Patent application number | Description | Published |
20090005292 | Novel Peptides that Bind to the Erythropoietin Receptor - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 01-01-2009 |
20090048166 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 02-19-2009 |
20090131317 | COMPOUNDS AND PEPTIDES THAT BIND THE TRAIL RECEPTOR - The present invention relates to peptides and compounds that bind to a TRAIL receptor or otherwise act as a TRAIL receptor agonist, as well as methods of treating human diseases using the same. In addition, methods of synthesizing the peptides and compounds described herein are provided by the present invention. | 05-21-2009 |
20090209457 | TREATMENT OF ANTI-ERYTHROPOIETIN ANTIBODY-MEDIATED DISORDERS WITH SYNTHETIC PEPTIDE-BASED EPO RECEPTOR AGONISTS - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat or to prevent anti-erythropoietin (EPO) antibody-mediated disorders such as pure red cell aplasia (PRCA) that are characterized by anti-EPO antibodies. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 08-20-2009 |
20110245176 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 10-06-2011 |
20110282029 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 11-17-2011 |
20120157660 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 06-21-2012 |
20130012685 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 01-10-2013 |
20130130979 | PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 05-23-2013 |
20130244939 | NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR - The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided. | 09-19-2013 |
Patent application number | Description | Published |
20080228169 | OVER-THE-WIRE CATHETER WITH LATERAL ACCESS - An over-the-wire catheter includes a guide wire lumen that is defined by a distal bracket and a proximal bracket. Both brackets are formed as part of the catheter, and the lumen is dimensioned for receiving a guide wire therethrough. Between the distal bracket and the proximal bracket is a lateral aperture that extends along the length of the catheter and provides for selective access to the guide wire during the use and operation of the catheter. | 09-18-2008 |
20090104194 | BI-DIRECTIONAL ANTIBODY FOR TREATMENT OF OCULAR DISORDERS - A system and method for treating ocular disorders are disclosed. Specifically, the system and method administer bi-directional antibodies to treat a retina. Structurally, each bi-directional antibody has a first receptor arm and a second receptor arm. Further, each first receptor arm possesses binding affinity for retinal cells and each second receptor arm possesses binding affinity for melanin. After the antibodies are administered to the retina, the first receptor arms attach to the retinal cells. Thereafter, melanin is delivered to the retina and the second receptor arms are fixed to the melanin. In this manner, melanin is concentrated at the retinal cells. | 04-23-2009 |
20100191222 | MYOCARDIAL INJECTOR WITH SPRING LOADED PROTECTIVE ARRAY - A system is provided for performing injections in the ventricle of a patient. The system includes an injection catheter with a proximal and distal end. Importantly, a flexible array is mounted at the distal end of the injection catheter and is moveable between a protective configuration and a flared configuration. Also, a needle of variable length is mounted on the distal end of the injection catheter and is covered by the flexible array when the array is in its protective configuration. In order to manipulate the flexible array, a locking mechanism is mounted on the proximal end of the injection catheter for engagement with the flexible array. When selectively operated, the locking mechanism moves the array from its protective configuration to the flared configuration, holds the array in its flared configuration for an injection, and subsequently moves the array back to its protective configuration. | 07-29-2010 |
20110054444 | Myocardial Injector with Spring Loaded Protective Array - A system is provided for performing injections in the ventricle of a patient. The system includes an injection catheter with a proximal and distal end. Importantly, a flexible array is mounted at the distal end of the injection catheter and is moveable between a protective configuration and a flared configuration. Also, a needle of variable length is mounted on the distal end of the injection catheter and is covered by the flexible array when the array is in its protective configuration. In order to manipulate the flexible array, a locking mechanism is mounted on the proximal end of the injection catheter for engagement with the flexible array. When selectively operated, the locking mechanism moves the array from its protective configuration to the flared configuration, holds the array in its flared configuration for an injection, and subsequently moves the array back to its protective configuration. | 03-03-2011 |
20110112623 | System and Method for Placing a Coronary Stent at the Ostium of a Blood Vessel - A system and method are provided that use a balloon/stent catheter for placing a stent at the ostium of a blood vessel. Included is a barrier member that is attached to the catheter at a location proximal the balloon. In use, the barrier member is reconfigured, prior to insertion of the balloon/stent portion of the catheter through the ostium. With this reconfiguration, a barrier (array) is established that limits advancement of the catheter into the blood vessel to ensure proper placement of the stent at the ostium. | 05-12-2011 |
20120165785 | Catheter System for a Needle Injector with an Automatic Needle/Barrier Extension - A catheter system includes a positioning catheter for receiving an injection needle into its lumen. The injection needle incorporates a web member mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the web member is biased to transition from a folded configuration, and into a flared configuration. Specifically, this transition occurs when the injection needle is deployed more than a predetermined distance “d” beyond the distal end of the catheter. In its flared configuration, the web member is disk-shaped and is oriented perpendicular to the needle. Thus, it acts as a barrier to limit the depth of insertion of the needle into target tissue of a patient, to a depth less than “d”, and to prevent perforation of the target tissue by the catheter tip. | 06-28-2012 |
20120179105 | Self-Aligning Abutment - A catheter system includes a flexible abutment at its distal end. Functionally, the abutment serves to stabilize and align (orient) the distal portion of the catheter as its distal tip is advanced into contact with a tissue surface. Structurally, the flexible abutment is an arrangement of wires that creates a hollow conical shaped frame having two open ends. One end is affixed to the distal end of the catheter. And, the other is presented as a plurality of separated end points that collectively define an annulus at a distal distance from the catheter's tip. For its operation, the flexible abutment is moved from a folded (tube-shaped) configuration, for travel through the vasculature of a patient, to a flared configuration with end points on the frame extended outwardly from the catheter axis, for contact with the tissue surface. | 07-12-2012 |
20140081207 | Catheter System for a Needle Injector with an Automatic Needle/Barrier Extension - A catheter system includes a positioning catheter for receiving an injection needle into its lumen. The injection needle incorporates a web member mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the web member is biased to transition from a folded configuration, and into a flared configuration. Specifically, this transition occurs when the injection needle is deployed more than a predetermined distance “d” beyond the distal end of the catheter. In its flared configuration, the web member is disk-shaped and is oriented perpendicular to the needle. Thus, it acts as a barrier to limit the depth of insertion of the needle into target tissue of a patient, to a depth less than “d”, and to prevent perforation of the target tissue by the catheter tip. | 03-20-2014 |
20150202381 | INJECTION NEEDLE INSERTION BARRIER - A catheter system includes a positioning catheter for receiving an injection needle into its lumen. Structurally, the injection needle incorporates a plurality of loops that are mounted directly onto its shaft. As the injection needle is moved in a distal direction to exit from the lumen of the catheter, the loops are individually biased to transition from a folded configuration, and into a deployed configuration. In their deployed configurations, the loops create a barrier that is oriented perpendicular to the needle. Thus, the barrier acts to limit the depth of insertion of the needle into target tissue of a patient, to a predetermined depth, and to prevent perforation of the target tissue by the catheter tip. | 07-23-2015 |