analysis of nucleoc acid synthesis reactions. | 02-02-2012 |
20120058469 | FUNCTIONALIZED CYANINE DYES (PEG) - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 03-08-2012 |
20120058473 | Molecular Adaptors for Dye Conjugates - In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. | 03-08-2012 |
20120058482 | FUNCTIONALIZED CYANINE DYES (PEG) - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 03-08-2012 |
20120077189 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES - The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores comprise trifunctional six membered aromatic moities. The invention also provides for sequencing methods and kits with scaffold-based labeled polymerase enzyme substrates. | 03-29-2012 |
20130071849 | FRET-LABELED COMPOUNDS AND USES THEREFOR - FRET-labeled compounds are provided for use in analytical reactions. In certain embodiments, FRET-labeled nucleotide analogs are used in place of naturally occurring nucleoside triphosphates or other analogs in analytical reactions comprising nucleic acids, for example, template-directed nucleic acid synthesis, DNA sequencing, RNA sequencing, single-base identification, hybridization, binding assays, and other analytical reactions. | 03-21-2013 |
20140005404 | Heteroarylcyanine Dyes | 01-02-2014 |
20140017674 | Methods and Compositions for Performing Analytical Operations - Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc. | 01-16-2014 |
20140038178 | CIS Reactive Oxygen Quenchers Integrated into Linkers - The present invention provides methods and compositions for performing illuminated reactions, particularly sequencing reactions, while mitigating and/or preventing photodamage to reactants that can result from prolonged illumination. In particular, the invention provides methods and compositions for incorporating photoprotective agents into conjugates comprising reporter molecules and nucleoside polyphosphates. | 02-06-2014 |
20140080127 | HETEROARYLCYANINE DYES - The present invention provides heteroaryl functionalized cyanine dyes including a reactive functional moiety, or which are conjugated to a carrier molecule. | 03-20-2014 |
20140093935 | CHARGED TRIPLET-STATE QUENCHERS FOR MITIGATION OF PHOTO-INDUCED DAMAGE - Mitigation of photo-induced damage in excitation illuminated reactions and analyses utilizing such reactions results in an enhanced performance for the reactions and the analyses. There is provided a novel class of triplet-state quenchers for mitigating photo-induced damage which are both simple in structure and effective at preventing and/or reducing photo-induced damage to reaction components of excitation illuminated reaction mixtures. Also provided are methods of using the compounds of the invention, devices and kits incorporating the compounds of the invention. | 04-03-2014 |
20150050659 | PROTECTED FLUORESCENT REAGENT COMPOUNDS - Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. | 02-19-2015 |
20150072894 | CYANINE DYES - The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 03-12-2015 |
20150125854 | METHODS AND COMPOSITIONS FOR PERFORMING ANALYTICAL OPERATIONS - Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc. | 05-07-2015 |
20150197794 | Phospholinked Dye Analogs with an Amino Acid Linker - In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention. | 07-16-2015 |
20150307933 | SCAFFOLD-BASED POLYMERASE ENZYME SUBSTRATES - The invention provides a novel class of scaffold-based labeled polymerase enzyme substrates. The polymerase enzyme substrates have a multivalent core or scaffold to which is attached fluorescent dye moieties and nucleoside phosphate moities. The polymerase enzyme substrates have multiple fluorescent dye moities and/or multiple nucleoside phosphate moieties. Preferred multivalent cores comprise trifunctional six membered aromatic moities. The invention also provides for sequencing methods and kits with scaffold-based labeled polymerase enzyme substrates. | 10-29-2015 |
20150344950 | Functionalized Cyanine Dyes (PEG) - The invention provides a novel class of cyanine dyes that are functionalized with a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates. | 12-03-2015 |
Patent application number | Description | Published |
20140067455 | METHOD AND APPARATUS FOR AUTOMATICALLY MANAGING USER ACTIVITIES USING CONTEXTUAL INFORMATION - An automatic calendar-managing system automatically updates a user's schedule in response to schedule-modifying events. During operation, the system can detect a schedule-modifying event, which can include an event that is likely to require the user to modify a set of scheduled activities. The system then generates a schedule modification, which includes at least one change to the user's set of scheduled activities, to account for the schedule-modifying event. The system can reschedule the user's set of scheduled activities to accommodate the schedule modification. | 03-06-2014 |
