Serafini
Andrea Serafini, Pinerolo (to) IT
Patent application number | Description | Published |
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20120155795 | BEARING HUB UNIT FOR A MOTOR-VEHICLE WHEEL - Bearing-hub unit for a motor-vehicle wheel, having an axis of rotation and provided with a stationary bearing outer ring bounded by a side surface transverse to the axis of rotation; a radially inner rotatable hub; a bearing inner ring fixed onto the hub and defining together with the outer ring a cavity devoid of any sealing device; an encoder arranged inside the cavity and fixed externally on the inner ring; and a protective cover which is made of non-ferromagnetic material and is mounted on the outer ring in axial abutment against the side surface so as to protect the encoder and close the cavity; there being provided a static sealing element which is joined to an outer edge of the protective cover and has a first sealing portion situated between the protective cover and the outer ring. | 06-21-2012 |
20130188896 | BEARING UNIT FOR A VEHICLE WHEEL - Bearing unit having an axis of rotation (A) and provided with a stationary ring and a rotatable ring, these rings being coaxial with each other and axially delimited on one side (L) by respective axial surfaces which are transverse to the axis (A); a magnetic encoder fixed to an outer cylindrical surface of the inner ring; and a protective cover mounted on the outer ring to protect the encoder and to close off a space formed between the two rings, the axial surface of the outer ring and the protective cover jointly delimiting a compartment for housing said encoder, which is positioned substantially outside the space and extends radially from the outer cylindrical surface to a boundary in the proximity of an outer cylindrical surface of the outer ring. | 07-25-2013 |
20140010489 | HUB-BEARING ASSEMBLY WITH SEALING DEVICE - A hub-bearing assembly ( | 01-09-2014 |
20140037239 | HUB BEARING ASSEMBLY WITH A SEALING DEVICE - A hub bearing assembly ( | 02-06-2014 |
20140193107 | BEARING UNIT FOR A VEHICLE WHEEL - A bearing unit having an axis of rotation and provided with a stationary ring and a rotatable ring arranged coaxially with respect to one another, a magnetic encoder fixed onto the inner ring and extending in front of an annular surface of the stationary ring; and a protective cover mounted on the external ring to protect the encoder and close off a space defined between the two rings; an annular channel being formed in the stationary ring and sealing means being arranged between the side wall and the axial lug within the annular channel so as to seal the cover and prevent the infiltration of impurities between the cover and the axial lug. | 07-10-2014 |
20140193108 | BEARING UNIT FOR A VEHICLE WHEEL - A bearing unit for a vehicle wheel is provided having an axis of rotation and a radially outer stationary ring including a tubular axial lug delimited by an outer cylindrical surface, and with a flange transverse to the axis of rotation and axially delimited. A radially inner rotatable ring defines, with the ring, a space. An encoder is fixed to the inner ring and extends outside of the space and in front of the axial lug. A protective cover mounted on the axial lug to protect the encoder and close off the space. The stationary ring includes a shaped annular channel formed across the axial surface and delimited axially by a bottom surface and the side wall with a bent edge arranged axially in abutment against the bottom surface of the annular channel. Sealing means are arranged between the bent edge and the bottom surface to seal the annular channel. | 07-10-2014 |
20140193109 | BEARING UNIT FOR A VEHICLE WHEEL - A bearing unit for a vehicle wheel having a radially outer stationary ring provided with an axial lug, with a flange transverse to an axis of rotation and with an annular channel formed between the axial lug and the flange and delimited axially by a bottom surface. A radially inner rotatable ring defining, together with the stationary ring, a space; an encoder fixed onto the inner ring and extending outside of the space and in front of the axial lug; a protective cover mounted on the axial lug to protect the encoder and close off the space and provided with a side wall mounted on the outer cylindrical surface and having a bent edge arranged axially in abutment against the bottom surface of the annular channel; sealing means disposed between the cylindrical side wall and the tubular axial lug to seal the cylindrical side wall on the outer cylindrical surface. | 07-10-2014 |
