Patent application number | Description | Published |
20110071305 | PRODUCTION OF 5-MEMBERED AND 6-MEMBERED CYCLIC ESTERS OF POLYOLS - Described herein are improved methods for the preparation of 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols by reaction with an organic acid RCOOH over a solid acidic substrate. The process is adaptable to a continuous process for simultaneously making and separating the cyclic esters from the sugar alcohols and anhydrosugar alcohols under mild conditions using the solid acid substrate as both the catalyst and a chromatographic bed for separation. The reactions are performed at mild temperatures of 700 C to 1000 C and the formation of the cyclic esters is nearly quantitative. Also described is a method for making 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols using microwave irradiation in the presence of the organic acid. | 03-24-2011 |
20120261618 | REDUCTION OF HMF ETHERS WITH METAL CATALYST - Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus with alkoxymethyl ether or ester moieties on the 5′ carbon and methanol on the 2′ carbon. Suitable metal catalyst include Raney nickel, a nickel catalyst with a zirconium promoter, a chromite catalyst with a barium, a palladium catalyst, such as palladium on carbon, or a ruthenium catalyst. Also provided are a new class of compounds, which are n-alkoxy hexane diols (i.e., 1,2 or 1,5 hexane diol ethers) and methods of making the same by reduction of furan or tetrahydrofuran deivatives. | 10-18-2012 |
20130296584 | Production of 5-Membered and 6-Membered Cyclic Esters of Polyols - Described herein are improved methods for the preparation of 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols by reaction with an organic acid RCOOH over a solid acidic substrate. The process is adaptable to a continuous process for simultaneously making and separating the cyclic esters from the sugar alcohols and anhydrosugar alcohols under mild conditions using the solid acid substrate as both the catalyst and a chromatographic bed for separation. The reactions are performed at mild temperatures of 70° C. to 100° C. and the formation of the cyclic esters is nearly quantitative. Also described is a method for making 5- and 6-membered cyclic mono and diesters of sugar alcohols and anhydrosugar alcohols using microwave irradiation in the presence of the organic acid. | 11-07-2013 |
20130303791 | PREPARATION OF AMINOMETHYL FURANS AND ALKOXYMETHYL FURAN DERIVATIVES FROM CARBOHYDRATES - Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H | 11-14-2013 |
20140148605 | PREPARATION OF AMINOMETHYL FURANS AND ALKOXYMETHYL FURAN DERIVATIVES FROM CARBOHYDRATES - Described herein are single step methods of making various classes of alkylamine derivatives of furan and tetrahydrofuran by simultaneous contact of a sugar with H | 05-29-2014 |
20140200299 | REDUCTION OF HMF ETHERS WITH METAL CATALYST - Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus with alkoxymethyl ether or ester moieties on the 5″ carbon and methanol on the 2′ carbon. Suitable metal catalyst include Raney nickel, a nickel catalyst with a zirconium promoter, a chromite catalyst with a barium, a palladium catalyst, such as palladium on carbon, or a ruthenium catalyst. Also provided are a new class of compounds, which are n-alkoxy hexane diols (i.e., 1,2 or 1,5 hexane diol ethers) and methods of making the same by reduction of furan or tetrahydrofuran derivatives. | 07-17-2014 |
20140239230 | REDUCTION OF HMF ETHERS WITH METAL CATALYST - Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus with alkoxymethyl ether or ester moieties on the 5′ carbon and methanol on the 2′ carbon. Suitable metal catalyst include Raney nickel, a nickel catalyst with a zirconium promoter, a chromite catalyst with a barium, a palladium catalyst, such as palladium on carbon, or a ruthenium catalyst. Also provided are a new class of compounds, which are n-alkoxy hexane diols (i.e., 1,2 or 1,5 hexane diol ethers) and methods of making the same by reduction of furan or tetrahydrofuran derivatives. | 08-28-2014 |
20140315262 | PROCESS FOR MAKING HMF AND HMF DERIVATIVES FROM SUGARS, WITH RECOVERY OF UNREACTED SUGARS SUITABLE FOR DIRECT FERMENTATION TO ETHANOL - Hydroxymethylfurfural is made from an aqueous hexose sugar solution, especially from a high fructose corn syrup product. By rapidly heating the sugar solution to the elevated temperatures involved as well as rapidly cooling the resultant product mixture, a limited per-pass conversion to HMF is obtained; correspondingly, however, the overall exposure of the HMF that is formed to acidic, elevated temperature conditions is also limited, so that byproducts are reduced. Separation and recovery of the products is simplified, and levels of HMF and other hexose dehydration products known to inhibit ethanol production by fermentation are reduced in the residual sugars product, to an extent whereby the residual sugars product is suited to be directly fermented to ethanol or for other uses. | 10-23-2014 |
20140316159 | PROCESS FOR MAKING LEVULINIC ACID - A process is described wherein a feed of a six-carbon carbohydrate-containing material or of a furanic dehydration product from a six-carbon carbohydrate-containing material or of a combination of these is supplied to a reactor in a controlled manner over time up to a desired combined or total feed level, and the feed is acid-hydrolyzed to produce levulinic acid. In certain embodiments, derivatives of the levulinic acid are prepared. | 10-23-2014 |
20150126599 | PROCESS FOR PRODUCING ISOHEXIDES - A process is described for producing an isohexide wherein an hexitol or a combination of hexitols is continuously dehydrated in the presence of an acid catalyst under vacuum using a thin film evaporator. | 05-07-2015 |
