Shchepinov, GB
Mikhail Shchepinov, Oxford GB
Patent application number | Description | Published |
---|---|---|
20110065196 | Trityl Derivatives for Enhancing Mass Spectrometry - The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, B | 03-17-2011 |
Mikhail S. Shchepinov, Oxford GB
Patent application number | Description | Published |
---|---|---|
20090131648 | Rigid dendrimeric structures - The present invention provides novel dendrimers having a multimeric structure obtainable by reaction of a core molecule having an adamantoid structure with branching synthons and terminating synthons, said dendrimers immobilised on a support and a method of hybridisation which uses said dendrimers immobilised on a support. | 05-21-2009 |
20110105609 | ALLEVIATING OXIDATIVE STRESS DISORDERS WITH PUFA DERIVATIVES - Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD). | 05-05-2011 |
Mikhail S. Shchepinov, Kingston Upon Thames GB
Patent application number | Description | Published |
---|---|---|
20110082100 | THERAPEUTIC SUBSTANCES THAT MODULATE GENOME METHYLATION - Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics. | 04-07-2011 |
20110082208 | THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE - Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally. | 04-07-2011 |
20140044692 | IMPAIRED ENERGY PROCESSING DISORDERS AND MITOCHONDRIAL DEFICIENCY - Some aspects of the invention provide for a method of treating Impaired Energy Processing Disorders and Mitochondrial Deficiencies using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds. | 02-13-2014 |
20140050712 | DISORDERS IMPLICATING PUFA OXIDATION - Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds. | 02-20-2014 |
20140142059 | THERAPEUTIC SUBSTANCES THAT MODULATE GENOME METHYLATION - Compounds containing nucleic acid bases or their precursors modified by enrichment at specific sites with heavy stable isotopes of elements naturally present at those sites in minute amount are useful for the treatment of diseases characterized by altered gene expression and altered pattern of epigenomic control. These compounds, when used as nutrients or in other medicinal application methods, can alter the DNA methylation pattern in a simple way through the well-understood mechanism of kinetic isotope effect (KIE). This effect could also be useful for modifying methylation kinetics in stem cell technology, cloning and as disease therapeutics. | 05-22-2014 |
20140147428 | NEURODEGENERATIVE DISORDERS AND MUSCLE DISEASES IMPLICATING PUFAS - Some aspects of the invention provide for a method of treating Alzheimer's Disease, Mild Cognitive Impairment, Frontotemperal Dementia, Amyotrophic Lateral Sclerosis and/or Multiple Sclerosis using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds. | 05-29-2014 |
Mikhail Sergeevich Shchepinov, Oxfordshire GB
Patent application number | Description | Published |
---|---|---|
20090029866 | Libraries of oligomers labeled with different tags - A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods. | 01-29-2009 |
20100160248 | ISOTOPICALLY MODIFIED COMPOUNDS AND THEIR USE AS FOOD SUPPLEMENTS - A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is | 06-24-2010 |
Mikhail Sergeevich Shchepinov, Oxford GB
Patent application number | Description | Published |
---|---|---|
20080248584 | Trityl derivatives for enhancing mass spectrometry - Compounds of formula (IIa): | 10-09-2008 |
20090023926 | Trityl Derivatives for Enhancing Mass Spectrometry - The present invention provides a compound of the formula: (IIa); having a reactive functional group M, capable of reacting with a biopolymer, BP, having at least one group capable of reacting with M to form a covalent linkage, to provide a biopolymer derivative of the formula: (IIIa). The biopolymer derivatives of the invention have enhanced ionisability with respect to free 10 biopolymer (Bp) enabling improved analysis of the biopolymer using mass spectrometry. The invention further provides specific examples of compounds formula (IIa), e.g. compounds of formula: (IIa-2 | 01-22-2009 |
Mikhail Sergeevich Shchepinov, Kingston Upon Thames GB
Patent application number | Description | Published |
---|---|---|
20150147457 | ISOTOPICALLY MODIFIED COMPOUNDS AND THEIR USE AS FOOD SUPPLEMENTS - A nutrient composition comprises an essential nutrient in which at least one exchangeable H atom is | 05-28-2015 |