20140374996 | Arrangement of a wheel hub connected to a constant velocity joint provided with a low friction seal device - An arrangement including a first and second sealing assembly disposed between an inner ring and an outer ring of the wheel hub and straddling the wheel hub and an outer ring of a constant velocity joint, and an annular step formed on the side of the constant velocity joint on a radially outer lateral surface of the inner ring, in a position adjacent to a sleeve portion of a first shield of the first sealing assembly from a flange portion radially extends so as to protrude towards the outer ring, the flange portion being provided towards the constant velocity joint with a signal generating element ( | 12-25-2014 |
20140376848 | Arrangement of a wheel hub connected to a constant velocity joint provided with a flexible seal device - An arrangement including a portion of a radially outer lateral surface of an inner ring of wheel hub on which an annular step is formed on the side of a constant velocity joint. The step is an L-shaped fold of a sleeve portion of a first shield that is protrudingly mounted, a flange portion of which shield radially extends so as to protrude towards an outer ring of a wheel hub, in front of a flange portion of a second shield; the L-shaped fold defines, with a wing thereof, a tubular element arranged straddling wheel hub and an outer ring of the constant velocity joint, which has a free end supporting an annular seal; an annular signal generating insert completely covers a face of the flange portion where it is provided with a shallow recess defining, together with the L-shaped fold, a thrust shoulder for mounting the first shield. | 12-25-2014 |
20150069825 | ARRANGEMENT OF A WHEEL HUB CONNECTED TO A CONSTANT VELOCITY JOINT PROVIDED WITH A SEAL DEVICE - Arrangement including a portion of a radially outer lateral surface of an inner ring of wheel hub having an annular step formed on a constant velocity joint. The step is adapted to receive a first shield, a flange portion that radially extends to protrude towards an outer ring of a wheel hub, in front of a flange portion of a second shield, from a first end of a sleeve portion of the first shield facing on the side opposite of the constant velocity joint and axially protrudes from the inner ring and towards the joint, defining a tubular element arranged straddling wheel hub and an outer ring of the constant velocity joint, having an opposite second end, supporting an annular seal; an annular signal generating insert covers a face of the flange portion, wherein a radially inner annular part of face defines a thrust shoulder for mounting the first shield. | 03-12-2015 |
20150115696 | WHEEL HUB BEARING UNIT FOR VEHICLES AND ASSOCIATED METHOD - A wheel hub bearing unit including a plurality of rolling bodies disposed between annular elements. One of the annular elements is a rotating element that includes a spindle on a side facing the outboard side of the vehicle having a mounting flange adapted to receive a vehicle wheel. A frontal surface of the mounting flange is covered by a layer of UV photopolimerizable synthetic plastic material having a predetermined thickness deposited on the frontal surface of the flange in the non-polimerized state by a mixed air spraying nozzle, by rotating the wheel hub bearing unit about a symmetry axis thereof with the nozzle arranged at a radial distance from a peripherally outer edge of the flange, and has a spraying axis which forms, with the symmetry axis, an angle from 20° to 80°; the synthetic plastic material being sprayed by the nozzle at a temperature higher than the room temperature. | 04-30-2015 |
20160039246 | ANNULAR SEALING ASSEMBLY, IN PARTICULAR FOR WHEEL HUBS - A sealing assembly comprises a first annular shield presenting an axial sleeve portion for the mounting angularly integral with one of said members, and a flange portion which radially extends from a first end of the sleeve portion, and a sealing member made of elastomeric material presenting an annular root portion, which overhangingly and radially extends from a peripheral edge of the flange portion and a first axially sealing annular lip, as well as a second radially sealing annular lip. The lips extend overhangingly and axially on the opposite side of the first end of the sleeve portion, from a same side as a thinned end of the root portion and are reciprocally and divergingly arranged to form in radial section a V-shape having a vertex facing towards the root portion and an axis parallel to the sleeve portion. | 02-11-2016 |
Andrea Serafini, Pinerolo IT
Patent application number | Description | Published |