20150140616 | PROCESS FOR MAKING FURFURAL - Processes are described for producing furfural from a mixture of pentoses and hexoses, by dehydrating and cyclizing pentoses to provide furfural using a water-soluble acid at elevated temperatures in the presence of a low-boiling, water-immiscible organic solvent, such as toluene, which is effective for extracting the furfural into an organic phase portion. In certain embodiments, a fermentation step occurs prior to the dehydration step to convert hexoses in the mixed pentoses and hexoses to ethanol while conserving pentoses therein for making furfural. | 05-21-2015 |
20150246865 | PROCESS FOR MAKING LEVULINIC ACID - A process is described wherein a feed of a six-carbon carbohydrate-containing material or of a furanic dehydration product from a six-carbon carbohydrate-containing material or of a combination of these is supplied to a reactor in a controlled manner over time, and the feed is acid-hydrolyzed to produce levulinic acid. In certain embodiments, derivatives of the levulinic acid are prepared. | 09-03-2015 |
20160052902 | CATALYTIC SYNTHESIS OF REDUCED FURAN DERIVATIVES - The present invention relates to catalytic synthesis of furan derivatives from alkoxymethylfurfural ethers or acyloxymethylfurfural esters. More particularly, the invention pertains to furan derivatives obtained by use of a multifunctional catalyst system to carry out both hydrogenation of furan starting material and hydrolysis of the reduced furan derivative in a single reaction. The process allows recovering and recycling of alcohol or acid from the reaction product. | 02-25-2016 |
Patent application number | Description | Published |
20090030215 | METHOD FOR PRODUCTION OF 5-HYDROXYMETHYL-2-FURFURAL FROM FRUCTOSE - A method of producing HMF by mixing or agitating an aqueous solution of fructose and inorganic acid catalyst with a water immiscible organic solvent to form an emulsion of the aqueous and organic phases. The mixture is heated in a flow-through reactor at elevated pressures and then separated into aqueous and organic phases to obtain HMF. The aqueous phase and the organic phase are mixed with an in-line mixer prior to, preferably, immediately before addition of the biphasic reaction mixture into the reactor. After separation, HMF is recovered from the aqueous and organic phases to obtain high yields of HMF without the presence of insoluble solid impurities. | 01-29-2009 |
20090156841 | CONVERSION OF CARBOHYDRATES TO HYDROXYMETHYLFURFURAL (HMF) AND DERIVATIVES - A method of producing substantially pure HMF, HMF esters and other derivatives from a carbohydrate source by contacting the carbohydrate source with a solid phase catalyst. A carbohydrate starting material is heated in a solvent in a column and continuously flowed through a solid phase catalyst in the presence of an organic acid, or heated with the organic acid and a solid catalyst in solution to form a HMF ester. Heating without organic acid forms HMF. The resulting product is purified by filtration to remove the unreacted starting materials and catalyst. The HMF ester or a mixture of HMF and HMF ester may then be oxidized to 2,5-furandicarboxylic acid (FDCA) by combining the HMF ester with an organic acid, cobalt acetate, manganese acetate and sodium bromide under pressure. Alternatively, the HMF ester may be reduced to form a furan or tetrahydrofuran diol. | 06-18-2009 |
20090253920 | METHOD FOR PREPARATION OF ANHYDROSUGAR ETHERS - A method for alkylation of an anhydrosugar compound in which a dialkyl carbonate is reacted with an anhydrosugar compound in the presence of a solid phase basic catalyst. A typical anhydrosugar compound is anhydrosugar alcohol, a dianhydromonoether and mixtures thereof. The reaction step uses zeolyte as the solid phase basic catalyst. The zeolite catalyst is typically a zeolite having ammonium groups. The reaction is carried out at a temperature below 240° C. and the reaction time is 2 hours or less. | 10-08-2009 |
20090281338 | PROCESSES FOR THE PREPARATION AND PURIFICATION OF HYDROXYMETHYLFURALDEHYDE DERIVATIVES - A method for utilizing an industrially convenient fructose source for a dehydration reaction converting a carbohydrate to a furan derivative is provided. Recovery methods also are provided. Embodiments of the methods improve upon the known methods of producing furan derivatives. | 11-12-2009 |
20110137052 | Processes for the Preparation and Purification of Hydroxymethylfuraldehyde and Derivatives - A method for utilizing an industrially convenient fructose source for a dehydration reaction converting a carbohydrate to a furan derivative is provided. Recovery methods also are provided. Embodiments of the methods improve upon the known methods of producing furan derivatives. | 06-09-2011 |
20120059178 | OXIDATION OF FURFURAL COMPOUNDS - The disclosure pertains to a process for oxidation of furan aldehydes such as 5-hydroxymethyl)furfural (HMF) and derivatives thereof such as 5-(alkoxymethyl)furfural (AMF), 5-(aryloxymethyl)furfural, 5-(cycloalkoxy-methyl)furfural and 5-(alkoxycarbonyl)furfural compounds in the presence of dissolved oxygen and a Co(II), Mn(II), Ce(III) salt catalyst or mixtures thereof. The products from HMF can be selectively chosen to be predominantly 2,5-diformylfuran (DFF), particularly by inclusion of an aliphatic ketone, like methyl ethyl ketone, or can be further oxidized to 2,5-furandicarboxylic acid (FDCA) by the omission of methyl ethyl ketone and inclusion of bromide. When the reactant is an ether derivative of HMF the products are surprisingly ester derivatives where either both the ether and aldehyde functional groups have been oxidized or just the ether function group thereby producing one or both of 5-ester-furan-2-acids (i.e., 5-alkoxycarbonylfurancarboxylic acids) or 5-ester-furan aldehydes, (i.e., -alkoxycarbonylfurfurals a. k. a, 5-(alkoxycarbonyl)furfural). | 03-08-2012 |
20130123520 | MICROWAVE ASSISTED SYNTHESIS OF DEHYDRATED SUGAR DERIVATIVES HYDROXYMETHYLFURFURAL, LEVULINIC ACID, ANHYDROSUGAR ALCOHOLS, AND ETHERS THEREOF - Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less. | 05-16-2013 |
20150284354 | MICROWAVE ASSISTED SYNTHESIS OF DEHYDRATED SUGAR DERIVATIVES HYDROXYMETHYLFURFURAL, LEVULINIC ACID, ANHYDROSUGAR ALCOHOLS, AND ETHERS THEREOF - Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less. | 10-08-2015 |