20140122383 | METHOD AND SYSTEM FOR PSYCHOLOGICAL ANALYSIS BY FUSING MULTIPLE-VIEW PREDICTIONS - One embodiment of the present invention provides a system for predicting a personality trait. During operation, the system initially obtains personality data associated with users. The system collects sample data associated with the users. Next, the system trains a predictor with the collected sample data and the personality data. Then, the system collects data associated with a particular user, and generates a personality trait score for the particular user by using the predictor to analyze the particular user's collected data. | 05-01-2014 |
20140122501 | METHOD AND SYSTEM FOR BUILDING AN ENTITY PROFILE FROM EMAIL ADDRESS AND NAME INFORMATION - An entity-profiling system obtains an electronic identifier for a target entity, such as an email address at which the target entity can be reached, and parses the electronic identifier to determine a name for the target entity. The system also parses the electronic identifier to determine a domain with which the target entity is associated. The system then obtains one or more Internet web pages associated with the target entity based on the entity's name and the domain, and generates a profile for the target entity based on the obtained Internet web pages. | 05-01-2014 |
20140317030 | METHOD AND APPARATUS FOR CUSTOMIZING CONVERSATION AGENTS BASED ON USER CHARACTERISTICS - A conversation-simulating system facilitates simulating an intelligent conversation with a human user. During operation, the system can receive a user-statement from the user during a simulated conversation, and generates a set of automatic-statements that each responds to the user-statement. The system then determines a set of behavior-characteristics for the user, and computes relevance scores for the automatic-statements based on the behavior-characteristics. Each relevance score indicates an outcome quality that the user is likely to perceive for the automatic-statement as a response to the user-statement. The system selects an automatic-statement that has a highest relevance score from the set of automatic-statements, and provides the selected automatic-statement to the user. | 10-23-2014 |
20140344174 | SYSTEM AND METHOD FOR DETECTING QUITTING INTENTION BASED ON ELECTRONIC-COMMUNICATION DYNAMICS - A quitting-intention estimating system facilitates detecting an entity's intention to quit an organization. During operation, the system obtains recent electronic-communication information associated with the entity under investigation, such as an employee of a corporation, or a volunteer of a non-profit organization. The system can determine the entity's quitting intention by determining a plurality of recent communication features from the electronic-communication information, for example, by using a variety of feature-extracting modules that extract the features from the entity's electronic communications. The system then computes a quitting-intention value for the entity under investigation, using a quitting-intention estimating function that takes the recent communication features as input. The quitting-intention estimating function detects a change in the entity's behavior from previous communication features, and generates a quitting-intention value which indicates a likelihood that the change in the entity's behavior corresponds to an intention to quit the organization. | 11-20-2014 |
20150161670 | SYSTEM AND METHOD FOR ESTIMATING AND CLUSTERING MULTIPLE-DIMENSION CHARACTERISTICS FOR AUCTION-BASED MESSAGE DELIVERY - One embodiment of the present invention provides a system for characteristics-based message delivery. During operation, the system receives activity data associated with a user, and infers a characteristic profile associated with the user based on the received activity data. The system further receives a plurality of messages, estimates the user's preference for the messages based on the inferred characteristic profile and content of the messages, selects a message from the plurality of messages based on the user's preference and a pre-determined bidding price associated with the message and the characteristic profile, and delivers the selected message to the user. | 06-11-2015 |
20150281162 | SYSTEM AND METHOD FOR PRIORITIZING MESSAGES BASED ON SENDERS AND CONTENT FOR DRIVERS - The system facilitates the selective display of messages to a user while the user is driving a vehicle. During operation, the system determines the priority of a message based on one or more of: a sender of the message; whether the message requests a response; a duration of time within which to read the message; and one or more rules. The system precludes the display of one or more messages while the user is driving a vehicle based on the respective priority of the messages. | 10-01-2015 |