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20090108539 | Annular Sealing Assembly, in Particular for Wheel Hubs - A sealing assembly ( | 04-30-2009 |
20100054643 | Bearing assembly with a protective cover for an encoder - A radially outer stationary bearing race ( | 03-04-2010 |
20110088467 | Sensor Mounting Cover for a Rolling-Contact Bearing - A sensor mounting cover is for a rolling-contact bearing and includes a transverse wall and an axial projection joined to the transverse wall and provided with a through-seat for housing a sensor. The sensor faces the bearing from a window defined by an inner edge of the seat and a closure element is associated with the axial projection and is arranged at least around the inner edge so as to close the window. | 04-21-2011 |
20110233874 | Annular Sealing Assembly, in Particular for Wheel Hubs - A sealing assembly ( | 09-29-2011 |
Bradley D. Serafini, Clover, SC US
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20160107355 | APPARATUS FOR INJECTION MOLDING ELONGATED OBJECTS - Injection molding apparatus includes: a mold structure having a main axis and a mold cavity; a core in the mold cavity, defining a mold envelope bounded by an inner sidewall, an inner endwall at one end of the inner sidewall, an outer sidewall spaced apart from the inner sidewall, and an outer endwall spaced apart from the inner endwall; a nozzle at an end of the cavity, including an interior channel communicating with the mold envelope; a pin in the nozzle, moveable between a closed position forming a part of the outer endwall and blocking flow between the interior channel and the mold envelope, and an open position permitting fluid flow; and a locking pin within the core and moveable between a retracted position free of the outer endwall, and an extended position received within the outer endwall, preventing relative lateral movement of the core and the mold cavity. | 04-21-2016 |
Daniel James Serafini, Churubusco, IN US
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20150047550 | RATCHET PLAYPEN COVER FOR A PONTOON BOAT - A playpen cover for a pontoon boat includes a cover panel sized to cover a pontoon boat deck, where the cover panel has loop channel. A ratchet loop is disposed in the loop channel and is attachable at ends of the ratchet loop to respective boat cleats. A ratchet system cooperable with the ratchet loop is disposed between the boat cleats. The ratchet loop attaches to the boat cleat and requires no fastener. | 02-19-2015 |
Elena Serafini, Pavia IT
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20080311635 | PROCESS FOR THE PREPARATION OF (S)(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID - A process for the preparation of (S)(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) of formula (I) or a salt thereof, | 12-18-2008 |
Filippo Serafini, Campogalliano (mo) IT
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20130178969 | MARKING OF PACKAGED CONSUMER PRODUCTS - A Packaging System comprising: a Packaging Line designed to produce Packaged Consumer Products; a Marking System designed to mark individual or packs of Packaged Consumer Products with graphical information, and a Line Controller designed to control the Packaging Line and the Marking System. The Marking System includes: Marking Equipment and a Marking Server. The Marking Server is designed to receive Production Batch Data and associated Template Identifier(s); and a Marking Device Controller. The Line Controller is designed to: receive Production Batch Data and generate Marking Instruction(s) for associated Marking Device Controller(s). The Marking Device Controller is designed to: receive Marking Instruction(s) from the Line Controller, fetch out from a Repository in the Marking Server stored Mark Layout Template(s) and Production Batch Data, and generate Marking Command(s) for Marking Device(s) controlled by the Marking Device Controller based on fetched Mark Layout Template(s) and Production Batch Data. | 07-11-2013 |
Henry P. Serafini, Leominster, MA US
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20150217103 | Arcuate Guide for Intravenous Tubes - An arcuate guide for retaining and guiding an intravenous tube over an angular change of direction. The arcuate guide has an arcuate retention structure with an arcuate channel structure and a plurality of locking members. The arcuate channel structure has an arcuate channel therein for receiving and guiding the intravenous tube over an angular change of direction, and the plurality of locking members are disposed in substantial alignment with the arcuate channel. The arcuate channel can be substantially U-shaped, such as by having a rounded base portion and arcuate first and second legs. The channel can have radiused distal edges. The arcuate channel can be adjustable in angular configuration to permit an adjustment of the angular change of direction of the intravenous tube. The locking members can have opposed legs spaced closer than opposed sidewalls of the arcuate channel. The opposed legs can be resiliently deflectable. | 08-06-2015 |