Patent application number | Description | Published |
20110060739 | SYSTEM AND METHOD TO RESEARCH DOCUMENTS IN ONLINE LIBRARIES - A method and system for storing and searching digital documents, such as digital catalogs, are described. The method in one embodiment comprises inputting digital documents, extracting content from the digital documents, and storing the extracted content in a database so that the content is searchable. The method can include generating a hierarchy of unique database and CMS objects from document covers and pages plus meta data. The method can further include receiving a search query from a user and, in response, identifying content extracted from one of the digital documents and stored in the database, which satisfies the query. The method can further include causing a result set to be output to the user, where the result set includes the identified content which satisfies the search query and an image of a particular page of the digital document from which the identified content was extracted. | 03-10-2011 |
20130191375 | SYSTEM AND METHOD TO RESEARCH DOCUMENTS IN ONLINE LIBRARIES - A method and system for storing and searching digital documents, such as digital catalogs, are described. The method in one embodiment comprises inputting digital documents, extracting content from the digital documents, and storing the extracted content in a database so that the content is searchable. The method can include generating a hierarchy of unique database and CMS objects from document covers and pages plus meta data. The method can further include receiving a search query from a user and, in response, identifying content extracted from one of the digital documents and stored in the database, which satisfies the query. The method can further include causing a result set to be output to the user, where the result set includes the identified content which satisfies the search query and an image of a particular page of the digital document from which the identified content was extracted. | 07-25-2013 |
Patent application number | Description | Published |
20120059670 | Bambam: parallel comparative analysis of high-throughput sequencing data - The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis. | 03-08-2012 |
20120066001 | Bambam: Parallel comparative analysis of high-throughput sequencing data - A differential sequence object is constructed on the basis of alignment of sub-strings via incremental synchronization of sequence strings using known positions of the sub-strings relative to a reference genome sequence. An output file is then generated that comprises only relevant changes with respect to the reference genome. | 03-15-2012 |
20140249847 | Healthcare Object Recognition Systems And Methods - Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated. | 09-04-2014 |
20140350130 | MDM2-Containing Double Minute Chromosomes And Methods Therefore - Contemplated systems and methods allow for computational genomic analysis using paired-end sequence analysis and split read refinement to thereby identify high-confidence breakpoints associated with high copy numbers and orientation of rearrangements, which is then the basis for full reconstruction of double minutes (DM). In especially preferred aspects, the DM will also include an oncogene or tumor suppressor gene, and/or may be found in blood or blood derived fluids. | 11-27-2014 |
20140368550 | Distributed System Providing Dynamic Indexing And Visualization Of Genomic Data - Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object. | 12-18-2014 |
20150088432 | SYSTEMS, METHODS, AND COMPOSITIONS FOR VIRAL-ASSOCIATED TUMORS - Contemplated systems and methods employ chimeric reference sequences that include a plurality of viral genome sequences to identify/quantify integration and co-amplification events. Most typically, the viral genome sequences are organized in the chimeric reference sequences as single chromosomes and the chimeric reference sequences are in BAM format. | 03-26-2015 |
20150134662 | Systems And Methods For Transmission And Pre-Processing Of Sequencing Data - “Omic” digital data transport systems and methods are disclosed. The disclosed systems and methods employ a transport server that assembles a transport group larger numbers of omic output files on the basis of machine specific annotation from one or more sequencing devices and user input related to one or more attributes for the omic output files. | 05-14-2015 |
20150261912 | SYSTEMS AND METHODS FOR TUMOR CLONALITY ANALYSIS - Systems and methods of genomic analysis are presented that provide a framework to determine a tumor's clonality, the number and proportion of all major clones, and the variants that distinguish them. Contemplated systems and methods also allow phasing mutations to parental alleles to so time their emergence within the population of tumor cells, and provide an accurate estimate of the amount of contaminating normal tissue that was present in the tumor biopsy. | 09-17-2015 |
20150278435 | Systems and Methods For RNA Analysis In Functional Confirmation Of Cancer Mutations - Contemplated systems and methods integrate genomic/exomic data with transcriptomic data by correlating a cancer associated mutation in the genome/exome with the transcription level of the affected gene carrying the mutation, particularly where the mutation is a 3-terminal nonsense mutation. | 10-01-2015 |
20150310228 | SECURED MOBILE GENOME BROWSING DEVICES AND METHODS THEREFOR - A secured mobile genome browsing device is disclosed. The device can store genome data in a webapp format within an isolated, secured container in memory. The device further comprises a genome browser module that identifies relevant genome data and renders the relevant genome data, including drug interacting information, on a display of the device according to genome browsing constraints. | 10-29-2015 |
