Patent application number | Description | Published |
20090049563 | USING CYTOSINE DEAMINASES TO DIMINISH RETROELEMENT TRANSFER FROM PIGS TO HUMANS - Transgenic pigs that express one or more non-porcine cytosine deaminases are described as well as methods of making and using such pigs. | 02-19-2009 |
20100105140 | PLAICE DNA TRANSPOSON SYSTEM - This document describes the Passport transposon system and methods of making and using the same. | 04-29-2010 |
20100146655 | METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ANIMALS - Transgenic artiodactyls are described as well as methods of making and using such artiodactyls. | 06-10-2010 |
20100251395 | USING CYTOSINE DEAMINASES TO DIMINISH RETROELEMENT TRANSFER FROM PIGS TO HUMANS - Transgenic pigs that express one or more non-porcine cytosine deaminases are described as well as methods of making and using such pigs. | 09-30-2010 |
20110059160 | METHODS AND COMPOSITIONS FOR TARGETED GENE MODIFICATION - Disclosed herein are methods and compositions for gene targeting utilizing fusion molecules comprising a recombinase domain and a sequence-specific DNA-binding domain. | 03-10-2011 |
20110197290 | METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ARTIODACTYLS - Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials. | 08-11-2011 |
20120220037 | METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ARTIODACTYLS - Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials. | 08-30-2012 |
20120222143 | GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME - Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs for use as progenitor cells to make founder animals. | 08-30-2012 |
20130090522 | METHOD AND MATERIALS FOR PRODUCING A GENETICALLY MODIFIED ANIMAL - Transgenic artiodactyls are described as well as methods of making and using such artiodactyls. | 04-11-2013 |
20130117870 | GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME - Compositions and methods for use of TALENs to make genetically modified livestock or other animals are set forth. Some of the embodiments of the invention provide for making an founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as a TALENs with a preferred truncation. | 05-09-2013 |
20140041066 | PRODUCTION OF FMDV-RESISTANT LIVESTOCK BY ALLELE SUBSTITUTION - A genetically modified livestock animal comprising a genomic modification to an eIF4G gene. Cells, genes, and proteins encompassing a protease-resistant eIF4G protein or gene. | 02-06-2014 |
20140201857 | HORNLESS LIVESTOCK - Compositions and methods for making livestock with a polled allele are presented, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions. | 07-17-2014 |
20140338007 | METHOD AND MATERIALS FOR PRODUCING A GENETICALLY MODIFIED ANIMAL - Transgenic artiodactyls are described as well as methods of making and using such artiodactyls. | 11-13-2014 |
20140351965 | SWINE GENETICALLY MODIFIED WITH SPECIFICITY FOR LDL-R KNOCKOUT - Compositions and methods for swine LDL-R gene knockouts. | 11-27-2014 |
20140359796 | GENETICALLY STERILE ANIMALS - A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis, wherein the disruption of the target gene prevents formation of functional gametes of the animal. Animals that create progeny with donor genetics, and methods of making and using the same. Cells, and methods of making and using the cells, with a genetic modification to disrupt a target gene selectively involved in gametogenesis. | 12-04-2014 |
20150067898 | EFFICIENT NON-MEIOTIC ALLELE INTROGRESSION - Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site. | 03-05-2015 |