John Sheldon Serafini, Hingham, MA US
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20150207812 | SYSTEMS AND METHODS FOR IDENTIFYING AND PERFORMING AN ACTION IN RESPONSE TO IDENTIFIED MALICIOUS NETWORK TRAFFIC - Computer-implemented systems, methods, and computer-readable media are provided for causing an action to be performed in response to a network communication, such as a malicious network communication. In accordance with some embodiments, a first network communication sent from a client device is received, and a protocol used in the first network communication is determined. Once the protocol is determined, the protocol may be implemented to enable a second network communication with the client device. An action to be performed based at least in part on the protocol may be identified, and an instruction may be sent to the client device in the second network communication. | 07-23-2015 |
Marco Serafini, Barcelona ES
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20140006503 | SOCIAL NETWORKING FEED DELIVERY SYSTEM AND METHOD | 01-02-2014 |
20140201184 | SEARCH ENGINE AND METHOD FOR PERFORMING A SEARCH FOR OBJECTS THAT CORRESPOND TO A SEARCH REQUEST - A search engine for finding objects that correspond to a search request, including an input module for receiving a keyword query from a user, and a search module being configured to map the keyword query to the identifiers of objects that semantically match the keyword or the plurality of keywords contained in the keyword query, and to generate a search result that contains a listing of matching object identifiers, is characterized in that the search module is further configured to generate the search result by considering network layer information about the user within the process of mapping the keyword query to identifiers of matching objects, wherein the network layer information include sophisticated information the search module receives from a dedicated entity. | 07-17-2014 |
Marco Serafini, Darmstadt DE
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20090285107 | Method and Apparatus for Monitoring a Status of Nodes of a Communication Network - The present invention relates to a method and apparatus for monitoring a status of nodes of a communication network. The method determines first node status data at a first node by diagnosing the own status of the first node and the status of at least one second node, sends the first node status data to at least one second node, receives second node status data from at least one second node, and determines node status evaluation data at the first node based on the determined first node status data and the received second node status data. Furthermore, improvements are proposed for the sake of efficiency and/or robustness of the method. | 11-19-2009 |
20120170464 | Method and Apparatus for Monitoring a Status of Nodes of a Communication Network - The present invention relates to a method and apparatus for monitoring a status of nodes of a communication network. The method determines first node status data at a first node by diagnosing the own status of the first node and the status of at least one second node, sends the first node status data to at least one second node, receives second node status data from at least one second node, and determines node status evaluation data at the first node based on the determined first node status data and the received second node status data. Furthermore, improvements are proposed for the sake of efficiency and/or robustness of the method. | 07-05-2012 |
Marta Serafini, Biassono IT
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20080311084 | Mapc Engraftment in the Hematopoietic System - The present invention relates to MAPCs and progeny derived therefrom to provide lymphohematopoietic cells in a tissue of the lymphohematopoietic system of a subject. | 12-18-2008 |
Massimo Serafini, Podenzano (pc) IT
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20140033982 | GRIPPING DEVICE FOR A MILKING UNIT - A gripping device ( | 02-06-2014 |
Mauro Serafini, Ancarano (te) IT