20160026752 | Systems And Methods For Comprehensive Analysis Of Molecular Profiles Across Multiple Tumor And Germline Exomes - Omics patient data are analyzed using sequences or diff objects of tumor and matched normal tissue to identify patient and disease specific mutations, using transcriptomic data to identify expression levels of the mutated genes, and pathway analysis based on the so obtained omic data to identify specific pathway characteristics for the diseased tissue. Most notably, many different tumors have shared pathway characteristics, and identification of a pathway characteristic of a tumor may thus indicate effective treatment options ordinarily not considered when tumor analysis is based on anatomical tumor type only. | 01-28-2016 |
20160070855 | Systems And Methods For Determination Of Provenance - Systems and methods for genomic analysis are contemplated in which idiosyncratic markers or marker constellations are employed to characterize and compare genomic sequences. In especially preferred aspects, the idiosyncratic markers are predetermined SNPs and a marker profile is used in a sample record to so allow cross reference to other marker profiles of other sequences. | 03-10-2016 |
Patent application number | Description | Published |
20100133281 | STORAGE CONTAINER WITH A COLLAPSIBLE BELLOWS UNIT - A storage container having a collapsible unit and a twist cap is described. The collapsible unit is a type of bellows which includes a base and a sidewall attached to the base. The sidewall has a spiral fold that traverses along a portion of the length of that the collapsible unit. The length can be compressed by folding the collapsible unit along the spiral fold. As the length of the collapsible unit is reduced, access to any remaining products, such as acne pad products, stored at the bottom of the collapsible unit can be more conveniently obtained. The cap of the storage container includes a ring collar; a sleeve attached to the ring collar; and a guide attached to the sleeve. When the cap is turned or twisted the guide and the spiral fold are configured to slidably engage each other which results in shortening the length of the collapsible unit. | 06-03-2010 |
20110031261 | MEDICATION DISPENSING SYSTEM AND METHOD OF USING SAME - A medication dispensing system and method of using same is presented. The medication dispensing system includes a base, a cap and pills. The base has plurality of concave niches for housing the pills. The cap is rotatably attached to the base in which the cap has a dispensing orifice for dispensing the pills. The medication dispensing system may also have a packaging unit containing a pill box composed of the base, cap and pills. The method of using the medication dispensing system includes the steps of obtaining, opening, inserting, removing, retrieving, turning, and rotating. | 02-10-2011 |
20140131350 | STORAGE CONTAINER WITH A COLLAPSIBLE BELLOWS UNIT - A storage container having a collapsible unit and a twist cap is described. The collapsible unit is a type of bellows which includes a base and a sidewall attached to the base. The sidewall has a spiral fold that traverses along a portion of the length of that the collapsible unit. The length can be compressed by folding the collapsible unit along the spiral fold. As the length of the collapsible unit is reduced, access to any remaining products, such as acne pad products, stored at the bottom of the collapsible unit can be more conveniently obtained. The cap of the storage container includes a ring collar; a sleeve attached to the ring collar; and a guide attached to the sleeve. When the cap is turned or twisted the guide and the spiral fold are configured to slideably engage each other which results in shortening the length of the collapsible unit. | 05-15-2014 |
Patent application number | Description | Published |
20080306952 | SYSTEM AND METHOD FOR GROUPING CLAIM RECORDS ASSOCIATED WITH A PROCEDURE - A system and computer-implemented method for grouping medical records implements a multi-level analysis of the records. The level of analysis for each record is determined based upon the time proximity of each record to the defining medical procedure or service (anchor procedure) to be analyzed. Once an anchor procedure is identified, claim records are processed to determine whether any of the records should be grouped with the anchor procedure into a procedure episode group (PEG). First, the date of service for each claim record is identified to determine whether the claim record falls within time window. The claim records falling within the window then are assessed to determine whether each claim record is sufficiently related to the anchor procedure (for example, by determining whether the diagnostic, procedure, or episode treatment group coding of each claim record is associated with the anchor procedure). The requisite level of relationship between the claim records and the anchor procedure depends upon the position of the records within the time window. Only those claim records having the requisite relationship level associated with the portion of the time window in which they fall are included in the PEG. | 12-11-2008 |
20110010368 | SYSTEM AND METHOD FOR GROUPING CLAIM RECORDS ASSOCIATED WITH A PROCEDURE - A system and computer-implemented method for grouping medical records implements a multi-level analysis of the records. The level of analysis for each record is determined based upon the time proximity of each record to the defining medical procedure or service (anchor procedure) to be analyzed. Once an anchor procedure is identified, claim records are processed to determine whether any of the records should be grouped with the anchor procedure into a procedure episode group (PEG). First, the date of service for each claim record is identified to determine whether the claim record falls within time window. The claim records falling within the window then are assessed to determine whether each claim record is sufficiently related to the anchor procedure (for example, by determining whether the diagnostic, procedure, or episode treatment group coding of each claim record is associated with the anchor procedure). The requisite level of relationship between the claim records and the anchor procedure depends upon the position of the records within the time window. Only those claim records having the requisite relationship level associated with the portion of the time window in which they fall are included in the PEG. | 01-13-2011 |
