Patent application number | Description | Published |
20080262412 | Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 10-23-2008 |
20090096134 | Process and Apparatus for Forming Medical Device Balloons - Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described. | 04-16-2009 |
20090123517 | MEDICAL DEVICES FOR RELEASING THERAPEUTIC AGENT AND METHODS OF MAKING THE SAME - An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted. | 05-14-2009 |
20090306769 | MEDICAL BALLOON MADE WITH HYBRID POLYMER-CERAMIC MATERIAL AND METHOD OF MAKING AND USING THE SAME - A medical device such as a catheter, stent or balloon, or a component thereof is formed by depositing an inorganic-organic hybrid composite material on an eliminatable shape form and removing the shape form, leaving the medical device or component thereof formed of the inorganic-organic hybrid composite material. Multiple layers of the inorganic-organic hybrid composite material can be used in the formation. A particular structure is an expandable balloon member for a catheter assembly. | 12-10-2009 |
20090318862 | BALLOON CATHETERS AND METHODS FOR MANUFACTURING BALLOONS FOR BALLOON CATHETERS - Catheters, balloons, and methods of manufacturing balloons for balloon catheters using lasers are disclosed. A catheter with a shaft sized for use with a 0.014 inch guide wire includes a polymeric balloon having a body portion with an inflated outer diameter of more than 6 millimeters. An inflatable balloon includes an inflated outer diameter to inner waist diameter ratio of 12.5 to 1. An inflatable polymeric balloon that has a body portion with two regions that have different molecular orientations is also provided. A method of processing an elongate polymeric material includes heating a portion of the polymeric material with a laser while longitudinally stretching the portion of the polymeric material. A method of manufacturing a balloon includes heating and longitudinally stretching a first and second portion of an elongate polymeric tube to form first and second end portion. The remaining body portion is radially expanded to form the balloon. | 12-24-2009 |
20090324679 | MEDICAL COPOLYMERS - According to an aspect of the present invention, medical copolymers are provided which comprise (a) a polymer backbone comprising (i) a plurality of āCāCā groups within the polymer backbone, (ii) a plurality of -R | 12-31-2009 |
20100094213 | HIGH PERFORMANCE BALLOON CATHETER/COMPONENT - Composite fiber reinforced balloons for medical devices prepared by applying a web of fibers to the exterior of a preformed underlying balloon and encasing the web with a matrix material to form a composite balloon. The fiber web is applied to at least the cone portion of the underlying balloon form. Either the cone portion of the underlying balloon form, or the web fibers applied to said cone portion, or both, have a friction-enhancing material coated thereon. | 04-15-2010 |
20100233404 | MEDICAL DEVICE TUBING WITH DISCRETE ORIENTATION REGIONS - Medical device polymeric tubing segments suitable for forming catheter shafts or as balloon parisons are formed with discrete regions having different orientation relative to each other. Wall thickness may also be varied of the length of the segment. | 09-16-2010 |
20100298769 | IMPLANTABLE MEDICAL DEVICES FOR THERAPEUTIC AGENT DELIVERY - Various aspects of the invention relate to implantable medical devices, which comprise a layer of material (e.g., in the form of a sheet, tube, etc.) that comprises a bioerodible polymer and a therapeutic agent. Other aspects of the invention relate to methods of forming such devices. Still other aspects of the invention relate to methods of treatment using such devices. | 11-25-2010 |
20110046539 | INTERNAL MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH A SOURCE OF ELECTRICAL POWER - The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents. | 02-24-2011 |
20110165284 | CATHETER BALLOON MOLD FORM AND MOLDING PROCESS - An immersion mold for a medical device balloon. The mold has a cavity adapted to receive a hollow parison expandable therein to form the balloon. The cavity has a length, a first end, a second end, and a cavity wall with inner and outer surfaces. The mold form cavity wall is provided with one or a plurality of through-holes along the length thereof to facilitate entrance and egress of a heated fluid. | 07-07-2011 |
20110166249 | POLYMERS HAVING LIPOPHILIC HYDROCARBON AND BIODEGRADABLE POLYMERIC SEGMENTS - The present invention pertains, among other things, to polymers having one or more lipophilic hydrocarbon segments and one or more biodegradable polymeric segments, to methods of making such polymers and to products formed using such polymers. | 07-07-2011 |
20110189377 | Coating for Medical Devices Comprising An Inorganic or Ceramic Oxide and a Therapeutic Agent - The invention relates generally to an implantable medical device for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. In particular, the invention pertains to an implantable medical device, such as an intravascular stem, having a coating comprising an inorganic or ceramic oxide, such as titanium oxide, and a therapeutic agent. | 08-04-2011 |
20110196347 | MEDICAL DEVICES EMPLOYING PIEZOELECTRIC MATERIALS FOR DELIVERY OF THERAPEUTIC AGENTS - In one aspect, the present invention provides therapeutic-agent-releasing medical devices which comprise at least one region of piezoelectric material. Therapeutic agent release is initiated or increased when the piezoelectric material is subjected to mechanical stress, which leads to the development of a voltage across the piezoelectric material. This voltage is used to initiate or increase therapeutic agent release. | 08-11-2011 |
20110251653 | IMPLANTABLE ELECTRODES CONTAINING POLYOXOMETALATE ANIONS AND METHODS OF MANUFACTURE AND USE - An implantable device includes at least one electrode comprising a conductive base and polyoxometalate anions disposed on or within the conductive base; and at least one conductor attached to the at least one electrode for conducting electrical energy to the at least one electrode. | 10-13-2011 |
20120013043 | MEDICAL DEVICES AND PROCESSES FOR PREPARING SAME - Medical balloons comprising a predetermined pattern of conductive materials and methods of making the same. | 01-19-2012 |
20120095396 | Drug Eluting Medical Device Utilizing Bioadhesives - A medical balloon having an inner surface and an outer surface comprising a first coating composition comprising at least one therapeutic agent, the first coating composition disposed on the balloon outer surface and forming an interface between the balloon outer surface and the first coating composition and a second coating composition comprising a bioadhesive, the second coating composition disposed on the first coating composition so as to not affect the interface between the balloon outer surface and the first coating composition, the bioadhesive selected so as to adhere to body tissue, and methods of making the same. | 04-19-2012 |
20120150286 | BIOERODIBLE ENDOPROSTHESIS WITH BIOSTABLE INORGANIC LAYERS - Medical devices such as endoprostheses (e.g., stents) containing one or more biostable layers (e.g., biostable inorganic layers) and a biodegradable underlying structure are disclosed. | 06-14-2012 |
20120232582 | VASCULAR CLOSURE PLUG WITH PROXIMAL CAP AND METHODS OF USE - The disclosure pertains to a vascular closure plug having a reinforced proximal end and methods of use therefor. The reinforcement may comprise a proximal force distributing member and a plurality of plug restraining members thereby tending to limit tearing or spreading of at least the proximal end of the vascular closure plug. In some embodiments, the reinforcement may also comprise a distal force distributing member and a plurality of plug restraining members, a circumferential collar, and/or a supplemental force distributing member. | 09-13-2012 |