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20120282366 | MOLD FOR FOOTWEAR BOTTOMS - A mold devised for molding of footwear bottoms, composed of overlapping layers made with expandible reticulable polyolefin material, as well as for molding of other manufactures with monolithic structure composed of overlapping layers of expandible reticulable polyolefin materials. | 11-08-2012 |
Mike Serafini, Homer Glen, IL US
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20130136947 | DRY-IN-PLACE CORROSION-RESISTANT COATING FOR ZINC OR ZINC-ALLOY COATED SUBSTRATES - A process for making a corrosion-resistant metal component. The process having the steps of: combining water, at least one zinc phosphate compound and at least one chromium compound, being chromium (III) or chromium (IV) compounds, to form a first solution; separately combining at least one silicate compound with water to form a second solution; combining the first solution with the second solution such as to form a mixed aqueous solution; optionally combining the mixed aqueous solution with at least one acrylic resin to form a coating mixture; and, applying the coating mixture to a metal substrate having a zinc or zinc-alloy surface to form a coating on the metal substrate, the coating providing chemical resistance for at least 150 hours in accordance with ASTM B117 standards where the zinc or zinc-alloy coating of the metal substrate has a weight of 0.04 oz/ft | 05-30-2013 |
20130302600 | DRY-IN-PLACE CORROSION-RESISTANT COATING FOR ZINC OR ZINC-ALLOY COATED SUBSTRATES - A process for making a corrosion-resistant metal component. The process having the steps of: combining water, at least one zinc phosphate compound and at least one chromium compound, being chromium (III) or chromium (IV) compounds, to form a first solution; separately combining at least one silicate compound with water to form a second solution; combining the first solution with the second solution such as to form a mixed aqueous solution; optionally combining the mixed aqueous solution with at least one acrylic resin to form a coating mixture; and, applying the coating mixture to a metal substrate having a zinc or zinc-alloy surface to form a coating on the metal substrate, the coating providing chemical resistance for at least 150 hours in accordance with ASTM B117 standards where the zinc or zinc-alloy coating of the metal substrate has a weight of 0.04 oz/ft | 11-14-2013 |
20140054518 | DRY-IN-PLACE CORROSION-RESISTANT COATING FOR ZINC OR ZINC-ALLOY COATED SUBSTRATES - A process for making a corrosion-resistant metal component. The process having the steps of: combining water, at least one zinc phosphate compound and at least one chromium compound, being chromium (III) or chromium (IV) compounds, to form a first solution; separately combining at least one silicate compound with water to form a second solution; combining the first solution with the second solution such as to form a mixed aqueous solution; optionally combining the mixed aqueous solution with at least one acrylic resin to form a coating mixture; and, applying the coating mixture to a metal substrate having a zinc or zinc-alloy surface to form a coating on the metal substrate, the coating providing chemical resistance for at least 150 hours in accordance with ASTM B 117 standards where the zinc or zinc-alloy coating of the metal substrate has a weight of 0.04 oz/ft | 02-27-2014 |
20150176135 | DRY-IN-PLACE CORROSION-RESISTANT COATING FOR ZINC OR ZINC-ALLOY COATED SUBSTRATES - A process for making a corrosion-resistant metal component. The process having the steps of: combining water, at least one zinc phosphate forming compound and at least one chromium forming compound, being chromium (III) or chromium (IV) compounds, to form a first solution; separately combining at least one silicate compound with water to form a second solution; combining the first solution with the second solution such as to form a mixed aqueous solution; optionally combining the mixed aqueous solution with at least one acrylic resin to form a coating mixture; and, applying the coating mixture to the zinc or zinc-alloy surface of the metal substrate forming a covalent bond with the zinc or zinc-alloy surface, and the coating providing chemical resistance for at least 150 hours in accordance with ASTM B117 standards where the zinc or zinc-alloy coating of the metal substrate has a weight of 0.04 oz/ft | 06-25-2015 |
Monica Serafini US