20130035960 | SYSTEM AND METHOD FOR GROUPING CLAIM RECORDS ASSOCIATED WITH A PROCEDURE - A system and computer-implemented method for grouping medical records implements a multi-level analysis of the records. The level of analysis for ach record is determined based upon the time proximity of each record to the defining medical procedure or service (anchor procedure) to be analyzed. Claim records are processed to determine whether any of the records should be grouped with the anchor procedure into a procedure episode group (PEG) using the date of service for each claim record and a level of relationship between the claim records and the anchor procedure. The requisite level of relationship between the claim records and the anchor procedure depends upon the position of the records within the time window. Claim records having the requisite relationship level associated with the portion of the time window in which they fall are included in the PEG. | 02-07-2013 |
20140089012 | System and Method for Grouping Claim Records Associated with a Procedure - A system and computer-implemented method for grouping medical records implements a multi-level analysis of the records. The level of analysis for each record is determined based upon the time proximity of each record to the defining medical procedure or service (anchor procedure) to be analyzed. Once an anchor procedure is identified, claim records are processed to determine whether any of the records should be grouped with the anchor procedure into a procedure episode group (PEG). First, the date of service for each claim record is identified to determine whether the claim record falls within time window. The claim records falling within the window then are assessed to determine whether each claim record is sufficiently related to the anchor procedure (for example, by determining whether the diagnostic, procedure, or episode treatment group coding of each claim record is associated with the anchor procedure). The requisite level of relationship between the claim records and the anchor procedure depends upon the position of the records within the time window. Only those claim records having the requisite relationship level associated with the portion of the time window in which they fall are included in the PEG. | 03-27-2014 |
Patent application number | Description | Published |
20130104595 | SYSTEMS AND METHODS FOR TREATING CARBON DIOXIDE | 05-02-2013 |
20130306322 | SYSTEM AND PROCESS FOR EXTRACTING OIL AND GAS BY HYDRAULIC FRACTURING - A fracturing system is described. The system includes an electric motor-driven pumping sub-system, configured to pump a pressurized fracturing fluid into at least one wellbore, under high pressure conditions sufficient to increase the downhole pressure of the wellbore, to exceed that of the fracture gradient of the solid matter surrounding the wellbore. The system also includes an electric power generation sub-system that provides energy to the pumping sub-system. The electric power generation sub-system includes a multitude of electric motors that are powered by a single electrical feed source. A related process for extracting hydrocarbons from a reservoir rock formation by the fracturing operation is also described. | 11-21-2013 |
20140151049 | APPARATUS AND METHOD OF DELIVERING A FLUID USING DIRECT PROPPANT INJECTION - An apparatus and method for delivering a fluid mixture using direct injection to a mixing apparatus. The apparatus including a proppant storage vessel configured to contain therein a proppant material and output a proppant output flow at ambient pressure to a solid feed pump assembly. The apparatus further including a fracturing fluid storage vessel configured to contain therein a fracturing fluid and output a fracturing fluid output flow at a fracture fluid blending pressure. The solid feed pump assembly configured to output to a mixing apparatus, a proppant output flow at the fracture fluid blending pressure. The mixing apparatus configured to output a fluid mixture of the proppant and the fracturing fluid at the fracture fluid blending pressure. The mixing apparatus coupled to a high pressure pump assembly and configured to deliver the fluid mixture therein to a downstream component at an injection pressure. | 06-05-2014 |
20140151051 | CO2 FRACTURING SYSTEM AND METHOD OF USE - An apparatus and method for delivering a thickened fluid mixture, including a CO | 06-05-2014 |
20140318792 | SYSTEM AND METHOD FOR ENHANCED RECOVERY OF OIL FROM AN OIL FIELD - An oil recovery system and method is disclosed. The system includes a solar power tower for receiving a first portion of water from a water treatment device. The solar power tower heats the first portion of water directly using solar radiation and generates a first steam. Further, the system includes a boiler for receiving a second portion of water from the water treatment device. The boiler heats the second portion of water and generates a second steam. Further, the system includes a flow control device coupled to the solar power tower and the boiler to receive at least one of the first steam and the second steam. The flow control device injects at least one of the first steam and the second steam to an oil field. | 10-30-2014 |
20150204166 | APPARATUS AND METHOD OF PREPARING AND DELIVERING A FLUID MIXTURE USING DIRECT PROPPANT INJECTION - An apparatus and method for preparing and delivering a fluid mixture. The apparatus including a high pressure differential solids feeder assembly and a pressurized mixing apparatus. The feeder assembly is coupled to a proppant storage vessel at ambient pressure and receives a continuous unpressurized proppant output flow from the proppant storage vessel. The feeder assembly is configured to output a continuous pressurized proppant output flow of sufficient mass to achieve continuous operation of the apparatus in an uninterrupted episode for an individual fracture stage. The pressurized mixing apparatus is coupled to the feeder assembly and in fluidic communication with the continuous pressurized proppant output flow and a continuous pressurized fracturing fluid flow. The pressurized mixing apparatus is configured to output a continuous flow of a pressurized fluid mixture of a sufficient volume and mass to achieve continuous operation of the apparatus in an uninterrupted episode for the individual fracture stage. | 07-23-2015 |
20150211512 | SYSTEM AND METHOD FOR DRIVING MULTIPLE PUMPS ELECTRICALLY WITH A SINGLE PRIME MOVER - A converterless motor-driven pump system includes an off-grid prime mover. The prime mover includes a rotational driveshaft that operates in response to a throttle or fuel input controller to control a rotation speed of the prime mover driveshaft. Operation of the throttle or fuel input controller is based on desired output characteristics of a pumping load. One or more electric power generators are driven by the off-grid prime mover to generate AC or DC power on an electrical bus shared by a plurality of variable speed electric motors. A plurality of pumps is connected to a common manifold shared by the plurality of pumps. The plurality of pumps is driven by the plurality of variable speed electric motors to generate a desired wellhead pressure or pumping load flow rate via the shared common manifold. | 07-30-2015 |
20150345258 | MODULAR ASSEMBLY FOR PROCESSING A FLOWBACK COMPOSITION STREAM AND METHODS OF PROCESSING THE SAME - A method for processing a flowback composition stream from a well head is provided. The flowback composition stream has a first flow rate and a first pressure. Method also includes controlling the first flow rate to a second flow rate by regulating the flowback composition stream to a second pressure. The method also includes separating the flowback composition stream into a first gas stream and a condensed stream The method includes discharging the condensed stream to a degasser and degassing a carbon dioxide rich gas from the condensed stream. The method also includes mixing the carbon dioxide rich gas stream with the first gas stream to produce a second gas stream. The method includes controlling the third flow rate of the second gas stream by regulating the third pressure of the second gas stream to a fourth pressure that is different than the third pressure. | 12-03-2015 |
Patent application number | Description | Published |
20120029317 | Methods For Validating Patient Identity - This disclosure describes systems and methods for monitoring a patient on a ventilator-oximeter system. The disclosure describes a novel approach determining if the oximeter and the ventilator are attached to the same patient and if not providing a warning. | 02-02-2012 |
20120071729 | Medical Ventilator With Integrated Oximeter Data - This disclosure describes systems and methods for managing the ventilation of a patient being ventilated by a medical ventilator. The disclosure describes a novel approach of displaying ventilator information integrated with oximeter information. The disclosure further describes a novel approach of alarming based on the integration of ventilator information with oximeter information. | 03-22-2012 |
20120136222 | Methods And Systems For Monitoring A Ventilator Patient With A Capnograph - This disclosure describes systems and methods for monitoring the ventilation of a patient being ventilated by a medical ventilator. The disclosure describes a novel approach of displaying integrated ventilator information with capnography data. The disclosure further describes a novel approach for removing cardiogenic artifacts. | 05-31-2012 |
20120272962 | METHODS AND SYSTEMS FOR MANAGING A VENTILATOR PATIENT WITH A CAPNOMETER - This disclosure describes systems and methods for managing the ventilation of a patient being ventilated by a medical ventilator. The disclosure describes a novel approach of displaying integrated ventilator information with capnometer data. The disclosure further describes a novel approach for determining if the ventilator breathing circuit is occluded or disconnected. | 11-01-2012 |
20130345532 | MEDICAL VENTILATOR WITH INTEGRATED OXIMETER DATA - This disclosure describes systems and methods for managing the ventilation of a patient being ventilated by a medical ventilator. The disclosure describes a novel approach of displaying ventilator information integrated with oximeter information. The disclosure further describes a novel approach of alarming based on the integration of ventilator information with oximeter information. | 12-26-2013 |
20140323874 | SYSTEMS AND METHODS FOR DETERMINING FLUID RESPONSIVENESS - Provided are systems and methods for processing a physiological signal in order to determine fluid responsiveness of a subject. In some embodiments, a respiration rate of the subject is received or determined, the signal is filtered based on the respiration rate to generate a filtered signal, and the filtered signal is processed to determine fluid responsiveness. In some embodiments, regular respiration is detected and fluid responsiveness is determined when regular respiration is detected. In some embodiments, the respiration of a subject is controlled, and fluid responsiveness is determined during controlled respiration. | 10-30-2014 |
20150013674 | SYSTEM AND METHOD FOR MONITORING AND REPORTING STATUS OF A VENTILATED PATIENT - The present disclosure provides a method of issuing an alert for optimizing interaction between a patient and a ventilatory system. The method includes ventilating a patient using a ventilatory system and retrieving one or more of current ventilatory settings, collected ventilatory data, and patient data. The method also includes detecting corruption of interaction between a patient and the ventilatory system, determining one or more root causes of the corruption, and determining and displaying a recommendation for resolving the corruption based on the one or more root causes. | 01-15-2015 |