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20130212965 | Assemblable Disposable Shuttering For Constructing Modular Formworks For Making Concrete Foundations - Assemblable disposable shuttering, for constructing modular formworks suitable for making foundations, said shuttering substantially configured as the lateral surface of a parallelepiped, having on the lateral faces a plurality of openings suitable toe release, during the filling casting, a part of the cement mixture into the foundation trench. | 08-22-2013 |
20140373481 | Lattice Girder Structure Using Innovative Multiple Joints For Roof Covering Purposes - Roof truss system comprising tie rods, struts, knee rafters, and innovative connection joints to cover buildings, especially suitable for being implemented by plastic materials. | 12-25-2014 |
Monica Serafini, Capraia E Limite IT
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20130140427 | SYSTEM OF DISPOSABLE MOULDS USED TO MAKE-UP MODULAR FORMWORKS TO BUILD-UP CONCRETE WALLS FEATURING COMPLEX SHAPES - System of disposable moulds for the realization of modular formworks to contain and modelize vertical concrete castings, comprising one basic element and a plurality of special elements, such as to let a limited quantity of cement mixture come out, suitable for being spread on the formwork faces to trim it. | 06-06-2013 |
Paolo Serafini, Miami Shores, FL US
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20120093761 | VACCINE COMPOSITIONS AND METHODS OF USE THEREOF - Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, siRNA, RNA or DNA to PAPCs or MHC class II positive cells (e.g. tumor cells). Antigens may be, for example, DNA that results in expression of the gene of interest and induction of a robust and specific immune response to the expressed protein in a subject (e.g., mammal). Antigens may also be immunogenic peptides or polypeptides that are processed and presented. In one embodiment, a nanoparticle -based method to deliver antigens in vivo as described herein includes injection of a vaccine composed of a DNA encoding at least one antigen, or at least one antigenic peptide or polypeptide conjugated to a charged dendrimer (e.g., PADRE-derivatized dendrimer) that is also conjugated to a T helper epitope (e.g., PADRE). Negatively-charged plasmids bind naturally to a positively-charged PADRE-dendrimer, while peptide or polypeptide antigens can be chemically linked to the PADRE-dendrimer if they are not negatively-charged. Alternatively, negatively-charged dendrimers may be used. The compositions, kits, vaccines and methods described herein have both prophylactic and treatment applications, i.e., can be used as a prophylactic to prevent onset of a disease or condition in a subject, as well as to treat a subject having a disease or condition. A vaccine as described herein can be used to mount an immune response against any infectious pathogen or cancer. | 04-19-2012 |
20120129199 | COMPOSITIONS, KITS AND METHODS FOR IN VITRO ANTIGEN PRESENTATION, ASSESSING VACCINE EFFICACY, AND ASSESSING IMMUNOTOXICITY OF BIOLOGICS AND DRUGS - Nanoparticle-based compositions, assays, kits, methods and platforms for delivering an antigen (peptides, proteins) or a nucleic acid encoding an antigen to professional APCs (PAPCs) result in the generation of autologous APCs that present a natural peptide repertoire of the antigen for use in assessing the efficacy of a vaccine (e.g., a cytotoxic T lymphocyte (CTL) response to a particular antigen) or other therapy or intervention (cell-based therapy, adjuvant therapy, etc.). The compositions, kits, assays and methods also can be used for delivering a drug or biologic or portion thereof to APCs for assessing the immunogenicity of drugs and biologics. The composition, kits, assays and methods involve the combined use of MHC targeting, universal DR binding peptides (e.g., PADRE, HA) with charged (e.g., positively-charged) highly branched polymeric dendrimers (e.g., PAMAM and other dendrimers) as vehicles for the targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs, giving rise to a new nanoparticle-based method for assessing the immune response (CTL response) to a vaccination or other therapy or intervention, or for assessing the immunogenicity of a biologic or drug. Targeted delivery of nucleic acids, peptides, biologics, drugs, or polypeptides to APCs for effective expression and processing generates more physiologically relevant target antigens for evaluation of cell-mediated immune responses to vaccination, for example, and provides a low-cost approach for rapid generation of reagents and development of assay systems for more accurate profiling of immunological responses to infection, immunization, and other therapies or interventions. Immunoevaluation kits using targeted nanoparticle-based antigen delivery are described herein. | 05-24-2012 |