20150019237 | HOLISTIC PATIENT ADVISORY SYSTEM, METHOD, AND SOFTWARE - A method for computer assisted holistic patient monitoring includes receiving patient parameters from at least one medical device monitoring a patient, receiving historical patient data from a database, receiving clinician-generated data from a remote device, generating advisory feedback based on the received patient parameters, the received historical data, and the received clinician-generated data, and outputting the advisory feedback for review by a clinician. The method may further include the step of receiving a clinician response to the advisory feedback and storing the clinician response in the database. Additionally, the advisory feedback may be delivered to a second remote device operated by a supervising clinician. In embodiments, the advisory feedback may include a differential analysis and modeling of a patient state, a request for additional examination, a status report on disease progress or disease improvements, and/or a status report indicating treatment incompatibilities and patient deteriorating conditions. | 01-15-2015 |
20150019256 | PATIENT STATUS UPDATE PORTAL - A patient communication system includes a patient communication device, a facility update device, a server, and a portal. The patient communication device is in the bedside environment of a patient within the medical facility. The patient uses the patient communication device to post statuses and send messages to individuals outside of the medical facility to the server. The facility update device provides updates to the server from clinicians and medical devices in the bedside environment of the patient. The server compiles the information from the patient communication device and from the facility update device and automatically posts the status updates to a portal associated with the patient. The portal is accessed by the individuals associated with the patient to receive updates concerning the status of the patient. | 01-15-2015 |
20150019257 | SYSTEM AND METHOD FOR PREDICTIVE CARE MANAGEMENT - Systems and methods for notifying clinicians of potential patient care risk scenarios and identifying remedial protocols to mitigate the risk. Patient data is downloaded from medical devices associated with the patient, such as, without limitation, a ventilator, bedside monitor, infusion pump, and/or dialysis machine. In addition physician medical orders and treatment notes are received. The patient data, medical orders, and treatment notes are analyzed by a state machine programmed to identify patient risk scenarios based upon known risk factors. Alerts and recommended courses of treatment are generated to enable caregivers to recognize high risk scenarios and to take preventative steps to reduce or avoid suboptimal outcomes. A plurality of state machines may be instantiated, enabling the system to monitor an arbitrary number of patients and treatment protocols. | 01-15-2015 |
20150034082 | OXYGENATION-VENTILATION METHODS AND SYSTEMS - The systems and methods include providing oxygenation-ventilation of a patient being monitored or treated with a medical system. The novel systems and methods may be configured to be able to simultaneously treat and/or monitor a patient with both a ventilator and an ECGE system. The novel systems and methods may monitor the patient and/or manage the treatment of a patient with a ventilator-ECGE system. | 02-05-2015 |
20150045687 | DETECTION OF EXPIRATORY AIRFLOW LIMITATION IN VENTILATED PATIENT - This disclosure describes systems and methods for monitoring and evaluating data associated with ventilatory parameters to detect expiratory airflow limitation in a ventilated patient. For example, a ventilator may monitor flow and/or pressure during ventilation of the patient. Based on the flow and/or pressure measurements, or ventilatory data derived therefrom, the ventilator may calculate expiratory resistance. Moreover, the ventilator may trend expiratory resistance over time to produce an expiratory resistance waveform. In embodiments, the ventilator may calculate the slope of the expiratory resistance waveform during an initial part of exhalation. If the slope of the expiratory resistance waveform during the initial part of exhalation breaches a defined slope threshold, the ventilator may determine that the patient exhibits expiratory airflow limitation. | 02-12-2015 |
Patent application number | Description | Published |
20110041850 | Method For Ventilation - The disclosure describes a method for automatically initiating ventilation, controlling ventilation, transitioning a ventilator to subject controlled ventilation, and weaning a subject from ventilation. The disclosure describes that the method for automatically initiating ventilation includes inputting a physical characteristic of the subject into a ventilator. The physical characteristic may be ideal body weight, height, or age. Based on the inputted physical characteristic, one or more ventilation parameters are calculated. The disclosure describes initiating ventilation based on the calculated parameters. During ventilation at least one physiological parameter of the subject is monitored. At least one ventilation parameter may be adjusted based on the monitoring of the physiological parameters and the inputted physical characteristic. | 02-24-2011 |
20110126832 | Exhalation Valve Assembly - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap. | 06-02-2011 |
20110126834 | Exhalation Valve Assembly With Integral Flow Sensor - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap. | 06-02-2011 |
20110126835 | Exhalation Valve Assembly With Integrated Filter And Flow Sensor - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap. | 06-02-2011 |
20110126836 | Exhalation Valve Assembly With Selectable Contagious/Non-Contagious Latch - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap. | 06-02-2011 |
20110126837 | Exhalation Valve Assembly With Integrated Filter - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap. | 06-02-2011 |
20110138315 | Quick Initiation Of Respiratory Support Via A Ventilator User Interface - This disclosure describes improved systems and methods for efficiently configuring respiratory settings and/or parameters in a ventilatory system. Specifically, the present methods and user interface provide an efficient and consistent means for configuring ventilatory settings for a new patient. Specifically, the ventilator may be preconfigured with appropriate parameter settings based on an institution-specific protocol, a physician-specific protocol, or other suitable protocol or specification. Indeed, the present disclosure provides an institution and/or physician with increased control over routine ventilatory settings by pre-configuring the ventilator with these routine settings. Further, the present disclosure provides increased assurance as to the consistency of the routine ventilatory settings by eliminating repeated data entry by clinicians, decreasing the chances of error. | 06-09-2011 |
20110230780 | WORK OF BREATHING DISPLAY FOR A VENTILATION SYSTEM - A breathing support system is provided. The system may include a breathing support device configured to deliver gas to a patient and a display device associated with the breathing support device. The display device may be configured to display a graphic indicating one or more measures regarding the patient's work of breathing. | 09-22-2011 |
20110249006 | VENTILATOR BREATH DISPLAY AND GRAPHIC INTERFACE - The invention is directed to a ventilation control system for controlling the ventilation of a patient. The ventilation control system utilizes a user-friendly user interface for the display of patient data and ventilator status. The user interface includes a graphic representation of a breath cycle that displays the breath cycle currently being ventilated, and is also responsive to changes in ventilation settings to assist the user in evaluation the effect of those changes on the ventilator strategy before the changes are implemented. | 10-13-2011 |
20120277616 | WORK OF BREATHING DISPLAY FOR A VENTILATION SYSTEM - A breathing support system is provided. The system may include a breathing support device configured to deliver gas to a patient and a display device associated with the breathing support device. The display device may he configured to display a work of breathing graphic indicating one or more work of breathing measures regarding the patient's breathing. | 11-01-2012 |
20120279501 | VENTILATOR BREATH DISPLAY AND GRAPHIC USER INTERFACE - The invention is directed to a ventilation control system for controlling the ventilation of a patient. The ventilation control system utilizes a user-friendly user interface for the display of patient data and ventilator status. The user interface includes a graphic representation of a breath cycle that displays the breath cycle currently being ventilated, and is also responsive to changes in ventilation settings to assist the user in evaluation the effect of those changes on the ventilator strategy before the changes are implemented. | 11-08-2012 |
20130233319 | EXHALATION VALVE ASSEMBLY WITH INTEGRAL FLOW SENSOR - An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled as to the environment. Other components may also be incorporated into the assembly Including a filter module, a flow meter and a condensate trap. | 09-12-2013 |
20130333703 | VENTILATOR BREATH DISPLAY AND GRAPHIC USER INTERFACE - The invention is directed to a ventilation control system for controlling the ventilation of a patient. The ventilation control system utilizes a user-friendly user interface for the display of patient data and ventilator status. The user interface includes a graphic representation of a breath cycle that displays the breath cycle currently being ventilated, and is also responsive to changes in ventilation settings to assist the user in evaluation the effect of those changes on the ventilator strategy before the changes are implemented. | 12-19-2013 |
20140290657 | METHOD FOR VENTILATION - The disclosure describes a method for automatically initiating ventilation, controlling ventilation, transitioning a ventilator to subject controlled ventilation, and weaning a subject from ventilation. The disclosure describes that the method for automatically initiating ventilation includes inputting a physical characteristic of the subject into a ventilator. The physical characteristic may be ideal body weight, height, or age. Based on the inputted physical characteristic, one or more ventilation parameters are calculated. The disclosure describes initiating ventilation based on the calculated parameters. During ventilation at least one physiological parameter of the subject is monitored. At least one ventilation parameter may be adjusted based on the monitoring of the physiological parameters and the inputted physical characteristic. | 10-02-2014 |
Patent application number | Description | Published |
20090069566 | LEAD-FREE PRIMARY EXPLOSIVE COMPOSITION AND METHOD OF PREPARATION - Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. | 03-12-2009 |
20110108172 | LEAD-FREE PRIMARY EXPLOSIVE COMPOSITION AND METHOD OF PREPARATION - Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. | 05-12-2011 |
20120077983 | LEAD-FREE PRIMARY EXPLOSIVE COMPOSITION - Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. | 03-29-2012 |
20130204005 | LEAD-FREE PRIMARY EXPLOSIVE COMPOSITION - Embodiments of the present subject matter provide a compound and material that may be used as a lead-free primary explosive. An embodiment of the present subject matter provides the compound copper(I) nitrotetrazolate. Certain embodiments of the present subject matter provide methods for preparing lead-free primary explosives. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. Certain embodiments of the present subject matter also provide methods for preparing copper(I) nitrotetrazolate. The method includes: providing cuprous salt; providing water; providing 5-nitrotetrazolate salt; combining the cuprous salt, water and 5-nitrotetrazolate salt to form a mixture; and heating the mixture. The method may also include providing cuprous chloride and providing sodium 5-nitrotetrazolate. | 08-08-2013 |