20140255433 | PDE5 INHIBITOR COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY - The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject. | 09-11-2014 |
Paolo Serafini, Baltimore, MD US
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20090074796 | Pde5 inhibitor compositions and methods for immunotherapy - The invention features methods and compositions featuring a PDE5 inhibitor for treating or preventing immunological-mediated disease in a subject. | 03-19-2009 |
Piero Serafini, Torino IT
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20150250889 | HEAT-SENSITIVE AMPHIPHILIC POLYURETHANE AND AQUEOUS SOLUTION CAPABLE OF BEING INJECTED BASED ON SUCH MATERIAL - A heat-sensitive sol-gel composition capable of being injected is described, composed of an aqueous solution of at least one amphiphilic polyurethane. | 09-10-2015 |
Robert M. Serafini, Santa Rosa, CA US
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20140210845 | METHOD AND APPARATUS FOR ENERGY DATA VISUALIZATION - A method and system for providing a visualization of energy data. In one embodiment, the method comprises establishing an energy visualization scale for visually depicting energy data in terms of one or more color parameters, where the energy data pertains to a distributed generator (DG); and generating a display image, based on the energy visualization scale, that depicts a plurality of energy data values in a grid layout across two dimensions in time. | 07-31-2014 |
Sergio Serafini, Marseille FR
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20090060145 | POSITIONING ADJUSTMENT OF A MOBILE RADIOLOGY FACILITY - The invention concerns a device for detecting a faulty positioning between a first element and a second element comprising an electromagnetic wave emitting unit designed to be secured to the first element and an electromagnetic wave receiving and processing unit designed to be secured to the second element. The latter unit co-operates with the electromagnetic wave emitting unit to detect a faulty positioning of the first element relative to the second element. When used for a mobile radiology facility, the first element is, for example, an X-ray generator, and second element is, for example, a radiological image sensor. | 03-05-2009 |
Siro Serafini, Vicenza IT
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20090312557 | PROCESS FOR THE PREPARATION OF EPSILON -ALKOXYCARBONYLLYSINES AND THEIR ANALOGUES - A process for the preparation of ω-alkoxycarbonylamino-α-aminoacids and α,ω orthogonally diprotected diaminoacids from α,ω-diaminoacids using 1-alkoxycarbonylbenzotriazoles as protecting agents is disclosed. In an alternative embodiment, carbamoylating agents in the presence of benzotriazoles are used instead of 1-alkoxycarbonylbenzotriazoles. This reaction is preferably applied to the preparation of ε-alkoxycarbonyllysines from lysine. A process for the preparation of t-butoxycarbonylbenzotriazoles and novel complexes of ω-alkoxycarbonylamino-α-aminoacids with benzotriazoles are also disclosed. | 12-17-2009 |
20110166364 | SYNTHESIS OF 3--5-[2-(PHENYLSULFONYL)ETHYL]-1H-INDOLE - The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt. | 07-07-2011 |
Siro Serafini, Alte Di Montecchio Maggiore IT
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20110118460 | PROCESS FOR THE SYNTHESIS OF QUETIAPINE - The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base. | 05-19-2011 |
Sonja Serafini, Urbino IT
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20130101463 | Apparatus and Kit For Encapsulating At Least One Compound For Therapeutic and/or Diagnostic Use in Erythrocytes - A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes; the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit; the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters; the apparatus allows a further concentration of the erythrocytes after they have been treated; the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner. | 04-25-2013 |
Stefano Serafini, Crevalcore IT
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20090288371 | WRAPPING METHOD AND UNIT FOR FOLDING A SHEET OF WRAPPING MATERIAL ABOUT A GROUP OF CIGARETTES - A wrapping method and unit for producing a package containing a group of cigarettes and having a cigarette extraction opening; a sheet of wrapping material, complete with the cigarette extraction opening, is fed into a pocket of a wrapping wheel so that the sheet of wrapping material folds into a U inside the pocket; then the group of cigarettes is fed into the pocket containing the U-folded sheet of wrapping material. | 11-26-2009 |
Tito Serafini, Belmont, CA US
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20100158905 | COMBINATION THERAPY OF ARTHRITIS WITH TRANILAST - Combination therapy is disclosed herein for the treatment an arthritic condition (e.g. rheumatoid arthritis, osteoarthritis or psoriatic arthritis). The therapies disclosed herein comprise administering tranilast or an analogous compound in combination with a pharmaceutical agent, such as a non-steroidal anti-inflammatory drug, a disease-modifying drug, a COX-2 inhibitor, an antibiotic, an analgesic or combination thereof. | 06-24-2010 |
20100160351 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HYPERURICEMIA AND RELATED DISORDERS - Disclosed is a pharmaceutical composition comprising (a) a first therapeutic agent, wherein the first therapeutic agent is a compound of formula II: | 06-24-2010 |
20110136835 | COMBINATION FORMULATIONS OF TRANILAST AND ALLOPURINOL AND METHODS RELATED THERETO - Disclosed is a pharmaceutical composition comprising tranilast or a pharmaceutically acceptable salt thereof and allopurinol or a pharmaceutically acceptable salt thereof, wherein the amount by weight of said allopurinol or pharmaceutically acceptable salt thereof in said composition is greater than the amount by weight of said tranilast or pharmaceutically acceptable salt thereof in said composition. | 06-09-2011 |
Tito A. Serafini, San Mateo, CA US
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20110314565 | Method for Isolating Cell-Type Specific mRNAS - The invention provides methods for isolating cell-type specific mRNAs by selectively isolating ribosomes or proteins that bind mRNA in a cell type specific manner, and, thereby, the mRNA hound to the ribosomes or proteins that bind mRNA. Ribosomes, which are riboprotein complexes, bind mRNA that is being actively translated in cells. According to the methods of the invention, cells are engineered to express a molecularly tagged ribosomal protein or protein that binds mRNA by introducing into the cell a nucleic acid comprising a nucleotide sequence encoding a ribosomal protein or protein that binds mRNA fused to a nucleotide sequence encoding a peptide tag. The tagged ribosome or mRNA binding protein can then be isolated, along with the mRNA bound to the tagged ribosome or mRNA binding protein, and the mRNA isolated and further used for gene expression analysis. The methods of the invention facilitate the analysis and quantification of gene expression in the selected cell type present within a heterogeneous cell mixture, without the need to isolate the cells of that cell type as a preliminary step. | 12-22-2011 |
20140196176 | Method for Isolating Cell-Type Specific mRNAs - The invention provides methods for isolating cell-type specific mRNAs by selectively isolating ribosomes or proteins that bind mRNA in a cell type specific manner, and, thereby, the mRNA hound to the ribosomes or proteins that bind mRNA. Ribosomes, which are riboprotein complexes, bind mRNA that is being actively translated in cells. According to the methods of the invention, cells are engineered to express a molecularly tagged ribosomal protein or protein that binds mRNA by introducing into the cell a nucleic acid comprising a nucleotide sequence encoding a ribosomal protein or protein that binds mRNA fused to a nucleotide sequence encoding a peptide tag. The tagged ribosome or mRNA binding protein can then be isolated, along with the mRNA bound to the tagged ribosome or mRNA binding protein, and the mRNA isolated and further used for gene expression analysis. The methods of the invention facilitate the analysis and quan | 07-10-2014 |
Tito A. Serafini, Belmont, CA US
Patent application number | Description | Published |
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20110250206 | MARKERS FOR DETERMINATION OF PATIENT RESPONSIVENESS - Compositions and methods are provided for prognostic classification of inflammatory diseases, e.g. inflammatory demyelinating disease, patients into subtypes, which subtypes are informative of the patient's need for therapy and responsiveness to a therapy of interest. The patterns of cytokines provides for a signature pattern that can identify patients likely to benefit from therapeutic intervention as well as discriminate patients that have a high probability of responsiveness to a therapy from those that have a low probability of responsiveness. Assessment of this signature pattern thus allows improved methods of care. In one embodiment of the invention, the autoimmune disease is multiple sclerosis or neuromyelitis optica. | 10-13-2011 |